Abstract:
Background:Gram-negative bacteria bloodstream infection (GNB-BSI) results in considerable mortality and hospitality costs in cirrhotic patients. β-lactam/β-lactamase inhibitor combinations (BLBLIs) and carbapenems (CARs) are widely recommended for treating GNB-BSI in cirrhotic patients, while the efficacy and cost-effectiveness of two strategies have never been evaluated. Therefore, we conducted a retrospective cohort study to evaluate the efficacy and the cost-effectiveness of BLBLIs and CARs. Patients and Methods:Cirrhotic patients with GNB-BSI treated by BLBLIs or CARs were included. A propensity score-matching analysis was performed to compare the efficacy between BLBLIs and CARs. A decision tree was used to estimate the clinical outcomes and direct costs of treating BSI using two strategies from the patients' perspective. Results:No statistically significant difference was found between the BLBLIs (n = 41) group and the CARs (n = 43) group regarding the time to defervescence (2.4 ± 0.2 vs 2.5 ± 0.3, P = 0.94). Thirty-seven patients from each group were matched in propensity-score-matched cohort, and there was no significant difference between two groups in terms of the time to defervescence (2.4 ± 0.3 vs 2.4 ± 0.3, P = 0.75) and success rate (86.5% vs 78.4%; OR = 0.57; P = 0.36). Based on the drug and hospital costs in China, cefoperazone/sulbactam was cost-effective in the present analysis under the willingness-to-pay threshold (¥64,644). Conclusion:The efficacy of BLBLIs is similar to CARs. Cefoperazone/sulbactam could be a cost-effective therapy in cirrhotic patients with GNB-BSI. Carbapenems-sparing regimens should be encouraged in regions with a low prevalence of MDR bacteria.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Dong Y,Li Y,Zhang Y,Sun D,Du Q,Zhang T,Teng M,Han R,Wang Y,Zhu L,Lei J,Dong Y,Wang Tdoi
10.2147/IDR.S241648subject
Has Abstractpub_date
2020-05-07 00:00:00pages
1327-1338issn
1178-6973pii
241648journal_volume
13pub_type
杂志文章abstract:Background:China is facing a great challenge of pulmonary nontuberculous mycobacteria (NTM) infections. This primary objective of this study was to assess the prevalence of NTM isolates among patients with presumptive TB in Fujian. Methods:The mycobacterial isolates were collected from the tuberculosis survey from Fuj...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S223828
更新日期:2019-11-12 00:00:00
abstract:Background:The prevalence of Helicobacter pylori resistance to metronidazole and clarithromycin is high in Indonesia. Moreover, the increasing levofloxacin resistance rates in the absence of bismuth treatment in Indonesia has led to the use of other antibiotics as alternative regimens. Methods:We determined the minimu...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S187063
更新日期:2019-01-31 00:00:00
abstract:Introduction:Candida species, one among the opportunistic fungi, has become a common pathogen causing vaginal thrush and nosocomial bloodstream infections (BSIs). This study aims to evaluate the prevalence and antifungal susceptibility of various Candida species and slime production by Candida species in BSIs and vulvo...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179462
更新日期:2018-11-23 00:00:00
abstract::Infections by drug-resistant bacteria are life-threatening. As iron is a vital element for the growth of bacteria, iron-chelating agents (siderophores) can be used to arrest their multiplication. Exogenous siderophores - exochelin-MS and deferoxamine-B - were evaluated for their inhibitory activity against methicillin...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S148602
更新日期:2018-01-09 00:00:00
abstract::Tuberculosis remains the world's second leading infectious cause of death, with nearly one-third of the global population latently infected. Treatment of latent tuberculosis infection is a mainstay of tuberculosis-control efforts in low-to medium-incidence countries. Isoniazid monotherapy has been the standard of care...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S29180
更新日期:2012-01-01 00:00:00
abstract:Objective:Evaluate host and pathogen factors associated with mortality in those with hospital acquired infections (HAI) in a tertiary intensive care unit in Brazil. Methods:Observational and analytical cohort single center study in a general intensive care unit (ICU) in Northeastern Brazil between January 2016 and Aug...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S264276
更新日期:2020-08-12 00:00:00
abstract:Background:Raw meat is one of the commonly consumed traditional diets in Ethiopia. However, unhygienic processing and distribution practices are risky for contamination of meat leading to human infection. This study was conducted to assess the presence of multi-drug resistant E. coli with special emphasis on E. coli O1...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S277890
