Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0.

abstract：OBJECTIVE:To determine HIV-1 RNA load during the third trimester of pregnancy and evaluate its effect on in utero and intra-partum/postpartum transmissions in a breastfeeding population. DESIGN:A nested case-control study within a PMTCT cohort of antiretroviral therapy naive pregnant women and their infants. METHODS:...

journal_title：Virology journal

authors： Duri K,Gumbo FZ,Kristiansen KI,Kurewa NE,Mapingure MP,Rusakaniko S,Chirenje MZ,Muller F,Stray-Pedersen B

更新日期：2010-08-02 00:00:00

abstract：:HIV expressed in genital secretions provides the inoculum from which transmitting variants are selected, both in sexual transmission and mother-to-infant transmission during partuition. Characterization of HIV levels and genotypes found in vaginal secretions and the impact of anti-retroviral therapy (ART) on this viru...

journal_title：Virology journal

authors： Randolph TC,Kissinger PJ,Clark RA,Lacour N,Amedee AM

更新日期：2008-07-29 00:00:00

abstract：BACKGROUND:Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-β in many cell types. Poly (I:C) is the most potent IFN inducer. In in vivo mouse studies, intraperitoneal injection of Poly (I:C) elicited ...

journal_title：Virology journal

authors： Li YG,Siripanyaphinyo U,Tumkosit U,Noranate N,A-Nuegoonpipat A,Pan Y,Kameoka M,Kurosu T,Ikuta K,Takeda N,Anantapreecha S

更新日期：2012-06-14 00:00:00

abstract：BACKGROUND:During the pandemic [Influenza A(H1N1)pdm09] period in 2009-2010, an influenza A (Inf-A) virus with H1N2 subtype (designated as A/Eastern India/N-1289/2009) was detected from a 25 years old male from Mizoram (North-eastern India). OBJECTIVE:To characterize full genome of the H1N2 influenza virus. METHODS:F...

journal_title：Virology journal

authors： Mukherjee TR,Agrawal AS,Chakrabarti S,Chawla-Sarkar M

更新日期：2012-10-11 00:00:00

abstract：BACKGROUND:Recently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationship of HLA-DP rs9277535 and HLA-DQ rs7453920 with the outcomes of HCV infection. METHODS:The rs927...

journal_title：Virology journal

authors： Huang P,Fan H,Tian T,Liao P,Li J,Yu R,Xia X,Feng Y,Wang J,Liu Y,Zhang Y,Yue M

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:Open reading frame 58 (ORF58) of varicella-zoster virus (VZV) lies at the 3'end of the Unique long (UL) region and its functional is unknown. In order to clarify whether ORF58 is essential for the growth of VZV, we constructed a deletion mutant of ORF58 (pOka-BACDelta58) from the Oka parental genome cloned i...

journal_title：Virology journal

authors： Yoshii H,Sadaoka K,Matsuura M,Nagaike K,Takahashi M,Yamanishi K,Mori Y

更新日期：2008-04-30 00:00:00

abstract：BACKGROUND:Human cytomegalovirus UL114 encodes a uracil-DNA glycosylase homolog that is highly conserved in all characterized herpesviruses that infect mammals. Previous studies demonstrated that the deletion of this nonessential gene delays significantly the onset of viral DNA synthesis and results in a prolonged repl...

journal_title：Virology journal

authors： Prichard MN,Lawlor H,Duke GM,Mo C,Wang Z,Dixon M,Kemble G,Kern ER

更新日期：2005-07-15 00:00:00

abstract：:Fatal influenza A virus infection is a major threat to public health throughout the world. Lung macrophages and neutrophils have critical roles for both the pathogenesis and viral clearance of fatal viral infections. These are complicated by the interaction of innate immunity and adaptive immunity against viral infect...

journal_title：Virology journal

authors： Lv J,Hua Y,Wang D,Liu A,An J,Li A,Wang Y,Wang X,Jia N,Jiang Q

更新日期：2014-03-26 00:00:00

abstract：BACKGROUND:H6 subtype influenza viruses were prevalent in domestic poultry and wild birds, which also could pose potential threat to humans. However, little is known about the prevalence of H6 subtype viruses in wild birds in eastern China, a crucial stopover or wintering site for migratory wild birds along the East As...

journal_title：Virology journal

authors： Hu C,Li X,Zhu C,Zhou F,Tang W,Wu D,Li Z,Zhou L,Liu J,Wei X,Cui J,Wang T,He G

更新日期：2020-04-29 00:00:00

abstract：BACKGROUND:Infection with Chikungunya alphavirus (CHIKV) can cause severe arthralgia and chronic arthritis in humans with persistence of the virus in perivascular macrophages of the synovial membrane by mechanisms largely ill-characterized. FINDINGS:We herein analysed the innate immune response (cytokine and programme...

