Abstract:
BACKGROUND:Human enterovirus 71 (EV-71) is known of having caused numerous outbreaks of hand-foot-mouth disease, and other clinical manifestations globally. In 2008, 989 EV-71 strains were isolated in Taiwan. RESULTS:In this study, the genetic and antigenic properties of these strains were analyzed and the genetic diversity of EV-71 subgenogroups surfacing in Taiwan was depicted, which includes 3 previously reported subgenogroups of C5, B5, and C4, and one C2-like subgenogroup. Based on the phylogenetic analyses using their complete genome nucleotide sequences and neutralization tests, the C2-like subgenogroup forms a genetically distinct cluster from other subgenogroups, and the antisera show a maximum of 128-fold decrease of neutralization titer against this subgenogroup. In addition, the subgenogroup C4 isolates of 2008 were found quite similar genetically to the Chinese strains that caused outbreaks in recent years and thus they should be carefully watched. CONCLUSIONS:Other than to be the first report describing the existence of C2-like subgenogroup of EV-71 in Taiwan, this article also foresees a potential of subgenogroup C4 outbreaks in Taiwan in the near future.
journal_name
Virol Jjournal_title
Virology journalauthors
Huang YP,Lin TL,Hsu LC,Chen YJ,Tseng YH,Hsu CC,Fan WB,Yang JY,Chang FY,Wu HSdoi
10.1186/1743-422X-7-277subject
Has Abstractpub_date
2010-10-20 00:00:00pages
277issn
1743-422Xpii
1743-422X-7-277journal_volume
7pub_type
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