Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase (SQLE) Gene.

Abstract:

Introduction:Trichophyton mentagrophytes and T. interdigitale are important causative agents of superficial mycoses, demonstrating emergent antifungal drug resistance. We studied the antifungal susceptibility profiles in Iranian isolates of these two species. Methods:A total of 96 T. interdigitale and 45 T. mentagrophytes isolates were subjected to molecular typing by ribosomal ITS region. Antifungal susceptibility profiles for terbinafine, griseofulvin, clotrimazole, efinaconazole, luliconazole, amorolfine and ciclopirox were obtained by CLSI broth microdilution method. The squalene epoxidase (SQLE) gene was subjected to sequencing for mutations, if any, in isolates exhibiting elevated MICs for terbinafine. Results:Luliconazole and efinaconazole showed the lowest MIC values against T. mentagrophytes and T. interdigitale isolates. There were five isolates with terbinafine MICs ≥32 µg/mL in our sample. They belonged to T. mentagrophytes type VIII and harbored two alternative SQLE gene sequence variants, leading to Phe397Leu and Ala448Thr or Leu393Ser and Ala448Thr substitutions in the enzyme. All terbinafine resistant strains could be inhibited by luliconazole and efinaconazole. Conclusion:This study documented a step in the global spread of resistance mechanisms in T. mentagrophytes. However, treatment alternatives for resistant isolates were available.

journal_name

Infect Drug Resist

authors

Taghipour S,Shamsizadeh F,Pchelin IM,Rezaei-Matehhkolaei A,Zarei Mahmoudabadi A,Valadan R,Ansari S,Katiraee F,Pakshir K,Zomorodian K,Abastabar M

doi

10.2147/IDR.S246025

subject

Has Abstract

pub_date

2020-03-13 00:00:00

pages

845-850

issn

1178-6973

pii

246025

journal_volume

13

pub_type

杂志文章
  • Fatal Prosthetic Valve Endocarditis Due to Aspergillus flavus in a Diabetic Patient.

    abstract::Aspergillus endocarditis (AE) accounts for a-quarter of all fungal endocarditis, mainly in immunocompromised hosts prior to heart-valve surgery with high mortality, even with treatment. Herein, we report a rare case of AE in a diabetic 60-year-old woman with a history of redo mitral valve prosthesis suspecious of acut...

    journal_title:Infection and drug resistance

    pub_type:

    doi:10.2147/IDR.S258637

    authors: Jalalian R,Shokohi T,Mirzakhani R,Ghasemian R,Hedayati MT,Ardalani S,Azizi S,Kalhori S,Kermani F,Mayahi S

    更新日期:2020-07-10 00:00:00

  • Evaluation of the Anti-Leishmanial Effect of Recombinant Clostridium α-Toxin.

    abstract:Background:Leishmaniasis is an infectious disease common in tropical and subtropical regions caused by the genus Leishmania, which is transmitted by the bite of female sandflies. In this study, we evaluate the anti-leishmanial effect of recombinant Clostridium α-toxin protein alone and the combination with glucantime t...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S257561

    authors: Namdar F,Khanahmad H,Ghayour Z,Mirzaei F,Namdar A,Aghaei M,Izadi S,Khamesipour F,Hejazi SH

    更新日期:2020-07-15 00:00:00

  • Multidrug and extensively drug-resistant tuberculosis from a general practice perspective.

    abstract::Despite intensive efforts to eradicate the disease, tuberculosis continues to be a major threat to Indian society, with an estimated prevalence of 3.45 million cases in 2006. Emergence of multidrug-resistant tuberculosis has complicated eradication attempts in recent years. Incomplete and/inadequate treatment are the ...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S10743

    authors: Yashodhara BM,Huat CB,Naik LN,Umakanth S,Hande M,Pappachan JM

    更新日期:2010-01-01 00:00:00

  • High-dose amikacin for achieving serum target levels in critically ill elderly patients.

    abstract:Introduction:To achieve target concentrations, the application of higher-than-standard doses of amikacin is proposed for the treatment of sepsis due to an increase in volume of distribution and clearance, but little data are available on aminoglycoside administration in critically ill elderly patients. Patients and me...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S150839

    authors: Sadeghi K,Hamishehkar H,Najmeddin F,Ahmadi A,Hazrati E,Honarmand H,Mojtahedzadeh M

