Genetic lesions within the 3a gene of SARS-CoV.

abstract：BACKGROUND:Chronic hepatitis C virus (HCV) genotype (GT) 3 infection with advanced liver disease has emerged as a challenging to treat by direct-acting antivirals (DAAs), but the efficacy of DAAs in Chinese HCV-GT3 patients is rarely reported. This study aimed to analyze the efficacy of sofosbuvir (SOF)-based regimens ...

journal_title：Virology journal

authors： Tao YC,Deng R,Wang ML,Lv DD,Yuan M,Wang YH,Chen EQ,Tang H

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Since its first appearance in the USA in 1999, West Nile virus (WNV) has spread in the Western hemisphere and continues to represent an important public health concern. In the absence of effective treatment, there is a medical need for the development of a safe and efficient vaccine. Live attenuated WNV vacc...

journal_title：Virology journal

authors： Spohn G,Jennings GT,Martina BE,Keller I,Beck M,Pumpens P,Osterhaus AD,Bachmann MF

更新日期：2010-07-06 00:00:00

abstract：:HIV expressed in genital secretions provides the inoculum from which transmitting variants are selected, both in sexual transmission and mother-to-infant transmission during partuition. Characterization of HIV levels and genotypes found in vaginal secretions and the impact of anti-retroviral therapy (ART) on this viru...

journal_title：Virology journal

authors： Randolph TC,Kissinger PJ,Clark RA,Lacour N,Amedee AM

更新日期：2008-07-29 00:00:00

abstract：BACKGROUND:Human astroviruses (HAstVs) are one of the important causes of acute gastroenteritis in children. Currently, eight HAstV genotypes have been identified and all but two (HAstV-6 and HAstV-7) have been fully sequenced. We here sequenced and analyzed the complete genome of a HAstV-6 strain (192-BJ07), which was...

journal_title：Virology journal

authors： Guo L,Gonzalez R,Wang W,Li Y,Paranhos-Baccalà G,Vernet G,Wang J

更新日期：2010-02-08 00:00:00

abstract：:We report the presence of three new O1 ElTor vibriophages named AS1, AS2 and AS3, isolated from the sewage and pond waters of the outskirts of Kolkata. A few phages, named AS4, with hexagonal heads and abnormally long tails with typical curly projections were also found in the water samples. ...

journal_title：Virology journal

authors： Sen A,Ghosh AN

更新日期：2005-04-11 00:00:00

abstract：BACKGROUND:Progressive multifocal leukoencephalopathy (PML) onset, caused by Polyomavirus JC (JCPyV) in patients affected by immune-mediated diseases during biological treatment, raised concerns about the safety profile of these agents. Therefore, the aims of this study were the JCPyV reactivation monitoring and the no...

journal_title：Virology journal

authors： Bellizzi A,Anzivino E,Rodio DM,Cioccolo S,Scrivo R,Morreale M,Pontecorvo S,Ferrari F,Di Nardo G,Nencioni L,Carluccio S,Valesini G,Francia A,Cucchiara S,Palamara AT,Pietropaolo V

更新日期：2013-09-30 00:00:00

abstract：BACKGROUND:The family Mesoniviridae (order Nidovirales) comprises of a group of positive-sense, single-stranded RNA ([+]ssRNA) viruses isolated from mosquitoes. FINDINGS:Thirteen novel insect-specific virus isolates were obtained from mosquitoes collected in Indonesia, Thailand and the USA. By electron microscopy, the...

journal_title：Virology journal

authors： Vasilakis N,Guzman H,Firth C,Forrester NL,Widen SG,Wood TG,Rossi SL,Ghedin E,Popov V,Blasdell KR,Walker PJ,Tesh RB

更新日期：2014-05-20 00:00:00

abstract：BACKGROUND:HIV-1 subtype B' isolates have been predominantly circulating in China. Their intra- and inter-subtype neutralization sensitivity to autologous and heterologous plasmas has not been well studied. RESULTS:Twelve HIV-1 B' clinical isolates obtained from patients were tested for their intra- and inter-subtype ...

journal_title：Virology journal

authors： OuYang Y,Sun J,Huang Y,Lu L,Xu W,Hu X,Hong K,Jiang S,Shao Y,Ma L

更新日期：2013-01-05 00:00:00

abstract：BACKGROUND:Multi-resistant Achromobacter xylosoxidans has been recognized as an emerging pathogen causing nosocomially acquired infections during the last years. Phages as natural opponents could be an alternative to fight such infections. Bacteriophages against this opportunistic pathogen were isolated in a recent stu...

