Influence of host resistance on viral adaptation: hepatitis C virus as a case study.

Abstract:

:Genetic and cellular studies have shown that the host's innate and adaptive immune responses are an important correlate of viral infection outcome. The features of the host's immune response (host resistance) reflect the coevolution between hosts and pathogens that has occurred over millennia, and that has also resulted in a number of strategies developed by viruses to improve fitness and survival within the host (viral adaptation). In this review, we discuss viral adaptation to host immune pressure via protein-protein interactions and sequence-specific mutations. Specifically, we will present the "state of play" on viral escape mutations to host T-cell responses in the context of the hepatitis C virus, and their influence on infection outcome.

journal_name

Infect Drug Resist

authors

Plauzolles A,Lucas M,Gaudieri S

doi

10.2147/IDR.S49891

subject

Has Abstract

pub_date

2015-04-07 00:00:00

pages

63-74

issn

1178-6973

pii

idr-8-063

journal_volume

8

pub_type

杂志文章,评审
  • Post-splenectomy sepsis: preventative strategies, challenges, and solutions.

    abstract::Removal of the spleen had already been established as a routine technique to treat splenic trauma and other diseases affecting the spleen before the anatomy, physiology, and function of the spleen were known in the mid-twentieth century. It is now widely accepted that the splenectomized individual is at increased risk...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S179902

    authors: Luu S,Spelman D,Woolley IJ

    更新日期:2019-09-12 00:00:00

  • Expression of the MexXY-OprM efflux system in Pseudomonas aeruginosa with discordant cefepime/ceftazidime susceptibility profiles.

    abstract::While MIC distributions and percent susceptibility for cefepime and ceftazidime are generally similar among Pseudomonas aeruginosa, we noted an increasing discordance in susceptibility favoring ceftazidime at our hospital. Quantitative reverse transcriptase-polymerase chain reaction was utilized to explore overexpress...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/idr.s4418

    authors: Laohavaleeson S,Lolans K,Quinn JP,Kuti JL,Nicolau DP

    更新日期:2008-01-01 00:00:00

  • Clinical Characteristics and Risk Factors for Bloodstream Infection Due to Carbapenem-Resistant Klebsiella pneumoniae in Patients with Hematologic Malignancies.

    abstract:Purpose:The aim was to examine the clinical characteristics and risk factors for bloodstream infection (BSI) due to carbapenem-resistant Klebsiella pneumoniae (CRKP) in patients with hematologic malignancies. Materials and Methods:A single-centre, retrospective case-control study representing 734 patients with hematol...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S272217

    authors: Zhang P,Wang J,Hu H,Zhang S,Wei J,Yang Q,Qu T

    更新日期:2020-09-22 00:00:00

  • Recurrent tuberculosis among HIV-coinfected patients: a case series from KwaZulu-Natal.

    abstract:Background:Recurrent tuberculosis (TB) following TB treatment completion in HIV-infected individuals remains a major public health burden. We assessed the role of various risk factors in mediating the development of recurrent TB and subsequent resistance to antiretroviral therapy and anti-TB drugs. Patients and method...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S150644

    authors: Naidoo K,Dookie N,Naidoo K,Yende-Zuma N,Chimukangara B,Bhushan A,Govender D,Gengiah S,Padayatchi N

    更新日期:2018-09-05 00:00:00

  • Clinical Outcomes and Prevalence of Hepatitis E Virus (HEV) Among Non-A-C Hepatitis Patients in Egypt.

    abstract:Background:Hepatitis E virus (HEV) is an emerging infectious agent that causes acute hepatitis in developing and developed countries. Diagnosis of HEV infection has not been routinely done in Egyptian hospitals, and clinicians do not prescribe ribavirin (RBV) for acute hepatitis cases of unknown etiology (AHUE). We aim...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S289766

    authors: Sayed IM,El-Mokhtar MA,Mahmoud MAR,Elkhawaga AA,Gaber S,Seddek NH,Abdel-Wahid L,Ashmawy AM,Alkareemy EAR