    更新日期:2018-02-13 00:00:00

  • Clinical characteristics of the first cases of invasive candidiasis in China due to pan-echinocandin-resistant Candida tropicalis and Candida glabrata isolates with delineation of their resistance mechanisms.

    abstract::Echinocandin antifungal agents have become the first-line therapy for invasive candidiasis (IC) in many countries. Despite their increasing use, resistance to this class of drug is, overall, still uncommon. Here, we report two patients from the People's Republic of China with IC, one with infection caused by pan-echin...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S152785

    authors: Xiao M,Fan X,Hou X,Chen SC,Wang H,Kong F,Sun ZY,Chu YZ,Xu YC

    更新日期:2018-01-23 00:00:00

  • Incidence, Bacterial Profiles, And Antimicrobial Resistance Of Culture-Proven Neonatal Sepsis In South China.

    abstract:Background:Neonatal sepsis (NS) is one of the leading causes of infant morbidity and mortality, but little is known about pathogen incidence and distribution in China. Methods:In this retrospective study (January 2012 to December 2016), culture-proven cases aged less than 28 days with diagnosed NS in the Guangzhou Wom...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S223597

    authors: Gao K,Fu J,Guan X,Zhu S,Zeng L,Xu X,Chang CY,Liu H

    更新日期:2019-12-03 00:00:00

  • Emergence of Almost Identical F36:A-:B32 Plasmids Carrying bla NDM-5 and qepA in Escherichia coli from Both Pakistan and Canada.

    abstract::The New Delhi Metallo-β-lactamase (NDM) producing Enterobacteriaceae is spreading worldwide. Although the blaNDM gene has been identified in animal associated Enterobacteriaceae isolates in many countries, little is known about its occurrence in animal products in Pakistan. In this study, 13 Escherichia coli isolates ...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S236766

    authors: Baloch Z,Lv L,Yi L,Wan M,Aslam B,Yang J,Liu JH

    更新日期:2019-12-30 00:00:00

  • Loss of Taste and Smell are Common Clinical Characteristics of Patients with COVID-19 in Somalia: A Retrospective Double Centre Study.

    abstract:Purpose:The purpose of this study was to identify the common clinical presentations and the evidence on the presence of ageusia and anosmia as an emerging coronavirus disease 2019 (COVID-19) symptom to better inform in both COVID-19 patients and clinicians. Patients and Methods:As part of a double-institutional collab...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S263632

    authors: Farah Yusuf Mohamud M,Garad Mohamed Y,Mohamed Ali A,Ali Adam B

    更新日期:2020-07-29 00:00:00

  • Investigating the Effect of Nano-Curcumin on the Expression of Biofilm Regulatory Genes of Pseudomonas aeruginosa.

    abstract:Background:Pseudomonas aeruginosa is an opportunistic pathogen that causes serious nosocomial infections, especially in immunodeficient patients and cystic fibrosis, cancer, and burned individuals. The biofilm that plays an important role in the virulence of P. aeruginosa is under the regulation of quorum sensing and t...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S263387

    authors: Sharifian P,Yaslianifard S,Fallah P,Aynesazi S,Bakhtiyari M,Mohammadzadeh M

    更新日期:2020-07-21 00:00:00

  • Plasma Fibrinogen as a Diagnostic Marker of Infection in Patients with Nonunions.

    abstract:Background:The timely and accurate diagnosis of infected nonunion is challenging, and there is a need for more efficient biomarkers. Previous studies have shown that fibrinogen plays an important role in mediating inflammation in bacterial infections and, therefore, could be a valuable biomarker for infected nonunion. ...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S269719

    authors: Wang XJ,Wang Z,Zhang ZT,Qiu XS,Chen M,Chen YX

    更新日期:2020-11-04 00:00:00

  • Favipiravir Use in COVID-19: Analysis of Suspected Adverse Drug Events Reported in the WHO Database.

