Abstract:
Introduction:Schistosomiasis is an important neglected tropical disease (NTD) in several developing countries. Praziquantel is the principle and efficacious chemotherapeutic agent that has been used to treat schistosomiasis for decades. Unfortunately, emerging resistance to praziquantel with accompanying reduced efficacy is reported in some localities. Hence, genetic diversity among parasite populations is of significant interest in assessing the effects of selective pressure generated by praziquantel therapy that might result in encouraging the emergence of new genotypes that are either non-susceptible or drug-resistant. The present study aimed to investigate the genetic diversity of Schistosoma haematobium among human populations using the RAPD technique to help clarify disease epidemiology and transmission. Materials and Methods:S. haematobium eggs were isolated from 50 of 134 patients from four different localities in Qena Governorate, Upper Egypt. These patients complained of terminal hematuria and burning micturition. Samples were used for molecular analysis using RAPD-PCR primers (A02, A07, A09, A10). Results:Twenty S. haematobium isolates (40%) were amplified using the selected RAPD primers. Amplification patterns of these isolates showed distinct variation in the size and number of amplified fragments, indicating high genetic variation among these isolates. Conclusion:To the best of our knowledge, this study is the first to characterize the genetic diversity of S. haematobium in human populations in Upper Egypt. Future studies on a larger geographic scale involving many districts in Upper Egypt should be encouraged. Information from such a study would provide better insight into clonal lineages of S. haematobium in this endemic area. In turn, understanding transmission of the parasite may have a major role in establishing control strategies for urogenital schistosomiasis in Upper Egypt.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
El-Kady AM,El-Amir MI,Hassan MH,Allemailem KS,Almatroudi A,Ahmad AAdoi
10.2147/IDR.S266928subject
Has Abstractpub_date
2020-10-15 00:00:00pages
3601-3611issn
1178-6973pii
266928journal_volume
13pub_type
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更新日期:2020-04-01 00:00:00
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doi:10.2147/IDR.S272982
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journal_title:Infection and drug resistance
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doi:10.2147/IDR.S179462
更新日期:2018-11-23 00:00:00
abstract::Despite intensive efforts to eradicate the disease, tuberculosis continues to be a major threat to Indian society, with an estimated prevalence of 3.45 million cases in 2006. Emergence of multidrug-resistant tuberculosis has complicated eradication attempts in recent years. Incomplete and/inadequate treatment are the ...
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doi:10.2147/IDR.S10743
更新日期:2010-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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