Abstract:
BACKGROUND:Newcastle disease (ND), caused by Newcastle disease virus (NDV), is a highly contagious disease of birds and has been one of the major causes of economic losses in the poultry industry. Despite routine vaccination programs, sporadic cases have occasionally occurred in the country and remain a constant threat to commercial poultry. Hence, the present study was aimed to characterize NDV isolates obtained from clinical cases in various locations of Malaysia between 2004 and 2007 based on sequence and phylogenetic analysis of partial F gene and C-terminus extension length of HN gene. RESULTS:The coding region of eleven NDV isolates fusion (F) gene and carboxyl terminal region of haemagglutinin-neuraminidase (HN) gene including extensions were amplified by reverse transcriptase PCR and directly sequenced. All the isolates have shown to have non-synonymous to synonymous base substitution rate ranging between 0.081 - 0.264 demonstrating presence of negative selection. Analysis based on F gene showed the characterized isolates possess three different types of protease cleavage site motifs; namely 112RRQKRF117, 112RRRKRF117 and 112GRQGRL117 and appear to show maximum identities with isolates in the region such as cockatoo/14698/90 (Indonesia), Ch/2000 (China), local isolate AF2240 indicating the high similarity of isolates circulating in the South East Asian countries. Meanwhile, one of the isolates resembles commonly used lentogenic vaccine strains. On further characterization of the HN gene, Malaysian isolates had C-terminus extensions of 0, 6 and 11 amino acids. Analysis of the phylogenetic tree revealed that the existence of three genetic groups; namely, genotype II, VII and VIII. CONCLUSIONS:The study concluded that the occurrence of three types of NDV genotypes and presence of varied carboxyl terminus extension lengths among Malaysian isolates incriminated for sporadic cases.
journal_name
Virol Jjournal_title
Virology journalauthors
Berhanu A,Ideris A,Omar AR,Bejo MHdoi
10.1186/1743-422X-7-183subject
Has Abstractpub_date
2010-08-08 00:00:00pages
183issn
1743-422Xpii
1743-422X-7-183journal_volume
7pub_type
杂志文章相关文献
Virology Journal文献大全abstract:BACKGROUND:Torquetenovirus (TTV) belongs to Anelloviridae family, infects nearly all people indefinitely without causing overt disease establishing a fine and successful interaction with the host. Increasing evidence have shown some human viruses exploit extracellular vesicles thereby helping viral persistence in the h...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1055-y
更新日期:2018-09-20 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) bivalent and quadrivalent vaccines have been widely implemented in worldwide organized immunization programs. A nonavalent HPV vaccine is now available in several countries. The objective was to describe the fraction of squamous non-invasive high-grade cervical intraepithelial lesi...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0879-1
更新日期:2017-11-06 00:00:00
abstract:BACKGROUND:Protease inhibitors (PIs) to treat hepatitis C (HCV) virus infection have been approved and others are under development. RESULTS:The aims of this study were to illustrate natural polymorphisms in the HCV protease and measure the frequency of PI resistance mutations in different HCV genotypes from PI-naïve ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-245
更新日期:2012-10-24 00:00:00
abstract:BACKGROUND:The ESCRT (endosomal sorting complex required for transport) machinery functions to sort cellular receptors into the lumen of the multivesicular body (MVB) prior to lysosomal degradation. ESCRT components can also be recruited by enveloped viruses to sites of viral assembly where they have been proposed to m...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-23
更新日期:2008-02-11 00:00:00
abstract:BACKGROUND:Both regulatory T cells (Tregs) and PD-1/PD-L1 pathway were critically involved in HCV viral persistence. However, the association between them was not well investigated. Herein, we aimed to investigate the distributional profiles of Tregs subsets and association between PD-1 expression on these subsets and ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-279
