Abstract:
:Vancomycin has usually been associated with nephrotoxicity. Generally, this toxicity is presented as proximal tubular cells injury with or without necrosis and as acute interstitial nephritis. However, development of both lesions is uncommonly described in literature. We present a case of vancomycin-induced nephrotoxicity resulting in both acute interstitial nephritis and tubular cells damage confirmed by renal biopsy. Peak and trough levels of 77.11 and 63.60 μg/mL, respectively, were obtained at the first plasma determination. After 8 more plasma determinations and several hemodialysis sessions, vancomycin levels were undetectable 1 month after therapy was stopped. To our knowledge, this is the case report with the highest vancomycin trough levels developing both lesions and describing total vancomycin washout after a biopsy-proven vancomycin toxicity. In conclusion, early vancomycin therapeutic drug monitoring should be performed in order to avoid toxicities where, as seen in our patient, antibiotic exposure could last around 1 month after last dose administration.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Barceló-Vidal J,Rodríguez-García E,Grau Sdoi
10.2147/IDR.S171669subject
Has Abstractpub_date
2018-07-30 00:00:00pages
1027-1030issn
1178-6973pii
idr-11-1027journal_volume
11pub_type
abstract::Ceftaroline is an advanced-generation cephalosporin antibiotic recently approved by the US Food and Drug Administration for the treatment of complicated skin and skin-structure infections (cSSSIs). This intravenous broad-spectrum antibiotic exerts potent bactericidal activity by inhibiting bacterial cell wall synthesi...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S17432
更新日期:2012-01-01 00:00:00
abstract:Background:Leishmaniasis is an infectious disease common in tropical and subtropical regions caused by the genus Leishmania, which is transmitted by the bite of female sandflies. In this study, we evaluate the anti-leishmanial effect of recombinant Clostridium α-toxin protein alone and the combination with glucantime t...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S257561
更新日期:2020-07-15 00:00:00
abstract:Introduction:Candida species, one among the opportunistic fungi, has become a common pathogen causing vaginal thrush and nosocomial bloodstream infections (BSIs). This study aims to evaluate the prevalence and antifungal susceptibility of various Candida species and slime production by Candida species in BSIs and vulvo...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179462
更新日期:2018-11-23 00:00:00
abstract:Introduction:β-lactam and fluoroquinolone antibiotics are usually used for the treatment of urinary tract infections (UTIs). The aim of this study was to determine the prevalence of plasmid-mediated quinolone resistance (PMQR) and extended spectrum β-lactamases (ESBLs) in Enterobacteriaceae isolated from UTIs. Materia...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S160720
更新日期:2018-07-23 00:00:00
abstract:Objective:An ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the determination of selinexor was established to investigate the effects of isavuconazole, itraconazole and fluconazole on the pharmacokinetics of selinexor in rats, respectively. Methods:Twenty-four healthy male rat...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S269831
更新日期:2020-09-14 00:00:00
abstract::Mycoplasma genitalium is one of the important causes of non-gonococcal urethritis. Rising incidence and emerging antimicrobial resistance are a major concern these days. The poor clinical outcomes with doxycycline therapy led to the use of azithromycin as the primary drug of choice. Single-dose azithromycin regimen ov...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S105469
更新日期:2017-09-01 00:00:00
abstract::Aspergillus endocarditis (AE) accounts for a-quarter of all fungal endocarditis, mainly in immunocompromised hosts prior to heart-valve surgery with high mortality, even with treatment. Herein, we report a rare case of AE in a diabetic 60-year-old woman with a history of redo mitral valve prosthesis suspecious of acut...
journal_title:Infection and drug resistance
pub_type:
doi:10.2147/IDR.S258637
更新日期:2020-07-10 00:00:00
abstract:Objective:The aim of this study was to investigate the in vitro antimicrobial susceptibilities of clinically important Gram-negative bacteria from seven intensive care units in Taiwan in 2016. Materials and methods:In total, 300 non-duplicate isolates of Escherichia coli (n=100), Klebsiella pneumoniae (n=100), and Pse...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S193638
更新日期:2019-03-04 00:00:00
abstract::Removal of the spleen had already been established as a routine technique to treat splenic trauma and other diseases affecting the spleen before the anatomy, physiology, and function of the spleen were known in the mid-twentieth century. It is now widely accepted that the splenectomized individual is at increased risk...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S179902
更新日期:2019-09-12 00:00:00
abstract:Introduction:Surgical site infections (SSIs) are one of the most frequently reported hospital acquired infections associated with significant spread of antibiotic resistance. Purpose:We aimed to evaluate a bundle-based approach in reducing SSI at acute surgical intensive care unit of the Emergency Hospital of Cairo Un...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S236814
更新日期:2020-01-28 00:00:00
abstract::Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immun...