journal_title：Virology journal

authors： Wittmann J,Dreiseikelmann B,Rohde M,Meier-Kolthoff JP,Bunk B,Rohde C

更新日期：2014-01-27 00:00:00

abstract：BACKGROUND:Human Enterovirus 71 (EV71) has emerged as the leading cause of viral encephalitis in children, especially in the Asia-Pacific regions. EV71 vaccine development is of high priority at present, and neutralization antibodies have been documented to play critical roles during in vitro and in vivo protection aga...

journal_title：Virology journal

authors： Li YX,Zhao H,Cao RY,Deng YQ,Han JF,Zhu SY,Ma J,Liu L,Qin ED,Qin CF

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Duck circovirus (DuCV) infection in farmed ducks is associated with growth problems or retardation syndromes. Rapid identification of DuCV infected ducks is essential to control DuCV effectively. Therefore, this study aims to develop of an assay for DuCV to be highly specific, sensitive, and simple without a...

journal_title：Virology journal

authors： Xie L,Xie Z,Zhao G,Liu J,Pang Y,Deng X,Xie Z,Fan Q,Luo S

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:Patchouli alcohol (PA) is a tricyclic sesquiterpene extracted from Pogostemonis Herba, which is a traditional Chinese medicine used for therapy of inflammatory diseases. Recent studies have shown that PA has various pharmacological activities, including anti-bacterial and anti-viral effects. METHODS:In this...

journal_title：Virology journal

authors： Yu Y,Zhang Y,Wang S,Liu W,Hao C,Wang W

更新日期：2019-12-23 00:00:00

abstract：BACKGROUND:Co-circulation of multiple dengue virus serotypes has been reported from many parts of the world including India, however concurrent infection with more than one serotype of dengue viruses in the same individual is rarely documented. An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occ...

journal_title：Virology journal

authors： Bharaj P,Chahar HS,Pandey A,Diddi K,Dar L,Guleria R,Kabra SK,Broor S

更新日期：2008-01-09 00:00:00

abstract：BACKGROUND:Most of the non-B HIV-1 subtypes are predominant in Sub-Saharan Africa and India although they have been found worldwide. In the last decade, immigration from these areas has increased considerably in Spain. The objective of this study was to evaluate the prevalence of non-B subtypes circulating in a cohort ...

journal_title：Virology journal

authors： de Felipe B,Pérez-Romero P,Abad-Fernández M,Fernandez-Cuenca F,Martinez-Fernandez FJ,Trastoy M,Mata Rdel C,López-Cortés LF,Leal M,Viciana P,Vallejo A

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:Tomato yellow leaf curl virus (TYLCV), a monopartite begomovirus (family Geminiviridae) is responsible for heavy yield losses for tomato production around the globe. In Oman at least five distinct begomoviruses cause disease in tomato, including TYLCV. Unusually, TYLCV infections in Oman are sometimes associ...

journal_title：Virology journal

authors： Ammara Ue,Mansoor S,Saeed M,Amin I,Briddon RW,Al-Sadi AM

更新日期：2015-03-04 00:00:00

abstract：BACKGROUND:Data about molecular diversity of commonly circulating type A influenza viruses in Ontario swine are scarce. Yet, this information is essential for surveillance of animal and public health, vaccine updates, and for understanding virus evolution and its large-scale spread. METHODS:The study population consis...

journal_title：Virology journal

authors： Grgić H,Costa M,Friendship RM,Carman S,Nagy É,Wideman G,Weese S,Poljak Z

更新日期：2014-11-22 00:00:00

abstract：BACKGROUND:Infections with papillomaviruses induce type-specific immune responses, mainly directed against the major capsid protein, L1. Based on the propensity of the L1 protein to self-assemble into virus-like particles (VLPs), type-specific vaccines have already been developed. In order to generate vaccines that tar...

journal_title：Virology journal

authors： Roth SD,Sapp M,Streeck RE,Selinka HC

更新日期：2006-10-02 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is a major cause of chronic hepatitis and hepatocellular carcinoma (HCC) and different HCV genotypes show characteristic variations in their pathological properties. Insulin resistance (IR) occurs early in HCV infection and may synergize with viral hepatitis in HCC development. Egypt ...

journal_title：Virology journal

authors： Mohamed AA,Loutfy SA,Craik JD,Hashem AG,Siam I

更新日期：2011-11-01 00:00:00

abstract：:Bats have been recognized as the natural reservoirs of a large variety of viruses. Special attention has been paid to bat coronaviruses as the two emerging coronaviruses which have caused unexpected human disease outbreaks in the 21st century, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Re...

journal_title：Virology journal

authors： Hu B,Ge X,Wang LF,Shi Z

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Chronic viral hepatitis B remains a global public health concern. Currently, several drugs, such as lamivudine and telbivudine, are recommended for treatment of patients with chronic hepatitis B. However, there are no conclusive results on the comparison of the efficacy of lamivudine (LAM) and telbivudine (L...

