Abstract:
BACKGROUND:At the moment, there are a number of publications describing gene expression profiling in virus-infected plants. Most of the data are limited to specific host-pathogen interactions involving a given virus and a model host plant - usually Arabidopsis thaliana. Even though several summarizing attempts have been made, a general picture of gene expression changes in susceptible virus-host interactions is lacking. METHODS:To analyze transcriptome response to virus infection, we have assembled currently available microarray data on changes in gene expression levels in compatible Arabidopsis-virus interactions. We used the mean r (Pearson's correlation coefficient) for neighboring pairs to estimate pairwise local similarity in expression in the Arabidopsis genome. RESULTS:Here we provide a functional classification of genes with altered expression levels. We also demonstrate that responsive genes may be grouped or clustered based on their co-expression pattern and chromosomal location. CONCLUSIONS:In summary, we found that there is a greater variety of upregulated genes in the course of viral pathogenesis as compared to repressed genes. Distribution of the responsive genes in combined viral databases differed from that of the whole Arabidopsis genome, thus underlining a role of the specific biological processes in common mechanisms of general resistance against viruses and in physiological/cellular changes caused by infection. Using integrative platforms for the analysis of gene expression data and functional profiling, we identified overrepresented functional groups among activated and repressed genes. Each virus-host interaction is unique in terms of the genes with altered expression levels and the number of shared genes affected by all viruses is very limited. At the same time, common genes can participate in virus-, fungi- and bacteria-host interaction. According to our data, non-homologous genes that are located in close proximity to each other on the chromosomes, and whose expression profiles are modified as a result of the viral infection, occupy 12% of the genome. Among them 5% form co-expressed and co-regulated clusters.
journal_name
Virol Jjournal_title
Virology journalauthors
Postnikova OA,Nemchinov LGdoi
10.1186/1743-422X-9-101subject
Has Abstractpub_date
2012-05-29 00:00:00pages
101issn
1743-422Xpii
1743-422X-9-101journal_volume
9pub_type
杂志文章相关文献
Virology Journal文献大全abstract:BACKGROUND:ORFV attenuated live vaccines have been the main prophylactic measure against contagious ecthyma in sheep and goats in the last decades, which play an important role in preventing the outbreak of the disease. However, the available vaccines do not induce lasting immunity in sheep and goats. On the other hand...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-562
更新日期:2011-12-29 00:00:00
abstract:BACKGROUND:The recent 2009 (H1N1) influenza A pandemic saw a rapid spread of the virus to essentially all parts of the world. In the course of its evolution, the virus acquired many mutations, some of which have been investigated in the context of increased severity due to high occurrences in fatal cases. For example, ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-297
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. FINDINGS:Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canoni...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-219
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Respiratory syncytial virus (RSV) is the leading viral pathogen associated with bronchiolitis and lower respiratory tract disease in infants and young children worldwide. The respiratory epithelium is the primary initiator of pulmonary inflammation in RSV infections, which cause significant perturbations of ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-114
更新日期:2008-10-06 00:00:00
abstract:BACKGROUND:Torque Teno Virus (TTV) was the first single stranded circular DNA virus to be discovered that infects humans. Although there have been numerous reports regarding the prevalence of TTV from other countries of South Asia, there is severe lack of information regarding its prevalence in Pakistan. Thus the prese...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-320
更新日期:2012-12-28 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection is a major public health problem with more than 170 million cases of chronic infections worldwide. There is no protective vaccine currently available for HCV, therefore the development of novel strategy to prevent chronic infection is important. We reported earlier that a re...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-118
更新日期:2010-06-07 00:00:00
abstract:BACKGROUND:A serological method to simultaneously detect antibodies against infectious laryngotracheitis virus (ILTV) and infectious bronchitis virus (IBV) is imperative for the differential diagnosis and evaluation of antibodies titers after vaccination. METHOD:The microspheres coated with purified recombinant glycop...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1048-x
更新日期:2018-09-21 00:00:00
abstract::Hepatitis C virus (HCV) is endemic worldwide, and it causes cirrhosis and other complications that often lead to death; nevertheless, our knowledge of the disease and its mechanisms is limited. HCV is most common in underdeveloped nations, including many in Africa and Asia. The virus is usually transmitted by parenter...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/1743-422X-9-57
更新日期:2012-03-02 00:00:00
abstract:BACKGROUND:Chronic viral hepatitis B remains a global public health concern. Currently, several drugs, such as lamivudine and telbivudine, are recommended for treatment of patients with chronic hepatitis B. However, there are no conclusive results on the comparison of the efficacy of lamivudine (LAM) and telbivudine (L...
