Abstract:
Background and purpose:Invasive nontyphoidal salmonellosis, mostly caused by serovars Typhimurium and Enteritidis of Salmonella enterica, has emerged as a major public health problem in sub-Saharan Africa. The aim of this study was the clinical and microbiological characterization of nontyphoidal salmonellosis episodes affecting febrile children in Mozambique. Patients and methods:The clinical records of the patients were evaluated, and S. enterica isolates were characterized with regard to serovar, phage type, antimicrobial resistance (phenotype/responsible genes), plasmid content, pulsed-field gel electrophoresis, and multilocus sequence typing. Results:Fifteen S. Typhimurium and 21 S. Enteritidis isolates were recovered from blood samples of 25 children, the majority with underlying risk factors. With regard to phage typing, most isolates were either untypeable or reacted but did not conform, revealing that a number of previously unrecognized patterns are circulating in Mozambique. Most isolates were multidrug-resistant, with nearly all of the responsible genes located on derivatives of serovar-specific virulence plasmids. ST313 and ST11 were the predominant sequence types associated with S. Typhimurium and S. Enteritidis, respectively, and the uncommon ST1479 was also detected in S. Enteritidis. A distinct XbaI fragment of ~350 kb was associated with pulsed-field gel electrophoresis patterns of multidrug-resistant isolates of S. Enteritidis. Nearly half of the children were coinfected with both serovars, a fact expected to aggravate the disease and hamper the treatment. However, particularly poor outcomes were not observed for the coinfected patients. Conclusion:Mixed Salmonella infections could frequently occur in febrile children in Mozambique. Additional studies are required to determine their actual impact and consequences, not only in this country, but also in other African countries.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
García V,Mandomando I,Ruiz J,Herrera-León S,Alonso PL,Rodicio MRdoi
10.2147/IDR.S147243subject
Has Abstractpub_date
2018-01-31 00:00:00pages
195-204issn
1178-6973pii
idr-11-195journal_volume
11pub_type
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S225947
更新日期:2019-12-16 00:00:00
abstract::The mortality rate for candidemia is approximately 30%-60%. However, prognostic factors in patients with candidemia have not yet been elucidated in detail. The aim of the present study was to analyze prognostic factors for candidemia using the mortality rate and Candida isolates of patients with candidemia. Seventy-fi...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S80677
更新日期:2015-07-08 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
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更新日期:2015-10-20 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S255889
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S165093
更新日期:2018-09-04 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
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更新日期:2019-05-10 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S150839
更新日期:2018-02-13 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S215084
更新日期:2019-07-09 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S22491
更新日期:2011-01-01 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
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更新日期:2020-12-29 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S273851
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S185753
更新日期:2018-12-18 00:00:00
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journal_title:Infection and drug resistance
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doi:10.2147/IDR.S269831
更新日期:2020-09-14 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
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更新日期:2019-05-27 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179462
更新日期:2018-11-23 00:00:00
abstract::Raltegravir, the only integrase (IN) inhibitor approved for use in HIV therapy, has recently been licensed. Raltegravir inhibits HIV-1 replication by blocking the IN strand transfer reaction. More than 30 mutations have been associated with resistance to raltegravir and other IN strand transfer inhibitors (INSTIs). Th...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S7775
更新日期:2011-01-01 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S159243
更新日期:2018-05-17 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S226687
更新日期:2020-01-16 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S274589
更新日期:2020-10-20 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S49891
更新日期:2015-04-07 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S236814
更新日期:2020-01-28 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S202906
更新日期:2019-06-20 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S252332
更新日期:2020-06-04 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S86341
更新日期:2015-08-07 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S239095
更新日期:2020-06-16 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S170715
更新日期:2018-10-17 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179642
更新日期:2018-11-15 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
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更新日期:2017-03-13 00:00:00
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journal_title:Infection and drug resistance
pub_type:
doi:10.2147/IDR.S163686
更新日期:2018-05-14 00:00:00