Changes in renal renin gene expression in fetal sheep.

Abstract:

:1. Renin gene expression was investigated in kidneys from 13 foetal and four adult sheep. 2. The levels of renal renin mRNA in foetuses were greater than those in adult sheep (P < 0.001). 3. There was no significant difference in renin mRNA levels between foetuses aged 91 and 134 days (term 150 days). 4. The levels of renin gene expression were higher (178 +/- 5 units; P < 0.001) in foetuses at 142 days than levels in 91 (144 +/- 4 units) and 134 days old foetuses (146 +/- 6 units). 5. It is concluded that the high level of renin gene expression in the foetal kidney is responsible for the high levels of renin in the foetal circulation.

authors

Zhang DY,Lumbers ER,Simonetta G

doi

10.1111/j.1440-1681.1996.tb01758.x

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

682-4

issue

8

eissn

0305-1870

issn

1440-1681

journal_volume

23

pub_type

杂志文章
  • Renin and the (pro)renin receptor in the renal collecting duct: Role in the pathogenesis of hypertension.

    abstract::The intrarenal renin-angiotensin system (RAS) plays a critical role in the pathogenesis and progression of hypertension and kidney disease. In angiotensin (Ang) II-dependent hypertension, collecting duct renin synthesis and secretion are stimulated despite suppression of juxtaglomerular (JG) renin. This effect is medi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/1440-1681.12319

    authors: Gonzalez AA,Prieto MC

    更新日期:2015-01-01 00:00:00

  • Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides a and B.

    abstract::1. The present study was designed to determine the effects of ginkgolide A, ginkgolide B and quercetin on CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes. 2. Hepatocytes were pretreated with ginkgolide A, ginkgolide B and quercetin (at 1, 3, 10 and 30 micromol/L) for 48 h and then...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04630.x

    authors: He N,Cai HB,Xie HG,Collins X,Edeki TI,Strom SC

    更新日期:2007-07-01 00:00:00

  • Sympathoinhibitory action of nociceptin in the rat spinal cord.

    abstract::1. Whole-cell patch recordings were made from antidromically identified sympathetic preganglionic neurons (SPN) of immature rat spinal cord slices. Bath application of nociceptin (0.1-1 micromol/L) suppressed excitatory postsynaptic potentials (EPSP) and hyperpolarized a population of SPN; these effects were naloxone ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2002.03635.x

    authors: Brailoiu GC,Lai CC,Chen CT,Hwang LL,Lin HH,Dun NJ

    更新日期:2002-03-01 00:00:00

  • Taurine inhibits development of atherosclerotic lesions in apolipoprotein E-deficient mice.

    abstract::1. The effects of taurine on the development of atherosclerotic lesions were investigated in apolipoprotein (apo) E-deficient mice, an animal model with severe hypercholesterolaemia and extensive atherosclerosis. These mice were fed a normal laboratory chow containing 2% taurine for 12 weeks. 2. Serum total cholestero...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2001.03527.x

    authors: Kondo Y,Toda Y,Kitajima H,Oda H,Nagate T,Kameo K,Murakami S

    更新日期:2001-10-01 00:00:00

  • Salt and water intake and sodium and potassium excretion in spontaneously hypertensive rats.

    abstract::1. Total fluid and saline intakes were greater in spontaneously hypertensive rats (SHR) than in normotensive rats (NTR). 2. Total fluid and saline intake were significantly elevated in prehypertensive SHR, 5 weeks old, compared with age-matched NTR, and the intakes fell with age in both strains but remained considerab...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1983.tb00172.x

    authors: May CN,Parsons BJ

    更新日期:1983-01-01 00:00:00

  • A controlled study of the effects of aerobic exercise on antihypertensive drug requirements of essential hypertensive patients in the general practice setting.

    abstract::1. To investigate the effect of an exercise training programme on antihypertensive drug requirements, 19 sedentary subjects (14 men and five women) with mild essential hypertension (systolic blood pressure greater than 140 mmHg but less than 180 mmHg), aged 29-55 years, were randomly assigned to 16 weeks of moderate i...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1440-1681.1991.tb01445.x

    authors: Allen DH,Puddey IB,Morton AR,Beilin LJ

    更新日期:1991-05-01 00:00:00

  • Effect of mineralocorticoids and salt loading on renin release, renal renin content and renal renin mRNA in mice.

