Transcriptome Analysis Reveals the Resistance Mechanism of Pseudomonas aeruginosa to Tachyplesin I.

abstract：Purpose:With the recommendation of World Health Organization (WHO) and as per the Ethiopian National Implementation Guideline, GeneXpert is used for rapid diagnosis of rifampicin (RIF)-resistant multidrug-resistant tuberculosis (MDR-TB) from the suspected TB patients; however, there were limited findings in Ethiopia pa...

journal_title：Infection and drug resistance

authors： Zewdie O,Dabsu R,Kifle E,Befikadu D

更新日期：2020-10-20 00:00:00

abstract：Background:Streptococcus pneumoniae is an important pathogen in chronic obstructive pulmonary disease (COPD). We aimed at showing the recent changes in the epidemiology of pneumococcal diseases in patients with COPD, especially after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Methods:Fro...

journal_title：Infection and drug resistance

authors： Shoji H,Vázquez-Sánchez DA,Gonzalez-Diaz A,Cubero M,Tubau F,Santos S,García-Somoza D,Liñares J,Yuste J,Martí S,Ardanuy C

更新日期：2018-09-04 00:00:00

abstract：Purpose:To assess the efficacy of amoxicillin, tetracycline, high-dose metronidazole, and a proton-pump inhibitor for third-line Helicobacter pylori eradication. Methods:We enrolled 70 consecutive patients who had registered, failed to respond to two rounds of H. pylori eradication, and undergone endoscopy for H. pylo...

journal_title：Infection and drug resistance

authors： Huang HT,Wang HM,Yang SC,Tai WC,Liang CM,Wu KL,Lee CH,Chuah SK

更新日期：2018-10-30 00:00:00

abstract：Background:Flomoxef is potentially effective against β-lactamase-producing Enterobacteriaceae because limited clinical data demonstrate its effectiveness against Enterobacteriaceae bloodstream infections (BSIs) based on its minimum inhibitory concentrations (MICs). This study was conducted to determine the optimal brea...

journal_title：Infection and drug resistance

authors： Lee CH,Chen IL,Li CC,Chien CC

更新日期：2018-11-27 00:00:00

abstract：:Background: The widespread use of antibiotics has resulted in a high incidence of antibiotic-associated diarrhea (AAD); moreover, the AAD-associated mortality rates have also increased. The effect of combined antibiotic administration on AAD in critically ill patients was analyzed to assist in antibiotic selection for...

journal_title：Infection and drug resistance

authors： Ma H,Zhang L,Zhang Y,Liu Y,He Y,Guo L

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Stenotrophomonas maltophilia shows wide-spectrum resistance to antimicrobials and causes various infections in immunocompromised or critically ill patients with high mortality. In this era of antibiotics resistance, a revival of old antibiotics is now featured. We examined the clinical usefulness of latamoxe...

journal_title：Infection and drug resistance

authors： Hagiya H,Tasaka K,Sendo T,Otsuka F

更新日期：2015-10-20 00:00:00

abstract：BACKGROUND:Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi. Although antibiotic therapy is usually effective early in the disease, relapse may occur when administration of antibiotics is discontinued. Studies have suggested that resistance and recurrence of Lyme disease might be due t...

journal_title：Infection and drug resistance

authors： Sapi E,Kaur N,Anyanwu S,Luecke DF,Datar A,Patel S,Rossi M,Stricker RB

更新日期：2011-01-01 00:00:00

abstract：:Streptococcus pneumonia is a rare cause of pyogenic sacroiliitis and osteomyelitis. A case of pneumococcal sacroiliitis and osteomyelitis is reported herein. The patient was a previously healthy 54-year-old man with a 3-day history of fever and a 3-week history of increasing right-side thigh pain. Computed tomography ...

journal_title：Infection and drug resistance

authors： Hadano Y,Chang B

更新日期：2018-08-03 00:00:00

abstract：Purpose:The problem of carbapenem-resistant Pseudomonas aeruginosa in health-care settings is growing worse. This study was conducted to investigate the rate of carbapenemase genes, antibiotic resistance, and virulence factors in carbapenem-resistant P. aeruginosa associated with hospital-acquired infections. Patients...

journal_title：Infection and drug resistance

authors： El-Mahdy R,El-Kannishy G

更新日期：2019-11-07 00:00:00

abstract：Objective:An ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the determination of selinexor was established to investigate the effects of isavuconazole, itraconazole and fluconazole on the pharmacokinetics of selinexor in rats, respectively. Methods:Twenty-four healthy male rat...

journal_title：Infection and drug resistance

authors： Li SL,Zhang Y,Cheng QS,Xin JZ,Dong ZQ,Qiu XJ

更新日期：2020-09-14 00:00:00

abstract：Background:The incidence of human papilloma virus (HPV) infections in conservative populations is increasing, yet vaccination is not routinely recommended by primary health care (PHC) physicians. The aim of this study is to evaluate PHC physicians' awareness of HPV infections and vaccination in Saudi Arabia. Materials...

