Abstract:
Background:Evidence suggests that genetic variations of exon 1 of mannose-binding lectin 2 (MBL2) may contribute to tuberculosis (TB) risk. Many studies have investigated the association between MBL2 exon 1 polymorphisms (rs1800450, rs1800451, and rs5030737) and TB risk, but yielded inconclusive results. Method:We conducted this meta-analysis of 26 eligible case-control studies that included 7952 cases and 9328 controls to identify the strength of association. Odds ratio (OR) and 95% CI were used to evaluate the strength of association. Statistical analyses were performed by using STATA 12.1. Results:We found a statistically significant correlation between MBL2 exon 1 polymorphisms and increased TB risk among three models: allele model (O vs A: OR =1.18, 95% CI: 1.01-1.38, Pheterogeneity<0.0001, I2=85.8%), homozygote comparison (OO vs AA: OR =1.49, 95%CI: 1.02-2.18, Pheterogeneity<0.0001, I2=79.1%), dominant model (AO/OO vs AA: OR =1.20, 95% CI: 1.01-1.43, Pheterogeneity<0.0001, I2=83.5%), especially in studies based on Asian populations among five models: allele model (O vs A: OR =1.29, 95% CI: 1.11-1.51, Pheterogeneity<0.0001, I2=66.0%), homozygote comparison (OO vs AA: OR =1.67, 95% CI: 1.09-2.55, Pheterogeneity=0.008, I2=54.2%), heterozygote comparison (AO vs AA: OR =1.26, 95% CI: 1.05-1.50, Pheterogeneity=0.001, I2=62.9%), dominant model (AO/OO vs. AA: OR =1.31, 95% CI: 1.10-1.56, Pheterogeneity=0.001, I2=64.2%), and recessive model (OO vs AO/AA: OR =1.50, 95% CI: 1.01-2.22, Pheterogeneity=0.023, I2=48.0%). Meta-regression results revealed that source of controls (p=0.009), but not ethnicity (p=0.687), genotyping method (p=0.231), and sample size (p=0.451) contributed to the source of heterogeneity. Conclusion:This meta-analysis suggests that MBL2 exon 1 polymorphisms may contribute to TB risk, especially in Asian populations.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Wu YJ,Yang X,Chen TD,Zhang ZX,You YZ,Fan ZDdoi
10.2147/IDR.S168465subject
Has Abstractpub_date
2018-08-20 00:00:00pages
1237-1248issn
1178-6973pii
idr-11-1237journal_volume
11pub_type
杂志文章abstract::The mortality rate for candidemia is approximately 30%-60%. However, prognostic factors in patients with candidemia have not yet been elucidated in detail. The aim of the present study was to analyze prognostic factors for candidemia using the mortality rate and Candida isolates of patients with candidemia. Seventy-fi...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S80677
更新日期:2015-07-08 00:00:00
abstract::Despite intensive efforts to eradicate the disease, tuberculosis continues to be a major threat to Indian society, with an estimated prevalence of 3.45 million cases in 2006. Emergence of multidrug-resistant tuberculosis has complicated eradication attempts in recent years. Incomplete and/inadequate treatment are the ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S10743
更新日期:2010-01-01 00:00:00
abstract:Purpose:To develop a rapid EDTA-modified carbapenem inactivation method (reCIM) combined with modified rapid carbapenem inactivation method (mrCIM) to detect carbapenemase and distinguish metallo-β-lactamases from carbapenemases in Enterobacteriaceae in 4 hrs. Materials and Methods:The sensitivities and specificities ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S249570
更新日期:2020-06-23 00:00:00
abstract:Introduction:Intravenous (IV) β-lactam antibiotics, excreted through bile into the gastrointestinal (GI) tract, may disrupt the gut microbiome by eliminating the colonization resistance from beneficial bacteria. This increases the risk for Clostridium difficile infection (CDI) and can promote antimicrobial resistance b...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S260258
更新日期:2020-07-22 00:00:00
abstract:Background:Hepatitis E virus (HEV) is an emerging infectious agent that causes acute hepatitis in developing and developed countries. Diagnosis of HEV infection has not been routinely done in Egyptian hospitals, and clinicians do not prescribe ribavirin (RBV) for acute hepatitis cases of unknown etiology (AHUE). We aim...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S289766
更新日期:2021-01-12 00:00:00
abstract:Purpose:The problem of carbapenem-resistant Pseudomonas aeruginosa in health-care settings is growing worse. This study was conducted to investigate the rate of carbapenemase genes, antibiotic resistance, and virulence factors in carbapenem-resistant P. aeruginosa associated with hospital-acquired infections. Patients...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S222329
更新日期:2019-11-07 00:00:00
abstract:BACKGROUND:Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. OBJECTIVE:To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany. PATIENTS AND METHODS:The research reported here was a prospective multicen...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S38945