journal_title:Virology journal
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1743-422X-7-211
更新日期:2010-09-03 00:00:00
abstract:BACKGROUND:Few studies have used quantitative polymerase chain reaction (qPCR) as an approach to measure virus neutralization assay endpoints. Its lack of use may not be surprising considering that sample nucleic acid extraction and purification can be expensive, labor-intensive, and rate-limiting. METHODS:Virus/antib...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-195
更新日期:2013-06-15 00:00:00
abstract:BACKGROUND:Citrus sudden death (CSD), a disease that rapidly kills orange trees, is an emerging threat to the Brazilian citrus industry. Although the causal agent of CSD has not been definitively determined, based on the disease's distribution and symptomatology it is suspected that the agent may be a new strain of Cit...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-9
更新日期:2008-01-16 00:00:00
abstract:BACKGROUND:Pseudorabies virus (PRV) of the family Herpesviridae is the causative agent of Aujeszky's disease. Attenuation of PRV by serial passaging in vitro is a well-established method; however, the dynamic variations occurring on viral genome during this process have not been characterized. METHODS:Genome sequencin...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1102-8
更新日期:2018-12-29 00:00:00
abstract::Here we report the case of a 54-year old, immunocompetent German patient with primary varicella whose Varicella-Zoster Virus (VZV)-specific T-cell responses could be detected early in infection and before the onset of seroconversion. This case demonstrates that the detection of VZV-specific T-cells may under certain c...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-54
更新日期:2010-03-06 00:00:00
abstract:BACKGROUND:One requisite of quantitative reverse transcription PCR (qRT-PCR) is to normalise the data with an internal reference gene that is invariant regardless of treatment, such as virus infection. Several studies have found variability in the expression of commonly used housekeeping genes, such as beta-actin (ACTB...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-230
更新日期:2012-10-08 00:00:00
abstract:BACKGROUND:Crimean-Congo Hemorrhagic Fever virus (CCHFV), a member of the genus Nairovirus, family Bunyaviridae, is a tick-borne pathogen causing severe disease in humans. To better understand the CCHFV life cycle and explore potential intervention strategies, we studied the biosynthesis and intracellular targeting of ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-2-42
更新日期:2005-04-25 00:00:00
abstract:BACKGROUND:Torque teno virus is a small chronically persisting circular negative ssDNA virus reaching near 100% prevalence. It is reported to be a marker for immune function in immunocompromised patients. The possibility of vertical maternal-fetal transmission remains controversial but incidence rate of TTV DNA in chil...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1007-6
更新日期:2018-05-30 00:00:00
abstract::Marek's disease is a highly contagious disease of poultry characterized by rapid-on set of T-cell lymphomas, which is caused by Marek's disease virus (MDV), but its pathogenic mechanism is still not very clear. Recently, some new progress were achieved in molecular character of MDV. Along with the genomic sequencing o...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-371
更新日期:2010-12-23 00:00:00
abstract::Increasing infections with Monkeypox and Cowpox viruses pose a continuous and growing threat to human health. The standard method for detecting poxvirus neutralizing antibodies is the plaque-reduction neutralization test that is specific but also time-consuming and laborious. Therefore, a rapid and reliable method was...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-139
更新日期:2011-03-25 00:00:00
abstract:BACKGROUND:The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein. Though mutants lacking agnoprotein are severely reduced in producing infectious virions, the exact function of this peptide remains incompletely understood. To elucidate the function of agnoprotein, we searched for novel ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0220-1
