Abstract:
Objective:In the present study, we aimed to describe the clinical features, diagnosis, treatment, and prognosis of spinal epidural abscess (SEA). Methods:The complete clinical data of 11 SEA patients who were treated in our hospital system from January 2015 to June 2018 were retrospectively analyzed. Moreover, the clinical features, diagnosis, treatment, and prognosis of 642 SEA cases collected from the foreign literature from 2010 to 2019 were also investigated. Results:Among our 11 SEA patients, nine cases had purulent inflammation, two cases had tuberculosis, two cases had infection caused by Staphylococcus aureus, one case had infection caused by Streptococcus constellatus, one case had infection caused by Klebsiella pneumoniae, five cases showed negative bacterial culture, and two cases had Mycobacterium tuberculosis. All 11 cases showed focal spinal pain, eight cases exhibited neurological deficits, and six cases experienced fever. Nine of the 11 cases involved the lumbosacral spine, one case involved the thoracic spine, and one case involved the cervical spine. Eight patients had a longer course of disease (>2 weeks), all 11 patients had vertebral osteomyelitis, and nine patients had intervertebral discitis. One patient had motor dysfunction of arms and legs, one patient had lower limb motor dysfunction, one patient had limb numbness, one patient experienced relapse after the conservative treatment, and one patient experienced relapse after the surgical treatment. The follow-up time was 15-24 months. Conclusion:The classic diagnosis of triads (focal spine pain, neurological deficit, and fever) was less specific for SEA. MRI examination, blood culture, tissue culture, and biopsy could be used for the diagnosis for SEA. Suppuritis was a common cause of SEA. Early detection, early diagnosis and early treatment, as well as the selection of the most suitable treatment regimen based on comprehensive evaluation, played crucial roles in a better prognosis of SEA. There was no statistically significant difference in terms of the general condition, diagnosis, treatment and prognosis between the patients with negative and positive culture results (P>0.05). For SEA patient with negative culture, antibiotic treatment should be used empirically.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Dai G,Li S,Yin C,Sun Y,Xu D,Wang Z,Luan L,Hou J,Wang Tdoi
10.2147/IDR.S257398subject
Has Abstractpub_date
2020-09-29 00:00:00pages
3325-3334issn
1178-6973pii
257398journal_volume
13pub_type
杂志文章abstract:Background:Heteroresistance is a phenomenon that occurs in all bacteria and can cause treatment failure. Yet, the exact mechanisms responsible for heteroresistance still remain unknown. The following study investigated the mechanisms of imipenem-heteroresistance and -resistance in Pseudomonas aeruginosa clinical isolat...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S249475
更新日期:2020-05-14 00:00:00
abstract::Purpose: To investigate antimicrobial resistance and risk factors for mortality of Klebsiella pneumoniae (KP) pneumonia in diabetics and nondiabetics. Patients and methods: A retrospective study was conducted among inpatients of KP pneumonia via electronic medical records in a territory hospital between January 2016 a...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S199642
更新日期:2019-05-07 00:00:00
abstract:Objective:An ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the determination of selinexor was established to investigate the effects of isavuconazole, itraconazole and fluconazole on the pharmacokinetics of selinexor in rats, respectively. Methods:Twenty-four healthy male rat...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S269831
更新日期:2020-09-14 00:00:00
abstract::We present here the first report of an OXA-181-producing Klebsiella pneumoniae isolated from the fecal specimen of a patient in China. The OXA-181-encoding gene blaOXA-181 was located on a 51 kb IncX3-type plasmid. Conjugation assay and whole-genome sequencing analysis revealed that this transferrable plasmid in the K...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S237793
更新日期:2020-04-06 00:00:00
abstract:Introduction:Candida species, one among the opportunistic fungi, has become a common pathogen causing vaginal thrush and nosocomial bloodstream infections (BSIs). This study aims to evaluate the prevalence and antifungal susceptibility of various Candida species and slime production by Candida species in BSIs and vulvo...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179462
更新日期:2018-11-23 00:00:00
abstract::Infectious diseases are known as one of the most life-threatening disabilities worldwide. Approximately 13 million deaths related to infectious diseases are reported each year. The only way to combat infectious diseases is by chemotherapy using antimicrobial agents and antibiotics. However, due to uncontrolled and unn...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S25076
