Abstract:
:Most viruses take advantage of endocytic pathways to gain entry into host cells and initiate infections. Understanding of virus entry via endocytosis is critically important for the design of antiviral strategies. Virus entry via endocytosis is a complex process involving hundreds of cellular proteins. The entire process is dictated by events occurring at multiple time and length scales. In this review, we discuss and evaluate the available means to investigate virus endocytic entry, from both experimental and theoretical/numerical modeling fronts, and highlight the importance of multiscale features. The complexity of the process requires investigations at a systems biology level, which involves the combination of different experimental approaches, the collaboration of experimentalists and theorists across different disciplines, and the development of novel multiscale models.
journal_name
Virol Jjournal_title
Virology journalauthors
Barrow E,Nicola AV,Liu Jdoi
10.1186/1743-422X-10-177subject
Has Abstractpub_date
2013-06-05 00:00:00pages
177issn
1743-422Xpii
1743-422X-10-177journal_volume
10pub_type
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