Activity of siderophores against drug-resistant Gram-positive and Gram-negative bacteria.

Abstract:

:Infections by drug-resistant bacteria are life-threatening. As iron is a vital element for the growth of bacteria, iron-chelating agents (siderophores) can be used to arrest their multiplication. Exogenous siderophores - exochelin-MS and deferoxamine-B - were evaluated for their inhibitory activity against methicillin-resistant Staphylococcus aureus and metallo-β-lactamase producers - Pseudomonas aeruginosa and Acinetobacter baumannii - by disc diffusion, micro-broth dilution, and turbidimetric growth assays. The drug-resistant isolates were inhibited by the synergistic activity of siderophores and antibiotics. Minimum inhibitory concentration of exochelin-MS+ampicillin for different isolates was between 0.05 and 0.5 mg/mL. Minimum inhibitory concentration of deferoxamine-B+ampicillin was 1.0 mg/mL and greater. Iron-chelation therapy could provide a complementary approach to overcome drug resistance in pathogenic bacteria.

journal_name

Infect Drug Resist

authors

Gokarn K,Pal RB

doi

10.2147/IDR.S148602

subject

Has Abstract

pub_date

2018-01-09 00:00:00

pages

61-75

issn

1178-6973

pii

idr-11-061

journal_volume

11

pub_type

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