Abstract:
:Tetracyclines have come a long way since they became available almost seven decades ago, with numerous enhancements allowing new agents to overcome bacterial mechanisms of resistance. However, these enhancements come with toxicities and pharmacokinetic disadvantages such as the gastrointestinal side-effects and poor oral bioavailability seen with the glycylcylcines. Omadacycline, a new and improved tetracycline, has demonstrated a broad spectrum of in vitro activity, has oral and intravenous formulations, improved safety compared to glycylcyclines, as well as clinical efficacy and safety for two types of infections: acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. This review will summarize salient points about its pharmacologic properties, available clinical efficacy, and safety data and omadacycline's place in therapy.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Burgos RM,Rodvold KAdoi
10.2147/IDR.S171352subject
Has Abstractpub_date
2019-07-02 00:00:00pages
1895-1915issn
1178-6973pii
171352journal_volume
12pub_type
杂志文章,评审abstract:Purpose:Plasmids of the incompatibility group X type 3 (IncX3) were described carrying various carbapenemase genes in carbapenemase-producing Enterobacteriaceae (CPE) worldwide and in the United Arab Emirates (UAE), as well. To understand the driving force behind the emergence of such plasmids in the UAE, the relations...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S210554
更新日期:2019-06-21 00:00:00
abstract:INTRODUCTION:The characteristics and antimicrobial resistance profiles of Staphylococcus aureus differs according to geographical regions and in relation to antibiotic usage. The aim of this study was to determine the biochemical characteristics of the prevalent S. aureus from Ekiti State, Nigeria, and to evaluate thre...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S48809
更新日期:2013-08-20 00:00:00
abstract:Introduction:Understanding drug resistance is important in drug selection for Helicobacter pylori (H. pylori) eradication, and drug resistance data are lacking in Beijing. Purpose:This cross-sectional study aimed to isolate H. pylori from patients with gastroduodenal diseases and to analyze drug resistance to clarithr...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S249370
更新日期:2020-07-06 00:00:00
abstract:Objective:In the present study, we aimed to describe the clinical features, diagnosis, treatment, and prognosis of spinal epidural abscess (SEA). Methods:The complete clinical data of 11 SEA patients who were treated in our hospital system from January 2015 to June 2018 were retrospectively analyzed. Moreover, the cli...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S257398
更新日期:2020-09-29 00:00:00
abstract:Introduction:Helicobacter pylori was discovered first in the stomachs of patients with gastritis and ulcers by Marshall and Warren in 1982. This discovery majorly affected many research areas of gastroenterology. Since then, the main aim has been to eradicate this microaerophilic bacterium from the stomachs of infected...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S223602
更新日期:2019-11-01 00:00:00
abstract::The treatment of urinary tract infections (UTIs) continues to evolve as common uropathogens increasingly become resistant to previously active antimicrobial agents. In addition, bacterial isolates, which were once considered to be either colonizers or contaminants, have emerged as true pathogens, likely related to the...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S15610
更新日期:2011-01-01 00:00:00
abstract::Lucio's phenomenon (LP) is a special reactional state associated with diffuse multibacillary leprosy; both exhibit a limitative global distribution mainly in Mexico and Central America. We report a case of a 28-year-old female leprosy patient in the People's Republic of China, together with LP and positive anticardiol...
journal_title:Infection and drug resistance
pub_type:
doi:10.2147/IDR.S202386
更新日期:2019-04-02 00:00:00
abstract:Purpose:Complicated urinary tract infections (cUTIs) are among the most frequent health-care-associated infections. In patients with cUTI, Pseudomonas aeruginosa deserves special attention, since it can affect patients with serious underlying conditions. Our aim was to gain insight into the risk factors and prognosis o...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S185753
更新日期:2018-12-18 00:00:00
abstract:Introduction:To achieve target concentrations, the application of higher-than-standard doses of amikacin is proposed for the treatment of sepsis due to an increase in volume of distribution and clearance, but little data are available on aminoglycoside administration in critically ill elderly patients. Patients and me...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S150839
更新日期:2018-02-13 00:00:00
abstract:Background:COVID-19 caused by SARS-CoV-2 virus emerged as an unprecedented challenge to discover effective drugs for its prevention and cure. Hyperinflammation-induced lung damage is one of the poor prognostic indicators causing a higher rate of morbidity and mortality of COVID-19 patients. Favipiravir, an antiviral dr...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S287934
更新日期:2020-12-14 00:00:00
abstract:Introduction:Surgical site infections (SSIs) are one of the most frequently reported hospital acquired infections associated with significant spread of antibiotic resistance. Purpose:We aimed to evaluate a bundle-based approach in reducing SSI at acute surgical intensive care unit of the Emergency Hospital of Cairo Un...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S236814
更新日期:2020-01-28 00:00:00
abstract::One of the main fundamental mechanisms of antibiotic resistance in Gram-negative bacteria comprises an effective change in the membrane permeability to antibiotics. The Gram-negative bacterial complex cell envelope comprises an outer membrane that delimits the periplasm from the exterior environment. The outer membran...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S144299
更新日期:2017-08-30 00:00:00
abstract:Background:Raw meat is one of the commonly consumed traditional diets in Ethiopia. However, unhygienic processing and distribution practices are risky for contamination of meat leading to human infection. This study was conducted to assess the presence of multi-drug resistant E. coli with special emphasis on E. coli O1...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S277890
更新日期:2020-10-27 00:00:00
abstract:Purpose:Respiratory viruses are important etiologies of community-acquired pneumonia (CAP). However, the impact of different RVs on the outcomes of CAP is not well elucidated. This study aims to compare the clinical features and severity of influenza (Flu-p) and non-influenza respiratory viruses-related pneumonia (NIRV...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S267102
