Abstract：
:Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immunosuppressed adults, especially post-transplant, resulting in serious disseminated, sometimes life-threatening end-organ complications. Herein, we report a case of a 68-year-old man with relapsed follicular lymphoma who developed HHV-6 pneumonitis. Eighteen months after achieving second complete remission by salvage immunochemotherapy with rituximab, the patient was complicated by pneumonia, with chest computed tomography finding showing disseminated nodular shadows with ground-glass opacity in both lungs. While empiric antibiotic and antifungal therapies did not improve the pneumonia, polymerase chain reaction-based viral screening tests on his bronchoalveolar lavage fluid detected the presence of HHV-6 DNA, and ganciclovir treatment quickly resolved the pneumonia, indicating that he suffered from HHV-6 pneumonitis. He had no other HHV-6-related end-organ damage, such as encephalitis. This case suggests that, although extremely rare, HHV-6 reactivation should be considered as one of the candidate pathogens for pulmonary complications of uncertain etiology in patients who have been treated with intensive immunosuppressive chemotherapy, even without hematopoietic stem cell transplantation. Furthermore, polymerase chain reaction-based viral screening testing on bronchoalveolar lavage fluid is a powerful diagnostic tool for pneumonitis due to viral reactivation, including HHV-6 reactivation.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Kuwahara-Ota S,Chinen Y,Mizuno Y,Takimoto-Shimomura T,Matsumura-Kimoto Y,Tanba K,Tsukamoto T,Mizutani S,Shimura Y,Kobayashi T,Horiike S,Kuroda Jdoi
10.2147/IDR.S163686subject
Has Abstractpub_date
2018-05-14 00:00:00pages
701-705issn
1178-6973pii
idr-11-701journal_volume
11pub_type
abstract：Introduction:Klebsiella pneumoniae carbapenemase (KPC) belongs to the Group-A β-lactamases that incorporate serine at their active site and hydrolyze various penicillins, cephalosporins, and carbapenems. Metallo-beta-lactamases (MBLs) are group-B enzymes that contain one or two essential zinc ions in the active sites a...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S262493
更新日期：2020-08-18 00:00:00
abstract：BACKGROUND:Biofilm formation inside inserted medical devices leads to their failure and acts as a source of refractory infections. The ultraviolet C (UVC) light is a potential therapy that can be used against the biofilm of bacterial pathogens. OBJECTIVE:We evaluated the efficacy of sublethal dose of UVC light with an...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S109343
更新日期：2016-08-19 00:00:00
abstract：Background and purpose:Invasive nontyphoidal salmonellosis, mostly caused by serovars Typhimurium and Enteritidis of Salmonella enterica, has emerged as a major public health problem in sub-Saharan Africa. The aim of this study was the clinical and microbiological characterization of nontyphoidal salmonellosis episodes...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S147243
更新日期：2018-01-31 00:00:00
abstract：:Aspergillus endocarditis (AE) accounts for a-quarter of all fungal endocarditis, mainly in immunocompromised hosts prior to heart-valve surgery with high mortality, even with treatment. Herein, we report a rare case of AE in a diabetic 60-year-old woman with a history of redo mitral valve prosthesis suspecious of acut...