journal_title：Virology journal

authors： Kumar S,Jaffar-Bandjee MC,Giry C,Connen de Kerillis L,Merits A,Gasque P,Hoarau JJ

更新日期：2012-12-19 00:00:00

abstract：BACKGROUND:Preeclampsia is a major health problem. Although, the pathophysiology of preeclampsia is not fully understood, there are recent studies on association between infections and preeclampsia. OBJECTIVE:The aim of the present study was to investigate the association between maternal seropositivity of rubella, He...

journal_title：Virology journal

authors： Alshareef SA,Eltom AM,Nasr AM,Hamdan HZ,Adam I

更新日期：2017-07-26 00:00:00

abstract：:Marek's disease is a highly contagious disease of poultry characterized by rapid-on set of T-cell lymphomas, which is caused by Marek's disease virus (MDV), but its pathogenic mechanism is still not very clear. Recently, some new progress were achieved in molecular character of MDV. Along with the genomic sequencing o...

journal_title：Virology journal

authors： Tian M,Zhao Y,Shi M,Lin Y,Zou N,Liu P,Wen X,Cao S,Huang Y

更新日期：2010-12-23 00:00:00

abstract：BACKGROUND:Tembusu virus is a newly emerging flavivirus that caused egg-drop syndrome in ducks in China. TMUV envelope protein is a major structural protein locates at the surface of tembusu virus particle. During tembusu virus infection, envelope protein plays a pivotal role in induction of neutralizing antibody. Howe...

journal_title：Virology journal

authors： Zhao D,Han K,Huang X,Zhang L,Wang H,Liu N,Tian Y,Liu Q,Yang J,Liu Y,Li Y

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:Porcine circovirus type-2b (PCV2b) is recognized as the etiological agent of the various clinical manifestations of porcine circovirus-associated disease (PCVAD). Previous studies have demonstrated effectiveness of chimeric PCV1-2 vaccines against PCV2b challenge. In this study, the efficacy of inactivated a...

journal_title：Virology journal

authors： Li J,Yu T,Wang X,Zhou J,Gao R,Zhang F,Gao X,Gao S,Liu X

更新日期：2015-07-30 00:00:00

abstract：:Recombination is known to play a role in the ability of various viruses to acquire sequence diversity. We consequently examined all available West Nile virus (WNV) whole genome sequences both phylogenetically and with a variety of computational recombination detection algorithms. We found that the number of distinct l...

journal_title：Virology journal

authors： Pickett BE,Lefkowitz EJ

更新日期：2009-10-12 00:00:00

abstract：BACKGROUND:Foot-and-mouth disease (FMD) is a highly contagious disease of livestock which causes severe economic loss in cloven-hoofed animals. Vaccination is still a major strategy in developing countries to control FMD. Currently, inactivated vaccine of FMDV has been used in many countries with limited success and sa...

journal_title：Virology journal

authors： Cao Y,Lu Z,Sun P,Fu Y,Tian F,Hao X,Bao H,Liu X,Liu Z

更新日期：2011-02-23 00:00:00

abstract：BACKGROUND:The mechanism by which HIV infection leads to a selective depletion of CD4 cells leading to immunodeficiency remains highly debated. Whether the loss of CD4 cells is a direct consequence of virus infection or bystander apoptosis of uninfected cells is also uncertain. RESULTS:We have addressed this issue in ...

journal_title：Virology journal

authors： Garg H,Joshi A,Ye C,Shankar P,Manjunath N

更新日期：2011-01-21 00:00:00

abstract：:More than 20 years ago, hantaviral antigens were reported in tissues of the Eurasian common shrew (Sorex araneus), Eurasian water shrew (Neomys fodiens) and common mole (Talpa europea), suggesting that insectivores, or soricomorphs, might serve as reservoirs of unique hantaviruses. Using RT-PCR, sequences of a genetic...

journal_title：Virology journal

authors： Song JW,Gu SH,Bennett SN,Arai S,Puorger M,Hilbe M,Yanagihara R

更新日期：2007-10-30 00:00:00

abstract：BACKGROUND:There are over 100 known human adenovirus (HAdV) types, which are able to cause a broad variety of different self-limiting but also lethal diseases especially in immunocompromised patients. Only limited information about the pathogenesis and biology of the majority of these virus types is available. In the p...

journal_title：Virology journal

authors： Mese K,Bunz O,Schellhorn S,Volkwein W,Jung D,Gao J,Zhang W,Baiker A,Ehrhardt A

更新日期：2020-04-09 00:00:00

abstract：BACKGROUND:Human enterovirus (EV) and parechovirus (HPeV) are significant causes of encephalitis and meningitis in children. The aim of this study was to determine the prevalence, type and viral RNA concentration of EV and HPeV in cerebrospinal fluid (CSF) samples in an unselected cohort of patients <18 years admitted ...