更新日期:2020-10-27 00:00:00
abstract:Introduction:Understanding drug resistance is important in drug selection for Helicobacter pylori (H. pylori) eradication, and drug resistance data are lacking in Beijing. Purpose:This cross-sectional study aimed to isolate H. pylori from patients with gastroduodenal diseases and to analyze drug resistance to clarithr...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S249370
更新日期:2020-07-06 00:00:00
abstract:Background:The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in a worldwide devastating effect with a diagnostic challenge. Identifying risk factors of severity aids in assessment for the need of early hospitalization. We aimed to demonstrate, for the first time, the clinical, laborator...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S272605
更新日期:2020-10-05 00:00:00
abstract:Background:Due to increasing colistin usage, the dissemination of the colistin-resistant gene mcr-1 has been increasingly investigated. The aim of this study was to determine whether a traveler on a short-term international trip to a developing country could bring mcr-1 back to their home country. Materials and method...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S153178
更新日期:2018-03-12 00:00:00
abstract:BACKGROUND:Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi. Although antibiotic therapy is usually effective early in the disease, relapse may occur when administration of antibiotics is discontinued. Studies have suggested that resistance and recurrence of Lyme disease might be due t...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S19201
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. OBJECTIVE:To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany. PATIENTS AND METHODS:The research reported here was a prospective multicen...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S38945
更新日期:2013-01-01 00:00:00
abstract::One of the main fundamental mechanisms of antibiotic resistance in Gram-negative bacteria comprises an effective change in the membrane permeability to antibiotics. The Gram-negative bacterial complex cell envelope comprises an outer membrane that delimits the periplasm from the exterior environment. The outer membran...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S144299
更新日期:2017-08-30 00:00:00
abstract:Purpose:To develop a rapid EDTA-modified carbapenem inactivation method (reCIM) combined with modified rapid carbapenem inactivation method (mrCIM) to detect carbapenemase and distinguish metallo-β-lactamases from carbapenemases in Enterobacteriaceae in 4 hrs. Materials and Methods:The sensitivities and specificities ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S249570
更新日期:2020-06-23 00:00:00
abstract:Purpose:Pseudomonas aeruginosa is associated with pulmonary function decline and high disease severity in non-cystic fibrosis (CF) bronchiectasis. The prevalence of nontuberculous mycobacteria (NTM) in non-CF bronchiectasis patients has increased recently. This study investigated the impact of NTM with or without P. ae...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S169789
更新日期:2018-08-10 00:00:00
abstract:Background:Leishmaniasis is an infectious disease common in tropical and subtropical regions caused by the genus Leishmania, which is transmitted by the bite of female sandflies. In this study, we evaluate the anti-leishmanial effect of recombinant Clostridium α-toxin protein alone and the combination with glucantime t...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S257561
更新日期:2020-07-15 00:00:00
abstract:Purpose:This research aimed to investigate the antibacterial activity and potential mechanism of luteolin against T. pyogenes. Materials and Methods:The broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of luteolin against various T. pyogenes strains. The potential mechanism...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S253363
更新日期:2020-06-10 00:00:00
abstract::Raoultella ornithinolytica is an encapsulated Gram-negative, oxidase-negative, catalase-positive, aerobic, non-motile rod that belongs to the Enterobacteriaceae family. This bacterium was initially classified in the genus Klebsiella as Klebsiella ornithinolytica, until the creation of the genus Raoultella in 2001. R. ...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S191387
更新日期:2020-04-15 00:00:00
abstract::While MIC distributions and percent susceptibility for cefepime and ceftazidime are generally similar among Pseudomonas aeruginosa, we noted an increasing discordance in susceptibility favoring ceftazidime at our hospital. Quantitative reverse transcriptase-polymerase chain reaction was utilized to explore overexpress...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/idr.s4418
