Abstract:
Purpose:With the recommendation of World Health Organization (WHO) and as per the Ethiopian National Implementation Guideline, GeneXpert is used for rapid diagnosis of rifampicin (RIF)-resistant multidrug-resistant tuberculosis (MDR-TB) from the suspected TB patients; however, there were limited findings in Ethiopia particularly in the study area showing the magnitude of RIF-resistant MDR-TB and related factors among suspected TB cases. Hence, we aimed to assess resistance to RIF as a biomarker for the detection of MDR-TB cases from the suspected TB patients in selected hospitals, Western Oromia, Ethiopia. Patients and Methods:We have conducted a cross-sectional review on 2300 registered GeneXpert data as clinically suspected TB cases in three governmental hospitals, Western Oromia, Ethiopia, between October 2015 and April 2016 to assess resistance to RIF as a biomarker for the detection of MDR-TB cases. Trained data collectors enumerated the data using pre-tested semi-structured questionnaires from the Gene Xpert records found in the registration logbook available at each hospital laboratories. Following checking the data for completeness, we have cleaned and entered our data into SPSS version 20 to compute different analyses. P-value of ≤0.05 was taken as statistically significant. Results:A total of 2300 TB suspected cases were included in the study. The overall prevalence of TB diagnosed by the GeneXpert assay was 21.3% (491/2300). In all TB confirmed cases, RIF-resistant TB accounted for 25.9% (127/491) which expressed rpoB gene mutations. Sex (being male), age (within 16-30 age group), patient category (relapse, loss to follow-up, treatment failure and had MDR-TB contact) were significantly associated with rifampicin-resistant TB. Relapse patient was 20 times more likely to develop MDR-TB when compared to the new patient (P-value= 0.01, COR = 20.0, 95%C.I = 17.5-42.5). Conclusion:The rifampicin-resistant TB is prevalent in all age groups. The strong association and high prevalence of RIF-resistant TB to failure after treatment in this study require more attention towards improving the treatment to minimize evolving of the MDR-TB cases.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Zewdie O,Dabsu R,Kifle E,Befikadu Ddoi
10.2147/IDR.S274589subject
Has Abstractpub_date
2020-10-20 00:00:00pages
3699-3705issn
1178-6973pii
274589journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi. Although antibiotic therapy is usually effective early in the disease, relapse may occur when administration of antibiotics is discontinued. Studies have suggested that resistance and recurrence of Lyme disease might be due t...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S19201
更新日期:2011-01-01 00:00:00
abstract::Purpose: The aim of this study was to use a network meta-analysis to evaluate the relative efficacy of various agents at preventing invasive fungal infections (IFIs). In this way, suitable prophylactic regimens may be selected for patients with hematopoietic stem cell transplantation (HSCT). Methods: We conducted a sy...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S203579
更新日期:2019-05-15 00:00:00
abstract:Objective:To explore the composition of the ocular microbiome in normal subjects and patients with Meibomian gland dysfunction (MGD). Subjects and methods:Seventy subjects (140 eyes) were enrolled in our study. Signs of dry eye were evaluated and bacterial species in the conjunctival sac (CS) and Meibomian gland (MG) ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S162135
更新日期:2018-10-11 00:00:00
abstract:Objective:To genetically characterize clusters of virulence factors (VFs) among extended spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae and assess whether these clusters are associated with genetic determinants or clinical outcomes. Methods:One hundred forty-eight E. coli and 82 K. pn...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179134
更新日期:2018-12-31 00:00:00
abstract:INTRODUCTION:In recent decades, antimicrobial resistance has become a public health problem, particularly in cases of healthcare-associated infections. Interaction between antibiotic consumption and resistance development is of particular interest regarding Gram-negative bacilli, whose growing resistance has represente...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S22491
更新日期:2011-01-01 00:00:00
abstract:Introduction:Escherichia (E.) coli can cause intestinal and extra-intestinal infections which ranged from mild to life-threatening infections. The severity of infection is a product of many factors including virulence properties and antimicrobial resistance. Objectives:To determine the antibiotic resistance pattern, t...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S241073
更新日期:2020-04-28 00:00:00