    更新日期:2021-01-12 00:00:00

  • Evaluation of Modified Rapid Carbapenem Inactivation Method (mrCIM) Combined with Rapid EDTA-Modified Carbapenem Inactivation Method (reCIM) to Detect Carbapenemase and Distinguish Metallo-Carbapenemase in Enterobacteriaceae Within Four Hours.

    abstract:Purpose:To develop a rapid EDTA-modified carbapenem inactivation method (reCIM) combined with modified rapid carbapenem inactivation method (mrCIM) to detect carbapenemase and distinguish metallo-β-lactamases from carbapenemases in Enterobacteriaceae in 4 hrs. Materials and Methods:The sensitivities and specificities ...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S249570

    authors: Wei Q,Sun J,Wang Z,Yan L,Zhang C,Xu X

    更新日期:2020-06-23 00:00:00

  • Diffuse multibacillary leprosy patient with Lucio's phenomenon and positive anticardiolipin antibody misdiagnosed as lupus erythematosus panniculitis in the People's Republic of China.

    abstract::Lucio's phenomenon (LP) is a special reactional state associated with diffuse multibacillary leprosy; both exhibit a limitative global distribution mainly in Mexico and Central America. We report a case of a 28-year-old female leprosy patient in the People's Republic of China, together with LP and positive anticardiol...

    journal_title:Infection and drug resistance

    pub_type:

    doi:10.2147/IDR.S202386

    authors: Gao W,Chen Z,Jiang H,Shi Y,Zhang W,Wang H

    更新日期:2019-04-02 00:00:00

  • Comparative effectiveness of antifungal agents in patients with hematopoietic stem cell transplantation: a systematic review and network meta-analysis.

    abstract::Purpose: The aim of this study was to use a network meta-analysis to evaluate the relative efficacy of various agents at preventing invasive fungal infections (IFIs). In this way, suitable prophylactic regimens may be selected for patients with hematopoietic stem cell transplantation (HSCT). Methods: We conducted a sy...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S203579

    authors: Su HC,Hua YM,Feng IJ,Wu HC

    更新日期:2019-05-15 00:00:00

  • Fatal Prosthetic Valve Endocarditis Due to Aspergillus flavus in a Diabetic Patient.

    abstract::Aspergillus endocarditis (AE) accounts for a-quarter of all fungal endocarditis, mainly in immunocompromised hosts prior to heart-valve surgery with high mortality, even with treatment. Herein, we report a rare case of AE in a diabetic 60-year-old woman with a history of redo mitral valve prosthesis suspecious of acut...

    journal_title:Infection and drug resistance

    pub_type:

    doi:10.2147/IDR.S258637

    authors: Jalalian R,Shokohi T,Mirzakhani R,Ghasemian R,Hedayati MT,Ardalani S,Azizi S,Kalhori S,Kermani F,Mayahi S

    更新日期:2020-07-10 00:00:00

  • Spoligotype and Drug Susceptibility Profiles of Mycobacterium tuberculosis Complex Isolates in Golestan Province, North Iran.

    abstract:Introduction:Despite the moderate incidence of tuberculosis (TB) in many parts of Iran, Golestan province had a permanently higher TB incidence rate than the national average. Moreover, Golestan province receives immigrants, mainly from TB-endemic areas of Iran and neighbor countries. Here, we aimed to characterize the...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S255889

    authors: Mansoori N,Vaziri F,Amini S,Khanipour S,Pourazar Dizaji S,Douraghi M

    更新日期:2020-07-01 00:00:00

  • Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections.