    abstract:Background:COVID-19 caused by SARS-CoV-2 virus emerged as an unprecedented challenge to discover effective drugs for its prevention and cure. Hyperinflammation-induced lung damage is one of the poor prognostic indicators causing a higher rate of morbidity and mortality of COVID-19 patients. Favipiravir, an antiviral dr...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S287934

    authors: Kaur RJ,Charan J,Dutta S,Sharma P,Bhardwaj P,Sharma P,Lugova H,Krishnapillai A,Islam S,Haque M,Misra S

    更新日期:2020-12-14 00:00:00

  • Clinical ineffectiveness of latamoxef for Stenotrophomonas maltophilia infection.

    abstract:OBJECTIVES:Stenotrophomonas maltophilia shows wide-spectrum resistance to antimicrobials and causes various infections in immunocompromised or critically ill patients with high mortality. In this era of antibiotics resistance, a revival of old antibiotics is now featured. We examined the clinical usefulness of latamoxe...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S90726

    authors: Hagiya H,Tasaka K,Sendo T,Otsuka F

    更新日期:2015-10-20 00:00:00

  • Indicators of Critical Illness and Predictors of Mortality in COVID-19 Patients.

    abstract::COVID-19 is an emerging disease all over the world and spreading at an unpredicted rate, resulting in significant influences on global economies and public health. Clinical, laboratory, and imaging characteristics have been partially described in some observational studies. Not enough systematic reviews on predictors ...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S261159

    authors: Aly MH,Rahman SS,Ahmed WA,Alghamedi MH,Al Shehri AA,Alkalkami AM,Hassan MH

    更新日期:2020-06-26 00:00:00

  • Therapeutic Drug Monitoring and Nephrotoxicity of Teicoplanin Therapy in Chinese Children: A Retrospective Study.

    abstract:Purpose:This study aims to 1) describe the distribution characteristics of teicoplanin trough concentration (Cmin) and explore the related influencing factors and 2) evaluate the nephrotoxicity of teicoplanin in children. Patients and Methods:A cohort of children who were treated with teicoplanin intravenously were in...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S272982

    authors: Sun D,Zhang T,Mi J,Dong Y,Liu Y,Zhang Y,Zhang D,Wang T,Cheng H,Dong Y

    更新日期:2020-11-12 00:00:00

  • Quinolone resistance mechanisms among third-generation cephalosporin resistant isolates of Enterobacter spp. in a Bulgarian university hospital.

    abstract::Background: There have been no reports in Bulgaria about quinolone resistance determinants among Enterobacter spp. Aims: To investigate plasmid and chromosomal quinolone resistance rates among 175 third-generation cephalosporin resistant Enterobacter spp. isolates (167 Enterobacter cloacae complex and eight Enterobact...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S204199

    authors: Markovska R,Stoeva T,Dimitrova D,Boyanova L,Stankova P,Mihova K,Mitov I

    更新日期:2019-05-28 00:00:00

  • Antifungal Activity of ZnO Nanoparticles and Nystatin and Downregulation of SAP1-3 Genes Expression in Fluconazole-Resistant Candida albicans Isolates from Vulvovaginal Candidiasis.

    abstract:Purpose:Antifungal resistance and virulence properties of Candida albicans (C. albicans) are growing health problems worldwide. The present study aims to investigate the effect of Zinc Oxide (ZnO) nanoparticles and Nystatin on SAP1-3 genes expression in C. albicans isolates of females with Vulvovaginal Candidiasis (VVC...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S226154

    authors: Hosseini SS,Joshaghani H,Shokohi T,Ahmadi A,Mehrbakhsh Z

    更新日期:2020-02-13 00:00:00

  • The Effect of Frequent Exposure to P. falciparum, HIV-Infection and Other Co-Morbidities on Development of Severe Malaria in Malawian Adults.

    abstract:Aim:Plasmodium falciparum malaria predominantly affects children residing in endemic areas. However, recently a significant number of Malawian adults, who otherwise should have attained some malaria-specific immunity, have been observed to succumb to either uncomplicated malaria (UM) or severe malaria (SM). In addition...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S230112

    authors: Munyenyembe AU,Gausi K,Hiestand J,Mallewa J,Mandala W

    更新日期:2020-01-07 00:00:00

  • Resistance to antimicrobial drugs in Ghana.

