Molecular Epidemiology and Mechanisms of High-Level Resistance to Meropenem and Imipenem in Pseudomonas aeruginosa.

abstract：Background:Heteroresistance is a phenomenon that occurs in all bacteria and can cause treatment failure. Yet, the exact mechanisms responsible for heteroresistance still remain unknown. The following study investigated the mechanisms of imipenem-heteroresistance and -resistance in Pseudomonas aeruginosa clinical isolat...

journal_title：Infection and drug resistance

authors： Xu Y,Zheng X,Zeng W,Chen T,Liao W,Qian J,Lin J,Zhou C,Tian X,Cao J,Zhou T

更新日期：2020-05-14 00:00:00

abstract：Objective:To genetically characterize clusters of virulence factors (VFs) among extended spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae and assess whether these clusters are associated with genetic determinants or clinical outcomes. Methods:One hundred forty-eight E. coli and 82 K. pn...

journal_title：Infection and drug resistance

authors： Surgers L,Boersma P,Girard PM,Homor A,Geneste D,Arlet G,Decré D,Boyd A

更新日期：2018-12-31 00:00:00

abstract：Background:The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in a worldwide devastating effect with a diagnostic challenge. Identifying risk factors of severity aids in assessment for the need of early hospitalization. We aimed to demonstrate, for the first time, the clinical, laborator...

journal_title：Infection and drug resistance

authors： Ramadan HK,Mahmoud MA,Aburahma MZ,Elkhawaga AA,El-Mokhtar MA,Sayed IM,Hosni A,Hassany SM,Medhat MA

更新日期：2020-10-05 00:00:00

abstract：:Vancomycin has usually been associated with nephrotoxicity. Generally, this toxicity is presented as proximal tubular cells injury with or without necrosis and as acute interstitial nephritis. However, development of both lesions is uncommonly described in literature. We present a case of vancomycin-induced nephrotoxi...

journal_title：Infection and drug resistance

authors： Barceló-Vidal J,Rodríguez-García E,Grau S

更新日期：2018-07-30 00:00:00

abstract：Background:Raw meat is one of the commonly consumed traditional diets in Ethiopia. However, unhygienic processing and distribution practices are risky for contamination of meat leading to human infection. This study was conducted to assess the presence of multi-drug resistant E. coli with special emphasis on E. coli O1...

journal_title：Infection and drug resistance

authors： Sebsibe MA,Asfaw ET

更新日期：2020-10-27 00:00:00

abstract：Introduction:Management of ventilator-associated pneumonia (VAP), the most common infection in patients on mechanical ventilation, should be tailored to local microbiological data. The aim of this study was to determine susceptibility patterns of organisms causing VAP to develop a treatment algorithm based on these fin...

journal_title：Infection and drug resistance

authors： Awad LS,Abdallah DI,Mugharbil AM,Jisr TH,Droubi NS,El-Rajab NA,Moghnieh RA

更新日期：2017-12-22 00:00:00

abstract：:Tuberculosis remains the world's second leading infectious cause of death, with nearly one-third of the global population latently infected. Treatment of latent tuberculosis infection is a mainstay of tuberculosis-control efforts in low-to medium-incidence countries. Isoniazid monotherapy has been the standard of care...

journal_title：Infection and drug resistance

authors： Norton BL,Holland DP

更新日期：2012-01-01 00:00:00

abstract：:Inorganic polyphosphate (polyP) and its metabolic enzymes are important in several cellular processes related with virulence and antibiotic susceptibility. Accordingly, bacterial polyP synthesis has been proposed as a good target for designing novel antivirulence molecules as alternative to conventional antibiotics. I...

journal_title：Infection and drug resistance

authors： Campos F,Álvarez JA,Ortiz-Severín J,Varas MA,Lagos CF,Cabrera R,Álvarez SA,Chávez FP

更新日期：2019-07-22 00:00:00

abstract：Objective:In the present study, we aimed to describe the clinical features, diagnosis, treatment, and prognosis of spinal epidural abscess (SEA). Methods:The complete clinical data of 11 SEA patients who were treated in our hospital system from January 2015 to June 2018 were retrospectively analyzed. Moreover, the cli...

journal_title：Infection and drug resistance

authors： Dai G,Li S,Yin C,Sun Y,Xu D,Wang Z,Luan L,Hou J,Wang T

更新日期：2020-09-29 00:00:00

abstract：Background:In Saudi Arabia, cross-border transmission of multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains might be particularly fostered by high immigration rates. Herein, we aimed to elucidate the transmission dynamics of MDR-MTBC strains and reveal a detailed prediction of all resistance-co...

journal_title：Infection and drug resistance

authors： Al-Ghafli H,Kohl TA,Merker M,Varghese B,Halees A,Niemann S,Al-Hajoj S

更新日期：2018-11-12 00:00:00

abstract：:We present here the first report of an OXA-181-producing Klebsiella pneumoniae isolated from the fecal specimen of a patient in China. The OXA-181-encoding gene blaOXA-181 was located on a 51 kb IncX3-type plasmid. Conjugation assay and whole-genome sequencing analysis revealed that this transferrable plasmid in the K...