    abstract::1. DOCA and 9 alpha-fludrocortisone were given to mice on a high-sodium diet for periods of up to 20 weeks, resulting in decreases in plasma renin concentration, renal renin concentration and renal renin mRNA with both treatments. 2. Plasma renin concentration was suppressed prior to suppression of renin mRNA and rena...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1989.tb01614.x

    authors: Barrett G,Morgan T,Smith M,Aldred P

    更新日期:1989-08-01 00:00:00

  • HERG-F463L potassium channels linked to long QT syndrome reduce I(Kr) current by a trafficking-deficient mechanism.

    abstract::1. Congenital long QT syndrome (LQTS) is a genetically heterogeneous disease. The aim of the present study was to identify the gene mutation in a Chinese family with LQTS and investigate the functional changes associated with the mutation. 2. Polymerase chain reaction and DNA sequencing were used to screen for the KCN...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2009.05150.x

    authors: Yang HT,Sun CF,Cui CC,Xue XL,Zhang AF,Li HB,Wang DQ,Shu J

    更新日期:2009-08-01 00:00:00

  • Autacoid interactions in the regulation of blood flow in the human placenta.

    abstract::1. Interactions between autacoids may play important roles in the regulation of blood flow in the foetal placenta. In order to investigate this aspect of placental haemodynamics, human normal-term placentae were perfused in vitro and the responses of the foetal vessels to various combinations of vasoactive agents were...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1998.tb02280.x

    authors: Gude NM,King RG,Brennecke SP

    更新日期:1998-09-01 00:00:00

  • Effects of taurine on serum cholesterol levels and development of atherosclerosis in spontaneously hyperlipidaemic mice.

    abstract::1. The effects of two naturally occurring substances, namely taurine and catechins, on serum cholesterol levels and on the progression of atherosclerotic lesions were evaluated using spontaneously hyperlipidaemic (SHL) mice as an animal model of atherogenesis. 2. Twelve weeks treatment of SHL mice with taurine (1% in ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2003.03828.x

    authors: Matsushima Y,Sekine T,Kondo Y,Sakurai T,Kameo K,Tachibana M,Murakami S

    更新日期:2003-04-01 00:00:00

  • Expression and functional activity of breast cancer resistance protein (BCRP, ABCG2) transporter in the human choriocarcinoma cell line BeWo.

    abstract::1. Breast cancer resistance protein (BCRP, ABCG2) is a drug efflux transporter that is believed to affect the drug disposition of several drugs and xenobiotics. In the present study, we evaluated the localization and functional expression of BCRP in the human choriocarcinoma cell line BeWo, an in vitro model of the hu...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2006.04324.x

    authors: Ceckova M,Libra A,Pavek P,Nachtigal P,Brabec M,Fuchs R,Staud F

    更新日期:2006-01-01 00:00:00

  • Quercetin activates human Kv1.5 channels by a residue I502 in the S6 segment.

    abstract::1. The aims of the present study were to investigate the pharmacological effects of quercetin on wild-type (WT) and mutant (I502A) human (h) Kv1.5 channel currents (I(kur)) and to identify whether mutation in the S6 segment is critical to activation of I(kur) by quercetin. 2. Experiments were performed on WT and site-...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2008.05061.x

    authors: Yang L,Ma JH,Zhang PH,Zou AR,Tu DN

    更新日期:2009-02-01 00:00:00

  • Tocolytic effect of parecoxib, a new parenteral cyclo-oxygenase-2-specific inhibitor, on the spontaneous and prostaglandin-induced contractions of rat isolated myometrium.

    abstract::1. The present study was undertaken to elucidate the effects of parecoxib, a novel cyclo-oxygenase (COX)-2 inhibitor, on spontaneous and prostaglandin-induced contractions of uterine smooth muscle. 2. Non-pregnant adult Wistar rats were decapitated and dissected to isolate myometrial strips. The tissue was mounted in ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04632.x

    authors: Ayar A

    更新日期:2007-08-01 00:00:00

  • Thymoquinone protects rat liver after partial hepatectomy under ischaemia/reperfusion through oxidative stress and endoplasmic reticulum stress prevention.

    abstract::Ischaemia reperfusion (I/R) is associated with liver injury and impaired regeneration during partial hepatectomy (PH). The aim of this study was to investigate the effect of thymoquinone (TQ), the active compound of essential oil obtained from Nigella sativa seeds, on rat liver after PH. Male Wistar rats were divided ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12961

    authors: Bouhlel A,Bejaoui M,Ben Mosbah I,Hadj Abdallah N,Ribault C,Viel R,Hentati H,Corlu A,Ben Abdennebi H