journal_title：Infection and drug resistance
pub_type：
doi：10.2147/IDR.S258637
更新日期：2020-07-10 00:00:00
abstract：Aim:Plasmodium falciparum malaria predominantly affects children residing in endemic areas. However, recently a significant number of Malawian adults, who otherwise should have attained some malaria-specific immunity, have been observed to succumb to either uncomplicated malaria (UM) or severe malaria (SM). In addition...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S230112
更新日期：2020-01-07 00:00:00
abstract：BACKGROUND:Multidrug-resistant tuberculosis (MDR-TB) did not receive major attention until recently in sub-Saharan Africa where the tuberculosis incidence and risk factors are highest. Factors leading to development of drug resistance need to be understood to develop appropriate control strategies for national programs...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S126274
更新日期：2017-03-13 00:00:00
abstract：:A lung abscess is an infectious pulmonary disease characterized by pus-filled cavity formation and often an air-fluid level. In this article, we described an indolent community-acquired lung abscess suspected as a tumor previously. A 56-year-old male presented with cough and expectoration for 2 months and hemoptysis f...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S218921
更新日期：2019-08-08 00:00:00
abstract：Purpose:The activity of the cationic antimicrobial peptide WLBU2 was evaluated against planktonic cells and biofilms of multi-drug resistant (MDR) Acinetobacter baumannii and Klebsiella pneumoniae, alone and in combination with classical antimicrobial agents. Methods:Control American Type Culture Collection (ATCC) str...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S215084
更新日期：2019-07-09 00:00:00
abstract：:Purpose: The rapid emergence of multidrug-resistant (MDR) bacteria and the lack of new therapies to eliminate them poses a major threat to global health. With the alarming rise in antimicrobial resistance (AMR), focus has now shifted to the use of the polymyxin class of antibiotics as the last line of defense for trea...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S196874
更新日期：2019-05-27 00:00:00
abstract：Purpose:Pseudomonas aeruginosa is associated with pulmonary function decline and high disease severity in non-cystic fibrosis (CF) bronchiectasis. The prevalence of nontuberculous mycobacteria (NTM) in non-CF bronchiectasis patients has increased recently. This study investigated the impact of NTM with or without P. ae...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S169789
更新日期：2018-08-10 00:00:00
abstract：Background:Due to increasing colistin usage, the dissemination of the colistin-resistant gene mcr-1 has been increasingly investigated. The aim of this study was to determine whether a traveler on a short-term international trip to a developing country could bring mcr-1 back to their home country. Materials and method...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S153178
更新日期：2018-03-12 00:00:00
abstract：Background:China is one of the high-burden countries for multidrug-resistant tuberculosis (MDR-TB), and pyrazinamide is one of the anti-TB drugs used for the shorter MDR-TB treatment regimen. The aim of this study was to determine the correlation between pncA gene mutations and resistance to four first-line anti-TB dru...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S222943
更新日期：2019-09-30 00:00:00
abstract：:Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is the first available agent in a new class of antiretroviral drugs. Raltegravir has been studied extensively in clinical trials, and has been well tolerated and highly effective in both treatment-naïve and -experienced patients. Resistance to raltegravir is unu...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/idr.s9689
更新日期：2010-01-01 00:00:00
abstract：Background:In Saudi Arabia, cross-border transmission of multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains might be particularly fostered by high immigration rates. Herein, we aimed to elucidate the transmission dynamics of MDR-MTBC strains and reveal a detailed prediction of all resistance-co...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S181124
更新日期：2018-11-12 00:00:00
abstract：BACKGROUND AND AIMS:Resistance mutation analogs to nucleos(t)ides have been described in treatment-naïve patients with chronic hepatitis B (CHB), with clinical implications. The aim of this study was to investigate primary resistance mutations and genotypes circulating in patients naïve to chronic hepatitis B, in the N...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S135420
更新日期：2017-07-05 00:00:00
abstract：Purpose:To develop a rapid EDTA-modified carbapenem inactivation method (reCIM) combined with modified rapid carbapenem inactivation method (mrCIM) to detect carbapenemase and distinguish metallo-β-lactamases from carbapenemases in Enterobacteriaceae in 4 hrs. Materials and Methods:The sensitivities and specificities ...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S249570
更新日期：2020-06-23 00:00:00
abstract：:The treatment of urinary tract infections (UTIs) continues to evolve as common uropathogens increasingly become resistant to previously active antimicrobial agents. In addition, bacterial isolates, which were once considered to be either colonizers or contaminants, have emerged as true pathogens, likely related to the...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S15610
更新日期：2011-01-01 00:00:00
abstract：Introduction:Escherichia (E.) coli can cause intestinal and extra-intestinal infections which ranged from mild to life-threatening infections. The severity of infection is a product of many factors including virulence properties and antimicrobial resistance. Objectives:To determine the antibiotic resistance pattern, t...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S241073
更新日期：2020-04-28 00:00:00
abstract：:Streptococcus pneumonia is a rare cause of pyogenic sacroiliitis and osteomyelitis. A case of pneumococcal sacroiliitis and osteomyelitis is reported herein. The patient was a previously healthy 54-year-old man with a 3-day history of fever and a 3-week history of increasing right-side thigh pain. Computed tomography ...