journal_title:Infection and drug resistance
pub_type:
doi:10.2147/IDR.S163686
更新日期:2018-05-14 00:00:00
abstract:Background:The ability of biofilm formation is an effective way for Acinetobacter baumannii survival from stressed conditions. This present study was aimed to evaluate the association between biofilm formation, structure, the expression levels of genes related to biofilm formation and biofilm-specific resistance of A. ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S228981
更新日期:2019-12-12 00:00:00
abstract::Infections by drug-resistant bacteria are life-threatening. As iron is a vital element for the growth of bacteria, iron-chelating agents (siderophores) can be used to arrest their multiplication. Exogenous siderophores - exochelin-MS and deferoxamine-B - were evaluated for their inhibitory activity against methicillin...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S148602
更新日期:2018-01-09 00:00:00
abstract:Background:The aim of this study was to evaluate the clinical performance of the BD Kiestra InoqulA automated specimen processing system with commonly encountered clinical microbiology specimens. Materials and Methods:Four types of clinical specimens (sputum, urine, normally sterile body fluids, and feces) were inocul...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S245173
更新日期:2020-04-01 00:00:00
abstract::Genetic and cellular studies have shown that the host's innate and adaptive immune responses are an important correlate of viral infection outcome. The features of the host's immune response (host resistance) reflect the coevolution between hosts and pathogens that has occurred over millennia, and that has also result...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S49891
更新日期:2015-04-07 00:00:00
abstract:Purpose:This research aimed to investigate the antibacterial activity and potential mechanism of luteolin against T. pyogenes. Materials and Methods:The broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of luteolin against various T. pyogenes strains. The potential mechanism...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S253363
更新日期:2020-06-10 00:00:00
abstract:Background and Objectives:Tuberculosis (TB) is a global public health issue. The emergence of multidrug-resistant (MDR) TB has further complicated the situation in the form of poor treatment outcomes and costs to individuals and health-care systems. We therefore aimed to measure the prevalence and associated risk facto...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S277477
更新日期:2020-11-10 00:00:00
abstract:Introduction:To achieve target concentrations, the application of higher-than-standard doses of amikacin is proposed for the treatment of sepsis due to an increase in volume of distribution and clearance, but little data are available on aminoglycoside administration in critically ill elderly patients. Patients and me...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S150839
更新日期:2018-02-13 00:00:00
abstract::Background: There have been no reports in Bulgaria about quinolone resistance determinants among Enterobacter spp. Aims: To investigate plasmid and chromosomal quinolone resistance rates among 175 third-generation cephalosporin resistant Enterobacter spp. isolates (167 Enterobacter cloacae complex and eight Enterobact...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S204199
更新日期:2019-05-28 00:00:00
abstract::Echinocandin antifungal agents have become the first-line therapy for invasive candidiasis (IC) in many countries. Despite their increasing use, resistance to this class of drug is, overall, still uncommon. Here, we report two patients from the People's Republic of China with IC, one with infection caused by pan-echin...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S152785
更新日期:2018-01-23 00:00:00
abstract:Background:Tachyplesin I is a cationic antimicrobial peptide with a typical cyclic antiparallel β-sheet structure. We previously demonstrated that long-term continuous exposure to increased concentration of tachyplesin I can induce resistant Gram-negative bacteria. However, no significant information is available about...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S226687
更新日期:2020-01-16 00:00:00
abstract::Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is the first available agent in a new class of antiretroviral drugs. Raltegravir has been studied extensively in clinical trials, and has been well tolerated and highly effective in both treatment-naïve and -experienced patients. Resistance to raltegravir is unu...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/idr.s9689
更新日期:2010-01-01 00:00:00
abstract::A systematic review was conducted to determine the distribution and prevalence of antibiotic-resistant bacteria (ARB), antimicrobial-resistant genes (ARGs), and antimicrobial-resistant gene determinants (ARGDs) in clinical, environmental, and farm settings and to identify key knowledge gaps in a bid to contain their s...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S170715
更新日期:2018-10-17 00:00:00
abstract:Purpose:This study examined patient- and hospital-level predictor variables that contribute to worse clinical and economic outcomes in patients with carbapenem-nonsusceptible respiratory infections. Patients and Methods:Electronic data (January 2013 to September 2015) were from 78 US hospitals. Nonduplicate, gram-nega...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S236026
更新日期:2020-03-09 00:00:00
abstract::Purpose: The aim of this study was to use a network meta-analysis to evaluate the relative efficacy of various agents at preventing invasive fungal infections (IFIs). In this way, suitable prophylactic regimens may be selected for patients with hematopoietic stem cell transplantation (HSCT). Methods: We conducted a sy...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S203579
更新日期:2019-05-15 00:00:00
abstract:Background:Due to increasing colistin usage, the dissemination of the colistin-resistant gene mcr-1 has been increasingly investigated. The aim of this study was to determine whether a traveler on a short-term international trip to a developing country could bring mcr-1 back to their home country. Materials and method...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S153178
更新日期:2018-03-12 00:00:00
abstract:BACKGROUND:Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi. Although antibiotic therapy is usually effective early in the disease, relapse may occur when administration of antibiotics is discontinued. Studies have suggested that resistance and recurrence of Lyme disease might be due t...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S19201
更新日期:2011-01-01 00:00:00
abstract::Purpose: The rapid emergence of multidrug-resistant (MDR) bacteria and the lack of new therapies to eliminate them poses a major threat to global health. With the alarming rise in antimicrobial resistance (AMR), focus has now shifted to the use of the polymyxin class of antibiotics as the last line of defense for trea...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S196874
更新日期:2019-05-27 00:00:00
abstract:Background:Flomoxef is potentially effective against β-lactamase-producing Enterobacteriaceae because limited clinical data demonstrate its effectiveness against Enterobacteriaceae bloodstream infections (BSIs) based on its minimum inhibitory concentrations (MICs). This study was conducted to determine the optimal brea...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S185670
更新日期:2018-11-27 00:00:00
abstract:Background:Raw meat is one of the commonly consumed traditional diets in Ethiopia. However, unhygienic processing and distribution practices are risky for contamination of meat leading to human infection. This study was conducted to assess the presence of multi-drug resistant E. coli with special emphasis on E. coli O1...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S277890
更新日期:2020-10-27 00:00:00