Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B.

Abstract:

BACKGROUND AND AIMS:Resistance mutation analogs to nucleos(t)ides have been described in treatment-naïve patients with chronic hepatitis B (CHB), with clinical implications. The aim of this study was to investigate primary resistance mutations and genotypes circulating in patients naïve to chronic hepatitis B, in the Northern and Northeastern regions of Brazil. METHODS:We conducted a study of resistance mutations and genotypic characterization of hepatitis B virus (HBV) in 189 treatment-naïve patients chronically infected with HBV. RESULTS:Drug resistance-associated mutations located in the RT domain of the P gene (rtHBV) were found in 6% of the treatment-naïve patients from the Northeastern Region. The mutations were rtA194T, rtL180M + rtM204V, rtS202I, rtM204I, and rtA181S. No patient in the Northern Region had the resistance mutation. In the gene S region, the frequency of vaccine escape mutations was 2.4% in the Northeastern Region and 8.6% in the Northern Region. CONCLUSION:This information before the start of treatment may contribute to clinical decision making, reducing treatment failure and the risk of progression to cirrhosis and hepatocellular carcinoma for CHB.

journal_name

Infect Drug Resist

authors

Pacheco SR,Dos Santos MIMA,Stocker A,Zarife MAS,Schinoni MI,Paraná R,Dos Reis MG,Silva LK

doi

10.2147/IDR.S135420

subject

Has Abstract

pub_date

2017-07-05 00:00:00

pages

201-207

issn

1178-6973

pii

idr-10-201

journal_volume

10

pub_type

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