当前位置： SCI文献检索 > Virology Journal期刊下所有文献 > Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K/Akt and ERK/MAPK signaling pathways.

Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K/Akt and ERK/MAPK signaling pathways.

Abstract：

BACKGROUND:Patchouli alcohol (PA) is a tricyclic sesquiterpene extracted from Pogostemonis Herba, which is a traditional Chinese medicine used for therapy of inflammatory diseases. Recent studies have shown that PA has various pharmacological activities, including anti-bacterial and anti-viral effects. METHODS:In this study, the anti-influenza virus (IAV) activities and mechanisms were investigated both in vitro and in vivo. The inhibitory effects of PA against IAV in vitro were evaluated by plaque assay and immunofluorescence assay. The neuraminidase inhibition assay, hemagglutination inhibition (HI) assay, and western blot assay were used to explore the anti-viral mechanisms. The anti-IAV activities in vivo were determined by mice pneumonia model and HE staining. RESULTS:The results showed that PA significantly inhibited different IAV strains multiplication in vitro, and may block IAV infection through inactivating virus particles directly and interfering with some early stages after virus adsorption. Cellular PI3K/Akt and ERK/MAPK signaling pathways may be involved in the anti-IAV actions of PA. Intranasal administration of PA markedly improved mice survival and attenuated pneumonia symptoms in IAV infected mice, comparable to the effects of Oseltamivir. CONCLUSIONS:Therefore, Patchouli alcohol has the potential to be developed into a novel anti-IAV agent in the future.

journal_name

Virol J

journal_title

Virology journal

authors

Yu Y,Zhang Y,Wang S,Liu W,Hao C,Wang W

doi

10.1186/s12985-019-1266-x

subject

Has Abstract

pub_date

2019-12-23 00:00:00

pages

163

issue

1

issn

1743-422X

pii

10.1186/s12985-019-1266-x

journal_volume

16

pub_type

杂志文章

相关文献

Virology Journal文献大全
  • Molecular characterization of human calicivirus associated with acute diarrheal disease in Mexican children.

    abstract：BACKGROUND:Human caliciviruses (HuCV) are emerging enteric pathogens that are a common cause of diarrhea in humans worldwide. Due to the paucity of information on the molecular characterization of HuCV circulating in Mexico, the aim of this work was to investigate the diversity and molecular epidemiology of the HuCV in...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-9-54

    authors： Gómez-Santiago F,Ribas-Aparicio RM,García-Lozano H

    更新日期：2012-02-23 00:00:00

  • Torquetenovirus detection in exosomes enriched vesicles circulating in human plasma samples.

    abstract：BACKGROUND:Torquetenovirus (TTV) belongs to Anelloviridae family, infects nearly all people indefinitely without causing overt disease establishing a fine and successful interaction with the host. Increasing evidence have shown some human viruses exploit extracellular vesicles thereby helping viral persistence in the h...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-018-1055-y

    authors： Martelli F,Macera L,Spezia PG,Medici C,Pistello M,Guasti D,Romagnoli P,Maggi F,Giannecchini S

    更新日期：2018-09-20 00:00:00

  • Nuclear localized Influenza nucleoprotein N-terminal deletion mutant is deficient in functional vRNP formation.

    abstract：BACKGROUND:The influenza RNA dependent RNA polymerase synthesizes viral RNA in the nucleus as functional viral ribonucleoprotein (vRNP) complexes with RNA and nucleoprotein (NP). The N-terminus of NP contains an unconventional nuclear localization signal (NLS) important for initial vRNP nuclear localization but which a...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-11-155

    authors： Sanchez A,Guerrero-Juarez CF,Ramirez J,Newcomb LL

    更新日期：2014-08-31 00:00:00

  • Capsid display of a conserved human papillomavirus L2 peptide in the adenovirus 5 hexon protein: a candidate prophylactic hpv vaccine approach.