journal_title：Infection and drug resistance

authors： Almughais ES,Alfarhan A,Salam M

更新日期：2018-11-15 00:00:00

abstract：:Tetracyclines have come a long way since they became available almost seven decades ago, with numerous enhancements allowing new agents to overcome bacterial mechanisms of resistance. However, these enhancements come with toxicities and pharmacokinetic disadvantages such as the gastrointestinal side-effects and poor o...

journal_title：Infection and drug resistance

authors： Burgos RM,Rodvold KA

更新日期：2019-07-02 00:00:00

abstract：:Infections due to multidrug-resistant Gram-negative bacteria (MDR-GNB), especially when carbapenem resistant, have been very difficult to manage in the last fifteen years, owing to the paucity of dependable therapeutic options. Cefiderocol is a siderophore cephalosporin recently approved by the Food and Drug Administr...

journal_title：Infection and drug resistance

authors： Giacobbe DR,Ciacco E,Girmenia C,Pea F,Rossolini GM,Sotgiu G,Tascini C,Tumbarello M,Viale P,Bassetti M,ISGRI-SITA (Italian Study Group on Resistant Infections of the Italian Society of Anti-infective Therapy).

更新日期：2020-12-29 00:00:00

abstract：Background:Tuberculosis is a communicable disease that is a major cause of ill health, one of the top 10 causes of death worldwide, and the leading cause of death from a single infectious agent, even ranking above human immuno-deficiency virus (HIV/AIDS). Objective:To assess the prevalence and associated risk factor...

journal_title：Infection and drug resistance

authors： Gebretsadik D,Ahmed N,Kebede E,Mohammed M,Belete MA

更新日期：2020-05-21 00:00:00

abstract：Background:China is one of the high-burden countries for multidrug-resistant tuberculosis (MDR-TB), and pyrazinamide is one of the anti-TB drugs used for the shorter MDR-TB treatment regimen. The aim of this study was to determine the correlation between pncA gene mutations and resistance to four first-line anti-TB dru...

journal_title：Infection and drug resistance

authors： Cao Z,Lan Y,Chen L,Xiang M,Peng Z,Zhang J,Zhang H

更新日期：2019-09-30 00:00:00

abstract：Background and objective:Acinetobacter baumannii (A. baumannii) is a common nosocomial pathogen, which developed multi-drug-resistance to different classes of antibiotics including carbapenems. This study examined ten common carbapenemase genes among 32 carbapenem-resistant A. baumannii clinical isolates recovered from...

journal_title：Infection and drug resistance

authors： El-Badawy MF,Abdelwahab SF,Alghamdi SA,Shohayeb MM

更新日期：2019-10-03 00:00:00

abstract：:Purpose:Mycoplasma pneumoniae is an important cause of community-acquired pneumonia (CAP). Information on the prevalence of M. pneumoniae in pediatric patients with CAP in Mexico is limited. The aim of this study was to detect M. pneumoniae in hospitalized pediatric patients with CAP. Patients and methods: We performe...

journal_title：Infection and drug resistance

authors： Merida-Vieyra J,Aquino-Andrade A,Palacios-Reyes D,Murata C,Ribas-Aparicio RM,De Colsa Ranero A

更新日期：2019-04-18 00:00:00

abstract：Purpose:Respiratory viruses are important etiologies of community-acquired pneumonia (CAP). However, the impact of different RVs on the outcomes of CAP is not well elucidated. This study aims to compare the clinical features and severity of influenza (Flu-p) and non-influenza respiratory viruses-related pneumonia (NIRV...

journal_title：Infection and drug resistance

authors： Chen L,Han XD,Li YL,Zhang CX,Xing XQ

更新日期：2020-10-08 00:00:00

abstract：Purpose:The activity of the cationic antimicrobial peptide WLBU2 was evaluated against planktonic cells and biofilms of multi-drug resistant (MDR) Acinetobacter baumannii and Klebsiella pneumoniae, alone and in combination with classical antimicrobial agents. Methods:Control American Type Culture Collection (ATCC) str...

journal_title：Infection and drug resistance

authors： Swedan S,Shubair Z,Almaaytah A

更新日期：2019-07-09 00:00:00

abstract：Introduction:Klebsiella pneumoniae carbapenemase (KPC) belongs to the Group-A β-lactamases that incorporate serine at their active site and hydrolyze various penicillins, cephalosporins, and carbapenems. Metallo-beta-lactamases (MBLs) are group-B enzymes that contain one or two essential zinc ions in the active sites a...

