Abstract:
BACKGROUND:Production of cassava (Manihot esculenta Crantz), a food security crop in sub-Saharan Africa, is threatened by the spread of cassava brown streak disease (CBSD) which manifests in part as a corky necrosis in the storage root. It is caused by either of two virus species, Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV), resulting in up to 100% yield loss in susceptible varieties. METHODS:This study characterized the response of 11 cassava varieties according to CBSD symptom expression and relative CBSV and UCBSV load in a field trial in Uganda. Relative viral load was measured using quantitative RT-PCR using COX as an internal housekeeping gene. RESULTS:A complex situation was revealed with indications of different resistance mechanisms that restrict virus accumulation and symptom expression. Four response categories were defined. Symptom expression was not always positively correlated with virus load. Substantially different levels of the virus species were found in many genotypes suggesting either resistance to one virus species or the other, or some form of interaction, antagonism or competition between virus species. CONCLUSIONS:A substantial amount of research still needs to be undertaken to fully understand the mechanism and genetic bases of resistance. This information will be useful in informing breeding strategies and restricting virus spread.
journal_name
Virol Jjournal_title
Virology journalauthors
Kaweesi T,Kawuki R,Kyaligonza V,Baguma Y,Tusiime G,Ferguson MEdoi
10.1186/s12985-014-0216-xsubject
Has Abstractpub_date
2014-12-20 00:00:00pages
216issn
1743-422Xpii
s12985-014-0216-xjournal_volume
11pub_type
杂志文章相关文献
Virology Journal文献大全abstract:BACKGROUND:Evaluation of the primary etiologic agents that cause aseptic meningitis outbreaks may provide valuable information regarding the prevention and management of aseptic meningitis. An outbreak of aseptic meningitis occurred from May to June, 2012, in Guangdong Province, China. In order to determine the etiolog...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-263
更新日期:2013-08-23 00:00:00
abstract:BACKGROUND:Acute gastroenteritis caused by bacteria, virus and parasite is an important cause of childhood morbidity and mortality in developing countries. Rotavirus and norovirus have been recognized as the most common pathogens causing acute gastroenteritis among children. However, there is still no valuable data abo...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-302
更新日期:2013-10-08 00:00:00
abstract:BACKGROUND:There are over 100 known human adenovirus (HAdV) types, which are able to cause a broad variety of different self-limiting but also lethal diseases especially in immunocompromised patients. Only limited information about the pathogenesis and biology of the majority of these virus types is available. In the p...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-020-01318-w
更新日期:2020-04-09 00:00:00
abstract:BACKGROUND:Chikungunya virus (CHIKV) is a mosquito-borne, arthrogenic Alphavirus that causes large epidemics in Africa, South-East Asia and India. Recently, CHIKV has been transmitted to humans in Southern Europe by invading and now established Asian tiger mosquitoes. To study the processing of envelope proteins E1 and...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-353
更新日期:2011-07-15 00:00:00
abstract:BACKGROUND:Pseudorabies virus (PRV) of the family Herpesviridae is the causative agent of Aujeszky's disease. Attenuation of PRV by serial passaging in vitro is a well-established method; however, the dynamic variations occurring on viral genome during this process have not been characterized. METHODS:Genome sequencin...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1102-8
更新日期:2018-12-29 00:00:00
abstract:BACKGROUND:Duck circovirus (DuCV) infection in farmed ducks is associated with growth problems or retardation syndromes. Rapid identification of DuCV infected ducks is essential to control DuCV effectively. Therefore, this study aims to develop of an assay for DuCV to be highly specific, sensitive, and simple without a...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-76
更新日期:2014-04-29 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) Core protein regulates multiple signaling pathways and alters cellular genes expression responsible for HCV induced pathogenesis leading to hepatocellular carcinoma (HCC). Prevalence of HCV genotype 3a associated HCC is higher in Pakistan as compare to the rest of world; however the m...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-522
更新日期:2011-11-23 00:00:00
abstract:BACKGROUND:The VP2 outer capsid protein Bluetongue Virus (BTV) is responsible for receptor binding, haemagglutination and eliciting host-specific immunity. However, the assembly of this outer capsid protein on the transcriptionally active viral core would block transcription of the virus. Thus assembly of the outer cap...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-4-7
更新日期:2007-01-15 00:00:00
abstract:BACKGROUND:The COVID-19 causing coronavirus is an enveloped RNA virus that utilizes an enzyme RNA dependent RNA polymerase for its replication. Favipiravir (FVP) triphosphate, a purine nucleoside analog, inhibits that enzyme. We have conducted this systematic review and meta-analysis on efficacy and safety of the drug ...
