Ambulatory blood pressure monitoring for evaluating the relationships between lifestyle, hypertension and cardiovascular risk.

abstract：:1. The vascular contractile effects of polymorphonuclear leucocytes (PMN) isolated from control rabbits and from rabbits made atherosclerotic by 1% cholesterol feeding for 8 weeks were examined. 2. Rings of control rabbit thoracic aorta with or without endothelium were mounted at 2 g tension in 10 mL organ baths and w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sobey CG,Hart JL,Woodman OL

更新日期：1994-02-01 00:00:00

abstract：:Non-cystic fibrosis (non-CF) bronchiectasis is a chronic pulmonary disease that can lead to malnutrition. Serum prealbumin and albumin level are related to inflammatory and nutritional status. Thus, we aimed to confirm our hypothesis that low serum albumin and prealbumin level, as well as body mass index (BMI), is cor...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li L,Li Z,Bi J,Li H,Wang S,Shao C,Song Y

更新日期：2020-09-01 00:00:00

abstract：:1. To characterize the anti-arrhythmic properties of a new calcium antagonist, monatepil [corrected], AJ-2615, the preventive effects of AJ-2615 were compared with those of the existing calcium antagonists, diltiazem and verapamil, in experimental models of arrhythmia. 2. AJ-2615 (0.1-3.0 mg/kg, i.v.) suppressed ventr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yamamoto T,Hosoki K,Karasawa T

更新日期：1993-07-01 00:00:00

abstract：:1. We have studied the role of kallikrein (KK) in the maintenance of renal function in chronic hypoxic rats (high altitude; HA), compared with control rats kept at sea level (SL). Hypoxia was induced by placing female Wistar rats (198-290 g) in an altitude chamber (5500 m) 15 h/day for 4 weeks. Experiments were also c...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen CF,Chen LW,Chien CT,Wu MS,Tsai TJ

更新日期：1996-09-01 00:00:00

abstract：:1. Rapid ventricular rate (VR) and rhythm irregularity during atrial fibrillation (AF) impair cardiac performance. Although digoxin has been widely used in patients with AF, its efficacy for the control of VR and rhythm irregularity is unsatisfactory. Whether low-dose amiodarone is more effective remains unclear. 2. W...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tse HF,Lam YM,Lau CP,Cheung BM,Kumana CR

更新日期：2001-05-01 00:00:00

abstract：:1. The efficacy of coumarin (1,2-benzopyrone) was examined for the regulation of hyperthyroidism in female rats. 2. Coumarin was administered (10 mg/kg per day for 15 days) to l-thyroxine (L-T(4))-induced hyperthyroid as well as to euthyroid rats and changes in serum concentrations of thyroid hormones and in associate...

journal_title：Clinical and experimental pharmacology & physiology

authors： Panda S,Kar A

更新日期：2007-11-01 00:00:00

abstract：:1. Twelve treated hypertensive patients (ages 58-71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period. 2. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wing LM,Bune AJ,Chalmers JP,Graham JR,West MJ

更新日期：1981-09-01 00:00:00

abstract：:1. Accumulating animal and human data suggest that nitric oxide (NO) is important for both coronary and peripheral haemodynamic control and metabolic regulation during performance of exercise. 2. While still controversial, NO of endothelial origin is thought to potentiate exercise-induced hyperaemia, both in the perip...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kingwell BA

更新日期：2000-04-01 00:00:00

abstract：:Cellular senescence is a state of irreversible cell growth arrest. Increasing evidence suggests that cellular senescence contribute to tumour suppression in vivo. However, only a few anti-cancer drugs have been discovered to induce cellular senescence. Searching for new compounds which can inhibit cancer cell growth b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Shang D,Wu Y,Ding Y,Lu Z,Shen Y,Zhu F,Liu H,Zhu C,Tu Z

更新日期：2018-05-01 00:00:00

abstract：:Alpha-pinene (α-pinene) is an organic compound, found in the oils of many species of coniferous trees, especially pine. α-Pinene reportedly has antioxidant and anti-inflammatory activities; however, its effects on osteoblasts are unknown. This study investigated the effects of α-pinene on osteoblast differentiation an...

