Abstract:
:Marek's disease is a highly contagious disease of poultry characterized by rapid-on set of T-cell lymphomas, which is caused by Marek's disease virus (MDV), but its pathogenic mechanism is still not very clear. Recently, some new progress were achieved in molecular character of MDV. Along with the genomic sequencing of MDV serotype 1, some novel open reading frames (ORFs) were predicted, and ORF72.2 was one of them which have no homologues in other MDV serotypes or in other alphaherpesvirus. In the study, ORF72.2 was firstly identified as a protein-coding gene by the method of reverse transcription polymerase chain reaction (RT-PCR), western blotting and indirect immunofluorescence assay. This study paved the way to conduct further studies to determine whether ORF72.2 plays a role in MDV replication and pathogenicity.
journal_name
Virol Jjournal_title
Virology journalauthors
Tian M,Zhao Y,Shi M,Lin Y,Zou N,Liu P,Wen X,Cao S,Huang Ydoi
10.1186/1743-422X-7-371subject
Has Abstractpub_date
2010-12-23 00:00:00pages
371issn
1743-422Xpii
1743-422X-7-371journal_volume
7pub_type
杂志文章相关文献
Virology Journal文献大全abstract::The original version of the acknowledgement unfortunately contained a mistake. ...
journal_title:Virology journal
pub_type: 已发布勘误
doi:10.1186/s12985-020-01439-2
更新日期:2020-11-09 00:00:00
abstract:BACKGROUND:Construction of conditionally-replicative Adenovirus (CRAd) is complex and time-consuming. While homologous recombination (HR) using a two-plasmid system in bacteria is commonly used to generate CRAds, alternative methods may be required when HR fails. Previously, in vitro ligation has been suggested to faci...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-18
更新日期:2009-02-07 00:00:00
abstract:BACKGROUND:Pseudorabies virus (PRV) of the family Herpesviridae is the causative agent of Aujeszky's disease. Attenuation of PRV by serial passaging in vitro is a well-established method; however, the dynamic variations occurring on viral genome during this process have not been characterized. METHODS:Genome sequencin...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1102-8
更新日期:2018-12-29 00:00:00
abstract:BACKGROUND:A novel human enterovirus (HEV) type within the species HEV-C, named EV109, was discovered from cases of respiratory illness in Nicaragua in September 2010. The aim of this study, was to retrospectively examine the presence and the role of EV109 in respiratory samples from two patients populations; infants b...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-183
更新日期:2012-09-04 00:00:00
abstract:BACKGROUND:The tumor suppressor gene p53 has been found to suppress HIV infection by various mechanisms, but the inhibition of HIV at an early stage of replication by host cell p53 and its downstream gene p21 has not been well studied. METHOD:VSV-G pseudotyped HIV-1 or HIV-2 viruses with GFP or luciferase reporter gen...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-0959-x
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:In adenoviruses, primary host cell recognition is generally performed by the head domains of their homo-trimeric fibre proteins. This first interaction is reversible. A secondary, irreversible interaction subsequently takes place via other adenovirus capsid proteins and leads to a productive infection. Altho...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0309-1
更新日期:2015-05-22 00:00:00
abstract:BACKGROUND:Enzootic nasal tumor virus (ENTV) is a betaretrovirus of sheep (ENTV-1) and goats (ENTV-2) associated with neoplastic transformation of epithelial cells of the ethmoid turbinate. Confirmation of the role of ENTV in the pathogenesis of enzootic nasal adenocarcinoma (ENA) has yet to be resolved due to the inab...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0795-4
更新日期:2017-07-26 00:00:00
abstract::A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-2-51
更新日期:2005-06-20 00:00:00
abstract:BACKGROUND:Swine-origin virus infection spreading widely could cause significant economic loss to porcine industry. Novel antiviral agents need to be developed to control this situation. METHODS:In this study, we evaluated the activities of five broad-spectrum antimicrobial peptides (AMPs) against several important sw...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-019-1199-4
更新日期:2019-07-31 00:00:00
abstract:BACKGROUND:Highly pathogenic avian influenza virus (AIV) subtype H5N1 remains a threat to poultry. Duck enteritis virus (DEV)-vectored vaccines expressing AIV H5N1 hemagglutinin (HA) may be viable AIV and DEV vaccine candidates. METHODS:To facilitate the generation and further improvement of DEV-vectored HA(H5) vaccin...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0354-9
更新日期:2015-08-13 00:00:00
abstract:BACKGROUND:More than a decade after the outbreak of human coronaviruses (HCoVs) SARS in Guangdong province and Hong Kong SAR of China in 2002, there is still no reoccurrence, but the evolution and recombination of the coronaviruses in this region are still unknown. Therefore, surveillance on the prevalence and the viru...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0896-0
更新日期:2017-11-22 00:00:00
abstract:BACKGROUND:Rotavirus (RV) is the main cause of severe gastroenteritis in children. An effective vaccination regime against RV can substantially reduce morbidity and mortality. Previous studies have demonstrated the efficacy of virus-like particles formed by RV VP2 and VP6 (VLP2/6), as well as that of recombinant adenov...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-3
更新日期:2011-01-05 00:00:00
abstract::Porcine Hokovirus (PHoV) was recently discovered in Hong Kong. This new Parvovirus of pigs is closely related to the human Parvoviruses 4 and 5 (PARV4/5) and bovine Hokovirus (BHoV). So far, nothing is known about the presence and prevalence of PHoV in regions of the world other than Hong Kong. A study was initiated t...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-171
更新日期:2010-07-25 00:00:00
abstract:BACKGROUND:A serological method to simultaneously detect antibodies against infectious laryngotracheitis virus (ILTV) and infectious bronchitis virus (IBV) is imperative for the differential diagnosis and evaluation of antibodies titers after vaccination. METHOD:The microspheres coated with purified recombinant glycop...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1048-x
更新日期:2018-09-21 00:00:00