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The genus Orbivirus includes several species that infect livestock - including Bluetongue virus (BTV) and African horse sickness virus (AHSV). These viruses have linear dsRNA genomes divided into ten segments, all of which have previously been assumed to be monocistronic. RESULTS:Bioinformatic evidence is p...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-48
更新日期:2008-04-14 00:00:00
abstract::Measles, caused by measles virus (MeV), is a common infection in children. MeV is a member of the genus Morbillivirus and is most closely related to rinderpest virus (RPV), which is a pathogen of cattle. MeV is thought to have evolved in an environment where cattle and humans lived in close proximity. Understanding th...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-52
更新日期:2010-03-04 00:00:00
abstract::HIV expressed in genital secretions provides the inoculum from which transmitting variants are selected, both in sexual transmission and mother-to-infant transmission during partuition. Characterization of HIV levels and genotypes found in vaginal secretions and the impact of anti-retroviral therapy (ART) on this viru...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-87
更新日期:2008-07-29 00:00:00
abstract:BACKGROUND:Reporting new cases of enterovirus (EV)-D68-associated acute flaccid myelitis (AFM) is essential to understand how the virus causes neurological damage and to characterize EV-D68 strains associated with AFM. CASE PRESENTATION:A previously healthy 4-year-old boy presented with sudden weakness and limited mob...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0678-0
更新日期:2017-01-11 00:00:00
abstract:BACKGROUND:The incidence of dengue, an infectious disease caused by dengue virus (DENV), has dramatically increased around the world in recent decades and is becoming a severe public health threat. However, there is currently no specific treatment for dengue fever, and licensed vaccine against dengue is not available. ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-333
更新日期:2011-06-30 00:00:00
abstract::Virology Journal is an exclusively on-line, Open Access journal devoted to the presentation of high-quality original research concerning human, animal, plant, insect bacterial, and fungal viruses. Virology Journal will establish a strategic alternative to the traditional virology communication process. ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-1-1
更新日期:2004-08-26 00:00:00
abstract:BACKGROUND:Tembusu virus is a newly emerging flavivirus that caused egg-drop syndrome in ducks in China. TMUV envelope protein is a major structural protein locates at the surface of tembusu virus particle. During tembusu virus infection, envelope protein plays a pivotal role in induction of neutralizing antibody. Howe...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1052-1
更新日期:2018-09-17 00:00:00
abstract::Much of the worlds' population is in active or imminent danger from established infectious pathogens, while sporadic and pandemic infections by these and emerging agents threaten everyone. RNA polymerases (RNApol) generate enormous genetic and consequent antigenic heterogeneity permitting both viruses and cellular pat...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/1743-422X-2-70
更新日期:2005-08-22 00:00:00
abstract::While improved drug regimens have greatly enhanced outcomes for patients with chronic viral infection, antiviral therapy is still not ideal due to drug toxicities, treatment costs, primary drug failure and emergent resistance. New antiviral agents, alternative treatment strategies and a better understanding of viral p...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-4-29
更新日期:2007-03-13 00:00:00
abstract:BACKGROUND:Recombinant Salmonella vaccine vectors may potentially be used to induce specific CD4+ T cell responses against foreign viral antigens. Such immune responses are required features of vaccines against pathogens such as human immunodeficiency virus type 1 (HIV-1). The aim of this study was to investigate the i...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-87
更新日期:2009-06-25 00:00:00
abstract:BACKGROUND:Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeutics to protect against CHIKV infection in humans. Animal models recapitulating human disease, especi...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0804-7
更新日期:2017-07-20 00:00:00