Abstract:
Background and Objectives:Tuberculosis (TB) is a global public health issue. The emergence of multidrug-resistant (MDR) TB has further complicated the situation in the form of poor treatment outcomes and costs to individuals and health-care systems. We therefore aimed to measure the prevalence and associated risk factors of MDR TB among TB patients in Makkah city. Patients and Methods:This was a cross-sectional study conducted at Al-Noor Specialist Hospital, a public-sector hospital in Makkah. We included records of 158 confirmed TB patients from the list of all patients admitted in the hospital from January 2009 to January 2019 by systematic random sampling. Data were collected on socio-demographics, clinical profile and drug resistance patterns. Analysis was done in SPSS version 21.0. Results:The mean age of the participants was 43.4 ± 18.7 years, and two-thirds (66.5%) were male. About 40% of the patients had chronic disease while lung disease other than TB was present in 5% patients. About 13% of cases were extrapulmonary infections. Prevalence of drug resistance was found to be 17.1% among TB patients. Among the resistant cases, streptomycin (25.9%) and isoniazid (11.1%) were the drugs most commonly affected by resistance. Prevalence of MDR TB was 5% among TB patients. Age, smoking, lung disease and previous TB were significant factors associated with MDR TB. Conclusion:Prevalence of MDR TB, although comparable to current national estimates, is higher compared to previous reports. There is a need to reduce this burden through strengthening TB control programs to prevent further emergence of a public health threat of MDR TB. History of previous TB was the strongest risk factor in this study. This calls physicians, program managers and policy makers to focus on counselling and support of TB patients for compliance with the regimen to complete treatment without interruption.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Sambas MFMK,Rabbani U,Al-Gethamy MMM,Surbaya SH,Alharbi FFI,Ahmad RGA,Qul HKH,Nassar SMS,Maddah AKMA,Darweesh BAKdoi
10.2147/IDR.S277477subject
Has Abstractpub_date
2020-11-10 00:00:00pages
4031-4038issn
1178-6973pii
277477journal_volume
13pub_type
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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pub_type: 杂志文章,评审
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journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
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doi:10.2147/IDR.S210554
更新日期:2019-06-21 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S175679
更新日期:2018-10-26 00:00:00
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更新日期:2020-01-16 00:00:00
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doi:10.2147/IDR.S249370
更新日期:2020-07-06 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S269719
更新日期:2020-11-04 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-20 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S267102
更新日期:2020-10-08 00:00:00
abstract::Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immun...
journal_title:Infection and drug resistance
pub_type:
doi:10.2147/IDR.S163686
更新日期:2018-05-14 00:00:00
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journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
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abstract:Background and purpose:Invasive nontyphoidal salmonellosis, mostly caused by serovars Typhimurium and Enteritidis of Salmonella enterica, has emerged as a major public health problem in sub-Saharan Africa. The aim of this study was the clinical and microbiological characterization of nontyphoidal salmonellosis episodes...
journal_title:Infection and drug resistance
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journal_title:Infection and drug resistance
pub_type: 杂志文章
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更新日期:2020-03-13 00:00:00
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