Raltegravir in combination with other antiretroviral agents for the treatment of HIV infection.

Abstract:

:Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is the first available agent in a new class of antiretroviral drugs. Raltegravir has been studied extensively in clinical trials, and has been well tolerated and highly effective in both treatment-naïve and -experienced patients. Resistance to raltegravir is unusual given its recent availability, but resistance with identified viral mutation pathways in the integrase gene in patients receiving the drug does occur.

journal_name

Infect Drug Resist

authors

Chirch LM,Steigbigel RT

doi

10.2147/idr.s9689

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

15-23

issn

1178-6973

journal_volume

3

pub_type

杂志文章
  • Mycoplasma genitalium infections: current treatment options and resistance issues.

    abstract::Mycoplasma genitalium is one of the important causes of non-gonococcal urethritis. Rising incidence and emerging antimicrobial resistance are a major concern these days. The poor clinical outcomes with doxycycline therapy led to the use of azithromycin as the primary drug of choice. Single-dose azithromycin regimen ov...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S105469

    authors: Sethi S,Zaman K,Jain N

    更新日期:2017-09-01 00:00:00

  • Molecular typing revealed the emergence of pvl-positive sequence type 22 methicillin-susceptible Staphylococcus aureus in Urumqi, Northwestern China.

    abstract:Background:Staphylococcus aureus is among the most common causes of health care- and community-associated infections worldwide. The distributions of different S. aureus clones change over time and also vary geographically. The purpose of this study was to determine the molecular type and antimicrobial resistance profil...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S202906

    authors: Yuan W,Liu J,Zhan Y,Wang L,Jiang Y,Zhang Y,Sun N,Hou N

    更新日期:2019-06-20 00:00:00

  • Predictors of Severity and Co-Infection Resistance Profile in COVID-19 Patients: First Report from Upper Egypt.

    abstract:Background:The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in a worldwide devastating effect with a diagnostic challenge. Identifying risk factors of severity aids in assessment for the need of early hospitalization. We aimed to demonstrate, for the first time, the clinical, laborator...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S272605

    authors: Ramadan HK,Mahmoud MA,Aburahma MZ,Elkhawaga AA,El-Mokhtar MA,Sayed IM,Hosni A,Hassany SM,Medhat MA

    更新日期:2020-10-05 00:00:00

  • Carbapenem-Resistant Enterobacter hormaechei ST1103 with IMP-26 Carbapenemase and ESBL Gene bla SHV-178.

    abstract:Purpose:To investigate the occurrence and genetic characteristics of the blaIMP-26-positive plasmid from a multidrug-resistant clinical isolate, Enterobacter hormaechei L51. Methods:Species identification was determined by MALDI-TOF MS and Sanger sequencing. Antimicrobial susceptibility testing was performed by the ag...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S232514

    authors: Gou JJ,Liu N,Guo LH,Xu H,Lv T,Yu X,Chen YB,Guo XB,Rao YT,Zheng BW

    更新日期:2020-02-20 00:00:00

  • Omadacycline: a novel aminomethylcycline.

    abstract::Tetracyclines have come a long way since they became available almost seven decades ago, with numerous enhancements allowing new agents to overcome bacterial mechanisms of resistance. However, these enhancements come with toxicities and pharmacokinetic disadvantages such as the gastrointestinal side-effects and poor o...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S171352

    authors: Burgos RM,Rodvold KA

    更新日期:2019-07-02 00:00:00

  • Emerging treatment options for acute bacterial skin and skin structure infections: focus on intravenous delafloxacin.

    abstract::The increase in hospitalization due to acute bacterial skin and skin structure infections (ABSSSI) caused by resistant pathogens supports the need for new treatment options. Antimicrobial options for ABSSSI that provide broad-spectrum coverage, including gram-negative pathogens and multidrug-resistant gram-positive ba...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S142140

    authors: Righi E,Carnelutti A,Vena A,Bassetti M

    更新日期:2018-04-04 00:00:00

  • Antifungal Activity of ZnO Nanoparticles and Nystatin and Downregulation of SAP1-3 Genes Expression in Fluconazole-Resistant Candida albicans Isolates from Vulvovaginal Candidiasis.

    abstract:Purpose:Antifungal resistance and virulence properties of Candida albicans (C. albicans) are growing health problems worldwide. The present study aims to investigate the effect of Zinc Oxide (ZnO) nanoparticles and Nystatin on SAP1-3 genes expression in C. albicans isolates of females with Vulvovaginal Candidiasis (VVC...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S226154

    authors: Hosseini SS,Joshaghani H,Shokohi T,Ahmadi A,Mehrbakhsh Z

    更新日期:2020-02-13 00:00:00

  • Overview of pneumococcal serotypes and genotypes causing diseases in patients with chronic obstructive pulmonary disease in a Spanish hospital between 2013 and 2016.

