Naturally occurring mutations to HCV protease inhibitors in treatment-naïve patients.

abstract：BACKGROUND:The incidence of dengue, an infectious disease caused by dengue virus (DENV), has dramatically increased around the world in recent decades and is becoming a severe public health threat. However, there is currently no specific treatment for dengue fever, and licensed vaccine against dengue is not available. ...

journal_title：Virology journal

authors： Zhang S,Liang M,Gu W,Li C,Miao F,Wang X,Jin C,Zhang L,Zhang F,Zhang Q,Jiang L,Li M,Li D

更新日期：2011-06-30 00:00:00

abstract：BACKGROUND:Public health risks associated to infection by human coronaviruses remain considerable and vaccination is a key option for preventing the resurgence of severe acute respiratory syndrome coronavirus (SARS-CoV). We have previously reported that antibodies elicited by a SARS-CoV vaccine candidate based on recom...

journal_title：Virology journal

authors： Yip MS,Leung NH,Cheung CY,Li PH,Lee HH,Daëron M,Peiris JS,Bruzzone R,Jaume M

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Avian influenza virus (AIV) is classified into two pathotypes, low pathogenic (LP) and high pathogenic (HP), based on virulence in chickens.Differences in pathogenicity between HPAIV and LPAIV might eventually be related to specific characteristics of strains, tissue tropism and host responses. METHODS:To s...

journal_title：Virology journal

authors： Post J,Burt DW,Cornelissen JB,Broks V,van Zoelen D,Peeters B,Rebel JM

更新日期：2012-03-06 00:00:00

abstract：BACKGROUND:Sequence and structural elements in the 3'-untranslated region (UTR) of Japanese encephalitis virus (JEV) are known to regulate translation and replication. We previously reported an abundant accumulation of small subgenomic flaviviral RNA (sfRNA) which is collinear with the highly conserved regions of the 3...

journal_title：Virology journal

authors： Fan YH,Nadar M,Chen CC,Weng CC,Lin YT,Chang RY

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:hyaluronic acid (HA), a non-sulphated glycosaminoglycan, is present in synovial fluid, vitreous humour serum and many connective tissues. Pharmaceutical preparations of HA are used in clinical practice for wound healing, joint pain, kerato-conjunctivitis, asthma, mouth care, oesophageal-reflux, and gastritis...

journal_title：Virology journal

authors： Cermelli C,Cuoghi A,Scuri M,Bettua C,Neglia RG,Ardizzoni A,Blasi E,Iannitti T,Palmieri B

更新日期：2011-03-25 00:00:00

abstract：:The suitability of V4 vaccine coated on cracked local grain (maize) and its husks and used for oral vaccination of chickens was assessed. Seventy-two (72) birds aged three (3) weeks and above were divided into six groups of twelve (12) birds per group. The birds were bled to determine their prevaccination HI antibody ...

journal_title：Virology journal

authors： Olabode AO,Ndako JA,Echeonwu GO,Nwankiti OO,Chukwuedo AA

更新日期：2010-03-23 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeutics to protect against CHIKV infection in humans. Animal models recapitulating human disease, especi...

journal_title：Virology journal

authors： Cirimotich CM,Vela EM,Garver J,Barnewall RE,Miller BD,Meister GT,Rogers JV

更新日期：2017-07-20 00:00:00

abstract：BACKGROUND:Chronic hepatitis C virus (HCV) genotype (GT) 3 infection with advanced liver disease has emerged as a challenging to treat by direct-acting antivirals (DAAs), but the efficacy of DAAs in Chinese HCV-GT3 patients is rarely reported. This study aimed to analyze the efficacy of sofosbuvir (SOF)-based regimens ...

journal_title：Virology journal

authors： Tao YC,Deng R,Wang ML,Lv DD,Yuan M,Wang YH,Chen EQ,Tang H

更新日期：2018-10-01 00:00:00

abstract：:The Filoviridae family comprises of Ebola and Marburg viruses, which are known to cause lethal hemorrhagic fever. However, there is no effective anti-viral therapy or licensed vaccines currently available for these human pathogens. The envelope glycoprotein (GP) of Ebola virus, which mediates entry into target cells, ...

journal_title：Virology journal

authors： Bhattacharyya S,Hope TJ

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Echovirus 6 (E6) infections are associated with aseptic meningitis and acute flaccid paralysis (AFP). But some infections, sometimes most of them, are asymptomatic. The mechanism of E6 virulence is unknown. Analyses of the molecular evolution of asymptomatic E6 may help understand why the infections show dif...

