Changes in renal renin gene expression in fetal sheep.

abstract：:1. Epidemiological evidence indicates that low birthweight increases the risk of a number of adult-onset diseases. It is now apparent that many babies with a low birthweight may have been subjected to a combination of reduced growth rates in utero as well as preterm birth. However, the long-term effects of preterm bir...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cock ML,Camm EJ,Louey S,Joyce BJ,Harding R

更新日期：2001-11-01 00:00:00

abstract：:An efficient animal model is fundamental for studies on the underlying mechanisms of constrictive pericarditis (CP). A novel CP rat model was established by pericardial injection composing of lipopolysaccharides (LPS) and talcum powder without thoracotomy. Pathological changes were confirmed by histological staining. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Qiao W,Xiao YJ,Wang X,Sun LJ,Chen YX,Ren WD

更新日期：2020-12-21 00:00:00

abstract：:1. This study investigated the effect of atrial natriuretic peptide on renin release from the kidney. The in vitro direct effect was examined in the animal experiment using renal cortical slices of rat, and the in vivo effect was observed in the human infusion study. 2. In the in vitro experiments, alpha-human atrial ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ishimitsu T,Hirata Y,Matsuoka H,Ishii M,Sugimoto T,Kangawa K,Matsuo H

更新日期：1992-10-01 00:00:00

abstract：:1. Ethionine administered acutely to the adult female rat markedly elevates and then lowers plasma iron concentration over several days. Liver iron undergoes a reverse cycle. 2. Ethionine does not cause changes in the blood parameters, including total plasma iron-binding capacity and plasma iron clearance. Erythrocyte...

journal_title：Clinical and experimental pharmacology & physiology

authors： Loh TT,Archdeacon JW

更新日期：1975-11-01 00:00:00

abstract：:1. Serial observations of blood pressure after unilateral adrenalectomy for aldosterone-producing adenoma revealed an incidence of hypotension (systolic BP less than fifth percentile for age- and sex-matched normal population) of 27% at 2 years, more than 5 times that predicted. 2. Serial observations of volume regula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gordon RD,Hawkins PG,Hamlet SM,Tunny TJ,Klemm SA,Backmann AW,Finn WL

更新日期：1989-04-01 00:00:00

abstract：:1. It has been proposed that hypertension alters the respiratory and cardiovascular responses to chemoreceptor stimulation. However, in studies of human hypertension or in genetic animal models of hypertension it has been difficult to unequivocally attribute the changes to hypertension per se, rather than to a genetic...

journal_title：Clinical and experimental pharmacology & physiology

authors： Groom AS,Malpas SC

更新日期：1997-03-01 00:00:00

abstract：:1. Adult soft-shelled turtles were exposed to hyperosmotic and dehydration stresses. 2. Acute treatment for 0.5, 1 or 2 h with sodium chloride (3.6%, single intramuscular injection, 2 mL volume) caused depletion of pineal serotonin contents followed by elevation of norepinephrine and epinephrine levels. In addition, i...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mahapatra MS,Mahata SK,Maiti B

更新日期：1991-10-01 00:00:00

abstract：:1. The influence of the passive force on the contraction and endothelium-dependent relaxation in aortae of normotensive Wistar Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) were compared. 2. Force changes of endothelium-intact and -removed preparations were measured isometrically by a force...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sekiguchi F,Adachi T,Matsubara H,Matsuda K,Kita K,Shimamura K,Sunano S

更新日期：1996-06-01 00:00:00

abstract：:1. Gastric emptying studies in small laboratory animals are hampered by the deficiency of a technique that is non-invasive and repeatable. The aim of the present study was to adapt the non-invasive [13C]-octanoic acid breath test, which has been validated in humans, to assess both liquid and solid gastric emptying in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Symonds EL,Butler RN,Omari TI

更新日期：2000-09-01 00:00:00

abstract：:1. The contractile effects of tea polyphenols (TP) and its four principle catechins, namely (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC) and (-)-epigallocatechin-3-gallate (EGCG), on rat aorta contractility were investigated using the isometric tension recording technique. 2. At co...