更新日期:2011-06-07 00:00:00
abstract:BACKGROUND:Andes virus (ANDV), a rodent-borne Hantavirus, is the major etiological agent of Hantavirus cardiopulmonary syndrome (HCPS) in South America, which is mainly characterized by a vascular leakage with high rate of fatal outcomes for infected patients. Currently, neither specific therapy nor vaccines are availa...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-223
更新日期:2011-05-13 00:00:00
abstract:BACKGROUND:HIV-1 entry into cells is a multifaceted process involving target cell CD4 and the chemokine receptors, CXCR4 or CCR5. The lipid composition of the host cell plays a significant role in the HIV fusion process as it orchestrates the appropriate disposition of CD4 and co-receptors required for HIV-1 envelope g...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-3-104
更新日期:2006-12-22 00:00:00
abstract:INTRODUCTION:Despite being a leading infectious cause of childhood disability globally, testing for cytomegalovirus (CMV) infections in pregnancy is generally not done in Sub-Sahara Africa (SSA), where breastfeeding practice is almost universal. Whilst CMV and human immunodeficiency virus (HIV) are both endemic in SSA,...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-021-01494-3
更新日期:2021-01-29 00:00:00
abstract:BACKGROUND:The epidemic pattern of respiratory syncytial virus (RSV) is quite different in regions of Europe (biennial epidemics in alternating cycles of approximately 9 and 15 months) than in the Western Hemisphere (annual epidemics). In order to determine if these differences are accounted for by the circulation of d...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-133
更新日期:2009-09-07 00:00:00
abstract::Lytic bacteriophage 0305phi8-36 forms visually observed aggregates during plaque formation. Aggregates intrinsically lower propagation potential. In the present study, the following observations indicate that lost propagation potential is regained with time: (1) Aggregates sometimes concentrate at the edge of clear pl...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-4-131
更新日期:2007-12-04 00:00:00
abstract:BACKGROUND:Data about molecular diversity of commonly circulating type A influenza viruses in Ontario swine are scarce. Yet, this information is essential for surveillance of animal and public health, vaccine updates, and for understanding virus evolution and its large-scale spread. METHODS:The study population consis...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0194-z
更新日期:2014-11-22 00:00:00
abstract::The most common etiologic agents causing chronic hepatitis are hepatitis C and B viruses (HCV and HBV, respectively). Chronic infection caused by HCV is considered one of the major causative agents of liver cirrhosis and hepatocellular carcinoma worldwide. In combination with the increasing rate of new HCV infections,...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/1743-422X-9-109
更新日期:2012-06-12 00:00:00
abstract:BACKGROUND:Containment of influenza A H1N1 virus spread was implemented successfully in Xiamen, with large-scale inoculation to reduce morbidity. To identify beneficial elements and to guide decision-making in epidemic containment, we analyzed the epidemiologic parameters and evaluated the control measures. METHOD:We ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-20
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) E6 and E7 oncoproteins play a crucial role in HPV-related diseases, such as cervical cancer, and can be used as ideal targets for therapeutic vaccines. Human leukocyte antigen (HLA) participates in the immune response to block HPV infection and invasion by its target/recognition fu...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-019-1168-y
更新日期:2019-05-28 00:00:00
abstract:BACKGROUND:The COVID-19 causing coronavirus is an enveloped RNA virus that utilizes an enzyme RNA dependent RNA polymerase for its replication. Favipiravir (FVP) triphosphate, a purine nucleoside analog, inhibits that enzyme. We have conducted this systematic review and meta-analysis on efficacy and safety of the drug ...