更新日期:2020-10-08 00:00:00
abstract:Introduction:Schistosomiasis is an important neglected tropical disease (NTD) in several developing countries. Praziquantel is the principle and efficacious chemotherapeutic agent that has been used to treat schistosomiasis for decades. Unfortunately, emerging resistance to praziquantel with accompanying reduced effica...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S266928
更新日期:2020-10-15 00:00:00
abstract:Introduction:Escherichia (E.) coli can cause intestinal and extra-intestinal infections which ranged from mild to life-threatening infections. The severity of infection is a product of many factors including virulence properties and antimicrobial resistance. Objectives:To determine the antibiotic resistance pattern, t...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S241073
更新日期:2020-04-28 00:00:00
abstract:Objective:The aim of this study was to investigate the in vitro antimicrobial susceptibilities of clinically important Gram-negative bacteria from seven intensive care units in Taiwan in 2016. Materials and methods:In total, 300 non-duplicate isolates of Escherichia coli (n=100), Klebsiella pneumoniae (n=100), and Pse...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S193638
更新日期:2019-03-04 00:00:00
abstract::Infections due to multidrug-resistant Gram-negative bacteria (MDR-GNB), especially when carbapenem resistant, have been very difficult to manage in the last fifteen years, owing to the paucity of dependable therapeutic options. Cefiderocol is a siderophore cephalosporin recently approved by the Food and Drug Administr...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S205309
更新日期:2020-12-29 00:00:00
abstract:BACKGROUND:Biofilm formation inside inserted medical devices leads to their failure and acts as a source of refractory infections. The ultraviolet C (UVC) light is a potential therapy that can be used against the biofilm of bacterial pathogens. OBJECTIVE:We evaluated the efficacy of sublethal dose of UVC light with an...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S109343
更新日期:2016-08-19 00:00:00
abstract:Background:Acinetobacter baumannii has emerged as an important pathogen associated with hospital- and community-acquired infections. Community-acquired A. baumannii pneumonia is characterized by a fulminant course and high mortality rates. In this study, we report the identification of a community-acquired carbapenem-r...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S202803
更新日期:2019-06-06 00:00:00
abstract:Background:The risks of gastrointestinal disorders and cancer are higher in chronic kidney disease (CKD) patients than the general population. There are only a few published reports on the association of helicobacter pylori (H. pylori) infection, endoscopic findings, and histology in these patients. This study was desi...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S228026
更新日期:2019-11-29 00:00:00
abstract::A systematic review was conducted to determine the distribution and prevalence of antibiotic-resistant bacteria (ARB), antimicrobial-resistant genes (ARGs), and antimicrobial-resistant gene determinants (ARGDs) in clinical, environmental, and farm settings and to identify key knowledge gaps in a bid to contain their s...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S170715
更新日期:2018-10-17 00:00:00
abstract::Infections by drug-resistant bacteria are life-threatening. As iron is a vital element for the growth of bacteria, iron-chelating agents (siderophores) can be used to arrest their multiplication. Exogenous siderophores - exochelin-MS and deferoxamine-B - were evaluated for their inhibitory activity against methicillin...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S148602
更新日期:2018-01-09 00:00:00
abstract:Purpose:To characterize the genetic feature of the carbapenems resistant Acinetobacter johnsonii strain Acsw19 isolated from municipal sludge. This strain was found to carry two copies of blaNDM-1,cmlB1-like gene, and blaOXA-211-like gene along with other 8 antimicrobial resistance genes, 3 plasmids, 15 genomic islands...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S236200
更新日期:2020-03-23 00:00:00
abstract:Purpose:This study examined patient- and hospital-level predictor variables that contribute to worse clinical and economic outcomes in patients with carbapenem-nonsusceptible respiratory infections. Patients and Methods:Electronic data (January 2013 to September 2015) were from 78 US hospitals. Nonduplicate, gram-nega...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S236026
更新日期:2020-03-09 00:00:00
abstract::While MIC distributions and percent susceptibility for cefepime and ceftazidime are generally similar among Pseudomonas aeruginosa, we noted an increasing discordance in susceptibility favoring ceftazidime at our hospital. Quantitative reverse transcriptase-polymerase chain reaction was utilized to explore overexpress...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/idr.s4418
更新日期:2008-01-01 00:00:00
abstract:Background:Neonatal sepsis (NS) is one of the leading causes of infant morbidity and mortality, but little is known about pathogen incidence and distribution in China. Methods:In this retrospective study (January 2012 to December 2016), culture-proven cases aged less than 28 days with diagnosed NS in the Guangzhou Wom...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S223597
更新日期:2019-12-03 00:00:00
abstract:Introduction:β-lactam and fluoroquinolone antibiotics are usually used for the treatment of urinary tract infections (UTIs). The aim of this study was to determine the prevalence of plasmid-mediated quinolone resistance (PMQR) and extended spectrum β-lactamases (ESBLs) in Enterobacteriaceae isolated from UTIs. Materia...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S160720
更新日期:2018-07-23 00:00:00
abstract:Background:Broad-scale evidence has shown the significant association between ambient air pollutants and the development of tuberculosis (TB). However, the impact of air quality on the risk of TB in Taiwan is still poorly understood. Objective:To develop a probabilistic integrated population-level risk assessment appr...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S227823
更新日期:2019-12-06 00:00:00
abstract::Background: There have been no reports in Bulgaria about quinolone resistance determinants among Enterobacter spp. Aims: To investigate plasmid and chromosomal quinolone resistance rates among 175 third-generation cephalosporin resistant Enterobacter spp. isolates (167 Enterobacter cloacae complex and eight Enterobact...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S204199
更新日期:2019-05-28 00:00:00