journal_title：Virology journal

authors： Sun H,Huang X,Lin K,Huang K,Chu J,Yang Z,Ma S

更新日期：2017-07-25 00:00:00

abstract：BACKGROUND:The VP2 outer capsid protein Bluetongue Virus (BTV) is responsible for receptor binding, haemagglutination and eliciting host-specific immunity. However, the assembly of this outer capsid protein on the transcriptionally active viral core would block transcription of the virus. Thus assembly of the outer cap...

journal_title：Virology journal

authors： Bhattacharya B,Noad RJ,Roy P

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:Human pegivirus-1 (HPgV-1) is a member of the Flaviviridae family whose genomic organization and mode of cellular entry is similar to that of hepatitis C virus (HCV). The E2 glycoprotein of HPgV-1 is the principle mediator in the virus-cell interaction and as such harbors most of HPgV-1's antigenic determina...

journal_title：Virology journal

authors： Vitrenko Y,Kostenko I,Kulebyakina K,Sorochynska K

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:Influenza A virus infects not only humans, but also other species including avian and swine. If a novel influenza A subtype acquires the ability to spread between humans efficiently, it could cause the next pandemic. Therefore it is necessary to understand the evolutionary processes of influenza A viruses in...

journal_title：Virology journal

authors： Furuse Y,Suzuki A,Kamigaki T,Oshitani H

更新日期：2009-05-29 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is a major human pathogen and member of the Flavivirus genus. Previous studies have identified neutralizing antibodies from Zika patients that bind to quaternary epitopes across neighboring envelope (E) proteins, called E dimer epitopes (EDE). An asparagine-linked glycan on the "glycan loop...

journal_title：Virology journal

authors： Henderson EA,Tam CC,Cheng LW,Ngono AE,Nguyen AV,Shresta S,McGee M,Padgett H,Grill LK,Martchenko Shilman M

更新日期：2020-03-31 00:00:00

abstract：BACKGROUND:Uukuniemi virus (UUKV) belongs to the Phlebovirus genus in the family Bunyaviridae. As a non-pathogenic virus for humans UUKV has served as a safe model bunyavirus in a number of studies addressing fundamental questions such as organization and regulation of viral genes, genome replication, structure and ass...

journal_title：Virology journal

authors： Katz A,Freiberg AN,Backström V,Schulz AR,Mateos A,Holm L,Pettersson RF,Vaheri A,Flick R,Plyusnin A

更新日期：2010-08-10 00:00:00

abstract：BACKGROUND:The genetic element s2m seems to represent one of very few examples of mobile genetic elements in viruses. The function remains obscure and a scattered taxonomical distribution has been reported by numerous groups. METHODS:We have searched GenBank in order to identify all viral accessions that have s2m(-lik...

journal_title：Virology journal

authors： Tengs T,Kristoffersen AB,Bachvaroff TR,Jonassen CM

更新日期：2013-04-25 00:00:00

abstract：:The original version of the acknowledgement unfortunately contained a mistake. ...

journal_title：Virology journal

authors： Signer J,Jonsdottir HR,Albrich WC,Strasser M,Züst R,Ryter S,Ackermann-Gäumann R,Lenz N,Siegrist D,Suter A,Schoop R,Engler OB

更新日期：2020-11-09 00:00:00

abstract：:In September 2012, a novel coronavirus was isolated from a patient in Saudi Arabia who had died of an acute respiratory illness and renal failure. The clinical presentation was reminiscent of the outbreak caused by the SARS-coronavirus (SARS-CoV) exactly ten years ago that resulted in over 8000 cases. Sequence analysi...

journal_title：Virology journal

authors： Khan G

更新日期：2013-02-28 00:00:00

abstract：BACKGROUND:A novel reassortant H7N9 influenza A virus has crossed the species barrier from poultry to cause human infections in China in 2013 and 2014. Rapid detection of the novel H7N9 virus is important to detect this virus in poultry and reduce the risk of an epidemic in birds or humans. FINDINGS:In this study, a m...

journal_title：Virology journal

authors： Xu X,Bao H,Ma Y,Sun J,Zhao Y,Wang Y,Shi J,Zeng X,Li Y,Wang X,Chen H

更新日期：2015-04-30 00:00:00

abstract：BACKGROUND:Genome-wide RNAi screening has been widely used to identify host proteins involved in replication and infection of different viruses, and numerous host factors are implicated in the replication cycles of these viruses, demonstrating the power of this approach. However, discrepancies on target identification ...