journal_title:Virology journal
pub_type: 杂志文章,meta分析
doi:10.1186/s12985-020-01412-z
更新日期:2020-09-24 00:00:00
abstract:BACKGROUND:Infection by any one of 15 high risk human papillomavirus (hrHPV) types causes most invasive cervical cancers. Their oncogenic genome is encapsidated by L1 (major) and L2 (minor) coat proteins. Current HPV prophylactic vaccines are composed of L1 virus-like particles (VLP) that elicit type restricted immunit...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0364-7
更新日期:2015-09-11 00:00:00
abstract::The NanoSight LM10 with Nanoparticle tracking analysis (NTA) software was evaluated for the quantification of latex particles, adenovirus 5, and influenza virus. The inter-day variability was determined by measuring the same sample over several consecutive days and the method's accuracy was demonstrated by using known...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-265
更新日期:2012-11-12 00:00:00
abstract::The Filoviridae family comprises of Ebola and Marburg viruses, which are known to cause lethal hemorrhagic fever. However, there is no effective anti-viral therapy or licensed vaccines currently available for these human pathogens. The envelope glycoprotein (GP) of Ebola virus, which mediates entry into target cells, ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-11
更新日期:2011-01-12 00:00:00
abstract:BACKGROUND:Saffold Virus (SAFV) is a human cardiovirus that is suspected of causing infection of the central nervous system (CNS) in children. While recent animal studies have started to elucidate the pathogenesis of SAFV, very little is known about the mechanisms behind it. METHOD:In this study, we attempted to eluci...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0654-8
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:Controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis B virus (HBV) infection. Thus, the aim of study was to analyze the changes in renal function of chronic hepatitis B (CHB) patients in response to anti-HBV therapy and the association with tre...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0712-x
更新日期:2017-03-09 00:00:00
abstract:BACKGROUND:H6 subtype influenza viruses were prevalent in domestic poultry and wild birds, which also could pose potential threat to humans. However, little is known about the prevalence of H6 subtype viruses in wild birds in eastern China, a crucial stopover or wintering site for migratory wild birds along the East As...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-020-01331-z
更新日期:2020-04-29 00:00:00
abstract:AIM:To investigate the enhancement of humoral immunity when CpG ODN (cytidine phosphate guanosine oligodeoxynucleotides) and aluminium adjuvants are complexed with the HCV (Hepatitis C virus) recombinant immunogen in mice. METHODS:After immunizing Balb/c mice with the recombination HCV antigen adjuvanted with pUCpGs10...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-507
更新日期:2011-11-04 00:00:00
abstract:BACKGROUND:Using a murine model of parainfluenza virus infection (mPIV1 or Sendai virus; SeV), we compared the inflammatory responses to lethal and sub-lethal infections in inbred DBA/2 mice. METHODS:Mice were intranasally inoculated with either 1.6×10(3) or 1.6×10(5) infectious units (IU) of SeV or diluent control. C...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-357
更新日期:2013-12-21 00:00:00
abstract:BACKGROUND:HIV-1 subtype B' isolates have been predominantly circulating in China. Their intra- and inter-subtype neutralization sensitivity to autologous and heterologous plasmas has not been well studied. RESULTS:Twelve HIV-1 B' clinical isolates obtained from patients were tested for their intra- and inter-subtype ...
journal_title:Virology journal
pub_type: 杂志文章,多中心研究
doi:10.1186/1743-422X-10-10
更新日期:2013-01-05 00:00:00
abstract:BACKGROUND:Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeutics to protect against CHIKV infection in humans. Animal models recapitulating human disease, especi...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0804-7
更新日期:2017-07-20 00:00:00
abstract:BACKGROUND:Hepatitis A virus is an infection of liver; it is hyperendemic in vast areas of the world including India. In most cases it causes an acute self limited illness but rarely fulminant. There is growing concern about change in pattern from asymptomatic childhood infection to an increased incidence of symptomati...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-254
更新日期:2011-05-23 00:00:00
abstract:BACKGROUND:Torque teno virus is a small chronically persisting circular negative ssDNA virus reaching near 100% prevalence. It is reported to be a marker for immune function in immunocompromised patients. The possibility of vertical maternal-fetal transmission remains controversial but incidence rate of TTV DNA in chil...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1007-6
更新日期:2018-05-30 00:00:00
abstract:BACKGROUND:Kadipiro virus (KDV) belongs to the Reoviridae family, which consists of segmented, non-enveloped, double-stranded RNA viruses. It has previously been isolated from Culex, Anopheles, Armigeres and Aedes mosquitoes in Indonesia and China. Here, we describe the isolation and characterization of SDKL1625 from A...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-0966-y
更新日期:2018-04-06 00:00:00
abstract:BACKGROUND:The mechanisms through which the avian influenza virus H5N1 modulate the host's innate immune defense during invasion, remains incompletely understood. RIG-I as a pattern recognition receptor plays an important role in mediating innate immune response induced by influenza virus. So, modulating RIG-I might be...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-145
更新日期:2012-08-03 00:00:00
abstract:BACKGROUND:Hepatitis C Virus (HCV) infected patients are frequently repeatedly exposed to the virus, but very few recombinants between two genotypes have been reported. FINDINGS:We describe the discovery of an HCV recombinant using a method developed in a United States clinical lab for HCV genotyping that employs sequ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-458
更新日期:2011-10-03 00:00:00