journal_title：Infection and drug resistance

authors： Urmi UL,Nahar S,Rana M,Sultana F,Jahan N,Hossain B,Alam MS,Mosaddek ASM,McKimm J,Rahman NAA,Islam S,Haque M

更新日期：2020-08-18 00:00:00

abstract：:The loss of polycationic antimicrobial peptides, polymyxins, due to adhesion to plastics is an important subject matter that influences in vitro susceptibility testing, including minimum inhibitory concentration (MIC) assays. This review reminds us that this issue can serve as a significant source of variation in the ...

journal_title：Infection and drug resistance

authors： Sharafi T,Ardebili A

更新日期：2019-08-27 00:00:00

abstract：Background:The timely and accurate diagnosis of infected nonunion is challenging, and there is a need for more efficient biomarkers. Previous studies have shown that fibrinogen plays an important role in mediating inflammation in bacterial infections and, therefore, could be a valuable biomarker for infected nonunion. ...

journal_title：Infection and drug resistance

authors： Wang XJ,Wang Z,Zhang ZT,Qiu XS,Chen M,Chen YX

更新日期：2020-11-04 00:00:00

abstract：Purpose:To investigate the occurrence and genetic characteristics of the blaIMP-26-positive plasmid from a multidrug-resistant clinical isolate, Enterobacter hormaechei L51. Methods:Species identification was determined by MALDI-TOF MS and Sanger sequencing. Antimicrobial susceptibility testing was performed by the ag...

journal_title：Infection and drug resistance

authors： Gou JJ,Liu N,Guo LH,Xu H,Lv T,Yu X,Chen YB,Guo XB,Rao YT,Zheng BW

更新日期：2020-02-20 00:00:00

abstract：OBJECTIVES:Moxifloxacin (MXF) has been advocated for the treatment of extensively drug-resistant (XDR) tuberculosis despite resistance to older-generation fluoroquinolones. We investigated the relationship between the minimum inhibitory concentration (MIC) of MXF and mutations in the gyrA and gyrB genes in Mycobacteriu...

journal_title：Infection and drug resistance

authors： Dookie N,Sturm AW,Moodley P

更新日期：2014-08-19 00:00:00

abstract：:Mycoplasma genitalium is one of the important causes of non-gonococcal urethritis. Rising incidence and emerging antimicrobial resistance are a major concern these days. The poor clinical outcomes with doxycycline therapy led to the use of azithromycin as the primary drug of choice. Single-dose azithromycin regimen ov...

journal_title：Infection and drug resistance

authors： Sethi S,Zaman K,Jain N

更新日期：2017-09-01 00:00:00

abstract：:Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is the first available agent in a new class of antiretroviral drugs. Raltegravir has been studied extensively in clinical trials, and has been well tolerated and highly effective in both treatment-naïve and -experienced patients. Resistance to raltegravir is unu...

journal_title：Infection and drug resistance

authors： Chirch LM,Steigbigel RT

更新日期：2010-01-01 00:00:00

abstract：:Raltegravir, the only integrase (IN) inhibitor approved for use in HIV therapy, has recently been licensed. Raltegravir inhibits HIV-1 replication by blocking the IN strand transfer reaction. More than 30 mutations have been associated with resistance to raltegravir and other IN strand transfer inhibitors (INSTIs). Th...

journal_title：Infection and drug resistance

authors： Mbisa JL,Martin SA,Cane PA

更新日期：2011-01-01 00:00:00

abstract：Introduction:Management of ventilator-associated pneumonia (VAP), the most common infection in patients on mechanical ventilation, should be tailored to local microbiological data. The aim of this study was to determine susceptibility patterns of organisms causing VAP to develop a treatment algorithm based on these fin...

journal_title：Infection and drug resistance

authors： Awad LS,Abdallah DI,Mugharbil AM,Jisr TH,Droubi NS,El-Rajab NA,Moghnieh RA

更新日期：2017-12-22 00:00:00

abstract：:The treatment of urinary tract infections (UTIs) continues to evolve as common uropathogens increasingly become resistant to previously active antimicrobial agents. In addition, bacterial isolates, which were once considered to be either colonizers or contaminants, have emerged as true pathogens, likely related to the...

journal_title：Infection and drug resistance

authors： Bush LM,Chaparro-Rojas F,Okeh V,Etienne J

更新日期：2011-01-01 00:00:00

abstract：:We present here the first report of an OXA-181-producing Klebsiella pneumoniae isolated from the fecal specimen of a patient in China. The OXA-181-encoding gene blaOXA-181 was located on a 51 kb IncX3-type plasmid. Conjugation assay and whole-genome sequencing analysis revealed that this transferrable plasmid in the K...

journal_title：Infection and drug resistance

authors： Liu C,Fang Y,Zeng Y,Lu J,Sun Q,Zhou H,Shen Z,Chen G

更新日期：2020-04-06 00:00:00