    abstract：BACKGROUND:Infection by any one of 15 high risk human papillomavirus (hrHPV) types causes most invasive cervical cancers. Their oncogenic genome is encapsidated by L1 (major) and L2 (minor) coat proteins. Current HPV prophylactic vaccines are composed of L1 virus-like particles (VLP) that elicit type restricted immunit...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-015-0364-7

    authors： Wu WH,Alkutkar T,Karanam B,Roden RB,Ketner G,Ibeanu OA

    更新日期：2015-09-11 00:00:00

  • High frequency of SEN virus infection in thalassemic patients and healthy blood donors in Iran.

    abstract：BACKGROUND:SEN virus is a blood-borne, circular ssDNA virus and possessing nine genotypes (A to I). Among nine genotypes, SENV-D and SENV-H genotypes have the strong link with patients with unknown (none-A to E) hepatitis infections. Infection with blood-borne viruses is the second important cause of death in thalassem...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-1

    authors： Karimi-Rastehkenari A,Bouzari M

    更新日期：2010-01-02 00:00:00

  • A dual function TAR Decoy serves as an anti-HIV siRNA delivery vehicle.

    abstract：:The TAR RNA of HIV was engineered as an siRNA delivery vehicle to develop a combinatorial therapeutic approach. The TAR backbone was found to be a versatile backbone for expressing siRNAs. Upon expression in human cells, pronounced and specific inhibition of reporter gene expression was observed with TARmiR. The resul...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-33

    authors： Unwalla HJ,Rossi JJ

    更新日期：2010-02-10 00:00:00

  • Epidemiological, molecular and clinical features of enterovirus 109 infection in children and in adult stem cell transplant recipients.

    abstract：BACKGROUND:A novel human enterovirus (HEV) type within the species HEV-C, named EV109, was discovered from cases of respiratory illness in Nicaragua in September 2010. The aim of this study, was to retrospectively examine the presence and the role of EV109 in respiratory samples from two patients populations; infants b...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-9-183

    authors： Debiaggi M,Ceresola ER,Sampaolo M,Alessandrino EP,Brerra R,Piazza A,Clementi M,Canducci F

    更新日期：2012-09-04 00:00:00

  • Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus).

    abstract：:More than 20 years ago, hantaviral antigens were reported in tissues of the Eurasian common shrew (Sorex araneus), Eurasian water shrew (Neomys fodiens) and common mole (Talpa europea), suggesting that insectivores, or soricomorphs, might serve as reservoirs of unique hantaviruses. Using RT-PCR, sequences of a genetic...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-4-114

    authors： Song JW,Gu SH,Bennett SN,Arai S,Puorger M,Hilbe M,Yanagihara R

    更新日期：2007-10-30 00:00:00

  • MicroRNA profiling of tomato leaf curl New Delhi virus (tolcndv) infected tomato leaves indicates that deregulation of mir159/319 and mir172 might be linked with leaf curl disease.

    abstract：BACKGROUND:Tomato leaf curl virus (ToLCV), a constituent of the genus Begomovirus, infects tomato and other plants with a hallmark disease symptom of upward leaf curling. Since microRNAs (miRs) are known to control plants developmental processes, we evaluated the roles of miRNAs in Tomato leaf curl New Delhi virus (ToL...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-281

    authors： Naqvi AR,Haq QM,Mukherjee SK

    更新日期：2010-10-25 00:00:00

  • No observed effect of homologous recombination on influenza C virus evolution.

    abstract：:The occurrence of homologous recombination in influenza viruses has been under some debate recently. To determine the extent of homologous recombination in influenza C virus, recombination analyses of all available gene sequences of influenza C virus were carried out. No recombination signal was found. With the previo...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-227

    authors： Han GZ,Boni MF,Li SS

    更新日期：2010-09-14 00:00:00

  • Analysis of the 5'UTR of HCV genotype 3 grown in vitro in human B cells, T cells, and macrophages.

