Abstract:
Purpose:This study aims to 1) describe the distribution characteristics of teicoplanin trough concentration (Cmin) and explore the related influencing factors and 2) evaluate the nephrotoxicity of teicoplanin in children. Patients and Methods:A cohort of children who were treated with teicoplanin intravenously were included in this retrospective study. Regression analysis was performed to explore the factors associated with the fluctuations of teicoplanin Cmin and the development of nephrotoxicity. Classification and regression tree analysis was used to identify the population at high risk for teicoplanin nephrotoxicity. Results:A total of 269 plasma samples from 186 children were collected. Underexposure (Cmin < 10 mg/L) was documented in 52.7% of cases. The Cmin/dose after administering the loading dose was strongly associated with age (P = 0.008), weight (P = 0.039), and serum creatinine (P = 0.022). The Cmin/dose after administering the maintenance dose was strongly associated with gender (P = 0.014) and serum creatinine (P = 0.006). Cmin (P = 0.012) and the concomitant treatment with amphotericin B (P = 0.001) were the independent risk factors for teicoplanin-related nephrotoxicity. Children who were concomitantly treated by amphotericin B with teicoplanin Cmin > 9.81 mg/L or patients with teicoplanin Cmin > 21.94 mg/L were at high risk for nephrotoxicity. Conclusion:The fluctuations of teicoplanin Cmin could be affected by age, weight, gender, and serum creatinine. Cmin and concomitant treatment with amphotericin B were the independent risk factors for nephrotoxicity. We suggested that the therapeutic drug monitoring of teicoplanin should be performed in children.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Sun D,Zhang T,Mi J,Dong Y,Liu Y,Zhang Y,Zhang D,Wang T,Cheng H,Dong Ydoi
10.2147/IDR.S272982subject
Has Abstractpub_date
2020-11-12 00:00:00pages
4105-4113issn
1178-6973pii
272982journal_volume
13pub_type
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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doi:10.2147/IDR.S248059
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doi:10.2147/IDR.S203579
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
pub_type: 杂志文章
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