Abstract:
BACKGROUND:Little is known at the molecular level concerning the differences and/or similarities between alcohol and hepatitis C virus induced liver disease. Global transcriptional profiling using oligonucleotide microarrays was therefore performed on liver biopsies from patients with cirrhosis caused by either chronic alcohol consumption or chronic hepatitis C virus (HCV). RESULTS:Global gene expression patterns varied significantly depending upon etiology of liver disease, with a greater number of differentially regulated genes seen in HCV-infected patients. Many of the gene expression changes specifically observed in HCV-infected cirrhotic livers were expectedly associated with activation of the innate antiviral immune response. We also compared severity (CTP class) of cirrhosis for each etiology and identified gene expression patterns that differentiated ethanol-induced cirrhosis by class. CTP class A ethanol-cirrhotic livers showed unique expression patterns for genes implicated in the inflammatory response, including those related to macrophage activation and migration, as well as lipid metabolism and oxidative stress genes. CONCLUSION:Stages of liver cirrhosis could be differentiated based on gene expression patterns in ethanol-induced, but not HCV-induced, disease. In addition to genes specifically regulating the innate antiviral immune response, mechanisms responsible for differentiating chronic liver damage due to HCV or ethanol may be closely related to regulation of lipid metabolism and to effects of macrophage activation on deposition of extracellular matrix components.
journal_name
Virol Jjournal_title
Virology journalauthors
Lederer SL,Walters KA,Proll S,Paeper B,Robinzon S,Boix L,Fausto N,Bruix J,Katze MGdoi
10.1186/1743-422X-3-98subject
Has Abstractpub_date
2006-11-22 00:00:00pages
98issn
1743-422Xpii
1743-422X-3-98journal_volume
3pub_type
杂志文章相关文献
Virology Journal文献大全abstract:AIM:To evaluate the efficacy and safety of Entecavir (ETV) plus adefovir (ADV) for chronic hepatitis B (CHB) patients after multiple nucleos(t)ide analogue (NAs) failure treatment. METHODS:Hepatitis B e antigen (HBeAg)-positive patients who had a suboptimal response or developed resistance to two or more previous NAs ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-162
更新日期:2013-05-25 00:00:00
abstract:BACKGROUND:Porcine sapovirus was first identified in the United States in 1980, hitherto, several Asian countries have detected this virus. In 2008, the first outbreak of gastroenteritis in piglets caused by porcine sapovirus in China was reported. The complete genome of the identified SaV strain Ch-sw-sav1 was sequenc...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-216
更新日期:2009-12-06 00:00:00
abstract:BACKGROUND:Tomato leaf curl virus (ToLCV), a constituent of the genus Begomovirus, infects tomato and other plants with a hallmark disease symptom of upward leaf curling. Since microRNAs (miRs) are known to control plants developmental processes, we evaluated the roles of miRNAs in Tomato leaf curl New Delhi virus (ToL...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-281
更新日期:2010-10-25 00:00:00
abstract::The prevalence of North American orthopoxviruses in nature is unknown and may be more difficult to ascertain due to wide spread use of vaccinia virus recombinant vaccines in the wild. A real time PCR assay was developed to allow for highly sensitive and specific detection of North American orthopoxvirus DNA in animal ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-313
更新日期:2011-06-20 00:00:00
abstract:BACKGROUND:Crimean-Congo Hemorrhagic Fever virus (CCHFV), a member of the genus Nairovirus, family Bunyaviridae, is a tick-borne pathogen causing severe disease in humans. To better understand the CCHFV life cycle and explore potential intervention strategies, we studied the biosynthesis and intracellular targeting of ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-2-42
更新日期:2005-04-25 00:00:00
abstract:BACKGROUND:Epstein-Barr virus (EBV) is associated with 20-40% of Hodgkin's Lymphoma (HL) cases. EBV-encoded latent membrane protein 1 (LMP1) is a well-known oncogenic protein and two C-terminal deletion variants, del30-LMP1 and del69-LMP1, have been described in animal models to be more tumorigenic than the wild-type f...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-94
更新日期:2014-05-19 00:00:00
abstract:BACKGROUND:Foot-and-mouth disease (FMD) is an extremely contagious viral disease of cattle, pigs, sheep, goats, and many cloven-hoofed wild animals. FMDV serotypes O and Asia 1 have circulated separately in China during the last fifty years, and eliminating infected animals and vaccination are the main policies to prev...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-186
