Abstract:
INTRODUCTION:In recent decades, antimicrobial resistance has become a public health problem, particularly in cases of healthcare-associated infections. Interaction between antibiotic consumption and resistance development is of particular interest regarding Gram-negative bacilli, whose growing resistance has represented a great challenge. OBJECTIVE:Assess the impact of restriction of cefepime use on antimicrobial susceptibility among the Gram-negative bacilli (GNB) most frequently involved in healthcare-associated infections (HAI). METHODS:DATA RELATING TO HOSPITAL OCCUPANCY AND MORTALITY RATES, INCIDENCE OF HAI, INCIDENCE OF GNB AS CAUSATIVE AGENTS OF HAI, ANTIMICROBIAL CONSUMPTION AT THE HOSPITAL AND ANTIMICROBIAL SUSCEPTIBILITY OF GNB RELATED TO HAI WERE COMPARED BETWEEN TWO PERIODS: a 24-month period preceding restriction of cefepime use and a 24-month period subsequent to this restriction. RESULTS:There was a significant drop in cefepime consumption after its restriction. Susceptibility of Acinetobacter baumanii improved relating to gentamicin, but it worsened in relation to imipenem, subsequent to this restriction. For Pseudomonas aeruginosa, there was no change in antimicrobial susceptibility. For Klebsiella pneumoniae and Enterobacter spp, there were improvements in susceptibility relating to ciprofloxacin. CONCLUSION:Restriction of cefepime use had a positive impact on K. pneumoniae and Enterobacter spp, given that after this restriction, their susceptibilities to ciprofloxacin improved. However, for A. baumanii, the impact was negative, given the worsening of susceptibility to imipenem.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Oliveira PR,Paula AP,Dal-Paz K,Felix CS,Rossi F,Silva JS,Lima ALdoi
10.2147/IDR.S22491subject
Has Abstractpub_date
2011-01-01 00:00:00pages
149-54issn
1178-6973pii
idr-4-149journal_volume
4pub_type
杂志文章abstract::Infections due to multidrug-resistant Gram-negative bacteria (MDR-GNB), especially when carbapenem resistant, have been very difficult to manage in the last fifteen years, owing to the paucity of dependable therapeutic options. Cefiderocol is a siderophore cephalosporin recently approved by the Food and Drug Administr...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
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更新日期:2020-12-29 00:00:00
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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更新日期:2020-11-24 00:00:00
abstract:Introduction:Despite the moderate incidence of tuberculosis (TB) in many parts of Iran, Golestan province had a permanently higher TB incidence rate than the national average. Moreover, Golestan province receives immigrants, mainly from TB-endemic areas of Iran and neighbor countries. Here, we aimed to characterize the...
journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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更新日期:2018-11-27 00:00:00
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journal_title:Infection and drug resistance
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更新日期:2021-01-12 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S257398
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journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
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更新日期:2017-08-30 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S178922
更新日期:2018-12-04 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S253363
更新日期:2020-06-10 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S222329
更新日期:2019-11-07 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S19201
更新日期:2011-01-01 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179462
更新日期:2018-11-23 00:00:00
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journal_title:Infection and drug resistance
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更新日期:2010-01-01 00:00:00
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更新日期:2015-10-20 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-09 00:00:00