Abstract:
:Infections due to multidrug-resistant Gram-negative bacteria (MDR-GNB), especially when carbapenem resistant, have been very difficult to manage in the last fifteen years, owing to the paucity of dependable therapeutic options. Cefiderocol is a siderophore cephalosporin recently approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMA) that may have the potential to fill some of the remaining gaps in the treatment of MDR-GNB infections. Among others, cefiderocol demonstrated in vitro activity against carbapenem-resistant Acinetobacter baumannii and metallo-β-lactamases producers. Clinical data from both registrative studies and post-marketing experiences are essential to confirm whether these promises from in vitro studies could readily translate into clinical practice, as well as to delineate the precise place in therapy for cefiderocol for the treatment of MDR-GNB in the near future. Because of its unique potential, it is essential to provide both randomized controlled trials (RCT) and real-life data to improve the ability of clinicians to exploit its benefit in both empirical and targeted treatment of MDR-GNB infections. In this narrative review, we discuss the emerging data from pivotal RCT and initial real-life experiences on the use of cefiderocol for the treatment of MDR-GNB infections.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Giacobbe DR,Ciacco E,Girmenia C,Pea F,Rossolini GM,Sotgiu G,Tascini C,Tumbarello M,Viale P,Bassetti M,ISGRI-SITA (Italian Study Group on Resistant Infections of the Italian Society of Anti-infective Therapy).doi
10.2147/IDR.S205309subject
Has Abstractpub_date
2020-12-29 00:00:00pages
4697-4711issn
1178-6973pii
205309journal_volume
13pub_type
杂志文章,评审abstract:Purpose:This study aims to 1) describe the distribution characteristics of teicoplanin trough concentration (Cmin) and explore the related influencing factors and 2) evaluate the nephrotoxicity of teicoplanin in children. Patients and Methods:A cohort of children who were treated with teicoplanin intravenously were in...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S272982
更新日期:2020-11-12 00:00:00
abstract:OBJECTIVES:Stenotrophomonas maltophilia shows wide-spectrum resistance to antimicrobials and causes various infections in immunocompromised or critically ill patients with high mortality. In this era of antibiotics resistance, a revival of old antibiotics is now featured. We examined the clinical usefulness of latamoxe...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S90726
更新日期:2015-10-20 00:00:00
abstract:Background:Colistin acts as the last line of defense against severe infections caused by carbapenem-resistant Enterobacteriaceae. Infections caused by extensively drug-resistant isolates coproducing MCR and carbapenemases have posed a serious public health concern. Purpose:In this study, we reported the first clinical...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S217168
更新日期:2019-09-19 00:00:00
abstract:Objective:To genetically characterize clusters of virulence factors (VFs) among extended spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae and assess whether these clusters are associated with genetic determinants or clinical outcomes. Methods:One hundred forty-eight E. coli and 82 K. pn...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179134
更新日期:2018-12-31 00:00:00
abstract:Introduction:Trichophyton mentagrophytes and T. interdigitale are important causative agents of superficial mycoses, demonstrating emergent antifungal drug resistance. We studied the antifungal susceptibility profiles in Iranian isolates of these two species. Methods:A total of 96 T. interdigitale and 45 T. mentagroph...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S246025
更新日期:2020-03-13 00:00:00
abstract::While methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has poor outcomes, we describe our experience with Ceftobiprole mainly as a combination therapy for the treatment of MRSA bacteremia. All the cases of MRSA bacteremia in our center at the King Abdulaziz Medical City (KAMC), Riyadh, that had undergone ...
journal_title:Infection and drug resistance
pub_type:
doi:10.2147/IDR.S254395
更新日期:2020-08-03 00:00:00
abstract:Background:The prevalence of Helicobacter pylori resistance to metronidazole and clarithromycin is high in Indonesia. Moreover, the increasing levofloxacin resistance rates in the absence of bismuth treatment in Indonesia has led to the use of other antibiotics as alternative regimens. Methods:We determined the minimu...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S187063
更新日期:2019-01-31 00:00:00
abstract:Purpose:Respiratory viruses are important etiologies of community-acquired pneumonia (CAP). However, the impact of different RVs on the outcomes of CAP is not well elucidated. This study aims to compare the clinical features and severity of influenza (Flu-p) and non-influenza respiratory viruses-related pneumonia (NIRV...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S267102
更新日期:2020-10-08 00:00:00
abstract:Purpose:Infections, in particular with multidrug-resistant organisms, are a burden for inpatient and outpatient care and the whole community. The pathogens "roam" with patients and their relatives, forming an epidemiological bridge between different care facilities. Patients could play an important role in infection co...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S178922
更新日期:2018-12-04 00:00:00
abstract::Raltegravir, the only integrase (IN) inhibitor approved for use in HIV therapy, has recently been licensed. Raltegravir inhibits HIV-1 replication by blocking the IN strand transfer reaction. More than 30 mutations have been associated with resistance to raltegravir and other IN strand transfer inhibitors (INSTIs). Th...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S7775
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi. Although antibiotic therapy is usually effective early in the disease, relapse may occur when administration of antibiotics is discontinued. Studies have suggested that resistance and recurrence of Lyme disease might be due t...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S19201
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. OBJECTIVE:To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany. PATIENTS AND METHODS:The research reported here was a prospective multicen...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S38945
更新日期:2013-01-01 00:00:00
abstract::COVID-19 is an emerging disease all over the world and spreading at an unpredicted rate, resulting in significant influences on global economies and public health. Clinical, laboratory, and imaging characteristics have been partially described in some observational studies. Not enough systematic reviews on predictors ...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S261159
更新日期:2020-06-26 00:00:00