更新日期:2013-01-01 00:00:00
abstract:Introduction:Trichophyton mentagrophytes and T. interdigitale are important causative agents of superficial mycoses, demonstrating emergent antifungal drug resistance. We studied the antifungal susceptibility profiles in Iranian isolates of these two species. Methods:A total of 96 T. interdigitale and 45 T. mentagroph...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S246025
更新日期:2020-03-13 00:00:00
abstract:Introduction:Klebsiella pneumoniae carbapenemase (KPC) belongs to the Group-A β-lactamases that incorporate serine at their active site and hydrolyze various penicillins, cephalosporins, and carbapenems. Metallo-beta-lactamases (MBLs) are group-B enzymes that contain one or two essential zinc ions in the active sites a...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S262493
更新日期:2020-08-18 00:00:00
abstract:Introduction:β-lactam and fluoroquinolone antibiotics are usually used for the treatment of urinary tract infections (UTIs). The aim of this study was to determine the prevalence of plasmid-mediated quinolone resistance (PMQR) and extended spectrum β-lactamases (ESBLs) in Enterobacteriaceae isolated from UTIs. Materia...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S160720
更新日期:2018-07-23 00:00:00
abstract:Introduction:Management of ventilator-associated pneumonia (VAP), the most common infection in patients on mechanical ventilation, should be tailored to local microbiological data. The aim of this study was to determine susceptibility patterns of organisms causing VAP to develop a treatment algorithm based on these fin...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S145827
更新日期:2017-12-22 00:00:00
abstract::The rapid detection of carbapenemase allows implementation of infection control measures and adaptation of antibiotic therapy. We evaluated the performances of the Xpert Carba-R V2® assay for the direct detection and identification of carbapenemase on positive blood cultures. We focused our evaluation on its detection...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S204436
更新日期:2019-10-23 00:00:00
abstract:Background:China is facing a great challenge of pulmonary nontuberculous mycobacteria (NTM) infections. This primary objective of this study was to assess the prevalence of NTM isolates among patients with presumptive TB in Fujian. Methods:The mycobacterial isolates were collected from the tuberculosis survey from Fuj...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S223828
更新日期:2019-11-12 00:00:00
abstract:Background:With an aging population, China is facing a huge burden of elderly patients with drug resistant tuberculosis (DR-TB), which has become a significant obstacle for the global TB control. There is still little study on DR-TB in the elderly in China so far. Thus, more research on the epidemiological characterist...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S277203
更新日期:2020-11-13 00:00:00
abstract::Purpose: To investigate antimicrobial resistance and risk factors for mortality of Klebsiella pneumoniae (KP) pneumonia in diabetics and nondiabetics. Patients and methods: A retrospective study was conducted among inpatients of KP pneumonia via electronic medical records in a territory hospital between January 2016 a...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S199642
更新日期:2019-05-07 00:00:00
abstract:Introduction:Duodenoscopes have been widely used for both diagnostic and therapeutic endoscopic retrograde cholangiopancreatography procedures. Numerous outbreaks of duodenoscope-associated infections involving multidrug-resistant bacteria have recently been reported. Plasma activated water (PAW) has been widely consid...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S159243
更新日期:2018-05-17 00:00:00
abstract:Purpose:With the recommendation of World Health Organization (WHO) and as per the Ethiopian National Implementation Guideline, GeneXpert is used for rapid diagnosis of rifampicin (RIF)-resistant multidrug-resistant tuberculosis (MDR-TB) from the suspected TB patients; however, there were limited findings in Ethiopia pa...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S274589
更新日期:2020-10-20 00:00:00
abstract:INTRODUCTION:In recent decades, antimicrobial resistance has become a public health problem, particularly in cases of healthcare-associated infections. Interaction between antibiotic consumption and resistance development is of particular interest regarding Gram-negative bacilli, whose growing resistance has represente...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S22491
更新日期:2011-01-01 00:00:00