journal_title：Infection and drug resistance

authors： Liu C,Fang Y,Zeng Y,Lu J,Sun Q,Zhou H,Shen Z,Chen G

更新日期：2020-04-06 00:00:00

abstract：:Background: The widespread use of antibiotics has resulted in a high incidence of antibiotic-associated diarrhea (AAD); moreover, the AAD-associated mortality rates have also increased. The effect of combined antibiotic administration on AAD in critically ill patients was analyzed to assist in antibiotic selection for...

journal_title：Infection and drug resistance

authors： Ma H,Zhang L,Zhang Y,Liu Y,He Y,Guo L

更新日期：2019-05-01 00:00:00

abstract：:Genetic and cellular studies have shown that the host's innate and adaptive immune responses are an important correlate of viral infection outcome. The features of the host's immune response (host resistance) reflect the coevolution between hosts and pathogens that has occurred over millennia, and that has also result...

journal_title：Infection and drug resistance

authors： Plauzolles A,Lucas M,Gaudieri S

更新日期：2015-04-07 00:00:00

abstract：:Purpose: The aim of this study was to use a network meta-analysis to evaluate the relative efficacy of various agents at preventing invasive fungal infections (IFIs). In this way, suitable prophylactic regimens may be selected for patients with hematopoietic stem cell transplantation (HSCT). Methods: We conducted a sy...

journal_title：Infection and drug resistance

authors： Su HC,Hua YM,Feng IJ,Wu HC

更新日期：2019-05-15 00:00:00

abstract：BACKGROUND:Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. OBJECTIVE:To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany. PATIENTS AND METHODS:The research reported here was a prospective multicen...

journal_title：Infection and drug resistance

authors： Wissing H,Ballus J,Bingold TM,Nocea G,Krobot KJ,Kaskel P,Kumar RN,Mavros P

更新日期：2013-01-01 00:00:00

abstract：Introduction:Despite the moderate incidence of tuberculosis (TB) in many parts of Iran, Golestan province had a permanently higher TB incidence rate than the national average. Moreover, Golestan province receives immigrants, mainly from TB-endemic areas of Iran and neighbor countries. Here, we aimed to characterize the...

journal_title：Infection and drug resistance

authors： Mansoori N,Vaziri F,Amini S,Khanipour S,Pourazar Dizaji S,Douraghi M

更新日期：2020-07-01 00:00:00

abstract：:One of the main fundamental mechanisms of antibiotic resistance in Gram-negative bacteria comprises an effective change in the membrane permeability to antibiotics. The Gram-negative bacterial complex cell envelope comprises an outer membrane that delimits the periplasm from the exterior environment. The outer membran...

journal_title：Infection and drug resistance

authors： Ghai I,Ghai S

更新日期：2017-08-30 00:00:00

abstract：Background:Gram-negative bacteria bloodstream infection (GNB-BSI) results in considerable mortality and hospitality costs in cirrhotic patients. β-lactam/β-lactamase inhibitor combinations (BLBLIs) and carbapenems (CARs) are widely recommended for treating GNB-BSI in cirrhotic patients, while the efficacy and cost-effe...

journal_title：Infection and drug resistance

authors： Dong Y,Li Y,Zhang Y,Sun D,Du Q,Zhang T,Teng M,Han R,Wang Y,Zhu L,Lei J,Dong Y,Wang T

更新日期：2020-05-07 00:00:00

abstract：Background:Colistin acts as the last line of defense against severe infections caused by carbapenem-resistant Enterobacteriaceae. Infections caused by extensively drug-resistant isolates coproducing MCR and carbapenemases have posed a serious public health concern. Purpose:In this study, we reported the first clinical...

journal_title：Infection and drug resistance

authors： Yuan Y,Li Y,Wang G,Li C,Xiang L,She J,Yang Y,Zhong F,Zhang L

更新日期：2019-09-19 00:00:00

abstract：Objective:Candida albicans is a yeast with multiple genotypes. It's a commensal fungus colonizing various sites. However, when the host's immune system weakens, it becomes pathogenic and is responsible for various lesions. In Burkina Faso, antifungal drugs are frequently used, particularly fluconazole, the most used sy...

journal_title：Infection and drug resistance

authors： Sawadogo PM,Zida A,Soulama I,Sermé SS,Guiguemdé KT,Junior R,Sangaré I,Bamba S,Ouédraogo-Traoré R,Guiguemdé TR

更新日期：2019-12-16 00:00:00

abstract：Background:The ability of biofilm formation is an effective way for Acinetobacter baumannii survival from stressed conditions. This present study was aimed to evaluate the association between biofilm formation, structure, the expression levels of genes related to biofilm formation and biofilm-specific resistance of A. ...