journal_title：Virology journal

authors： Zhao S,Tang L,Fan X,Chen L,Zhou R,Dai X

更新日期：2010-09-03 00:00:00

abstract：BACKGROUND:About half of the world's population are living in the endemic area of dengue viruses implying that a rapid-mass vaccination may be required. In addition, a major target of dengue vaccine are children, thus, a needle-free administration is more attractive. These problems may be overcome by the alternative ro...

journal_title：Virology journal

authors： Nantachit N,Sunintaboon P,Ubol S

更新日期：2016-08-18 00:00:00

abstract：BACKGROUND:Due to the high prevalence of viral infections having no specific treatment and the constant appearance of resistant viral strains, the development of novel antiviral agents is essential. The aim of this study was to evaluate the antiviral activity against bovine viral diarrhea virus, herpes simplex virus ty...

journal_title：Virology journal

authors： Visintini Jaime MF,Redko F,Muschietti LV,Campos RH,Martino VS,Cavallaro LV

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND:Public health risks associated to infection by human coronaviruses remain considerable and vaccination is a key option for preventing the resurgence of severe acute respiratory syndrome coronavirus (SARS-CoV). We have previously reported that antibodies elicited by a SARS-CoV vaccine candidate based on recom...

journal_title：Virology journal

authors： Yip MS,Leung NH,Cheung CY,Li PH,Lee HH,Daëron M,Peiris JS,Bruzzone R,Jaume M

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Open reading frame 58 (ORF58) of varicella-zoster virus (VZV) lies at the 3'end of the Unique long (UL) region and its functional is unknown. In order to clarify whether ORF58 is essential for the growth of VZV, we constructed a deletion mutant of ORF58 (pOka-BACDelta58) from the Oka parental genome cloned i...

journal_title：Virology journal

authors： Yoshii H,Sadaoka K,Matsuura M,Nagaike K,Takahashi M,Yamanishi K,Mori Y

更新日期：2008-04-30 00:00:00

abstract：BACKGROUND:A novel human enterovirus (HEV) type within the species HEV-C, named EV109, was discovered from cases of respiratory illness in Nicaragua in September 2010. The aim of this study, was to retrospectively examine the presence and the role of EV109 in respiratory samples from two patients populations; infants b...

journal_title：Virology journal

authors： Debiaggi M,Ceresola ER,Sampaolo M,Alessandrino EP,Brerra R,Piazza A,Clementi M,Canducci F

更新日期：2012-09-04 00:00:00

abstract：:The Filoviridae family comprises of Ebola and Marburg viruses, which are known to cause lethal hemorrhagic fever. However, there is no effective anti-viral therapy or licensed vaccines currently available for these human pathogens. The envelope glycoprotein (GP) of Ebola virus, which mediates entry into target cells, ...

journal_title：Virology journal

authors： Bhattacharyya S,Hope TJ

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Human papillomaviruses (HPVs), a group of non-enveloped small viruses with double-stranded circular DNA which lead to multiple skin diseases such as benign warts, are commonly seen in clinics. The current HPV detection systems aim mainly at mucosal HPVs, however, an efficient clinical approach for cutaneous ...

journal_title：Virology journal

authors： Wang Y,Ge G,Mao R,Wang Z,Sun YZ,Du YG,Gao XH,Qi RQ,Chen HD

更新日期：2020-07-09 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) is a novel target and molecule in the negative regulation of immune homeostasis. The present study aimed to investigate the dynamic expression of TIPE2 mRNA during the progression of chronic hepatitis B virus (HBV) infection. METHODS:A total of 19...

journal_title：Virology journal

authors： Liu Y,Jin J,Ji J,Gao XM,Fan YC

更新日期：2019-10-28 00:00:00

abstract：BACKGROUND:Uukuniemi virus (UUKV) belongs to the Phlebovirus genus in the family Bunyaviridae. As a non-pathogenic virus for humans UUKV has served as a safe model bunyavirus in a number of studies addressing fundamental questions such as organization and regulation of viral genes, genome replication, structure and ass...

journal_title：Virology journal

authors： Katz A,Freiberg AN,Backström V,Schulz AR,Mateos A,Holm L,Pettersson RF,Vaheri A,Flick R,Plyusnin A

更新日期：2010-08-10 00:00:00

abstract：BACKGROUND:Porcine circovirus type 2 (PCV2), the causative agent of postweaning multisystemic wasting syndrome (PMWS), is a serious economic problem in the swine industry. Different genotypes (PCV2a, PCV2b and PCV2d) of the virus are present in the clinical cases in China, and it is necessary to elucidate the pathogeni...

journal_title：Virology journal

authors： Guo LJ,Lu YH,Huang LP,Wei YW,Wu HL,Liu CM

更新日期：2011-06-10 00:00:00