Clinical relevance of deferasirox trough levels in β-thalassemia patients.

Abstract:

:We evaluated the role of deferasirox therapeutic drug monitoring in order to avoid toxicity or treatment failure. Plasma concentrations, measured between two consecutive liver iron determinations, were determined at the end of dosing interval. Fifty-four β-thalassemic adult patients were enrolled: 50% were males; median age was 32.3 years (IQR 19.1-41.7 years) and median body mass index was 22.25 kg/m2 (IQR 20.24-23.75 kg/m2 ). The mean deferasirox dose was 28.6 ± 6.3 mg/kg/d and mean plasma concentration was 17.3 ± 16.8 μg/mL. Drug levels showed lower results in males. Deferasirox concentration was significantly correlated with serum creatinine levels (P = .01) and serum ferritin (P < .0001). The assessment of deferasirox therapeutic drug monitoring could help clinicians to predict patient responses and to optimize the therapy.

authors

Allegra S,Massano D,De Francia S,Longo F,Piccione F,Pirro E,Cusato J,D'Avolio A,Piga A

doi

10.1111/1440-1681.12879

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

213-216

issue

2

eissn

0305-1870

issn

1440-1681

journal_volume

45

pub_type

信件
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