更新日期:2011-04-23 00:00:00
abstract::Duck hepatitis virus (DHV-1) is a worldwide distributed picornavirus that causes acute and fatal disease in young ducklings. Recently, the complete genome of DHV-1 has been determined and comparative sequence analysis has shown that possesses the typical picornavirus organization but exhibits several unique features. ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-147
更新日期:2011-03-31 00:00:00
abstract:BACKGROUND:Construction of conditionally-replicative Adenovirus (CRAd) is complex and time-consuming. While homologous recombination (HR) using a two-plasmid system in bacteria is commonly used to generate CRAds, alternative methods may be required when HR fails. Previously, in vitro ligation has been suggested to faci...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-18
更新日期:2009-02-07 00:00:00
abstract:BACKGROUND:West Nile virus (WNV) is an emerging zoonotic pathogen which is harmful to human and animal health. Effective vaccination in susceptible hosts should protect against WNV infection and significantly reduce viral transmission between animals and from animals to humans. A versatile vaccine suitable for differen...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0568-5
更新日期:2016-06-24 00:00:00
abstract:BACKGROUND:Few studies have used quantitative polymerase chain reaction (qPCR) as an approach to measure virus neutralization assay endpoints. Its lack of use may not be surprising considering that sample nucleic acid extraction and purification can be expensive, labor-intensive, and rate-limiting. METHODS:Virus/antib...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-195
更新日期:2013-06-15 00:00:00
abstract:BACKGROUND:Finding new biomarkers for the early detection of cervical cancer is an essential requirement in this field. In this study, we aimed to evaluate the expression level of potential biomarkers in progression of cervical cancer in patients with cervical cancer compared to normal subjects. METHODS:The expression...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-019-1220-y
更新日期:2019-10-07 00:00:00
abstract::More than 20 years ago, hantaviral antigens were reported in tissues of the Eurasian common shrew (Sorex araneus), Eurasian water shrew (Neomys fodiens) and common mole (Talpa europea), suggesting that insectivores, or soricomorphs, might serve as reservoirs of unique hantaviruses. Using RT-PCR, sequences of a genetic...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-4-114
更新日期:2007-10-30 00:00:00
abstract:BACKGROUND:Post-transplant lymphoproliferative disorders (PTLD) are serious complications in lung transplant recipients. No consensus on EBV DNAemia levels predictive of PTLD has been reached. In addition, in many instances EBV DNAemia is determined in patients with suggestive symptoms only. METHODS:The characteristic...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-421
更新日期:2011-09-05 00:00:00
abstract:BACKGROUND:Longitudinal mark-recapture studies of rodents in two sites in the Mbaracayú Biosphere Reserve in the Interior Atlantic Forest of eastern Paraguay have revealed a complex and intriguing pattern of hantaviruses harbored by rodents in this area. Full-length sequencing and phylogenetic analyses were conducted f...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-399
更新日期:2011-08-12 00:00:00
abstract:BACKGROUND:At the moment, there are a number of publications describing gene expression profiling in virus-infected plants. Most of the data are limited to specific host-pathogen interactions involving a given virus and a model host plant - usually Arabidopsis thaliana. Even though several summarizing attempts have bee...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-101
更新日期:2012-05-29 00:00:00
abstract::Hepatitis E virus (HEV) is a zoonotic pathogen of which several species of animal were reported as reservoirs. Swine stands out as the major reservoir for HEV infection in humans, as suggested by the close genetic relationship of swine and human virus and cross-species infection of HEV. Up to now, the mechanism of cro...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-482
更新日期:2011-10-27 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection is of growing concern in public health with around 350 million chronically infected individuals worldwide. Although the IFN-alpha/rivabirin is the only approved therapy with 10-30% clinical efficacy, the protective molecular mechanism involved during the treatment is still u...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-2-81
更新日期:2005-09-12 00:00:00