abstract:Purpose:To assess the efficacy of amoxicillin, tetracycline, high-dose metronidazole, and a proton-pump inhibitor for third-line Helicobacter pylori eradication. Methods:We enrolled 70 consecutive patients who had registered, failed to respond to two rounds of H. pylori eradication, and undergone endoscopy for H. pylo...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S185511
更新日期:2018-10-30 00:00:00
abstract::Raoultella ornithinolytica is an encapsulated Gram-negative, oxidase-negative, catalase-positive, aerobic, non-motile rod that belongs to the Enterobacteriaceae family. This bacterium was initially classified in the genus Klebsiella as Klebsiella ornithinolytica, until the creation of the genus Raoultella in 2001. R. ...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S191387
更新日期:2020-04-15 00:00:00
abstract:Purpose:Antifungal resistance and virulence properties of Candida albicans (C. albicans) are growing health problems worldwide. The present study aims to investigate the effect of Zinc Oxide (ZnO) nanoparticles and Nystatin on SAP1-3 genes expression in C. albicans isolates of females with Vulvovaginal Candidiasis (VVC...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S226154
更新日期:2020-02-13 00:00:00
abstract:Objective:To explore the composition of the ocular microbiome in normal subjects and patients with Meibomian gland dysfunction (MGD). Subjects and methods:Seventy subjects (140 eyes) were enrolled in our study. Signs of dry eye were evaluated and bacterial species in the conjunctival sac (CS) and Meibomian gland (MG) ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S162135
更新日期:2018-10-11 00:00:00
abstract:Background:Recurrent tuberculosis (TB) following TB treatment completion in HIV-infected individuals remains a major public health burden. We assessed the role of various risk factors in mediating the development of recurrent TB and subsequent resistance to antiretroviral therapy and anti-TB drugs. Patients and method...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S150644
更新日期:2018-09-05 00:00:00
abstract:Purpose:Pseudomonas aeruginosa possesses a large number of resistance mechanisms to different antimicrobials with carbapenems being the most powerful in treating resistant P. aeruginosa. Hence, it is imperative to explore different mechanisms of carbapenems-resistance in P. aeruginosa to achieve successful treatment th...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S233808
更新日期:2020-01-30 00:00:00
abstract::The mortality rate for candidemia is approximately 30%-60%. However, prognostic factors in patients with candidemia have not yet been elucidated in detail. The aim of the present study was to analyze prognostic factors for candidemia using the mortality rate and Candida isolates of patients with candidemia. Seventy-fi...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S80677
更新日期:2015-07-08 00:00:00
abstract:INTRODUCTION:In recent decades, antimicrobial resistance has become a public health problem, particularly in cases of healthcare-associated infections. Interaction between antibiotic consumption and resistance development is of particular interest regarding Gram-negative bacilli, whose growing resistance has represente...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S22491
更新日期:2011-01-01 00:00:00
abstract:Background:With an aging population, China is facing a huge burden of elderly patients with drug resistant tuberculosis (DR-TB), which has become a significant obstacle for the global TB control. There is still little study on DR-TB in the elderly in China so far. Thus, more research on the epidemiological characterist...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S277203
更新日期:2020-11-13 00:00:00
abstract:Purpose:The flavohemoprotein (gFlHb) in Giardia plays an important role in managing nitrosative and oxidative stress, and potentially also in virulence and nitroimidazole drug tolerance. The aim of this study was to analyze the genetic diversity of gFlHb in Giardia assemblages A and B clinical isolates. Methods:gFlHb ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S274543
更新日期:2020-12-18 00:00:00
abstract:Purpose:The purpose of this study was to identify the common clinical presentations and the evidence on the presence of ageusia and anosmia as an emerging coronavirus disease 2019 (COVID-19) symptom to better inform in both COVID-19 patients and clinicians. Patients and Methods:As part of a double-institutional collab...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S263632
更新日期:2020-07-29 00:00:00
abstract:OBJECTIVE:Many components of the immune system undergo adverse changes during intense physical activity in athletes, leading to a heightened risk of respiratory tract infections. This study evaluated the reduction in infectious processes in athletes due to intensive training with anapsos. METHODS:The study compared at...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S29113
更新日期:2012-01-01 00:00:00
abstract:Purpose:This research aimed to investigate the antibacterial activity and potential mechanism of luteolin against T. pyogenes. Materials and Methods:The broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of luteolin against various T. pyogenes strains. The potential mechanism...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S253363
更新日期:2020-06-10 00:00:00
abstract:Background:Streptococcus pneumoniae is an important pathogen in chronic obstructive pulmonary disease (COPD). We aimed at showing the recent changes in the epidemiology of pneumococcal diseases in patients with COPD, especially after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Methods:Fro...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S165093
更新日期:2018-09-04 00:00:00
abstract:Objective:Candida albicans is a yeast with multiple genotypes. It's a commensal fungus colonizing various sites. However, when the host's immune system weakens, it becomes pathogenic and is responsible for various lesions. In Burkina Faso, antifungal drugs are frequently used, particularly fluconazole, the most used sy...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S225947
更新日期:2019-12-16 00:00:00
abstract::Background: There have been no reports in Bulgaria about quinolone resistance determinants among Enterobacter spp. Aims: To investigate plasmid and chromosomal quinolone resistance rates among 175 third-generation cephalosporin resistant Enterobacter spp. isolates (167 Enterobacter cloacae complex and eight Enterobact...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S204199
更新日期:2019-05-28 00:00:00
abstract:Purpose:To investigate the occurrence and genetic characteristics of the blaIMP-26-positive plasmid from a multidrug-resistant clinical isolate, Enterobacter hormaechei L51. Methods:Species identification was determined by MALDI-TOF MS and Sanger sequencing. Antimicrobial susceptibility testing was performed by the ag...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S232514
更新日期:2020-02-20 00:00:00