journal_title：Virology journal

authors： Cheng H,Koning K,O'Hearn A,Wang M,Rumschlag-Booms E,Varhegyi E,Rong L

更新日期：2015-11-24 00:00:00

abstract：BACKGROUND:To construct a recombinant adenovirus containing CDglyTK double suicide genes and evaluate the killing effect of the double suicide genes driven by kinase domain insert containing receptor (KDR) promoter on human umbilical vein endothelial cells. METHODS:Human KDR promoter, Escherichia coli (E. coli) cytosi...

journal_title：Virology journal

authors： Jia W,Mei L,Wang Y,Liu L,Che G

更新日期：2011-02-21 00:00:00

abstract：BACKGROUND:The major obstacle to cure of HIV type-1 infection is the presence of the HIV reservoir, hidden from the immune system and insensitive to combined antiretroviral therapy (cART). Eradication approaches have been hindered by the difficulty for accurately monitoring its size in vivo, especially in the lymphoid ...

journal_title：Virology journal

authors： Rochat MA,Schlaepfer E,Kuster SP,Li D,Audige A,Ivic S,Fahrny A,Speck RF

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:Influenza virus continues to cause significant hospitalization rates in infants and young children. A 2-dose regime of trivalent inactivated vaccine is required to generate protective levels of hemagglutination inhibiting (HAI) antibodies. A vaccine preparation with enhanced immunogenicity is therefore desir...

journal_title：Virology journal

authors： Harris K,Ream R,Gao J,Eichelberger MC

更新日期：2011-05-21 00:00:00

abstract：BACKGROUND:With the clinical development of several antiviral intervention strategies for influenza, it becomes crucial to explore viral load shedding in the nasal cavity as a biomarker for treatment success, but also to explore sampling strategies for sensible and reliable virus collection. FINDINGS:In this study, 24...

journal_title：Virology journal

authors： Van Wesenbeeck L,Meeuws H,D'Haese D,Ispas G,Houspie L,Van Ranst M,Stuyver LJ

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:Production of cassava (Manihot esculenta Crantz), a food security crop in sub-Saharan Africa, is threatened by the spread of cassava brown streak disease (CBSD) which manifests in part as a corky necrosis in the storage root. It is caused by either of two virus species, Cassava brown streak virus (CBSV) and ...

journal_title：Virology journal

authors： Kaweesi T,Kawuki R,Kyaligonza V,Baguma Y,Tusiime G,Ferguson ME

更新日期：2014-12-20 00:00:00

abstract：BACKGROUND:Mumps virus (MuV) is a highly infectious paramyxovirus closely related to measles virus (MeV). Despite the availability of a mumps vaccine, outbreaks continue to occur and no treatment options are available. Vitamin A and other naturally occurring retinoids inhibit the replication of MeV in vitro. METHODS:A...

journal_title：Virology journal

authors： Soye KJ,Trottier C,Di Lenardo TZ,Restori KH,Reichman L,Miller WH Jr,Ward BJ

更新日期：2013-11-14 00:00:00

abstract：BACKGROUND:Host serine proteases are essential for the influenza virus life cycle because the viral haemagglutinin is synthesized as a precursor which requires proteolytic maturation. Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effec...

journal_title：Virology journal

authors： Bahgat MM,Błazejewska P,Schughart K

更新日期：2011-01-20 00:00:00

abstract：:Bats have been recognized as the natural reservoirs of a large variety of viruses. Special attention has been paid to bat coronaviruses as the two emerging coronaviruses which have caused unexpected human disease outbreaks in the 21st century, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Re...

journal_title：Virology journal

authors： Hu B,Ge X,Wang LF,Shi Z

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Classical swine fever virus (CSFV) is the member of the genus Pestivirus under the family Flaviviridae. The 5' untranslated region (UTR) of CSFV contains the IRES, which is a highly structured element that recruits the translation machinery. The 3' UTR is usually the recognition site of the viral replicase t...

journal_title：Virology journal

authors： Nadar M,Chan MY,Huang SW,Huang CC,Tseng JT,Tsai CH

更新日期：2011-07-06 00:00:00

abstract：:Earlier, we detected viral RNAs packaged in the porcine adenovirus (PAdV) -3 virions. Using Southern blot analysis, we further demonstrated that the viral RNAs were predominantly packaged in CsCl purified mature capsids (containing viral genome) than empty/intermediate capsids. Some of the packaged viral RNAs appear t...

journal_title：Virology journal

authors： Xing L,Tikoo SK

更新日期：2009-02-05 00:00:00