abstract:BACKGROUND:Infection with Chikungunya alphavirus (CHIKV) can cause severe arthralgia and chronic arthritis in humans with persistence of the virus in perivascular macrophages of the synovial membrane by mechanisms largely ill-characterized. FINDINGS:We herein analysed the innate immune response (cytokine and programme...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-313
更新日期:2012-12-19 00:00:00
abstract:BACKGROUND:The highly pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) emerging in China exhibits high fatality to pigs. However, the mechanism related to the increased pathogenicity of the virus remains unclear. In the present study, the differences in tissue tropism between the highly pathogenic...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-203
更新日期:2012-09-17 00:00:00
abstract:BACKGROUND:Acute gastroenteritis caused by bacteria, virus and parasite is an important cause of childhood morbidity and mortality in developing countries. Rotavirus and norovirus have been recognized as the most common pathogens causing acute gastroenteritis among children. However, there is still no valuable data abo...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-302
更新日期:2013-10-08 00:00:00
abstract:BACKGROUND:Influenza virus continues to cause significant hospitalization rates in infants and young children. A 2-dose regime of trivalent inactivated vaccine is required to generate protective levels of hemagglutination inhibiting (HAI) antibodies. A vaccine preparation with enhanced immunogenicity is therefore desir...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-251
更新日期:2011-05-21 00:00:00
abstract:BACKGROUND:Nonstructural glycoprotein 4 (NSP4) encoded by rotavirus is the only viral protein currently believed to function as an enterotoxin. NSP4 is synthesized as an intracellular transmembrane glycoprotein and as such is essential for virus assembly. Infection of polarized Caco-2 cells with rotavirus also results ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-551
更新日期:2011-12-20 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV)-associated malignancy remain a main cause of cancer in men and women. Cancer immunotherapy has represented great potential as a new promising cancer therapeutic approach. Here, we report Mesenchymal stem cells (MSCs) as a carrier for the delivery of oncolytic Newcastle disease viru...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-020-01326-w
更新日期:2020-05-05 00:00:00
abstract:BACKGROUND:Ebola viruses (EBOVs) cause severe hemorrhagic fever with a high mortality rate. At present, there are no licensed vaccines or efficient therapies to combat EBOV infection. Previous studies have shown that both humoral and cellular immune responses are crucial for controlling Ebola infection. CD8+ T cells pl...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-111
更新日期:2012-06-13 00:00:00
abstract:BACKGROUND:Emergence and re-emergence of porcine epidemic diarrhea virus (PEDV) in North America, Asia and Europe has caused severe economic loss to the global swine industry. However, the virome of PEDV infected pigs and its effect on disease severity remains unknown. The advancements of sequencing technology have mad...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1001-z
更新日期:2018-05-25 00:00:00
abstract:BACKGROUND:Production of cassava (Manihot esculenta Crantz), a food security crop in sub-Saharan Africa, is threatened by the spread of cassava brown streak disease (CBSD) which manifests in part as a corky necrosis in the storage root. It is caused by either of two virus species, Cassava brown streak virus (CBSV) and ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0216-x
更新日期:2014-12-20 00:00:00
abstract::The triple-gene-block protein 2 (TGBp2) of Bamboo mosaic virus (BaMV) is a transmembrane protein which was proposed to be involved in viral RNA binding during virus transport. Here, we report on the RNA-binding properties of TGBp2. Using tyrosine fluorescence spectroscopy and UV-crosslinking assays, the TGBp2 solubili...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-50
更新日期:2009-05-07 00:00:00
abstract:BACKGROUND:Nuclear factor-kappaB (NF-κB) is an inducible transcription factor that plays a key role in inflammation and immune responses, as well as in the regulation of cell proliferation and survival. Previous studies by our group and others have demonstrated that porcine reproductive and respiratory syndrome virus (...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-83
更新日期:2012-04-30 00:00:00
abstract:BACKGROUND:Public health risks associated to infection by human coronaviruses remain considerable and vaccination is a key option for preventing the resurgence of severe acute respiratory syndrome coronavirus (SARS-CoV). We have previously reported that antibodies elicited by a SARS-CoV vaccine candidate based on recom...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-82
更新日期:2014-05-06 00:00:00
abstract:BACKGROUND:The context and purpose of the study included 1) bacterial expression of viral protein 6 (VP6) of porcine rotavirus (PRV) and generation of rabbit polyclonal antiserum to the VP6 protein; 3) establishment of a discrimination ELISA to distinguish PRV from a panel of other porcine viruses. RESULTS:The VP6 gen...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-91
更新日期:2013-03-22 00:00:00
abstract:BACKGROUND:The global spread of the highly pathogenic avian influenza H5N1 virus has stimulated interest in a better understanding of the mechanisms of H5N1 dispersal, including the potential role of migratory birds as carriers. Although wild birds have been found dead during H5N1 outbreaks, evidence suggests that othe...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-71
更新日期:2008-06-04 00:00:00
abstract:BACKGROUND:The genetic element s2m seems to represent one of very few examples of mobile genetic elements in viruses. The function remains obscure and a scattered taxonomical distribution has been reported by numerous groups. METHODS:We have searched GenBank in order to identify all viral accessions that have s2m(-lik...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-132
更新日期:2013-04-25 00:00:00
abstract:BACKGROUND:Influenza A virus poses a continuous threat to global public health. Design of novel universal drugs and vaccine requires a careful analysis of different strains of Influenza A viral genome from diverse hosts and subtypes. We performed a systematic in silico analysis of Influenza A viral segments of all avai...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-44
更新日期:2011-01-27 00:00:00