abstract:BACKGROUND:Rodent borne hantaviruses are emerging viruses infecting humans through inhalation. They cause hemorrhagic fever with renal syndrome and hemorrhagic cardiopulmonary syndrome. Recently, hantaviruses have been detected in other small mammals such as Soricomorpha (shrews, moles) and Chiroptera (bats), suggested...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-020-01477-w
更新日期:2020-12-29 00:00:00
abstract::A previous study has identified two types of recombinant variants of Potato virus Y strain NTN (PVY(NTN)) in China and sequenced the complete genome of the variant PVY(NTN)-HN2. In this study, the complete genome of isolate PVY(NTN)-HN1 was fully sequenced and analyzed. The most striking difference between the two var...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-207
更新日期:2011-05-07 00:00:00
abstract::During the outbreak of SARS in 2002/3, a prototype virus was isolated from a patient in Frankfurt/Germany (strain Frankfurt-1). As opposed to all other SARS-Coronavirus strains, Frankfurt-1 has a 45-nucleotide deletion in the transmembrane domain of its ORF 7b protein. When over-expressed in HEK 293 cells, the full-le...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-131
更新日期:2009-08-24 00:00:00
abstract::Adenovirus has a wide tissue tropism. The virus attaches to the surface of cells via the fiber protein knob binding to the Coxsackie and Adenovirus receptor known as CAR. Virus entry inside cells is facilitated by integrins αVβ3 and αVβ5. Mice platelets are shown to be the predominant Ad binding blood cell type and th...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-456
更新日期:2011-09-30 00:00:00
abstract:BACKGROUND:Respiratory syncytial virus (RSV) is the leading viral pathogen associated with bronchiolitis and lower respiratory tract disease in infants and young children worldwide. The respiratory epithelium is the primary initiator of pulmonary inflammation in RSV infections, which cause significant perturbations of ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-114
更新日期:2008-10-06 00:00:00
abstract:BACKGROUND:Since its emergence in March 2009, the pandemic 2009 H1N1 influenza A virus has posed a serious threat to public health. To trace the evolutionary path of these new pathogens, we performed a selection-pressure analysis of a large number of hemagglutinin (HA) and neuraminidase (NA) gene sequences of H1N1 infl...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-183
更新日期:2011-04-21 00:00:00
abstract:BACKGROUND:Aedes aegypti is a competent arthropod vector of chikungunya virus (CHIKV). The rate at which the virus disseminate in the vector is limited by temperature of their environment which can be an important determinant of geographical and seasonal limits to transmission by the arthropods in the tropics. This stu...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0566-7
更新日期:2016-06-29 00:00:00
abstract::In September 2012, a novel coronavirus was isolated from a patient in Saudi Arabia who had died of an acute respiratory illness and renal failure. The clinical presentation was reminiscent of the outbreak caused by the SARS-coronavirus (SARS-CoV) exactly ten years ago that resulted in over 8000 cases. Sequence analysi...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/1743-422X-10-66
更新日期:2013-02-28 00:00:00
abstract:BACKGROUND:Infection with hepatitis B virus (HBV) is major public health concern. The limitations of available antiviral drugs require development of novel approaches to inhibit HBV replication. This study was conducted to identify functional elements and new siRNA target sites within the highly conserved regions of th...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-216
更新日期:2010-09-08 00:00:00
abstract:BACKGROUND:Recombinant Salmonella vaccine vectors may potentially be used to induce specific CD4+ T cell responses against foreign viral antigens. Such immune responses are required features of vaccines against pathogens such as human immunodeficiency virus type 1 (HIV-1). The aim of this study was to investigate the i...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-87
更新日期:2009-06-25 00:00:00
abstract::The suitability of V4 vaccine coated on cracked local grain (maize) and its husks and used for oral vaccination of chickens was assessed. Seventy-two (72) birds aged three (3) weeks and above were divided into six groups of twelve (12) birds per group. The birds were bled to determine their prevaccination HI antibody ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-67
更新日期:2010-03-23 00:00:00
abstract:BACKGROUND:Cervical cancer is a major public health problem worldwide. While Romania has the highest incidence of cervical cancer in Europe, the prevalence of HPV has not been evaluated. We report the first data on HPV prevalence and type distribution in Northeast Romania. METHODS:HPV prevalence and genotype distribut...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-558
更新日期:2011-12-22 00:00:00