journal_title：Clinical and experimental pharmacology & physiology

authors： Min HY,Son HE,Jang WG

更新日期：2020-05-01 00:00:00

abstract：:1. The transport of taurocholic acid from portal blood to bile was studied in the anaesthetized rat by injecting a radiolabelled pulse of bile acid. 2. The transport process was very rapid, 50% of the dose being secreted within 5 min, and the total dose within 15 min. 3. The transport process had a large capacity. The...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iser JH,Packer JS,Smallwood RA,Hoffman NE

更新日期：1976-01-01 00:00:00

abstract：:The aim of the present study was to determine the effects of increased cAMP levels in response to pituitary adenylate cyclase-activating polypeptide 27 (PACAP27) on atrial atrial natriuretic peptide (ANP) secretion in rabbit atria. A perfused beating atrial model was used in the present study and cAMP efflux and ANP l...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Y,Liu LP,Liang ZL,Li XL,Jin YZ,Cui X

更新日期：2008-10-01 00:00:00

abstract：:Bone is a remarkable living tissue that provides a framework for animal body support and motion. However, under excessive loads and deformations, bone is prone is to damage through fracture. Furthermore, once the bone is weakened by osteoporosis, bone fracture can occur even after only minimal trauma. Various techniqu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang L,Richardson M,Mendis P

更新日期：2012-08-01 00:00:00

abstract：:Both opiates and dopamine play important roles in learning and memory. Although synergistic action between these two neurotransmitters has been found, their functional roles remain unclear. Here, low dose morphine (2.5 mg/kg) and low dose dopamine receptor agonists (apomorphine 0.05 mg/kg; SKF38393 0.01 mg/kg; bromocr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen Y,Fu Y,An Y,Cao J,Wang J,Zhang J

更新日期：2018-04-01 00:00:00

abstract：:We evaluated the role of deferasirox therapeutic drug monitoring in order to avoid toxicity or treatment failure. Plasma concentrations, measured between two consecutive liver iron determinations, were determined at the end of dosing interval. Fifty-four β-thalassemic adult patients were enrolled: 50% were males; medi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Allegra S,Massano D,De Francia S,Longo F,Piccione F,Pirro E,Cusato J,D'Avolio A,Piga A

更新日期：2018-02-01 00:00:00

abstract：:1. There is mounting evidence that a wide range of antidepressants share the common feature of increasing hippocampal neurogenesis. The specificity of this association has suggested that an ability to increase neurogenesis might be a useful paradigm to screen for compounds with antidepressant activity. 2. The hope of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nandam LS,Jhaveri D,Bartlett P

更新日期：2007-05-01 00:00:00

abstract：:1. The effects of isoprenaline on the pressure-flow relationships in the peripheral circulation were studied in five anaesthetized dogs during right heart bypass procedures. 2. Isoprenaline (1 mug/kg per min) produced a significant drop in arterial pressure and arterial resistance. 3. There was a significant decrease ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Green JF

更新日期：1975-03-01 00:00:00

abstract：:1. We previously reported that volatile anaesthetics produce incidences of a transient opisthotonus in mice, a sign of CNS stimulation. This study was performed to investigate mechanisms by which enflurane-induced opisthotonus (EIO) occurs. 2. The effects of pretreatment of N-methyl-D-aspartate (NMDA) antagonists dizo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Komatsu H,Nogaya J,Ueki M,Yokono S,Ogli K

更新日期：1994-06-01 00:00:00

abstract：:Lamotrigine (LTG) is one of the most widely used antiepileptic drugs. Confusion still exists in the literature as to the relative influence of age, body weight, and concomitant drug therapy on LTG pharmacokinetics. So, the objective of this study is to evaluate the influence of patient-related factors and comedication...

journal_title：Clinical and experimental pharmacology & physiology

authors： Baldoni AO,Freitas-Lima P,de Santi Ferreira FI,Martinez EZ,Queiroz RH,Sakamoto AC,Alexandre V,Perucca E,Pereira LR

更新日期：2016-07-01 00:00:00

abstract：:1. Renin gene expression was investigated in kidneys from 13 foetal and four adult sheep. 2. The levels of renal renin mRNA in foetuses were greater than those in adult sheep (P < 0.001). 3. There was no significant difference in renin mRNA levels between foetuses aged 91 and 134 days (term 150 days). 4. The levels of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang DY,Lumbers ER,Simonetta G