    abstract:Background:Streptococcus pneumoniae is an important pathogen in chronic obstructive pulmonary disease (COPD). We aimed at showing the recent changes in the epidemiology of pneumococcal diseases in patients with COPD, especially after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Methods:Fro...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S165093

    authors: Shoji H,Vázquez-Sánchez DA,Gonzalez-Diaz A,Cubero M,Tubau F,Santos S,García-Somoza D,Liñares J,Yuste J,Martí S,Ardanuy C

    更新日期:2018-09-04 00:00:00

  • Molecular Epidemiology and Mechanisms of High-Level Resistance to Meropenem and Imipenem in Pseudomonas aeruginosa.

    abstract:Purpose:Pseudomonas aeruginosa possesses a large number of resistance mechanisms to different antimicrobials with carbapenems being the most powerful in treating resistant P. aeruginosa. Hence, it is imperative to explore different mechanisms of carbapenems-resistance in P. aeruginosa to achieve successful treatment th...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S233808

    authors: Hassuna NA,Darwish MK,Sayed M,Ibrahem RA

    更新日期:2020-01-30 00:00:00

  • Genotype Analysis of Clinical Candida albicans Isolates Using PCRs Targeting 25S rDNA and ALT Repeat Sequences of the RPS and Antifungal Susceptibility in Ouagadougou (Burkina Faso).

    abstract:Objective:Candida albicans is a yeast with multiple genotypes. It's a commensal fungus colonizing various sites. However, when the host's immune system weakens, it becomes pathogenic and is responsible for various lesions. In Burkina Faso, antifungal drugs are frequently used, particularly fluconazole, the most used sy...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S225947

    authors: Sawadogo PM,Zida A,Soulama I,Sermé SS,Guiguemdé KT,Junior R,Sangaré I,Bamba S,Ouédraogo-Traoré R,Guiguemdé TR

    更新日期:2019-12-16 00:00:00

  • Detection of Mycoplasma pneumoniae in Mexican children with community-acquired pneumonia: experience in a tertiary care hospital.

    abstract::Purpose:Mycoplasma pneumoniae is an important cause of community-acquired pneumonia (CAP). Information on the prevalence of M. pneumoniae in pediatric patients with CAP in Mexico is limited. The aim of this study was to detect M. pneumoniae in hospitalized pediatric patients with CAP. Patients and methods: We performe...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S193076

    authors: Merida-Vieyra J,Aquino-Andrade A,Palacios-Reyes D,Murata C,Ribas-Aparicio RM,De Colsa Ranero A

    更新日期:2019-04-18 00:00:00

  • Care Bundle Approach to Reduce Surgical Site Infections in Acute Surgical Intensive Care Unit, Cairo, Egypt.

    abstract:Introduction:Surgical site infections (SSIs) are one of the most frequently reported hospital acquired infections associated with significant spread of antibiotic resistance. Purpose:We aimed to evaluate a bundle-based approach in reducing SSI at acute surgical intensive care unit of the Emergency Hospital of Cairo Un...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S236814

    authors: Wassef M,Mukhtar A,Nabil A,Ezzelarab M,Ghaith D

    更新日期:2020-01-28 00:00:00

  • Comparative effectiveness of antifungal agents in patients with hematopoietic stem cell transplantation: a systematic review and network meta-analysis.

    abstract::Purpose: The aim of this study was to use a network meta-analysis to evaluate the relative efficacy of various agents at preventing invasive fungal infections (IFIs). In this way, suitable prophylactic regimens may be selected for patients with hematopoietic stem cell transplantation (HSCT). Methods: We conducted a sy...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S203579

    authors: Su HC,Hua YM,Feng IJ,Wu HC

    更新日期:2019-05-15 00:00:00

  • Comparison of the Clinical Characteristics and Severity of Influenza and Non-influenza Respiratory Virus-Related Pneumonia in China: A Multicenter, Real-World Study.

    abstract:Purpose:Respiratory viruses are important etiologies of community-acquired pneumonia (CAP). However, the impact of different RVs on the outcomes of CAP is not well elucidated. This study aims to compare the clinical features and severity of influenza (Flu-p) and non-influenza respiratory viruses-related pneumonia (NIRV...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S267102

    authors: Chen L,Han XD,Li YL,Zhang CX,Xing XQ

    更新日期:2020-10-08 00:00:00

  • A study on biofilm production and antifungal drug resistance among Candida species from vulvovaginal and bloodstream infections.

