Abstract:
:Mycoplasma genitalium is one of the important causes of non-gonococcal urethritis. Rising incidence and emerging antimicrobial resistance are a major concern these days. The poor clinical outcomes with doxycycline therapy led to the use of azithromycin as the primary drug of choice. Single-dose azithromycin regimen over a period of time was changed to extended regimen following studies showing better clinical cures and less risk of resistance development. However, emerging macrolide resistance, either due to transmission of resistance or drug pressure has further worsened the management of this infection. The issues of drug resistance and treatment failures also exist in cases of M. genitalium infection. At present, the emergence of multidrug-resistant (MDR) M. genitalium strains is an alarming sign for its treatment and the associated public health impact due to its complications. However, newer drugs like pristinamycin, solithromycin, sitafloxacin, and others have shown a hope for the clinical cure, but need further clinical trials to optimize the therapeutic dosing schedules and formulate appropriate treatment regimens. Rampant and inappropriate use of these newer drugs will further sabotage future attempts to manage MDR strains. There is currently a need to formulate diagnostic algorithms and etiology-based treatment regimens rather than the syndromic approach, preferably using combination therapy instead of a monotherapy. Awareness about the current guidelines and recommended treatment regimens among clinicians and local practitioners is of utmost importance. Antimicrobial resistance testing and global surveillance are required to assess the efficacy of current treatment regimens and for guiding future research for the early detection and management of MDR M. genitalium infections.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Sethi S,Zaman K,Jain Ndoi
10.2147/IDR.S105469subject
Has Abstractpub_date
2017-09-01 00:00:00pages
283-292issn
1178-6973pii
idr-10-283journal_volume
10pub_type
杂志文章,评审abstract::A lung abscess is an infectious pulmonary disease characterized by pus-filled cavity formation and often an air-fluid level. In this article, we described an indolent community-acquired lung abscess suspected as a tumor previously. A 56-year-old male presented with cough and expectoration for 2 months and hemoptysis f...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S218921
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abstract:Objective:An ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the determination of selinexor was established to investigate the effects of isavuconazole, itraconazole and fluconazole on the pharmacokinetics of selinexor in rats, respectively. Methods:Twenty-four healthy male rat...
journal_title:Infection and drug resistance
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abstract::While MIC distributions and percent susceptibility for cefepime and ceftazidime are generally similar among Pseudomonas aeruginosa, we noted an increasing discordance in susceptibility favoring ceftazidime at our hospital. Quantitative reverse transcriptase-polymerase chain reaction was utilized to explore overexpress...
journal_title:Infection and drug resistance
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doi:10.2147/idr.s4418
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179642
更新日期:2018-11-15 00:00:00
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journal_title:Infection and drug resistance
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doi:10.2147/IDR.S175679
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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更新日期:2020-02-13 00:00:00
abstract::Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is the first available agent in a new class of antiretroviral drugs. Raltegravir has been studied extensively in clinical trials, and has been well tolerated and highly effective in both treatment-naïve and -experienced patients. Resistance to raltegravir is unu...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/idr.s9689
更新日期:2010-01-01 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S21769
更新日期:2011-01-01 00:00:00
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S227823
更新日期:2019-12-06 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S178922
更新日期:2018-12-04 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S171352
更新日期:2019-07-02 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S179902
更新日期:2019-09-12 00:00:00
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journal_title:Infection and drug resistance
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doi:10.2147/IDR.S257561
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S241648
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S228981
更新日期:2019-12-12 00:00:00
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journal_title:Infection and drug resistance
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更新日期:2018-09-04 00:00:00
abstract:Introduction:Helicobacter pylori was discovered first in the stomachs of patients with gastritis and ulcers by Marshall and Warren in 1982. This discovery majorly affected many research areas of gastroenterology. Since then, the main aim has been to eradicate this microaerophilic bacterium from the stomachs of infected...
journal_title:Infection and drug resistance
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S248059
更新日期:2020-05-21 00:00:00
abstract::Infections by drug-resistant bacteria are life-threatening. As iron is a vital element for the growth of bacteria, iron-chelating agents (siderophores) can be used to arrest their multiplication. Exogenous siderophores - exochelin-MS and deferoxamine-B - were evaluated for their inhibitory activity against methicillin...
journal_title:Infection and drug resistance
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abstract:Background:China is facing a great challenge of pulmonary nontuberculous mycobacteria (NTM) infections. This primary objective of this study was to assess the prevalence of NTM isolates among patients with presumptive TB in Fujian. Methods:The mycobacterial isolates were collected from the tuberculosis survey from Fuj...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S223828
更新日期:2019-11-12 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S228026
更新日期:2019-11-29 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
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更新日期:2017-08-30 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S202906
更新日期:2019-06-20 00:00:00