更新日期：1996-08-01 00:00:00

abstract：:1. Pulmonary veins are the most important focus for the initiation of atrial fibrillation. Diabetes mellitus may be associated with hypertonicity and increased occurrence of atrial fibrillation. 2. The purpose of the present study was to investigate whether hypertonicity alters the electrophysiological characteristics...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lee SH,Chen YC,Cheng CC,Higa S,Chen YJ,Chen SA

更新日期：2009-04-01 00:00:00

abstract：:1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor-active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD-2, flash chromatography and gel permeation chro...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wynne KN,Familari M,Boublik JH,Drummer OH,Rae ID,Funder JW

更新日期：1987-10-01 00:00:00

abstract：:1. Asthma and chronic obstructive pulmonary disease (COPD) are chronic airway diseases characterized by airflow obstruction. The beta(2)-adrenoceptor mediates bronchodilatation in response to exogenous and endogenous beta-adrenoceptor agonists. 2. Single nucleotide polymorphisms in the beta(2)-adrenoceptor gene (ADRB2...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang IA,Ng T,Molenaar P,Fong KM

更新日期：2007-10-01 00:00:00

abstract：:1. The effect of bromocriptine (a prolactin suppressant drug) on the serum levels of calcium was studied in the male rat. The drug was administered subcutaneously at a dosage of 100 microgram per 100 g body weight three times per day. 2. Chronic treatment with bromocriptine had no significant effect on the serum calci...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tan CM,Tan GJ

更新日期：1978-09-01 00:00:00

abstract：:1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in healthy patients undergoing third molar dental extraction. P...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reith D,Medlicott NJ,Kumara De Silva R,Yang L,Hickling J,Zacharias M

更新日期：2009-01-01 00:00:00

abstract：:The authors have previously demonstrated that a low and intermittent peripheral dose of rapamycin (1 mg/kg three times/week) to rats inhibited mTORC1 signalling, but avoided the hyperlipidemia and diabetes-like syndrome associated with higher doses of rapamycin. The dosing regimen reduced food intake, body weight, adi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Toklu HZ,Bruce EB,Sakarya Y,Carter CS,Morgan D,Matheny MK,Kirichenko N,Scarpace PJ,Tümer N

更新日期：2016-09-01 00:00:00

abstract：:1. Activation of bulbospinal neurons projecting from the C1 area of the rostral ventrolateral medulla evokes a pressor response. The nature of the neurotransmitters involved in mediating this response at spinal cord level has not been established. 2. Amino acid antagonists were introduced into the spinal subarachnoid ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mills EH,Minson JB,Pilowsky PM,Chalmers JP

更新日期：1988-02-01 00:00:00

abstract：:Glycerophospholipids (GPs) and sphingolipids (SPs) are important lipid components in the body and play biological functions. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are important nutrients, and their supplements are commonly used for preventing some diseases. However, the effect of n-3 PUFAs on the human glyce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yan M,Cai WB,Hua T,Cheng Q,Ai D,Jiang HF,Zhang X

更新日期：2020-07-01 00:00:00

abstract：:The resistance of breast cancer cells to drugs is a major obstacle to effective cancer chemotherapy. Here, we study the function mechanisms of long non-coding RNA XIST in chemoresistance of breast cancer to doxorubicin. We examined the 50% inhibitive concentration of doxorubicin to MDA-MB-231 and MDA-MB-231/ADM cells,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang M,Wang F,Xiang Z,Huang T,Zhou WB

更新日期：2020-08-01 00:00:00

abstract：:1. Infusion of salbutamol (3.0 microgram/min after a bolus injection of 100 microgram) produced hypokalaemia in conscious dogs. 2. Measurement of arterial and coronary sinus potassium differences revealed no significant potassium loss from the heart with established hypokalaemia. 3. Shortly after the initial salbutamo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wahlqvist ML,Shanahan EA,Dennis PM,Pullan PT,Wilmshurst EG

更新日期：1978-11-01 00:00:00