    更新日期:2018-05-07 00:00:00

  • Recent developments concerning diet and hypertension.

    abstract::1. Recent data from randomized controlled dietary trials have shown blood pressure-lowering effects of foodstuffs and dietary patterns to be of practical importance for both individual and population blood pressure control. 2. The salient studies include Dietary Approaches to Stop Hypertension (DASH) trials, on comple...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2001.03562.x

    authors: Beilin LJ,Burke V,Puddey IB,Mori TA,Hodgson JM

    更新日期:2001-12-01 00:00:00

  • The effects of isosteviol against myocardium injury induced by ischaemia-reperfusion in the isolated guinea pig heart.

    abstract::1. This study aimed to investigate the protective effects of isosteviol against myocardial ischaemia-reperfusion (IR) injury and its effects on mitochondrial adenosine triphosphate (ATP)-sensitive potassium channel (mitoK(ATP)) activity in vitro. 2. Groups of eight guinea pigs were treated as follows: constant perfusi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04599.x

    authors: Xu D,Zhang S,Foster DJ,Wang J

    更新日期:2007-05-01 00:00:00

  • Increase in serum total angiotensin-converting enzyme activity with enalapril therapy in humans: a controlled trial.

    abstract::1. In a controlled, randomized double-blind trial, 15 patients with essential hypertension were treated with enalapril 5-20 mg/day, or doxazosin 1-8 mg/day, during a 7 week dose titration phase. This was followed by 7 weeks of combined treatment with doxazosin and enalapril. 2. Blood was taken after a 2 week placebo r...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1440-1681.1992.tb00456.x

    authors: Stokes GS,Monaghan JC,Marwood JF,Okoro EO,Johnston H

    更新日期:1992-05-01 00:00:00

  • Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease.

    abstract::Non-alcoholic fatty liver disease (NAFLD) has been considered as a multi-factorial metabolic syndrome. MicroRNA-375 (MiR-375) was significantly up-regulated in serum of NAFLD patients and the role of miR-375 was addressed as a putative biomarker of NAFLD progression. However, the specific function of miR-375 in the pr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12940

    authors: Lei L,Zhou C,Yang X,Li L

    更新日期:2018-08-01 00:00:00

  • Blunted renal vasoconstriction in patients with subclinical contrast-induced renal injury.

    abstract::Contrast media are considered to cause acute kidney injury by activating various factors that induce renal vasoconstriction. We analysed the renal microvascular haemodynamic response using the Doppler flow wire method. Then changes in urinary liver-type fatty acid-binding protein levels following contrast medium admin...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 信件

    doi:10.1111/1440-1681.12653

    authors: Kurihara O,Seino Y,Shibata Y,Matsushita M,Komiyama H,Kato K,Murakami D,Munakata R,Takano M,Miyauchi Y,Hata N,Shimizu W

    更新日期:2016-11-01 00:00:00

  • Nucleocytoplasmic shuttling: The ins and outs of quantitative imaging.

    abstract::Nucleocytoplasmic protein shuttling is integral to the transmission of signals between the nucleus and the cytoplasm. The nuclear/cytoplasmic distribution of proteins of interest can be determined via fluorescence microscopy, following labelling of the target protein with fluorophore-conjugated antibodies (immunofluor...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/1440-1681.12969

    authors: Molenaar C,Weeks KL

    更新日期:2018-10-01 00:00:00

  • Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channels.

    abstract::1. One hour exposure to hyperoxia has been shown previously to limit a subsequent ischaemia-reperfusion injury in spontaneously breathing rats. We tested the cardioprotective effect of a shorter period of hyperoxia during mechanical ventilation and the possible contribution of reactive oxygen species (ROS) and mitocho...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04745.x

    authors: Colantuono G,Tiravanti EA,Di Venosa N,Cazzato A,Rastaldo R,Cagiano R,D'Agostino D,Federici A,Fiore T

    更新日期:2008-01-01 00:00:00

  • Multiple oscillators, dynamic synchronization and sympathetic control.

    abstract::1. Intermittent bursts of activity are a robust feature of the discharges of sympathetic nerves. There are at least two major mechanisms producing such discharges: (i) phasic inputs influencing sympathetic circuits; and (ii) oscillators embedded within sympathetic networks. The functional significance of patterned and...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1681.2001.03414.x

    authors: Gilbey MP

    更新日期:2001-01-01 00:00:00

  • The syndrome of hypertension and hyperkalaemia with normal GFR. A unique pathophysiological mechanism for hypertension?