    abstract：BACKGROUND:Previously, we have reported the isolation and molecular characterization of human Hepatitis C virus genotype 1 (HCV-1) from infected patients. We are now reporting an analysis of HCV obtained from patients infected with HCV genotype 3 (HCV-3) as diagnosed by clinical laboratories. RESULTS:HCV was cultured ...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-155

    authors： Revie D,Alberti MO,Prichard JG,Kelley AS,Salahuddin SZ

    更新日期：2010-07-13 00:00:00

  • The infectivity and pathogenicity of a foot-and-mouth disease virus persistent infection strain from oesophageal-pharyngeal fluid of a Chinese cattle in 2010.

    abstract：BACKGROUND:Foot-and mouth disease (FMD) is an acute, febrile, and contagious vesicular disease affecting cloven-hoofed animals. Some animals may become persistent infected carriers when they contact FMD virus (FMDV), and persistent infected animals are a dangerous factor to cause FMD outbreak. FINDINGS:300 OP (oesopha...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-8-536

    authors： Bao HF,Li D,Sun P,Zhou Q,Hu J,Bai XW,Fu YF,Lu ZJ,Liu ZX

    更新日期：2011-12-14 00:00:00

  • Interaction between Bluetongue virus outer capsid protein VP2 and vimentin is necessary for virus egress.

    abstract：BACKGROUND:The VP2 outer capsid protein Bluetongue Virus (BTV) is responsible for receptor binding, haemagglutination and eliciting host-specific immunity. However, the assembly of this outer capsid protein on the transcriptionally active viral core would block transcription of the virus. Thus assembly of the outer cap...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-4-7

    authors： Bhattacharya B,Noad RJ,Roy P

    更新日期：2007-01-15 00:00:00

  • Specific and quantitative detection of Human polyomaviruses BKPyV and JCPyV in the healthy Pakistani population.

    abstract：BACKGROUND:The BK Polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections are widespread in human population and have been associated with severe kidney and brain disorders, respectively. The viruses remain latent primarily in reno-urinary tract, reactivating only in case of a compromised immune system. The seroepi...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-017-0752-2

    authors： Hussain I,Tasneem F,Umer M,Pervaiz A,Raza M,Arshad MI,Shahzad N

    更新日期：2017-04-24 00:00:00

  • Avian influenza virus H5N1 induces rapid interferon-beta production but shows more potent inhibition to retinoic acid-inducible gene I expression than H1N1 in vitro.

    abstract：BACKGROUND:The mechanisms through which the avian influenza virus H5N1 modulate the host's innate immune defense during invasion, remains incompletely understood. RIG-I as a pattern recognition receptor plays an important role in mediating innate immune response induced by influenza virus. So, modulating RIG-I might be...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-9-145

    authors： Mi Z,Ma Y,Tong Y

    更新日期：2012-08-03 00:00:00

  • Occurrence and distribution of pepper veinal mottle virus and cucumber mosaic virus in pepper in Ibadan, Nigeria.

    abstract：:Viral diseases constitute obstacles to pepper production in the world. In Nigeria, pepper plants are primarily affected by pepper veinal mottle virus (PVMV), Cucumber mosaic virus (CMV), Pepper leaf curl Virus (TLCV), Tobacco mosaic virus (TMV), Pepper mottle virus (PMV) and a host of other viruses. The experiment was...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-9-79

    authors： Arogundade O,Balogun OS,Kareem KT

    更新日期：2012-04-11 00:00:00

  • Active vaccination with vaccinia virus A33 protects mice against lethal vaccinia and ectromelia viruses but not against cowpoxvirus; elucidation of the specific adaptive immune response.