    abstract:BACKGROUND:Antimicrobial drug resistance is a global issue that affects health, economic, and social development. The problem has been attributed to misuse of antimicrobial agents. PURPOSE:To identify the agents of bacterial infection in Ghana, determine their antibiogram, and the possibility of setting up a surveilla...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S21769

    authors: Newman MJ,Frimpong E,Donkor ES,Opintan JA,Asamoah-Adu A

    更新日期:2011-01-01 00:00:00

  • Clinical Characteristics and Risk Factors for Bloodstream Infection Due to Carbapenem-Resistant Klebsiella pneumoniae in Patients with Hematologic Malignancies.

    abstract:Purpose:The aim was to examine the clinical characteristics and risk factors for bloodstream infection (BSI) due to carbapenem-resistant Klebsiella pneumoniae (CRKP) in patients with hematologic malignancies. Materials and Methods:A single-centre, retrospective case-control study representing 734 patients with hematol...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S272217

    authors: Zhang P,Wang J,Hu H,Zhang S,Wei J,Yang Q,Qu T

    更新日期:2020-09-22 00:00:00

  • Human herpesvirus-6 pneumonitis in a patient with follicular lymphoma following immunochemotherapy with rituximab.

    abstract::Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immun...

    journal_title:Infection and drug resistance

    pub_type:

    doi:10.2147/IDR.S163686

    authors: Kuwahara-Ota S,Chinen Y,Mizuno Y,Takimoto-Shimomura T,Matsumura-Kimoto Y,Tanba K,Tsukamoto T,Mizutani S,Shimura Y,Kobayashi T,Horiike S,Kuroda J

    更新日期:2018-05-14 00:00:00

  • The prevalence of plasmid-mediated quinolone resistance and ESBL-production in Enterobacteriaceae isolated from urinary tract infections.

    abstract:Introduction:β-lactam and fluoroquinolone antibiotics are usually used for the treatment of urinary tract infections (UTIs). The aim of this study was to determine the prevalence of plasmid-mediated quinolone resistance (PMQR) and extended spectrum β-lactamases (ESBLs) in Enterobacteriaceae isolated from UTIs. Materia...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S160720

    authors: Azargun R,Sadeghi MR,Soroush Barhaghi MH,Samadi Kafil H,Yeganeh F,Ahangar Oskouee M,Ghotaslou R

    更新日期:2018-07-23 00:00:00

  • Carbapenem-Resistant Enterobacter hormaechei ST1103 with IMP-26 Carbapenemase and ESBL Gene bla SHV-178.

    abstract:Purpose:To investigate the occurrence and genetic characteristics of the blaIMP-26-positive plasmid from a multidrug-resistant clinical isolate, Enterobacter hormaechei L51. Methods:Species identification was determined by MALDI-TOF MS and Sanger sequencing. Antimicrobial susceptibility testing was performed by the ag...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S232514

    authors: Gou JJ,Liu N,Guo LH,Xu H,Lv T,Yu X,Chen YB,Guo XB,Rao YT,Zheng BW

    更新日期:2020-02-20 00:00:00

  • The Antibacterial Activity and Mechanism of Action of Luteolin Against Trueperella pyogenes.

    abstract:Purpose:This research aimed to investigate the antibacterial activity and potential mechanism of luteolin against T. pyogenes. Materials and Methods:The broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of luteolin against various T. pyogenes strains. The potential mechanism...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S253363

    authors: Guo Y,Liu Y,Zhang Z,Chen M,Zhang D,Tian C,Liu M,Jiang G

    更新日期:2020-06-10 00:00:00

  • Durability, safety, and efficacy of rilpivirine in clinical practice: results from the SCOLTA Project.