    abstract:Introduction:Candida species, one among the opportunistic fungi, has become a common pathogen causing vaginal thrush and nosocomial bloodstream infections (BSIs). This study aims to evaluate the prevalence and antifungal susceptibility of various Candida species and slime production by Candida species in BSIs and vulvo...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S179462

    authors: Tulasidas S,Rao P,Bhat S,Manipura R

    更新日期:2018-11-23 00:00:00

  • Primary Drug-Resistance Pattern and Trend in Elderly Tuberculosis Patients in Shandong, China, from 2004 to 2019.

    abstract:Background:With an aging population, China is facing a huge burden of elderly patients with drug resistant tuberculosis (DR-TB), which has become a significant obstacle for the global TB control. There is still little study on DR-TB in the elderly in China so far. Thus, more research on the epidemiological characterist...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S277203

    authors: An Q,Song W,Liu J,Tao N,Liu Y,Zhang Q,Xu T,Li S,Liu S,Li Y,Yu C,Li H

    更新日期:2020-11-13 00:00:00

  • Efficacy of a 14-day quadruple-therapy regimen for third-line Helicobacter pylori eradication.

    abstract:Purpose:To assess the efficacy of amoxicillin, tetracycline, high-dose metronidazole, and a proton-pump inhibitor for third-line Helicobacter pylori eradication. Methods:We enrolled 70 consecutive patients who had registered, failed to respond to two rounds of H. pylori eradication, and undergone endoscopy for H. pylo...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S185511

    authors: Huang HT,Wang HM,Yang SC,Tai WC,Liang CM,Wu KL,Lee CH,Chuah SK

    更新日期:2018-10-30 00:00:00

  • A community-acquired lung abscess attributable to odontogenic flora.

    abstract::A lung abscess is an infectious pulmonary disease characterized by pus-filled cavity formation and often an air-fluid level. In this article, we described an indolent community-acquired lung abscess suspected as a tumor previously. A 56-year-old male presented with cough and expectoration for 2 months and hemoptysis f...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S218921

    authors: Guo W,Gao B,Li L,Gai W,Yang J,Zhang Y,Wang L

    更新日期:2019-08-08 00:00:00

  • Salmonella enterica serovars Typhimurium and Enteritidis causing mixed infections in febrile children in Mozambique.

    abstract:Background and purpose:Invasive nontyphoidal salmonellosis, mostly caused by serovars Typhimurium and Enteritidis of Salmonella enterica, has emerged as a major public health problem in sub-Saharan Africa. The aim of this study was the clinical and microbiological characterization of nontyphoidal salmonellosis episodes...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S147243

    authors: García V,Mandomando I,Ruiz J,Herrera-León S,Alonso PL,Rodicio MR

    更新日期:2018-01-31 00:00:00

  • Resistance To First-Line Antituberculosis Drugs And Prevalence Of pncA Mutations In Clinical Isolates Of Mycobacterium tuberculosis From Zunyi, Guizhou Province Of China.

    abstract:Background:China is one of the high-burden countries for multidrug-resistant tuberculosis (MDR-TB), and pyrazinamide is one of the anti-TB drugs used for the shorter MDR-TB treatment regimen. The aim of this study was to determine the correlation between pncA gene mutations and resistance to four first-line anti-TB dru...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S222943

    authors: Cao Z,Lan Y,Chen L,Xiang M,Peng Z,Zhang J,Zhang H

    更新日期:2019-09-30 00:00:00

  • Clinical Outcomes and Prevalence of Hepatitis E Virus (HEV) Among Non-A-C Hepatitis Patients in Egypt.

    abstract:Background:Hepatitis E virus (HEV) is an emerging infectious agent that causes acute hepatitis in developing and developed countries. Diagnosis of HEV infection has not been routinely done in Egyptian hospitals, and clinicians do not prescribe ribavirin (RBV) for acute hepatitis cases of unknown etiology (AHUE). We aim...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S289766

    authors: Sayed IM,El-Mokhtar MA,Mahmoud MAR,Elkhawaga AA,Gaber S,Seddek NH,Abdel-Wahid L,Ashmawy AM,Alkareemy EAR

    更新日期:2021-01-12 00:00:00

  • Epidemiology Of Human Pulmonary Infection With Nontuberculous Mycobacteria In Southeast China: A Prospective Surveillance Study.

    abstract:Background:China is facing a great challenge of pulmonary nontuberculous mycobacteria (NTM) infections. This primary objective of this study was to assess the prevalence of NTM isolates among patients with presumptive TB in Fujian. Methods:The mycobacterial isolates were collected from the tuberculosis survey from Fuj...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S223828

    authors: Lin S,Wei S,Zhao Y,Lin J,Pang Y

    更新日期:2019-11-12 00:00:00

  • Combined administration of antibiotics increases the incidence of antibiotic-associated diarrhea in critically ill patients.