    abstract:Objective:Evaluate host and pathogen factors associated with mortality in those with hospital acquired infections (HAI) in a tertiary intensive care unit in Brazil. Methods:Observational and analytical cohort single center study in a general intensive care unit (ICU) in Northeastern Brazil between January 2016 and Aug...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S264276

    authors: Otero ML,Menezes RC,Ferreira IBB,Issa FL,Agareno G,Carmo TA,Arriaga MB,Fukutani KF,Pamplona Neto L,Agareno S,Filgueiras Filho NM,Akrami KM,Andrade BB

    更新日期:2020-08-12 00:00:00

  • A study on biofilm production and antifungal drug resistance among Candida species from vulvovaginal and bloodstream infections.

    abstract:Introduction:Candida species, one among the opportunistic fungi, has become a common pathogen causing vaginal thrush and nosocomial bloodstream infections (BSIs). This study aims to evaluate the prevalence and antifungal susceptibility of various Candida species and slime production by Candida species in BSIs and vulvo...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S179462

    authors: Tulasidas S,Rao P,Bhat S,Manipura R

    更新日期:2018-11-23 00:00:00

  • Raoultella ornithinolytica: Emergence and Resistance.

    abstract::Raoultella ornithinolytica is an encapsulated Gram-negative, oxidase-negative, catalase-positive, aerobic, non-motile rod that belongs to the Enterobacteriaceae family. This bacterium was initially classified in the genus Klebsiella as Klebsiella ornithinolytica, until the creation of the genus Raoultella in 2001. R. ...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S191387

    authors: Hajjar R,Ambaraghassi G,Sebajang H,Schwenter F,Su SH

    更新日期:2020-04-15 00:00:00

  • The use of platensimycin and platencin to fight antibiotic resistance.

    abstract::Infectious diseases are known as one of the most life-threatening disabilities worldwide. Approximately 13 million deaths related to infectious diseases are reported each year. The only way to combat infectious diseases is by chemotherapy using antimicrobial agents and antibiotics. However, due to uncontrolled and unn...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S25076

    authors: Allahverdiyev AM,Bagirova M,Abamor ES,Ates SC,Koc RC,Miraloglu M,Elcicek S,Yaman S,Unal G

    更新日期:2013-09-18 00:00:00

  • Clarithromycin-Susceptible But Virulent Helicobacter pylori Strains Infecting Iranian Patients' Stomachs.

    abstract:Introduction:Helicobacter pylori was discovered first in the stomachs of patients with gastritis and ulcers by Marshall and Warren in 1982. This discovery majorly affected many research areas of gastroenterology. Since then, the main aim has been to eradicate this microaerophilic bacterium from the stomachs of infected...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S223602

    authors: Khani S,Talebi Bezmin Abadi A,Mohabati Mobarez A

    更新日期:2019-11-01 00:00:00

  • Rifampicin-Resistant Multidrug-Resistant Tuberculosis Cases in Selected Hospitals in Western Oromia, Ethiopia: Cross-Sectional Retrospective Study.

    abstract:Purpose:With the recommendation of World Health Organization (WHO) and as per the Ethiopian National Implementation Guideline, GeneXpert is used for rapid diagnosis of rifampicin (RIF)-resistant multidrug-resistant tuberculosis (MDR-TB) from the suspected TB patients; however, there were limited findings in Ethiopia pa...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S274589

    authors: Zewdie O,Dabsu R,Kifle E,Befikadu D

    更新日期:2020-10-20 00:00:00

  • Emerging treatment options for acute bacterial skin and skin structure infections: focus on intravenous delafloxacin.

    abstract::The increase in hospitalization due to acute bacterial skin and skin structure infections (ABSSSI) caused by resistant pathogens supports the need for new treatment options. Antimicrobial options for ABSSSI that provide broad-spectrum coverage, including gram-negative pathogens and multidrug-resistant gram-positive ba...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S142140

    authors: Righi E,Carnelutti A,Vena A,Bassetti M

    更新日期:2018-04-04 00:00:00

  • Whole-Genome Analysis of Two Copies of bla NDM-1 Gene Carrying Acinetobacter johnsonii Strain Acsw19 Isolated from Sichuan, China.