更新日期:2013-09-18 00:00:00
abstract:Introduction:Despite the moderate incidence of tuberculosis (TB) in many parts of Iran, Golestan province had a permanently higher TB incidence rate than the national average. Moreover, Golestan province receives immigrants, mainly from TB-endemic areas of Iran and neighbor countries. Here, we aimed to characterize the...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S255889
更新日期:2020-07-01 00:00:00
abstract:Background:Raw meat is one of the commonly consumed traditional diets in Ethiopia. However, unhygienic processing and distribution practices are risky for contamination of meat leading to human infection. This study was conducted to assess the presence of multi-drug resistant E. coli with special emphasis on E. coli O1...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S277890
更新日期:2020-10-27 00:00:00
abstract:Background:Hepatitis E virus (HEV) is an emerging infectious agent that causes acute hepatitis in developing and developed countries. Diagnosis of HEV infection has not been routinely done in Egyptian hospitals, and clinicians do not prescribe ribavirin (RBV) for acute hepatitis cases of unknown etiology (AHUE). We aim...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S289766
更新日期:2021-01-12 00:00:00
abstract:Background:Neonatal sepsis (NS) is one of the leading causes of infant morbidity and mortality, but little is known about pathogen incidence and distribution in China. Methods:In this retrospective study (January 2012 to December 2016), culture-proven cases aged less than 28 days with diagnosed NS in the Guangzhou Wom...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S223597
更新日期:2019-12-03 00:00:00
abstract::A systematic review was conducted to determine the distribution and prevalence of antibiotic-resistant bacteria (ARB), antimicrobial-resistant genes (ARGs), and antimicrobial-resistant gene determinants (ARGDs) in clinical, environmental, and farm settings and to identify key knowledge gaps in a bid to contain their s...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S170715
更新日期:2018-10-17 00:00:00
abstract:Background:Tachyplesin I is a cationic antimicrobial peptide with a typical cyclic antiparallel β-sheet structure. We previously demonstrated that long-term continuous exposure to increased concentration of tachyplesin I can induce resistant Gram-negative bacteria. However, no significant information is available about...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S226687
更新日期:2020-01-16 00:00:00
abstract:Introduction:Klebsiella pneumoniae carbapenemase (KPC) belongs to the Group-A β-lactamases that incorporate serine at their active site and hydrolyze various penicillins, cephalosporins, and carbapenems. Metallo-beta-lactamases (MBLs) are group-B enzymes that contain one or two essential zinc ions in the active sites a...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S262493
更新日期:2020-08-18 00:00:00
abstract::Purpose: Treatment-refractory Giardia cases have increased rapidly within the last decade. No markers of resistance nor a standardized susceptibility test have been established yet, but several enzymes and their pathways have been associated with metronidazole (MTZ) resistant Giardia. Very limited data are available r...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S177997
更新日期:2019-05-10 00:00:00
abstract:Purpose:The flavohemoprotein (gFlHb) in Giardia plays an important role in managing nitrosative and oxidative stress, and potentially also in virulence and nitroimidazole drug tolerance. The aim of this study was to analyze the genetic diversity of gFlHb in Giardia assemblages A and B clinical isolates. Methods:gFlHb ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S274543
更新日期:2020-12-18 00:00:00
abstract:Background:The risks of gastrointestinal disorders and cancer are higher in chronic kidney disease (CKD) patients than the general population. There are only a few published reports on the association of helicobacter pylori (H. pylori) infection, endoscopic findings, and histology in these patients. This study was desi...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S228026
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. OBJECTIVE:To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany. PATIENTS AND METHODS:The research reported here was a prospective multicen...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S38945
更新日期:2013-01-01 00:00:00
abstract:Purpose:This research aimed to investigate the antibacterial activity and potential mechanism of luteolin against T. pyogenes. Materials and Methods:The broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of luteolin against various T. pyogenes strains. The potential mechanism...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S253363
更新日期:2020-06-10 00:00:00
abstract::Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immun...