    abstract：:Vaccinia virus protein A33 (A33VACV) plays an important role in protection against orthopoxviruses, and hence is included in experimental multi-subunit smallpox vaccines. In this study we show that single-dose vaccination with recombinant Sindbis virus expressing A33VACV, is sufficient to protect mice against lethal c...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-10-229

    authors： Paran N,Lustig S,Zvi A,Erez N,Israely T,Melamed S,Politi B,Ben-Nathan D,Schneider P,Lachmi B,Israeli O,Stein D,Levin R,Olshevsky U

    更新日期：2013-07-10 00:00:00

  • Chitosan can stop or postpone the death of the suckling mice challenged with foot-and-mouth disease virus.

    abstract：UNLABELLED:In the study, a method called "hardening in liquid phase" for preparing chitosan granules with glutaraldehyde as crosslinker and Tween 80 as surfactant and paraffin liquid as dispersant was established. The chitosan granules were light yellow and insoluble in water or oil, but they swelled in acid solution a...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-125

    authors： Li D

    更新日期：2010-06-12 00:00:00

  • A simplified in vitro ligation approach to clone an E1B55k-deleted double-targeted conditionally-replicative adenovirus.

    abstract：BACKGROUND:Construction of conditionally-replicative Adenovirus (CRAd) is complex and time-consuming. While homologous recombination (HR) using a two-plasmid system in bacteria is commonly used to generate CRAds, alternative methods may be required when HR fails. Previously, in vitro ligation has been suggested to faci...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-6-18

    authors： Haviv YS

    更新日期：2009-02-07 00:00:00

  • Oligomerization of the human immunodeficiency virus type 1 (HIV-1) Vpu protein--a genetic, biochemical and biophysical analysis.

    abstract：BACKGROUND:The human immunodeficiency virus type 1(HIV-1) is a complex retrovirus and the causative agent of acquired immunodeficiency syndrome (AIDS). The HIV-1 Vpu protein is an oligomeric integral membrane protein essential for particle release, viral load and CD4 degradation. In silico models show Vpu to form penta...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-4-81

    authors： Hussain A,Das SR,Tanwar C,Jameel S

    更新日期：2007-08-29 00:00:00

  • Seroprevalence of human respiratory syncytial virus and human metapneumovirus in healthy population analyzed by recombinant fusion protein-based enzyme linked immunosorbent assay.

    abstract：BACKGROUND:Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are two of the most frequent respiratory pathogens that circulate worldwide. Infection with either virus can lead to hospitalization of young children, immunocompromised people and the elderly.A better understanding of the epidemiologi...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-9-130

    authors： Sastre P,Ruiz T,Schildgen O,Schildgen V,Vela C,Rueda P

    更新日期：2012-07-02 00:00:00

  • Inhibition of HIV early replication by the p53 and its downstream gene p21.

    abstract：BACKGROUND:The tumor suppressor gene p53 has been found to suppress HIV infection by various mechanisms, but the inhibition of HIV at an early stage of replication by host cell p53 and its downstream gene p21 has not been well studied. METHOD:VSV-G pseudotyped HIV-1 or HIV-2 viruses with GFP or luciferase reporter gen...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-018-0959-x

    authors： Shi B,Sharifi HJ,DiGrigoli S,Kinnetz M,Mellon K,Hu W,de Noronha CMC

    更新日期：2018-03-27 00:00:00

  • Subcellular localization and interactions of Infectious Salmon Anemia Virus (ISAV) M1 and NEP as well as host Hsc70.

    abstract：BACKGROUND:Infectious salmon anemia virus (ISAV) is an important fish pathogen that causes high mortality in farmed Atlantic salmon. The ISAV genome consists of eight single-stranded, negative-sense RNA segments. The six largest segments contain one open reading frame (ORF) each, and encode three polymerase proteins, n...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-017-0702-z

    authors： Zhang W,Cai C,Lin L,Tao YJ,Jin M

    更新日期：2017-02-15 00:00:00

  • Whole-genome sequencing of human Pegivirus variant from an Egyptian patient co-infected with hepatitis C virus: a case report.