journal_title：Clinical and experimental pharmacology & physiology

authors： Shen JZ,Zheng XF,Wei EQ,Kwan CY

更新日期：2003-01-01 00:00:00

abstract：:1. The alpha-adrenoceptor antagonist, phentolamine, was administered intravenously, to conscious or anaesthetized rats, before or after the beta-adrenoceptor antagonist, propanolol. 2. The bradycardia which followed the combined administration of propranolol and phentolamine exceeded that induced by propranolol alone,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Oates HF,Stoker LM

更新日期：1980-03-01 00:00:00

abstract：:1. Hepatic sulphobromophthalein (BSP) transport was studied in guinea-pigs pretreated intraperitoneally with 0.7 ml of diethyl maleate to depress hepatic glutathione levels. 2. Diethyl maleate depressed the hepatic transport of infused conjugated BSP from hepatocytes into bile without influencing hepatic uptake. 3. Un...

journal_title：Clinical and experimental pharmacology & physiology

authors： Whelan G

更新日期：1980-11-01 00:00:00

abstract：:Glycerophospholipids (GPs) and sphingolipids (SPs) are important lipid components in the body and play biological functions. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are important nutrients, and their supplements are commonly used for preventing some diseases. However, the effect of n-3 PUFAs on the human glyce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yan M,Cai WB,Hua T,Cheng Q,Ai D,Jiang HF,Zhang X

更新日期：2020-07-01 00:00:00

abstract：:In the present study, we investigated whether mood stabilizer lithium (Li) protects against d-amphetamine (AMP)-induced mania-like behaviours via modulating the novel proinflammatory potential. Repeated treatment with AMP resulted in significant increases in proinflammatory cyclooxygenase-2 (COX-2) and indolemaine-2,3...

journal_title：Clinical and experimental pharmacology & physiology

authors： Phan DH,Shin EJ,Jeong JH,Tran HQ,Sharma N,Nguyen BT,Jung TW,Nah SY,Saito K,Nabeshima T,Kim HC

更新日期：2020-05-01 00:00:00

abstract：:1. The present study sought to explain the mechanism leading to reduced availability of propranolol when given after a priming dose in the single-pass perfused rat liver. 2. Extracellular sucrose space (as a measure of sinusoidal relaxation) in perfused rat liver before and after propranolol or propranolol and N(G)-ni...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu X,Zou Y,Khlentzos AM,Yang Y,Nikolovski J,Weiss M,Roberts MS

更新日期：2010-10-01 00:00:00

abstract：:1. Low-voltage electrical stimulation (LVES) in skeletal muscle at a level far below the threshold of muscle contraction has been reported to promote local angiogenesis. However, the mechanism underlying the promotion of local angiogenesis by LVES has not been fully elucidated. In the present study, we evaluated wheth...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nagasaka M,Kohzuki M,Fujii T,Kanno S,Kawamura T,Onodera H,Itoyama Y,Ichie M,Sato Y

更新日期：2006-07-01 00:00:00

abstract：:1. The influence of the intact kidney on blood pressure, extracellular fluid volume (ECF, ferrocyanide space) and ECF volume distribution was studied in rats 60 days after constriction of the contralateral renal artery. 2. Renal artery constriction increased both blood pressure and ECF levels. The rise of both variabl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kunes J,Jelínek J

更新日期：1979-09-01 00:00:00

abstract：:1. Patients were grouped into categories of 'no airways disease', 'obstructive airways disease without response to bronchodilator' and 'obstructive airways disease with bronchodilator responsiveness'. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Krzanowski JJ,Polson JB,Goldman AL,Ebel TA,Szentivanyi A

更新日期：1979-01-01 00:00:00

abstract：:1. Effects of FR139317, an endothelin ETA receptor antagonist, on renal haemodynamic and excretory responses to acute nitric oxide (NO) blockade were examined using anaesthetized rats. 2. Intrarenal arterial infusion of NG-nitro-L-arginine (NOARG), the NO synthase inhibitor, at a rate of 40 micrograms/kg per min, prod...

journal_title：Clinical and experimental pharmacology & physiology

authors： Matsumura Y,Kuro T,Hashimoto N,Taira S

更新日期：1998-06-01 00:00:00

abstract：:Ageing is associated with increased prevalences of both atrial and ventricular arrhythmias, reflecting disruption of the normal sequence of ion channel activation and inactivation generating the propagated cardiac action potential. Experimental models with specific ion channel genetic modifications have helped clarify...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jeevaratnam K,Chadda KR,Salvage SC,Valli H,Ahmad S,Grace AA,Huang CL