journal_title：Virology journal

authors： Vollbach S,Müller A,Drexler JF,Simon A,Drosten C,Eis-Hübinger AM,Panning M

更新日期：2015-11-25 00:00:00

abstract：BACKGROUND:Newcastle Disease (ND) is a highly contagious and economically devastating disease of poultry. At present, limited molecular epidemiological data are available regarding the causes of ND outbreaks in vaccinated commercial poultry farms. Knowing the genomic characteristics of Newcastle disease virus (NDV) inf...

journal_title：Virology journal

authors： Umali DV,Ito H,Suzuki T,Shirota K,Katoh H,Ito T

更新日期：2013-11-09 00:00:00

abstract：BACKGROUND:Classical swine fever (CSF) is a highly contagious fatal infectious disease caused by classical swine fever virus (CSFV). A better understanding of CSFV replication is important for the study of pathogenic mechanism of CSF. With the development of novel RNA in situ Hybridization method, quantitatively locali...

journal_title：Virology journal

authors： Zhang Q,Xu L,Zhang Y,Wang T,Zou X,Zhu Y,Zhao Y,Li C,Chen K,Sun Y,Sun J,Zhao Q,Wang Q

更新日期：2017-04-18 00:00:00

abstract：BACKGROUND:Echovirus 6 (E6) infections are associated with aseptic meningitis and acute flaccid paralysis (AFP). But some infections, sometimes most of them, are asymptomatic. The mechanism of E6 virulence is unknown. Analyses of the molecular evolution of asymptomatic E6 may help understand why the infections show dif...

journal_title：Virology journal

authors： Sun H,Huang X,Lin K,Huang K,Chu J,Yang Z,Ma S

更新日期：2017-07-25 00:00:00

abstract：BACKGROUND:The Epstein-Barr virus (EBV) is associated with lymphoid malignancies, including Burkitt's lymphoma (BL), and can transform human B cells in vitro. EBV-harboring cell lines are widely used to investigate lymphocyte transformation and oncogenesis. Qualitative EBV gene expression has been extensively described...

journal_title：Virology journal

authors： Bernasconi M,Berger C,Sigrist JA,Bonanomi A,Sobek J,Niggli FK,Nadal D

更新日期：2006-06-06 00:00:00

abstract：BACKGROUND:Papillomaviruses (PVs) establish a persistent infection in the proliferating basal cells of the epithelium. The viral genome is replicated and maintained as a low-copy nuclear plasmid in basal keratinocytes. Bovine and human papillomaviruses (BPV and HPV) are known to utilize two viral proteins; E1, a DNA he...

journal_title：Virology journal

authors： Pittayakhajonwut D,Angeletti PC

更新日期：2010-06-10 00:00:00

abstract：BACKGROUND:Chronic viral hepatitis B remains a global public health concern. Currently, several drugs, such as lamivudine and telbivudine, are recommended for treatment of patients with chronic hepatitis B. However, there are no conclusive results on the comparison of the efficacy of lamivudine (LAM) and telbivudine (L...

journal_title：Virology journal

authors： Zhao S,Tang L,Fan X,Chen L,Zhou R,Dai X

更新日期：2010-09-03 00:00:00

abstract：BACKGROUND:Newcastle disease (ND), caused by Newcastle disease virus (NDV), is a highly contagious disease of birds and has been one of the major causes of economic losses in the poultry industry. Despite routine vaccination programs, sporadic cases have occasionally occurred in the country and remain a constant threat...

journal_title：Virology journal

authors： Berhanu A,Ideris A,Omar AR,Bejo MH

更新日期：2010-08-08 00:00:00

abstract：:Lytic bacteriophage 0305phi8-36 forms visually observed aggregates during plaque formation. Aggregates intrinsically lower propagation potential. In the present study, the following observations indicate that lost propagation potential is regained with time: (1) Aggregates sometimes concentrate at the edge of clear pl...

journal_title：Virology journal

authors： Serwer P,Hayes SJ,Lieman K

更新日期：2007-12-04 00:00:00

abstract：BACKGROUND:Herpesviruses are ubiquitous pathogens that infect and cause recurrent disease in multiple animal species. Feline herpesvirus-1 (FHV-1), a member of the alphaherpesvirus family, causes respiratory illness and conjunctivitis, and approximately 80% of domestic cats are latently infected. Oral administration of...

journal_title：Virology journal

authors： Semenkow SL,Johnson NM,Maggs DJ,Margulies BJ

更新日期：2014-02-22 00:00:00

abstract：BACKGROUND:Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are two of the most frequent respiratory pathogens that circulate worldwide. Infection with either virus can lead to hospitalization of young children, immunocompromised people and the elderly.A better understanding of the epidemiologi...

journal_title：Virology journal

authors： Sastre P,Ruiz T,Schildgen O,Schildgen V,Vela C,Rueda P

更新日期：2012-07-02 00:00:00