abstract:Background:Staphylococcus aureus is considered one of the major threats regarding food safety worldwide. Methicillin-resistant S. aureus (MRSA) strains in livestock, companion animals, and wild animals continue to be a potential risk to people working with them. Aim:The current research aims to investigate the potenti...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S252332
更新日期:2020-06-04 00:00:00
abstract:Background:With an aging population, China is facing a huge burden of elderly patients with drug resistant tuberculosis (DR-TB), which has become a significant obstacle for the global TB control. There is still little study on DR-TB in the elderly in China so far. Thus, more research on the epidemiological characterist...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S277203
更新日期:2020-11-13 00:00:00
abstract:OBJECTIVES:Stenotrophomonas maltophilia shows wide-spectrum resistance to antimicrobials and causes various infections in immunocompromised or critically ill patients with high mortality. In this era of antibiotics resistance, a revival of old antibiotics is now featured. We examined the clinical usefulness of latamoxe...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S90726
更新日期:2015-10-20 00:00:00
abstract:Background:Broad-scale evidence has shown the significant association between ambient air pollutants and the development of tuberculosis (TB). However, the impact of air quality on the risk of TB in Taiwan is still poorly understood. Objective:To develop a probabilistic integrated population-level risk assessment appr...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S227823
更新日期:2019-12-06 00:00:00
abstract:BACKGROUND:Antimicrobial drug resistance is a global issue that affects health, economic, and social development. The problem has been attributed to misuse of antimicrobial agents. PURPOSE:To identify the agents of bacterial infection in Ghana, determine their antibiogram, and the possibility of setting up a surveilla...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S21769
更新日期:2011-01-01 00:00:00
abstract:Background and Objectives:Tuberculosis (TB) is a global public health issue. The emergence of multidrug-resistant (MDR) TB has further complicated the situation in the form of poor treatment outcomes and costs to individuals and health-care systems. We therefore aimed to measure the prevalence and associated risk facto...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S277477
更新日期:2020-11-10 00:00:00
abstract::The New Delhi Metallo-β-lactamase (NDM) producing Enterobacteriaceae is spreading worldwide. Although the blaNDM gene has been identified in animal associated Enterobacteriaceae isolates in many countries, little is known about its occurrence in animal products in Pakistan. In this study, 13 Escherichia coli isolates ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S236766
更新日期:2019-12-30 00:00:00
abstract::Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is the first available agent in a new class of antiretroviral drugs. Raltegravir has been studied extensively in clinical trials, and has been well tolerated and highly effective in both treatment-naïve and -experienced patients. Resistance to raltegravir is unu...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/idr.s9689
更新日期:2010-01-01 00:00:00
abstract:Background:The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in a worldwide devastating effect with a diagnostic challenge. Identifying risk factors of severity aids in assessment for the need of early hospitalization. We aimed to demonstrate, for the first time, the clinical, laborator...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S272605
更新日期:2020-10-05 00:00:00
abstract:Introduction:Candida species, one among the opportunistic fungi, has become a common pathogen causing vaginal thrush and nosocomial bloodstream infections (BSIs). This study aims to evaluate the prevalence and antifungal susceptibility of various Candida species and slime production by Candida species in BSIs and vulvo...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179462
更新日期:2018-11-23 00:00:00
abstract:Purpose:To characterize the genetic feature of the carbapenems resistant Acinetobacter johnsonii strain Acsw19 isolated from municipal sludge. This strain was found to carry two copies of blaNDM-1,cmlB1-like gene, and blaOXA-211-like gene along with other 8 antimicrobial resistance genes, 3 plasmids, 15 genomic islands...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S236200
更新日期:2020-03-23 00:00:00
abstract:Introduction:Helicobacter pylori was discovered first in the stomachs of patients with gastritis and ulcers by Marshall and Warren in 1982. This discovery majorly affected many research areas of gastroenterology. Since then, the main aim has been to eradicate this microaerophilic bacterium from the stomachs of infected...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S223602
更新日期:2019-11-01 00:00:00
