Abstract:
Purpose:Antifungal resistance and virulence properties of Candida albicans (C. albicans) are growing health problems worldwide. The present study aims to investigate the effect of Zinc Oxide (ZnO) nanoparticles and Nystatin on SAP1-3 genes expression in C. albicans isolates of females with Vulvovaginal Candidiasis (VVC) isolated from Sayad Shirazi Obstetrics and Gynecology Hospital in Northeastern Iran during 2017-2018. Patients and Methods:In this descriptive-analytic study, vaginal samples were collected from 280 VVC women. 196 (70%) of C. albicans isolates were identified by phenotypic and ITS genotypic methods. Susceptibility to Fluconazole C. albicans isolates was determined by the disk diffusion method. Detection of ERG11 gene was done by RT-PCR technique. Results:It was revealed that PCR amplified the ERG11 gene in all of the Fluconazole-resistant isolates. Real-time PCR was used to survey the effects of 3±1.7µg/mL concentrations of ZnO nanoparticles and Nystatin on expression of SAP1-3 genes before and after treatment. 186 (95%) susceptible C. albicans and 10 (5%) Fluconazole-resistant C. albicans isolates from VVC were exposed to sub-minimum inhibitory concentrations (Sub-MIC) of ZnO-np (range=0.02-12 μg/mL). Sub-MIC concentration was used for each strain, which reduced the expression of SAP1-3 genes to 1.8 MIC in the vaginal swabs. The observed reduction in gene expression was significant for both ZnO nanoparticles and Nystatin (P=0.01 and P=0.07, respectively). Conclusion:ZnO as antifungal agent can well reduce the growth and gene expression of SAP1-3 in the pathogenesis of VVC.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Hosseini SS,Joshaghani H,Shokohi T,Ahmadi A,Mehrbakhsh Zdoi
10.2147/IDR.S226154subject
Has Abstractpub_date
2020-02-13 00:00:00pages
385-394issn
1178-6973pii
226154journal_volume
13pub_type
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S227823
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
pub_type: 杂志文章
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S269719
更新日期:2020-11-04 00:00:00
abstract::Infectious diseases are known as one of the most life-threatening disabilities worldwide. Approximately 13 million deaths related to infectious diseases are reported each year. The only way to combat infectious diseases is by chemotherapy using antimicrobial agents and antibiotics. However, due to uncontrolled and unn...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
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journal_title:Infection and drug resistance
pub_type: 杂志文章
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S178922
更新日期:2018-12-04 00:00:00
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journal_title:Infection and drug resistance
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doi:10.2147/IDR.S160122
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journal_title:Infection and drug resistance
pub_type: 杂志文章
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更新日期:2018-10-26 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
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更新日期:2020-02-20 00:00:00