journal_title:Virology journal
pub_type: 杂志文章,meta分析
doi:10.1186/s12985-020-01412-z
更新日期:2020-09-24 00:00:00
abstract:BACKGROUND:Recombinant Salmonella vaccine vectors may potentially be used to induce specific CD4+ T cell responses against foreign viral antigens. Such immune responses are required features of vaccines against pathogens such as human immunodeficiency virus type 1 (HIV-1). The aim of this study was to investigate the i...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-87
更新日期:2009-06-25 00:00:00
abstract:BACKGROUND:Infection with Chikungunya alphavirus (CHIKV) can cause severe arthralgia and chronic arthritis in humans with persistence of the virus in perivascular macrophages of the synovial membrane by mechanisms largely ill-characterized. FINDINGS:We herein analysed the innate immune response (cytokine and programme...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-313
更新日期:2012-12-19 00:00:00
abstract:BACKGROUND:Containment of influenza A H1N1 virus spread was implemented successfully in Xiamen, with large-scale inoculation to reduce morbidity. To identify beneficial elements and to guide decision-making in epidemic containment, we analyzed the epidemiologic parameters and evaluated the control measures. METHOD:We ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-20
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:Open reading frame 58 (ORF58) of varicella-zoster virus (VZV) lies at the 3'end of the Unique long (UL) region and its functional is unknown. In order to clarify whether ORF58 is essential for the growth of VZV, we constructed a deletion mutant of ORF58 (pOka-BACDelta58) from the Oka parental genome cloned i...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-54
更新日期:2008-04-30 00:00:00
abstract:BACKGROUND:The influenza RNA dependent RNA polymerase synthesizes viral RNA in the nucleus as functional viral ribonucleoprotein (vRNP) complexes with RNA and nucleoprotein (NP). The N-terminus of NP contains an unconventional nuclear localization signal (NLS) important for initial vRNP nuclear localization but which a...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-155
更新日期:2014-08-31 00:00:00
abstract:BACKGROUND:Lymphocytes provide invaluable whistle blowers of changes due to infections. We use the information registered by these cells using their mRNAs as they encounter the pathogen to develop patterns of expression that correspond to that specific pathogen. Venezuelan equine encephalitis (VEE) is a mosquito-borne ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-4-82
更新日期:2007-08-29 00:00:00
abstract:BACKGROUND:Sequence and structural elements in the 3'-untranslated region (UTR) of Japanese encephalitis virus (JEV) are known to regulate translation and replication. We previously reported an abundant accumulation of small subgenomic flaviviral RNA (sfRNA) which is collinear with the highly conserved regions of the 3...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-492
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:We have characterised a new highly divergent geminivirus species, Eragrostis curvula streak virus (ECSV), found infecting a hardy perennial South African wild grass. ECSV represents a new genus-level geminivirus lineage, and has a mixture of features normally associated with other specific geminivirus genera...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-36
更新日期:2009-03-25 00:00:00
abstract:BACKGROUND:Patchouli alcohol (PA) is a tricyclic sesquiterpene extracted from Pogostemonis Herba, which is a traditional Chinese medicine used for therapy of inflammatory diseases. Recent studies have shown that PA has various pharmacological activities, including anti-bacterial and anti-viral effects. METHODS:In this...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-019-1266-x
更新日期:2019-12-23 00:00:00
abstract:BACKGROUND:Increased numbers of Interleukin-17-producing CD4+ T cells (Th17) have been found in association with hepatitis B virus (HBV)-induced liver injury. However, the mechanism underlying the increase of Th17 responses in patients with HBV infection remains unclear. In this study, we investigate the possible regul...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-270
更新日期:2011-06-03 00:00:00