    abstract::Rilpivirine is associated with a good efficacy and safety profile. However, data from real-life settings are scarce. Methods:We investigated the durability, safety and efficacy of Rilpivirine-based antiretroviral therapy in a prospective, observational, multicenter study. Results:We enrolled 499 HIV-infected patient...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S152090

    authors: Bagella P,De Socio GV,Ricci E,Menzaghi B,Martinelli C,Squillace N,Maggi P,Orofino G,Calza L,Carenzi L,Celesia BM,Penco G,Di Biagio A,Valsecchi L,Vichi F,Colombo V,Parruti G,Dentone C,Falasca K,Bonfanti P,Madeddu G

    更新日期:2018-04-26 00:00:00

  • Emerging treatment options for acute bacterial skin and skin structure infections: focus on intravenous delafloxacin.

    abstract::The increase in hospitalization due to acute bacterial skin and skin structure infections (ABSSSI) caused by resistant pathogens supports the need for new treatment options. Antimicrobial options for ABSSSI that provide broad-spectrum coverage, including gram-negative pathogens and multidrug-resistant gram-positive ba...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S142140

    authors: Righi E,Carnelutti A,Vena A,Bassetti M

    更新日期:2018-04-04 00:00:00

  • An antibiotic stewardship exercise in the ICU: building a treatment algorithm for the management of ventilator-associated pneumonia based on local epidemiology and the 2016 Infectious Diseases Society of America/American Thoracic Society guidelines.

    abstract:Introduction:Management of ventilator-associated pneumonia (VAP), the most common infection in patients on mechanical ventilation, should be tailored to local microbiological data. The aim of this study was to determine susceptibility patterns of organisms causing VAP to develop a treatment algorithm based on these fin...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S145827

    authors: Awad LS,Abdallah DI,Mugharbil AM,Jisr TH,Droubi NS,El-Rajab NA,Moghnieh RA

    更新日期:2017-12-22 00:00:00

  • A Systematic Review of Vancomycin Dosing in Patients with Hematologic Malignancies or Neutropenia.

    abstract:Objective:To provide a comprehensive review of vancomycin dosing in patients with hematologic malignancies or neutropenia. Methods:PubMed, Embase and the Cochrane Library were searched through April 2, 2020. Original studies relevant to vancomycin dosing regimen in adults with hematologic malignancies or neutropenia w...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S239095

    authors: He N,Dong F,Liu W,Zhai S

    更新日期:2020-06-16 00:00:00

  • Studies on 11 Cases of Spinal Epidural Abscess and Literature Review.

    abstract:Objective:In the present study, we aimed to describe the clinical features, diagnosis, treatment, and prognosis of spinal epidural abscess (SEA). Methods:The complete clinical data of 11 SEA patients who were treated in our hospital system from January 2015 to June 2018 were retrospectively analyzed. Moreover, the cli...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S257398

    authors: Dai G,Li S,Yin C,Sun Y,Xu D,Wang Z,Luan L,Hou J,Wang T

    更新日期:2020-09-29 00:00:00

  • Rifampicin-Resistant Multidrug-Resistant Tuberculosis Cases in Selected Hospitals in Western Oromia, Ethiopia: Cross-Sectional Retrospective Study.

    abstract:Purpose:With the recommendation of World Health Organization (WHO) and as per the Ethiopian National Implementation Guideline, GeneXpert is used for rapid diagnosis of rifampicin (RIF)-resistant multidrug-resistant tuberculosis (MDR-TB) from the suspected TB patients; however, there were limited findings in Ethiopia pa...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S274589

    authors: Zewdie O,Dabsu R,Kifle E,Befikadu D

    更新日期:2020-10-20 00:00:00

  • Clinical Outcomes and Prevalence of Hepatitis E Virus (HEV) Among Non-A-C Hepatitis Patients in Egypt.

    abstract:Background:Hepatitis E virus (HEV) is an emerging infectious agent that causes acute hepatitis in developing and developed countries. Diagnosis of HEV infection has not been routinely done in Egyptian hospitals, and clinicians do not prescribe ribavirin (RBV) for acute hepatitis cases of unknown etiology (AHUE). We aim...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S289766

    authors: Sayed IM,El-Mokhtar MA,Mahmoud MAR,Elkhawaga AA,Gaber S,Seddek NH,Abdel-Wahid L,Ashmawy AM,Alkareemy EAR

    更新日期:2021-01-12 00:00:00