abstract:Introduction:Klebsiella pneumoniae carbapenemase (KPC) belongs to the Group-A β-lactamases that incorporate serine at their active site and hydrolyze various penicillins, cephalosporins, and carbapenems. Metallo-beta-lactamases (MBLs) are group-B enzymes that contain one or two essential zinc ions in the active sites a...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S262493
更新日期:2020-08-18 00:00:00
abstract::Purpose: To investigate antimicrobial resistance and risk factors for mortality of Klebsiella pneumoniae (KP) pneumonia in diabetics and nondiabetics. Patients and methods: A retrospective study was conducted among inpatients of KP pneumonia via electronic medical records in a territory hospital between January 2016 a...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S199642
更新日期:2019-05-07 00:00:00
abstract:Objective:Evaluate host and pathogen factors associated with mortality in those with hospital acquired infections (HAI) in a tertiary intensive care unit in Brazil. Methods:Observational and analytical cohort single center study in a general intensive care unit (ICU) in Northeastern Brazil between January 2016 and Aug...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S264276
更新日期:2020-08-12 00:00:00
abstract:Aim:Plasmodium falciparum malaria predominantly affects children residing in endemic areas. However, recently a significant number of Malawian adults, who otherwise should have attained some malaria-specific immunity, have been observed to succumb to either uncomplicated malaria (UM) or severe malaria (SM). In addition...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S230112
更新日期:2020-01-07 00:00:00
abstract::Infections due to multidrug-resistant Gram-negative bacteria (MDR-GNB), especially when carbapenem resistant, have been very difficult to manage in the last fifteen years, owing to the paucity of dependable therapeutic options. Cefiderocol is a siderophore cephalosporin recently approved by the Food and Drug Administr...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S205309
更新日期:2020-12-29 00:00:00
abstract:Introduction:Intravenous (IV) β-lactam antibiotics, excreted through bile into the gastrointestinal (GI) tract, may disrupt the gut microbiome by eliminating the colonization resistance from beneficial bacteria. This increases the risk for Clostridium difficile infection (CDI) and can promote antimicrobial resistance b...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S260258
更新日期:2020-07-22 00:00:00
abstract::Enterococci have been implicated as an emerging important cause of several diseases and multiple antibiotic resistance. However, there is little information about the prevalence of pathogenic and/or antibiotic-resistant Enterococcus faecalis in ready-to-eat foods in Nigeria. Here we report the pathogenic potential of ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S61381
更新日期:2015-06-26 00:00:00
abstract:Background:Flomoxef is potentially effective against β-lactamase-producing Enterobacteriaceae because limited clinical data demonstrate its effectiveness against Enterobacteriaceae bloodstream infections (BSIs) based on its minimum inhibitory concentrations (MICs). This study was conducted to determine the optimal brea...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S185670
更新日期:2018-11-27 00:00:00
abstract:Background:Colistin acts as the last line of defense against severe infections caused by carbapenem-resistant Enterobacteriaceae. Infections caused by extensively drug-resistant isolates coproducing MCR and carbapenemases have posed a serious public health concern. Purpose:In this study, we reported the first clinical...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S217168
更新日期:2019-09-19 00:00:00
abstract::A lung abscess is an infectious pulmonary disease characterized by pus-filled cavity formation and often an air-fluid level. In this article, we described an indolent community-acquired lung abscess suspected as a tumor previously. A 56-year-old male presented with cough and expectoration for 2 months and hemoptysis f...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S218921
更新日期:2019-08-08 00:00:00
abstract:Purpose:The purpose of this study was to identify the common clinical presentations and the evidence on the presence of ageusia and anosmia as an emerging coronavirus disease 2019 (COVID-19) symptom to better inform in both COVID-19 patients and clinicians. Patients and Methods:As part of a double-institutional collab...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S263632
更新日期:2020-07-29 00:00:00
abstract:Purpose:To investigate the occurrence and genetic characteristics of the blaIMP-26-positive plasmid from a multidrug-resistant clinical isolate, Enterobacter hormaechei L51. Methods:Species identification was determined by MALDI-TOF MS and Sanger sequencing. Antimicrobial susceptibility testing was performed by the ag...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S232514
更新日期:2020-02-20 00:00:00