abstract:BACKGROUND:The mechanisms through which the avian influenza virus H5N1 modulate the host's innate immune defense during invasion, remains incompletely understood. RIG-I as a pattern recognition receptor plays an important role in mediating innate immune response induced by influenza virus. So, modulating RIG-I might be...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-145
更新日期:2012-08-03 00:00:00
abstract::Filamentous bacteriophages have been used in numerous applications for the display of antibodies and random peptide libraries. Here we describe the introduction of a 13 amino acid sequence LASIFEAQKIEWR (designated BT, which is biotinylated in vivo by E. coli) into the N termini of four of the five structural proteins...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-495
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:The mechanism by which HIV infection leads to a selective depletion of CD4 cells leading to immunodeficiency remains highly debated. Whether the loss of CD4 cells is a direct consequence of virus infection or bystander apoptosis of uninfected cells is also uncertain. RESULTS:We have addressed this issue in ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-34
更新日期:2011-01-21 00:00:00
abstract:BACKGROUND:Respiratory syncytial virus (RSV), human Rhinovirus (HRV) and human Metapneumo Virus (HMPV) are important viral pathogens causing acute respiratory tract infections in the hospitalized patients. Sensitive and accurate detection of RSV, HRV and HMPV is necessary for clinical diagnosis and treatment. RESULTS:...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1061-0
更新日期:2018-10-30 00:00:00
abstract:BACKGROUND:To explore the relationship between enteroviruses and hospitalized children with hand, foot and mouth disease (HFMD) complicated with nervous system disease. 234 hospitalized HFMD patients treated in Shengjing Hospital, Liaoning Province were analyzed retrospectively. Based on the presence and severity of ne...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-8
更新日期:2012-01-09 00:00:00
abstract:BACKGROUND:Kadipiro virus (KDV) belongs to the Reoviridae family, which consists of segmented, non-enveloped, double-stranded RNA viruses. It has previously been isolated from Culex, Anopheles, Armigeres and Aedes mosquitoes in Indonesia and China. Here, we describe the isolation and characterization of SDKL1625 from A...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-0966-y
更新日期:2018-04-06 00:00:00
abstract:BACKGROUND:Emergence and re-emergence of porcine epidemic diarrhea virus (PEDV) in North America, Asia and Europe has caused severe economic loss to the global swine industry. However, the virome of PEDV infected pigs and its effect on disease severity remains unknown. The advancements of sequencing technology have mad...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1001-z
更新日期:2018-05-25 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) causes significant morbidity and mortality globally primarily due to its ability to cause hepatitis, liver cirrhosis and hepatocellular carcinoma. The Kenya National Blood Transfusion Services screens for Hepatitis B antibodies using the chemiluminescent microparticle immunoassay meth...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-020-01447-2
更新日期:2020-11-13 00:00:00
abstract:BACKGROUND:Viruses interact with host cellular factors to construct a more favourable environment for their efficient replication. Expression of cyclophilin B (CypB), a cellular peptidyl-prolyl cis-trans isomerase (PPIase), was found to be significantly up-regulated. Recently, a number of studies have shown that CypB i...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0781-x
更新日期:2017-06-15 00:00:00
abstract::The NanoSight LM10 with Nanoparticle tracking analysis (NTA) software was evaluated for the quantification of latex particles, adenovirus 5, and influenza virus. The inter-day variability was determined by measuring the same sample over several consecutive days and the method's accuracy was demonstrated by using known...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-265
更新日期:2012-11-12 00:00:00
abstract:BACKGROUND:Classical swine fever (CSF) caused by virulent strains of Classical swine fever virus (CSFV) is a haemorrhagic disease of pigs, characterized by disseminated intravascular coagulation, thrombocytopoenia and immunosuppression, and the swine endothelial vascular cell is one of the CSFV target cells. In this re...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-4
更新日期:2010-01-11 00:00:00