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Mouse macrophage innate immune response to Chikungunya virus infection.

Abstract：

BACKGROUND:Infection with Chikungunya alphavirus (CHIKV) can cause severe arthralgia and chronic arthritis in humans with persistence of the virus in perivascular macrophages of the synovial membrane by mechanisms largely ill-characterized. FINDINGS:We herein analysed the innate immune response (cytokine and programmed cell death) of RAW264.7 mouse macrophages following CHIKV infection. We found that the infection was restrained to a small percentage of cells and was not associated with a robust type I IFN innate immune response (IFN-α4 and ISG56). TNF-α, IL-6 and GM-CSF expression were upregulated while IFN-γ, IL-1α, IL-2, IL-4, IL-5, IL-10 or IL-17 expression could not be evidenced prior to and after CHIKV exposure. Although CHIKV is known to drive apoptosis in many cell types, we found no canonical signs of programmed cell death (cleaved caspase-3, -9) in infected RAW264.7 cells. CONCLUSION:These data argue for the capacity of CHIKV to infect and drive a specific innate immune response in RAW264.7 macrophage cell which seems to be polarized to assist viral persistence through the control of apoptosis and IFN signalling.

journal_name

Virol J

journal_title

Virology journal

authors

Kumar S,Jaffar-Bandjee MC,Giry C,Connen de Kerillis L,Merits A,Gasque P,Hoarau JJ

doi

10.1186/1743-422X-9-313

subject

Has Abstract

pub_date

2012-12-19 00:00:00

pages

313

issn

1743-422X

pii

1743-422X-9-313

journal_volume

9

pub_type

杂志文章

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