更新日期:2008-01-01 00:00:00
abstract::The rapid detection of carbapenemase allows implementation of infection control measures and adaptation of antibiotic therapy. We evaluated the performances of the Xpert Carba-R V2® assay for the direct detection and identification of carbapenemase on positive blood cultures. We focused our evaluation on its detection...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S204436
更新日期:2019-10-23 00:00:00
abstract:Backgrounds:The aim of this study was to evaluate both phenotypic and genotypic determinants of mupirocin resistance among methicillin-resistant Staphylococcus aureus (MRSA) and methicillin susceptible S. aureus (MSSA) strains recovered from different clinical samples of children who were admitted to the Children's Med...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S185610
更新日期:2019-01-03 00:00:00
abstract:Objective:Candida albicans is a yeast with multiple genotypes. It's a commensal fungus colonizing various sites. However, when the host's immune system weakens, it becomes pathogenic and is responsible for various lesions. In Burkina Faso, antifungal drugs are frequently used, particularly fluconazole, the most used sy...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S225947
更新日期:2019-12-16 00:00:00
abstract:Introduction:To achieve target concentrations, the application of higher-than-standard doses of amikacin is proposed for the treatment of sepsis due to an increase in volume of distribution and clearance, but little data are available on aminoglycoside administration in critically ill elderly patients. Patients and me...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S150839
更新日期:2018-02-13 00:00:00
abstract:INTRODUCTION:The characteristics and antimicrobial resistance profiles of Staphylococcus aureus differs according to geographical regions and in relation to antibiotic usage. The aim of this study was to determine the biochemical characteristics of the prevalent S. aureus from Ekiti State, Nigeria, and to evaluate thre...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S48809
更新日期:2013-08-20 00:00:00
abstract:Background:In Saudi Arabia, cross-border transmission of multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains might be particularly fostered by high immigration rates. Herein, we aimed to elucidate the transmission dynamics of MDR-MTBC strains and reveal a detailed prediction of all resistance-co...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S181124
更新日期:2018-11-12 00:00:00
abstract::Mycoplasma genitalium is one of the important causes of non-gonococcal urethritis. Rising incidence and emerging antimicrobial resistance are a major concern these days. The poor clinical outcomes with doxycycline therapy led to the use of azithromycin as the primary drug of choice. Single-dose azithromycin regimen ov...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S105469
更新日期:2017-09-01 00:00:00
abstract::Purpose: The aim of this study was to use a network meta-analysis to evaluate the relative efficacy of various agents at preventing invasive fungal infections (IFIs). In this way, suitable prophylactic regimens may be selected for patients with hematopoietic stem cell transplantation (HSCT). Methods: We conducted a sy...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S203579
更新日期:2019-05-15 00:00:00
abstract:Background:China is one of the high-burden countries for multidrug-resistant tuberculosis (MDR-TB), and pyrazinamide is one of the anti-TB drugs used for the shorter MDR-TB treatment regimen. The aim of this study was to determine the correlation between pncA gene mutations and resistance to four first-line anti-TB dru...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S222943
更新日期:2019-09-30 00:00:00
abstract:Purpose:This study examined patient- and hospital-level predictor variables that contribute to worse clinical and economic outcomes in patients with carbapenem-nonsusceptible respiratory infections. Patients and Methods:Electronic data (January 2013 to September 2015) were from 78 US hospitals. Nonduplicate, gram-nega...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S236026
更新日期:2020-03-09 00:00:00
abstract:Background:Broad-scale evidence has shown the significant association between ambient air pollutants and the development of tuberculosis (TB). However, the impact of air quality on the risk of TB in Taiwan is still poorly understood. Objective:To develop a probabilistic integrated population-level risk assessment appr...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S227823
更新日期:2019-12-06 00:00:00