journal_title:Infection and drug resistance
pub_type:
doi:10.2147/IDR.S163686
更新日期:2018-05-14 00:00:00
abstract:BACKGROUND:Biofilm formation inside inserted medical devices leads to their failure and acts as a source of refractory infections. The ultraviolet C (UVC) light is a potential therapy that can be used against the biofilm of bacterial pathogens. OBJECTIVE:We evaluated the efficacy of sublethal dose of UVC light with an...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S109343
更新日期:2016-08-19 00:00:00
abstract:Introduction:Duodenoscopes have been widely used for both diagnostic and therapeutic endoscopic retrograde cholangiopancreatography procedures. Numerous outbreaks of duodenoscope-associated infections involving multidrug-resistant bacteria have recently been reported. Plasma activated water (PAW) has been widely consid...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S159243
更新日期:2018-05-17 00:00:00
abstract::Tetracyclines have come a long way since they became available almost seven decades ago, with numerous enhancements allowing new agents to overcome bacterial mechanisms of resistance. However, these enhancements come with toxicities and pharmacokinetic disadvantages such as the gastrointestinal side-effects and poor o...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S171352
更新日期:2019-07-02 00:00:00
abstract:Background:Infection prevention and control (IPC) is a globally relevant aspect of all health systems impacting the health and safety of both patients and healthcare workers. However, best practices remain a challenge in healthcare delivery especially in resource limited situations. The primary objective of this study ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S273851
更新日期:2020-11-24 00:00:00
abstract::The treatment of urinary tract infections (UTIs) continues to evolve as common uropathogens increasingly become resistant to previously active antimicrobial agents. In addition, bacterial isolates, which were once considered to be either colonizers or contaminants, have emerged as true pathogens, likely related to the...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S15610
更新日期:2011-01-01 00:00:00
abstract::The mortality rate for candidemia is approximately 30%-60%. However, prognostic factors in patients with candidemia have not yet been elucidated in detail. The aim of the present study was to analyze prognostic factors for candidemia using the mortality rate and Candida isolates of patients with candidemia. Seventy-fi...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S80677
更新日期:2015-07-08 00:00:00
abstract:Purpose:This study aims to 1) describe the distribution characteristics of teicoplanin trough concentration (Cmin) and explore the related influencing factors and 2) evaluate the nephrotoxicity of teicoplanin in children. Patients and Methods:A cohort of children who were treated with teicoplanin intravenously were in...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S272982
更新日期:2020-11-12 00:00:00
abstract:Background and purpose:Invasive nontyphoidal salmonellosis, mostly caused by serovars Typhimurium and Enteritidis of Salmonella enterica, has emerged as a major public health problem in sub-Saharan Africa. The aim of this study was the clinical and microbiological characterization of nontyphoidal salmonellosis episodes...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S147243
更新日期:2018-01-31 00:00:00
abstract:Background:Flomoxef is potentially effective against β-lactamase-producing Enterobacteriaceae because limited clinical data demonstrate its effectiveness against Enterobacteriaceae bloodstream infections (BSIs) based on its minimum inhibitory concentrations (MICs). This study was conducted to determine the optimal brea...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S185670
更新日期:2018-11-27 00:00:00
abstract::Echinocandin antifungal agents have become the first-line therapy for invasive candidiasis (IC) in many countries. Despite their increasing use, resistance to this class of drug is, overall, still uncommon. Here, we report two patients from the People's Republic of China with IC, one with infection caused by pan-echin...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S152785
更新日期:2018-01-23 00:00:00
abstract:Introduction:To achieve target concentrations, the application of higher-than-standard doses of amikacin is proposed for the treatment of sepsis due to an increase in volume of distribution and clearance, but little data are available on aminoglycoside administration in critically ill elderly patients. Patients and me...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S150839
更新日期:2018-02-13 00:00:00