Abstract:
:1. Infusion of salbutamol (3.0 microgram/min after a bolus injection of 100 microgram) produced hypokalaemia in conscious dogs. 2. Measurement of arterial and coronary sinus potassium differences revealed no significant potassium loss from the heart with established hypokalaemia. 3. Shortly after the initial salbutamol bolus and before steady-state hypokalaemia had been achieved during salbutamol infusion, a prolongation of QTc occurred; this corresponded to a significant myocardial potassium of -0.12 mmol/l plasma. 4. Urinary electrolyte excretions indicated that the hypokalaemia was not due to urinary potassium loss. 5. It was deduced that potassium had moved intracellularly. No change in hydrogen ion status occurred to account for this. Pronounced rises in plasma insulin immunoreactivities during salbutamol infusions suggested this as one mechanism for potassium shifts.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Wahlqvist ML,Shanahan EA,Dennis PM,Pullan PT,Wilmshurst EGdoi
10.1111/j.1440-1681.1978.tb00717.xsubject
Has Abstractpub_date
1978-11-01 00:00:00pages
617-25issue
6eissn
0305-1870issn
1440-1681journal_volume
5pub_type
杂志文章abstract::1. The effects on the coronary and systemic haemodynamics of intravenous and intracoronary injections of two benzfuran derivatives, amiodarone and its brominated analogue (L8040), were studied in open-chest anaesthetized dogs. The effects of L8040 on cardiac intracellular potentials after 6 weeks of 20 mg/kg intraperi...
journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1111/j.1440-1681.1976.tb00620.x
更新日期:1976-09-01 00:00:00
abstract::1. Patients were grouped into categories of 'no airways disease', 'obstructive airways disease without response to bronchodilator' and 'obstructive airways disease with bronchodilator responsiveness'. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of ...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1979.tb00013.x
更新日期:1979-01-01 00:00:00
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更新日期:2007-09-01 00:00:00
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doi:10.1111/1440-1681.12503
更新日期:2016-01-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
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更新日期:1996-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-09-01 00:00:00
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更新日期:1995-02-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:1988-02-01 00:00:00
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更新日期:2002-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-05-01 00:00:00
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更新日期:1988-12-01 00:00:00
abstract::1. Heparan sulfate proteoglycan in the basal lamina of smooth muscle cells is important in the maintenance of the 'contractile', high volume fraction of myofilaments (Vvmyo) phenotype. The mechanism by which this occurs may involve the continuous internalization of heparan sulfate by the smooth muscle cells themselves...
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doi:10.1111/1440-1681.12947
更新日期:2018-10-01 00:00:00
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doi:10.1111/1440-1681.12395
更新日期:2015-06-01 00:00:00
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更新日期:1989-04-01 00:00:00
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更新日期:1988-06-01 00:00:00
abstract::1. The antinociceptive effect of prostaglandins E1, E2 and F2alpha was studied in albino rats. Though all three prostaglandins produced similar degrees of sedation, only prostaglandin E1 (PGE1) produced a dose-related antinociceptive activity. 2. The antinociceptive activities of equi-analgesic doses of morphine (7.5....
journal_title:Clinical and experimental pharmacology & physiology
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更新日期:1977-05-01 00:00:00
abstract::1. The present review focuses on the cytotoxic effects of iodinated contrast media (CM) that are shared by all types of CM. 2. Although the clinical nephrotoxicity of CM has been progressively improved, all currently available CM still possess a level of cytotoxicity, which is probably caused by iodine. 3. The toxicit...
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pub_type: 杂志文章,评审
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更新日期:2011-05-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1992.tb00501.x
更新日期:1992-07-01 00:00:00
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更新日期:2006-03-01 00:00:00
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更新日期:2005-07-01 00:00:00
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doi:10.1111/1440-1681.13402
更新日期:2020-09-05 00:00:00
abstract::1. The effects of the Class I anti-arrhythmic drugs quinidine, procainamide, lidocaine, phenytoin and tocainide on mitochondrial lactate dehydrogenase activity were compared in guinea-pig heart preparations. 2. All the tested drugs inhibited the enzyme activity in a concentration-dependent fashion, exhibiting varying ...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1993.tb01671.x
更新日期:1993-04-01 00:00:00
abstract::1. Mammalian heart muscle is extremely sensitive to the external calcium concentration. It reacts to alterations of the external calcium concentration with an immediate adaptation of contractile force. 2. In mammalian heart there is a network of large transverse tubules throughout the cell. These structures are regula...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1681.1977.tb02377.x
更新日期:1977-01-01 00:00:00
abstract::1. The present study was undertaken to elucidate the effects of parecoxib, a novel cyclo-oxygenase (COX)-2 inhibitor, on spontaneous and prostaglandin-induced contractions of uterine smooth muscle. 2. Non-pregnant adult Wistar rats were decapitated and dissected to isolate myometrial strips. The tissue was mounted in ...
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.2007.04632.x
更新日期:2007-08-01 00:00:00