    abstract:Purpose:To characterize the genetic feature of the carbapenems resistant Acinetobacter johnsonii strain Acsw19 isolated from municipal sludge. This strain was found to carry two copies of blaNDM-1,cmlB1-like gene, and blaOXA-211-like gene along with other 8 antimicrobial resistance genes, 3 plasmids, 15 genomic islands...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S236200

    authors: Tang L,Shen W,Zhang Z,Zhang J,Wang G,Xiang L,She J,Hu X,Zou G,Zhu B,Zhou Y

    更新日期:2020-03-23 00:00:00

  • PAU-1, a Novel Plasmid-Encoded Ambler Class A β-Lactamase Identified in a Clinical Pseudomonas aeruginosa Isolate.

    abstract:Purpose:The aim of this work was to identify a novel β-lactamase gene blaPAU-1 encoded on the plasmid of a clinical Pseudomonas aeruginosa isolate. Materials and methods:The clinical P. aeruginosa isolates were isolated from a hospital in southern China. Molecular cloning was performed to analyze the function of the r...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S225288

    authors: Wang J,Xu T,Ying J,Zhou W,Chen Q,Qian C,Zhu X,Shen K,Li P,Li K,Bao Q,Lu J

    更新日期:2019-12-05 00:00:00

  • Epidemiology Of Human Pulmonary Infection With Nontuberculous Mycobacteria In Southeast China: A Prospective Surveillance Study.

    abstract:Background:China is facing a great challenge of pulmonary nontuberculous mycobacteria (NTM) infections. This primary objective of this study was to assess the prevalence of NTM isolates among patients with presumptive TB in Fujian. Methods:The mycobacterial isolates were collected from the tuberculosis survey from Fuj...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S223828

    authors: Lin S,Wei S,Zhao Y,Lin J,Pang Y

    更新日期:2019-11-12 00:00:00

  • Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase (SQLE) Gene.

    abstract:Introduction:Trichophyton mentagrophytes and T. interdigitale are important causative agents of superficial mycoses, demonstrating emergent antifungal drug resistance. We studied the antifungal susceptibility profiles in Iranian isolates of these two species. Methods:A total of 96 T. interdigitale and 45 T. mentagroph...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S246025

    authors: Taghipour S,Shamsizadeh F,Pchelin IM,Rezaei-Matehhkolaei A,Zarei Mahmoudabadi A,Valadan R,Ansari S,Katiraee F,Pakshir K,Zomorodian K,Abastabar M

    更新日期:2020-03-13 00:00:00

  • Systematic review in South Africa reveals antibiotic resistance genes shared between clinical and environmental settings.

    abstract::A systematic review was conducted to determine the distribution and prevalence of antibiotic-resistant bacteria (ARB), antimicrobial-resistant genes (ARGs), and antimicrobial-resistant gene determinants (ARGDs) in clinical, environmental, and farm settings and to identify key knowledge gaps in a bid to contain their s...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S170715

    authors: Ekwanzala MD,Dewar JB,Kamika I,Momba MNB

    更新日期:2018-10-17 00:00:00

  • The Effect of Frequent Exposure to P. falciparum, HIV-Infection and Other Co-Morbidities on Development of Severe Malaria in Malawian Adults.

    abstract:Aim:Plasmodium falciparum malaria predominantly affects children residing in endemic areas. However, recently a significant number of Malawian adults, who otherwise should have attained some malaria-specific immunity, have been observed to succumb to either uncomplicated malaria (UM) or severe malaria (SM). In addition...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S230112

    authors: Munyenyembe AU,Gausi K,Hiestand J,Mallewa J,Mandala W

    更新日期:2020-01-07 00:00:00

  • Antimicrobial resistance and risk factors for mortality of pneumonia caused by Klebsiella pneumoniae among diabetics: a retrospective study conducted in Shanghai, China.