abstract:Purpose:The activity of the cationic antimicrobial peptide WLBU2 was evaluated against planktonic cells and biofilms of multi-drug resistant (MDR) Acinetobacter baumannii and Klebsiella pneumoniae, alone and in combination with classical antimicrobial agents. Methods:Control American Type Culture Collection (ATCC) str...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S215084
更新日期:2019-07-09 00:00:00
abstract::Echinocandin antifungal agents have become the first-line therapy for invasive candidiasis (IC) in many countries. Despite their increasing use, resistance to this class of drug is, overall, still uncommon. Here, we report two patients from the People's Republic of China with IC, one with infection caused by pan-echin...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S152785
更新日期:2018-01-23 00:00:00
abstract:Objective:To provide a comprehensive review of vancomycin dosing in patients with hematologic malignancies or neutropenia. Methods:PubMed, Embase and the Cochrane Library were searched through April 2, 2020. Original studies relevant to vancomycin dosing regimen in adults with hematologic malignancies or neutropenia w...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S239095
更新日期:2020-06-16 00:00:00
abstract:Background:In Saudi Arabia, cross-border transmission of multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains might be particularly fostered by high immigration rates. Herein, we aimed to elucidate the transmission dynamics of MDR-MTBC strains and reveal a detailed prediction of all resistance-co...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S181124
更新日期:2018-11-12 00:00:00
abstract:Introduction:Surgical site infections (SSIs) are one of the most frequently reported hospital acquired infections associated with significant spread of antibiotic resistance. Purpose:We aimed to evaluate a bundle-based approach in reducing SSI at acute surgical intensive care unit of the Emergency Hospital of Cairo Un...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S236814
更新日期:2020-01-28 00:00:00
abstract::Removal of the spleen had already been established as a routine technique to treat splenic trauma and other diseases affecting the spleen before the anatomy, physiology, and function of the spleen were known in the mid-twentieth century. It is now widely accepted that the splenectomized individual is at increased risk...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S179902
更新日期:2019-09-12 00:00:00
abstract::Ceftaroline is an advanced-generation cephalosporin antibiotic recently approved by the US Food and Drug Administration for the treatment of complicated skin and skin-structure infections (cSSSIs). This intravenous broad-spectrum antibiotic exerts potent bactericidal activity by inhibiting bacterial cell wall synthesi...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S17432
更新日期:2012-01-01 00:00:00
abstract:Purpose:Plasmids of the incompatibility group X type 3 (IncX3) were described carrying various carbapenemase genes in carbapenemase-producing Enterobacteriaceae (CPE) worldwide and in the United Arab Emirates (UAE), as well. To understand the driving force behind the emergence of such plasmids in the UAE, the relations...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S210554
更新日期:2019-06-21 00:00:00
abstract:Background:The prevalence of Helicobacter pylori resistance to metronidazole and clarithromycin is high in Indonesia. Moreover, the increasing levofloxacin resistance rates in the absence of bismuth treatment in Indonesia has led to the use of other antibiotics as alternative regimens. Methods:We determined the minimu...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S187063
更新日期:2019-01-31 00:00:00
abstract::The New Delhi Metallo-β-lactamase (NDM) producing Enterobacteriaceae is spreading worldwide. Although the blaNDM gene has been identified in animal associated Enterobacteriaceae isolates in many countries, little is known about its occurrence in animal products in Pakistan. In this study, 13 Escherichia coli isolates ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S236766
更新日期:2019-12-30 00:00:00
abstract:Purpose:The aim was to examine the clinical characteristics and risk factors for bloodstream infection (BSI) due to carbapenem-resistant Klebsiella pneumoniae (CRKP) in patients with hematologic malignancies. Materials and Methods:A single-centre, retrospective case-control study representing 734 patients with hematol...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S272217
更新日期:2020-09-22 00:00:00
abstract:Purpose:This research aimed to investigate the antibacterial activity and potential mechanism of luteolin against T. pyogenes. Materials and Methods:The broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of luteolin against various T. pyogenes strains. The potential mechanism...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S253363
更新日期:2020-06-10 00:00:00