journal_title：Infection and drug resistance
pub_type：
doi：10.2147/IDR.S160122
更新日期：2018-08-03 00:00:00
abstract：Objective:An ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the determination of selinexor was established to investigate the effects of isavuconazole, itraconazole and fluconazole on the pharmacokinetics of selinexor in rats, respectively. Methods:Twenty-four healthy male rat...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S269831
更新日期：2020-09-14 00:00:00
abstract：INTRODUCTION:In recent decades, antimicrobial resistance has become a public health problem, particularly in cases of healthcare-associated infections. Interaction between antibiotic consumption and resistance development is of particular interest regarding Gram-negative bacilli, whose growing resistance has represente...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S22491
更新日期：2011-01-01 00:00:00
abstract：Purpose:Pseudomonas aeruginosa possesses a large number of resistance mechanisms to different antimicrobials with carbapenems being the most powerful in treating resistant P. aeruginosa. Hence, it is imperative to explore different mechanisms of carbapenems-resistance in P. aeruginosa to achieve successful treatment th...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S233808
更新日期：2020-01-30 00:00:00
abstract：BACKGROUND:Antimicrobial drug resistance is a global issue that affects health, economic, and social development. The problem has been attributed to misuse of antimicrobial agents. PURPOSE:To identify the agents of bacterial infection in Ghana, determine their antibiogram, and the possibility of setting up a surveilla...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S21769
更新日期：2011-01-01 00:00:00
abstract：Background:Streptococcus pneumoniae is an important pathogen in chronic obstructive pulmonary disease (COPD). We aimed at showing the recent changes in the epidemiology of pneumococcal diseases in patients with COPD, especially after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Methods:Fro...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S165093
更新日期：2018-09-04 00:00:00
abstract：Introduction:Duodenoscopes have been widely used for both diagnostic and therapeutic endoscopic retrograde cholangiopancreatography procedures. Numerous outbreaks of duodenoscope-associated infections involving multidrug-resistant bacteria have recently been reported. Plasma activated water (PAW) has been widely consid...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S159243
更新日期：2018-05-17 00:00:00
abstract：Objectives:We investigated the in vitro antimicrobial susceptibilities of clinically important Gram-negative bacteria (GNB) from 16 major teaching hospitals in Taiwan in 2017. Materials and methods:Escherichia coli (n=686) and Klebsiella pneumoniae bloodstream isolates (n=673), non-typhoid Salmonella (NTS; n=221) from...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S175679
更新日期：2018-10-26 00:00:00
abstract：:Purpose: To investigate antimicrobial resistance and risk factors for mortality of Klebsiella pneumoniae (KP) pneumonia in diabetics and nondiabetics. Patients and methods: A retrospective study was conducted among inpatients of KP pneumonia via electronic medical records in a territory hospital between January 2016 a...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S199642
更新日期：2019-05-07 00:00:00
abstract：:A systematic review was conducted to determine the distribution and prevalence of antibiotic-resistant bacteria (ARB), antimicrobial-resistant genes (ARGs), and antimicrobial-resistant gene determinants (ARGDs) in clinical, environmental, and farm settings and to identify key knowledge gaps in a bid to contain their s...
journal_title：Infection and drug resistance
pub_type： 杂志文章,评审
doi：10.2147/IDR.S170715
更新日期：2018-10-17 00:00:00
abstract：:Purpose: Treatment-refractory Giardia cases have increased rapidly within the last decade. No markers of resistance nor a standardized susceptibility test have been established yet, but several enzymes and their pathways have been associated with metronidazole (MTZ) resistant Giardia. Very limited data are available r...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S177997
更新日期：2019-05-10 00:00:00
abstract：BACKGROUND:Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi. Although antibiotic therapy is usually effective early in the disease, relapse may occur when administration of antibiotics is discontinued. Studies have suggested that resistance and recurrence of Lyme disease might be due t...
journal_title：Infection and drug resistance
pub_type： 杂志文章
doi：10.2147/IDR.S19201
更新日期：2011-01-01 00:00:00