更新日期：2017-12-01 00:00:00

abstract：:1. The common pathological alteration in virtually every progressive chronic kidney disease (CKD) is renal fibrosis. 2. This review focuses on some growth factors, which are particularly well-established in contributing to fibrosis, such as the profibrotic, transforming growth factor-β, and connective tissue growth fa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boor P,Floege J

更新日期：2011-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder with an incompletely defined aetiology that is associated with memory and cognitive impairment. Currently available therapeutics only provide temporary assistance with symptoms. In spite of plentiful research in the field and the generation of thousands of studi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zamani E,Parviz M,Roghani M,Mohseni-Moghaddam P

更新日期：2019-01-01 00:00:00

abstract：:1. CYP2C19 is a polymorphism of cytochrome P450, which is responsible for the metabolism of many drugs. The genetic polymorphism shows interethnic variation and it has been demonstrated that the frequency of poor metabolizers (PM) and the distribution of alleles of CYP2C19 vary among Chinese ethnic nationalities. The ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang JH,Li PQ,Fu QY,Li QX,Cai WW

更新日期：2007-05-01 00:00:00

abstract：:1. Resveratrol (RSV), a polyphenol in red wine, exhibits cardioprotective effects in vitro, such as inhibition of angiotensin II- or phenylephrine-induced cardiomyocyte hypertrophy in rat neonatal myocyte cultures and suppression of cardiac fibroblast proliferation. The aim of the present study was to investigate the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang DL,Zhang HG,Xu YL,Gao YH,Yang XJ,Hao XQ,Li XH

更新日期：2010-02-01 00:00:00

abstract：:1. In order to explore the mechanisms responsible for the hypernoradrenergic innervation of the vasculature in the spontaneously hypertensive rat (SHR) the tissue content of nerve growth factor messenger ribonucleic acid (NGFmRNA) was examined. 2. The concentration of NGFmRNA was markedly elevated in mesenteric veins ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Falckh PH,Harkin LA,Head RJ

更新日期：1992-08-01 00:00:00

abstract：:1. Synthetic human endothelin was injected intravenously over the range 1.5-50 micrograms to examine its cardiovascular actions in conscious sheep. 2. Mean arterial pressure increased by 9-21 mmHg within 30-120 s over the range 5-50 micrograms endothelin. The increase in blood pressure was associated with increased ca...

journal_title：Clinical and experimental pharmacology & physiology

authors： Scoggins BA,Spence CD,Parkes DG,McDonald M,Wade JD,Coghlan JP

更新日期：1989-04-01 00:00:00

abstract：:1. In rat isolated tail arteries and atria in which transmitter stores are labelled with (3H)-noradrenaline, isoprenaline in low concentrations facilitates the stimulation-induced efflux of tritium. 2. This effect is dependent on the frequency and duration of electrical stimulation, being observed only at low frequenc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Medgett IC,McCulloch MW,Rand MJ,Story DF

更新日期：1980-09-01 00:00:00

abstract：:1. Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2. We studied the possible cross-talk between PAR2 and vanilloid receptor 1 (VR1). The VR1 antagonist capsazepine partially inhibited the PAR2-mediated increase in gastri...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawabata A,Kinoshita M,Kuroda R,Kakehi K

更新日期：2002-04-01 00:00:00

abstract：:Pathogenic inflammation mediated by overactive type 1 helper T cell (Th1) responses could exacerbate and perpetuate Crohn's disease. Programmed death (PD)-1 and its ligand PD-L1 pathway could be upregulated to suppress inflammation. We wondered why this pathway is ineffective at suppressing pathogenic Th1 inflammation...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ma F,Zhao M,Song Z,Wang Z

更新日期：2019-09-01 00:00:00

abstract：:1. The effects of clomiphene (CLM) on cardiac outward K+ current components from rat isolated ventricular myocytes were investigated using the whole-cell patch-clamp technique. Clomiphene (10 micromol/L) significantly inhibited both peak (Ipeak) and end-pulse (Ilate) outward currents (elicited by a 500 msec voltage st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Borg JJ,Hancox JC,Hogg DS,James AF,Kozlowski RZ

更新日期：2004-01-01 00:00:00