Abstract:
:Infections by drug-resistant bacteria are life-threatening. As iron is a vital element for the growth of bacteria, iron-chelating agents (siderophores) can be used to arrest their multiplication. Exogenous siderophores - exochelin-MS and deferoxamine-B - were evaluated for their inhibitory activity against methicillin-resistant Staphylococcus aureus and metallo-β-lactamase producers - Pseudomonas aeruginosa and Acinetobacter baumannii - by disc diffusion, micro-broth dilution, and turbidimetric growth assays. The drug-resistant isolates were inhibited by the synergistic activity of siderophores and antibiotics. Minimum inhibitory concentration of exochelin-MS+ampicillin for different isolates was between 0.05 and 0.5 mg/mL. Minimum inhibitory concentration of deferoxamine-B+ampicillin was 1.0 mg/mL and greater. Iron-chelation therapy could provide a complementary approach to overcome drug resistance in pathogenic bacteria.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Gokarn K,Pal RBdoi
10.2147/IDR.S148602subject
Has Abstractpub_date
2018-01-09 00:00:00pages
61-75issn
1178-6973pii
idr-11-061journal_volume
11pub_type
杂志文章abstract:Purpose:The purpose of this study was to identify the common clinical presentations and the evidence on the presence of ageusia and anosmia as an emerging coronavirus disease 2019 (COVID-19) symptom to better inform in both COVID-19 patients and clinicians. Patients and Methods:As part of a double-institutional collab...
journal_title:Infection and drug resistance
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doi:10.2147/IDR.S263632
更新日期:2020-07-29 00:00:00
abstract::One of the main fundamental mechanisms of antibiotic resistance in Gram-negative bacteria comprises an effective change in the membrane permeability to antibiotics. The Gram-negative bacterial complex cell envelope comprises an outer membrane that delimits the periplasm from the exterior environment. The outer membran...
journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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abstract::[This corrects the article DOI: 10.2147/IDR.S258379.]. ...
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