    abstract::Based on 28 reported patients, constant features of the syndrome of hypertension and hyperkalaemia are hyperkalaemia, hyperchloraemia, normal renal glomerular function and, in all adult patients, hypertension. Inconstant features include short stature, intellectual impairment and muscle weakness. Levels of renin and a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1986.tb00358.x

    authors: Gordon RD

    更新日期:1986-04-01 00:00:00

  • Hypoxia-activated prodrugs as antitumour agents: strategies for maximizing tumour cell killing.

    abstract::1. Hypoxia arises in solid tumour because of inefficient blood supply. While hypoxic cells are resistant to radiotherapy and probably to many chemotherapeutic drugs they can, in principle, be turned to advantage through the development of hypoxia-activated cytotoxic drugs (bioreductive drugs). 2. Three general approac...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1995.tb01956.x

    authors: Wilson WR,Pruijn FB

    更新日期:1995-11-01 00:00:00

  • Pathophysiology of renal tissue damage by iodinated contrast media.

    abstract::1. The present review focuses on the cytotoxic effects of iodinated contrast media (CM) that are shared by all types of CM. 2. Although the clinical nephrotoxicity of CM has been progressively improved, all currently available CM still possess a level of cytotoxicity, which is probably caused by iodine. 3. The toxicit...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2011.05503.x

    authors: Sendeski MM

    更新日期:2011-05-01 00:00:00

  • Competition by second messenger systems for receptor interaction and activation: implications for tissue-specific responses and disease therapy.

    abstract::1. At any one instant, most receptors are now recognized to be able to stimulate multiple signal transduction pathways in a cell when activated by an appropriate hormone. These different signalling pathways appear to allow for distinct cellular responses, such as cell proliferation, differentiation, and shape change. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1997.tb02104.x

    authors: Crouch MF,Frew IJ,Simson L,Davy DA

    更新日期:1997-08-01 00:00:00

  • Systemic adenosine increase during cold pressor test is dependent on sympathetic activation.

    abstract::1. Following local vasoconstriction-inducing stimuli, such as the cold pressor test (CPT), significant changes occur in haemodynamics, with a rise in arterial blood pressure and heart rate (HR) due to the activation of the sympathetic nervous system. Among the compensatory mechanisms to local ischaemia, the endogenous...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.1999.03126.x

    authors: Pasini FL,Capecchi PL,Colafati M,Randisi P,Puccetti L,Di Perri T

    更新日期:1999-10-01 00:00:00

  • New insights into the treatment of hypertension.

    abstract::1. The choice of initial pharmacological therapy is one area where the different hypertension management guidelines vary in recommending either the use of diuretics and beta-blockers as preferred drugs or choosing from any of the five major classes of antihypertensives. 2. Improvement in cardiovascular morbidity and m...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1997.tb02733.x

    authors: Tomlinson B

    更新日期:1997-12-01 00:00:00

  • Effect of nisoldipine on stress-induced myocardial damage in the conscious pig.

    abstract::1. The effect of the calcium channel blocker nisoldipine on the myocardial content of lipid peroxidation products (malondialdehyde (MDA), conjugated double bonds (CDB), fluorescent end-products (RF) and mitochondrial adenine nucleotides) was investigated in conscious pigs (n = 14) subjected to 24 h of immobilization s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1990.tb01258.x

    authors: Herbaczyńska-Cedro K,Lewicki Z,Barcikowski B,Famulski K,Gordon-Majszak W,Kłoś J,Wutzen J,Ceremuzyński L

    更新日期:1990-01-01 00:00:00

  • Unexpected incidence of low blood pressure 2 years after unilateral adrenalectomy for primary aldosteronism.

    abstract::1. Serial observations of blood pressure after unilateral adrenalectomy for aldosterone-producing adenoma revealed an incidence of hypotension (systolic BP less than fifth percentile for age- and sex-matched normal population) of 27% at 2 years, more than 5 times that predicted. 2. Serial observations of volume regula...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1989.tb01558.x

    authors: Gordon RD,Hawkins PG,Hamlet SM,Tunny TJ,Klemm SA,Backmann AW,Finn WL

    更新日期:1989-04-01 00:00:00