    abstract::Background: The widespread use of antibiotics has resulted in a high incidence of antibiotic-associated diarrhea (AAD); moreover, the AAD-associated mortality rates have also increased. The effect of combined antibiotic administration on AAD in critically ill patients was analyzed to assist in antibiotic selection for...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S194715

    authors: Ma H,Zhang L,Zhang Y,Liu Y,He Y,Guo L

    更新日期:2019-05-01 00:00:00

  • Infection control perception and behavior: a question of sex and gender? Results of the AHOI feasibility study.

    abstract:Purpose:Infections, in particular with multidrug-resistant organisms, are a burden for inpatient and outpatient care and the whole community. The pathogens "roam" with patients and their relatives, forming an epidemiological bridge between different care facilities. Patients could play an important role in infection co...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S178922

    authors: Goerig T,Dittmann K,Kramer A,Diedrich S,Heidecke CD,Huebner NO

    更新日期:2018-12-04 00:00:00

  • A Systematic Review of Vancomycin Dosing in Patients with Hematologic Malignancies or Neutropenia.

    abstract:Objective:To provide a comprehensive review of vancomycin dosing in patients with hematologic malignancies or neutropenia. Methods:PubMed, Embase and the Cochrane Library were searched through April 2, 2020. Original studies relevant to vancomycin dosing regimen in adults with hematologic malignancies or neutropenia w...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S239095

    authors: He N,Dong F,Liu W,Zhai S

    更新日期:2020-06-16 00:00:00

  • Impact of concomitant nontuberculous mycobacteria and Pseudomonas aeruginosa isolates in non-cystic fibrosis bronchiectasis.

    abstract:Purpose:Pseudomonas aeruginosa is associated with pulmonary function decline and high disease severity in non-cystic fibrosis (CF) bronchiectasis. The prevalence of nontuberculous mycobacteria (NTM) in non-CF bronchiectasis patients has increased recently. This study investigated the impact of NTM with or without P. ae...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S169789

    authors: Hsieh MH,Lin CY,Wang CY,Fang YF,Lo YL,Lin SM,Lin HC

    更新日期:2018-08-10 00:00:00

  • Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study.

    abstract:BACKGROUND:Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. OBJECTIVE:To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany. PATIENTS AND METHODS:The research reported here was a prospective multicen...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S38945

    authors: Wissing H,Ballus J,Bingold TM,Nocea G,Krobot KJ,Kaskel P,Kumar RN,Mavros P

    更新日期:2013-01-01 00:00:00

  • Systematic review in South Africa reveals antibiotic resistance genes shared between clinical and environmental settings.

    abstract::A systematic review was conducted to determine the distribution and prevalence of antibiotic-resistant bacteria (ARB), antimicrobial-resistant genes (ARGs), and antimicrobial-resistant gene determinants (ARGDs) in clinical, environmental, and farm settings and to identify key knowledge gaps in a bid to contain their s...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章,评审

    doi:10.2147/IDR.S170715

    authors: Ekwanzala MD,Dewar JB,Kamika I,Momba MNB

    更新日期:2018-10-17 00:00:00

  • Alternative eradication regimens for Helicobacter pylori infection in Indonesian regions with high metronidazole and levofloxacin resistance.

    abstract:Background:The prevalence of Helicobacter pylori resistance to metronidazole and clarithromycin is high in Indonesia. Moreover, the increasing levofloxacin resistance rates in the absence of bismuth treatment in Indonesia has led to the use of other antibiotics as alternative regimens. Methods:We determined the minimu...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S187063

    authors: Miftahussurur M,Waskito LA,Syam AF,Nusi IA,Siregar G,Richardo M,Bakry AF,Rezkitha YAA,Wibawa IDN,Yamaoka Y

    更新日期:2019-01-31 00:00:00

  • Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase (SQLE) Gene.

    abstract:Introduction:Trichophyton mentagrophytes and T. interdigitale are important causative agents of superficial mycoses, demonstrating emergent antifungal drug resistance. We studied the antifungal susceptibility profiles in Iranian isolates of these two species. Methods:A total of 96 T. interdigitale and 45 T. mentagroph...

    journal_title:Infection and drug resistance

    pub_type: 杂志文章

    doi:10.2147/IDR.S246025

    authors: Taghipour S,Shamsizadeh F,Pchelin IM,Rezaei-Matehhkolaei A,Zarei Mahmoudabadi A,Valadan R,Ansari S,Katiraee F,Pakshir K,Zomorodian K,Abastabar M

    更新日期:2020-03-13 00:00:00