journal_title：Infection and drug resistance

authors： Amin M,Navidifar T,Shooshtari FS,Rashno M,Savari M,Jahangirmehr F,Arshadi M

更新日期：2019-12-12 00:00:00

abstract：Purpose:Pseudomonas aeruginosa is associated with pulmonary function decline and high disease severity in non-cystic fibrosis (CF) bronchiectasis. The prevalence of nontuberculous mycobacteria (NTM) in non-CF bronchiectasis patients has increased recently. This study investigated the impact of NTM with or without P. ae...

journal_title：Infection and drug resistance

authors： Hsieh MH,Lin CY,Wang CY,Fang YF,Lo YL,Lin SM,Lin HC

更新日期：2018-08-10 00:00:00

abstract：Purpose:The purpose of this study was to identify the common clinical presentations and the evidence on the presence of ageusia and anosmia as an emerging coronavirus disease 2019 (COVID-19) symptom to better inform in both COVID-19 patients and clinicians. Patients and Methods:As part of a double-institutional collab...

journal_title：Infection and drug resistance

authors： Farah Yusuf Mohamud M,Garad Mohamed Y,Mohamed Ali A,Ali Adam B

更新日期：2020-07-29 00:00:00

abstract：Background:Hepatitis E virus (HEV) is an emerging infectious agent that causes acute hepatitis in developing and developed countries. Diagnosis of HEV infection has not been routinely done in Egyptian hospitals, and clinicians do not prescribe ribavirin (RBV) for acute hepatitis cases of unknown etiology (AHUE). We aim...

journal_title：Infection and drug resistance

authors： Sayed IM,El-Mokhtar MA,Mahmoud MAR,Elkhawaga AA,Gaber S,Seddek NH,Abdel-Wahid L,Ashmawy AM,Alkareemy EAR

更新日期：2021-01-12 00:00:00

abstract：Purpose:To investigate the occurrence and genetic characteristics of the blaIMP-26-positive plasmid from a multidrug-resistant clinical isolate, Enterobacter hormaechei L51. Methods:Species identification was determined by MALDI-TOF MS and Sanger sequencing. Antimicrobial susceptibility testing was performed by the ag...

journal_title：Infection and drug resistance

authors： Gou JJ,Liu N,Guo LH,Xu H,Lv T,Yu X,Chen YB,Guo XB,Rao YT,Zheng BW

更新日期：2020-02-20 00:00:00

abstract：Background:Carbapenem-resistant Proteeae (CRP) is a group of multidrug-resistant (MDR) microorganisms that raise special treatment problems due to their intrinsic resistance to colistin. In this study, our aim is to provide a phenotypic and molecular characterization of the carbapenemases secreted by CRP strains isolat...

journal_title：Infection and drug resistance

authors： Rus M,Licker M,Musuroi C,Seclaman E,Muntean D,Cirlea N,Tamas A,Vulpie S,Horhat FG,Baditoiu L

更新日期：2020-12-31 00:00:00

abstract：Introduction:Candida species, one among the opportunistic fungi, has become a common pathogen causing vaginal thrush and nosocomial bloodstream infections (BSIs). This study aims to evaluate the prevalence and antifungal susceptibility of various Candida species and slime production by Candida species in BSIs and vulvo...

journal_title：Infection and drug resistance

authors： Tulasidas S,Rao P,Bhat S,Manipura R

更新日期：2018-11-23 00:00:00

abstract：Background:Evidence suggests that genetic variations of exon 1 of mannose-binding lectin 2 (MBL2) may contribute to tuberculosis (TB) risk. Many studies have investigated the association between MBL2 exon 1 polymorphisms (rs1800450, rs1800451, and rs5030737) and TB risk, but yielded inconclusive results. Method:We con...

journal_title：Infection and drug resistance

authors： Wu YJ,Yang X,Chen TD,Zhang ZX,You YZ,Fan ZD

更新日期：2018-08-20 00:00:00

abstract：:Ceftaroline is an advanced-generation cephalosporin antibiotic recently approved by the US Food and Drug Administration for the treatment of complicated skin and skin-structure infections (cSSSIs). This intravenous broad-spectrum antibiotic exerts potent bactericidal activity by inhibiting bacterial cell wall synthesi...

journal_title：Infection and drug resistance

authors： Hernandez PO,Lema S,Tyring SK,Mendoza N

更新日期：2012-01-01 00:00:00

abstract：:The mortality rate for candidemia is approximately 30%-60%. However, prognostic factors in patients with candidemia have not yet been elucidated in detail. The aim of the present study was to analyze prognostic factors for candidemia using the mortality rate and Candida isolates of patients with candidemia. Seventy-fi...

journal_title：Infection and drug resistance

authors： Hirano R,Sakamoto Y,Kudo K,Ohnishi M

更新日期：2015-07-08 00:00:00