    abstract：BACKGROUND:Human pegivirus (HPgV) is structurally similar to hepatitis C virus (HCV) and was discovered 20 years ago. Its distribution, natural history and exact rule of this viral group in human hosts remain unclear. Our aim was to determine, by deep next-generation sequencing (NGS), the entire genome sequence of HPgV...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-019-1242-5

    authors： Soliman HK,Abouelhoda M,El Rouby MN,Ahmed OS,Esmat G,Hassan ZK,Hafez MM,Mehaney DA,Selvaraju M,Darwish RK,Osman YA,Zekri AN

    更新日期：2019-11-11 00:00:00

  • Human immunodeficiency virus type 1 ((HIV-1) subtypes in the northwest region, Cameroon.

    abstract：BACKGROUND:The high genetic diversity of HIV-1 has been shown to influence the global distribution, disease progression, treatment success, and the development of an effective vaccine. Despite the low HIV prevalence in Cameroon, all the major HIV subtypes alongside several circulating recombinant forms (CRFs) and uniqu...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-019-1209-6

    authors： Abongwa LE,Nyamache AK,Torimiro JN,Okemo P,Charles F

    更新日期：2019-08-15 00:00:00

  • The role of cholesterol and sphingolipids in chemokine receptor function and HIV-1 envelope glycoprotein-mediated fusion.

    abstract：BACKGROUND:HIV-1 entry into cells is a multifaceted process involving target cell CD4 and the chemokine receptors, CXCR4 or CCR5. The lipid composition of the host cell plays a significant role in the HIV fusion process as it orchestrates the appropriate disposition of CD4 and co-receptors required for HIV-1 envelope g...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-3-104

    authors： Ablan S,Rawat SS,Viard M,Wang JM,Puri A,Blumenthal R

    更新日期：2006-12-22 00:00:00

  • Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellul

    abstract：:Retroviral transduction involves integrase-dependent linkage of viral and host DNA that leaves an intermediate that requires post-integration repair (PIR). We and others proposed that PIR hijacks the host cell double-strand DNA break (DSB) repair pathways. Nevertheless, the geometry of retroviral DNA integration diffe...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-5-11

    authors： Smith JA,Wang FX,Zhang H,Wu KJ,Williams KJ,Daniel R

    更新日期：2008-01-22 00:00:00

  • Potential effects of telbivudine and entecavir on renal function: a systematic review and meta-analysis.

    abstract：BACKGROUND:To assess the potential effects of telbivudine (LdT) and entecavir (ETV) on renal function in patients with chronic hepatitis B (CHB), we performed a meta-analysis of the relevant data available on these agents to evaluate their effects on the estimated glomerular filtration rate (eGFR) during treatment. ME...

    journal_title：Virology journal

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/s12985-016-0522-6

    authors： Wu X,Cai S,Li Z,Zheng C,Xue X,Zeng J,Peng J

    更新日期：2016-04-09 00:00:00

  • Intramuscular immunization of mice with live influenza virus is more immunogenic and offers greater protection than immunization with inactivated virus.

    abstract：BACKGROUND:Influenza virus continues to cause significant hospitalization rates in infants and young children. A 2-dose regime of trivalent inactivated vaccine is required to generate protective levels of hemagglutination inhibiting (HAI) antibodies. A vaccine preparation with enhanced immunogenicity is therefore desir...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-8-251

    authors： Harris K,Ream R,Gao J,Eichelberger MC

    更新日期：2011-05-21 00:00:00

  • Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement.

    abstract：BACKGROUND:Dengue viruses (DENV) are the most important arboviruses of humans and cause significant disease. Infection with DENV elicits antibody responses to the envelope glycoprotein, predominantly against immunodominant, cross-reactive, weakly-neutralizing epitopes. These weakly-neutralizing antibodies are implicate...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-9-115

    authors： Hughes HR,Crill WD,Chang GJ

    更新日期：2012-06-18 00:00:00