    abstract::Purpose: To investigate antimicrobial resistance and risk factors for mortality of Klebsiella pneumoniae (KP) pneumonia in diabetics and nondiabetics. Patients and methods: A retrospective study was conducted among inpatients of KP pneumonia via electronic medical records in a territory hospital between January 2016 a...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S199642

    authors: Liu B,Yi H,Fang J,Han L,Zhou M,Guo Y

    更新日期:2019-05-07 00:00:00

  • Predictors of Severity and Co-Infection Resistance Profile in COVID-19 Patients: First Report from Upper Egypt.

    abstract:Background:The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in a worldwide devastating effect with a diagnostic challenge. Identifying risk factors of severity aids in assessment for the need of early hospitalization. We aimed to demonstrate, for the first time, the clinical, laborator...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S272605

    authors: Ramadan HK,Mahmoud MA,Aburahma MZ,Elkhawaga AA,El-Mokhtar MA,Sayed IM,Hosni A,Hassany SM,Medhat MA

    更新日期:2020-10-05 00:00:00

  • Antifungal Activity of ZnO Nanoparticles and Nystatin and Downregulation of SAP1-3 Genes Expression in Fluconazole-Resistant Candida albicans Isolates from Vulvovaginal Candidiasis.

    abstract:Purpose:Antifungal resistance and virulence properties of Candida albicans (C. albicans) are growing health problems worldwide. The present study aims to investigate the effect of Zinc Oxide (ZnO) nanoparticles and Nystatin on SAP1-3 genes expression in C. albicans isolates of females with Vulvovaginal Candidiasis (VVC...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S226154

    authors: Hosseini SS,Joshaghani H,Shokohi T,Ahmadi A,Mehrbakhsh Z

    更新日期:2020-02-13 00:00:00

  • Mycoplasma genitalium infections: current treatment options and resistance issues.

    abstract::Mycoplasma genitalium is one of the important causes of non-gonococcal urethritis. Rising incidence and emerging antimicrobial resistance are a major concern these days. The poor clinical outcomes with doxycycline therapy led to the use of azithromycin as the primary drug of choice. Single-dose azithromycin regimen ov...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S105469

    authors: Sethi S,Zaman K,Jain N

    更新日期:2017-09-01 00:00:00

  • UPLC-MS/MS Measurement of the Effect of Isavuconazole, Itraconazole and Fluconazole on the Pharmacokinetics of Selinexor in Rats.

    abstract:Objective:An ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the determination of selinexor was established to investigate the effects of isavuconazole, itraconazole and fluconazole on the pharmacokinetics of selinexor in rats, respectively. Methods:Twenty-four healthy male rat...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S269831

    authors: Li SL,Zhang Y,Cheng QS,Xin JZ,Dong ZQ,Qiu XJ

    更新日期:2020-09-14 00:00:00

  • Multidrug and extensively drug-resistant tuberculosis from a general practice perspective.

    abstract::Despite intensive efforts to eradicate the disease, tuberculosis continues to be a major threat to Indian society, with an estimated prevalence of 3.45 million cases in 2006. Emergence of multidrug-resistant tuberculosis has complicated eradication attempts in recent years. Incomplete and/inadequate treatment are the ...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S10743

    authors: Yashodhara BM,Huat CB,Naik LN,Umakanth S,Hande M,Pappachan JM

    更新日期:2010-01-01 00:00:00

  • A community-acquired lung abscess attributable to odontogenic flora.

    abstract::A lung abscess is an infectious pulmonary disease characterized by pus-filled cavity formation and often an air-fluid level. In this article, we described an indolent community-acquired lung abscess suspected as a tumor previously. A 56-year-old male presented with cough and expectoration for 2 months and hemoptysis f...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S218921

    authors: Guo W,Gao B,Li L,Gai W,Yang J,Zhang Y,Wang L

    更新日期:2019-08-08 00:00:00