Possible participation of NMDA and glycine receptors but not GABAA receptors in enflurane-induced opisthotonus in mice.

Abstract:

:1. We previously reported that volatile anaesthetics produce incidences of a transient opisthotonus in mice, a sign of CNS stimulation. This study was performed to investigate mechanisms by which enflurane-induced opisthotonus (EIO) occurs. 2. The effects of pretreatment of N-methyl-D-aspartate (NMDA) antagonists dizocilpine (MK-801; DIZ) and ketamine (KET), GABAA antagonists picrotoxin (PIC), pentylenetetrazol (PTZ) and glycine antagonist strychnine (STR) on the incidence of EIO were determined. Prior to exposure to 2.0% enflurane in air, male ddN mice were given intraperitoneal injections of 0.2 mL saline (control), 0.5-5.0 mg/kg DIZ, 20-80 mg/kg KET, 2.9 mg/kg PIC, 40.0 mg/kg PTZ and 0.75 mg/kg STR. After the injection, the behavioural state of the mice was observed for 20 min (the pre-enflurane period). During the exposure to enflurane the time for immobilization, that is, anaesthetic induction time (IT), and the incidence of EIO were measured. 3. Dizocilpine (1.0-5.0 mg/kg) and KET (80 mg/kg) significantly (P < 0.01) reduced both the incidence of EIO and IT in a dose-dependent manner. During the pre-enflurane period DIZ produced incidences (5-40%) of transient seizures in a dose-dependent manner, while KET did not induce them at all. The two GABAA antagonists had no detectable effect on the EIO. Strychnine significantly enhanced the EIO. These CNS stimulants resulted in a 3-10% incidence of transient seizure and/or opisthotonus during the pre-enflurane period, but there was no correlation between DIZ-induced seizure and EIO. 4. These results suggest that the EIO is mediated by the NMDA and the STR-sensitive glycine receptors, but not the GABAA receptor.(ABSTRACT TRUNCATED AT 250 WORDS)

authors

Komatsu H,Nogaya J,Ueki M,Yokono S,Ogli K

doi

10.1111/j.1440-1681.1994.tb02546.x

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

495-9

issue

6

eissn

0305-1870

issn

1440-1681

journal_volume

21

pub_type

杂志文章
  • Neuropharmacology of nicotine: effects on the autoregulation of acetylcholine release by substance P and methionine enkephalin in rodent cerebral slices and toxicological implications.

    abstract::1. The neuronal release of acetylcholine (ACh) and its autoregulation by neuromodulators, substance P (SP) and methionine enkephalin (MEK), have been studied using superfused rodent cerebral slices. Nicotine exerts significant effects on autoregulation of ACh release, which may have toxicological implications. 2. Posi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1995.tb01997.x

    authors: Sastry BV

    更新日期:1995-04-01 00:00:00

  • Opioid receptors mediate inotropic and depressor effects of apelin in rats with 2K1C-induced chronic renovascular hypertension.

    abstract::Apelin receptors (APJ) cross-talk with other G-protein-coupled receptors. However, the role of APJ interaction with opioid receptors (OPR) on the cardiovascular effects of apelin in hypertension is not clear. Renovascular hypertension was induced by placing a Plexiglas clip on the left kidney of rats. After 16 weeks, ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12860

    authors: Rostamzadeh F,Najafipour H,Yeganeh-Hajahmadi M,Joukar S

    更新日期:2018-02-01 00:00:00

  • Does the baroreceptor-heart rate reflex indicate the capacity of the arterial baroreceptors to control blood pressure?

    abstract::1. We have examined the question asked in the title by studying: the carotid baroreceptor reflex in man with a variable-pressure neck chamber; the carotid baroreceptor reflex in conscious rabbits with a variable-pressure capsule around the carotid bifurcation; and the barorecptor-heart rate reflex. 2. At rest, the ass...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1980.tb00099.x

    authors: Ludbrook J,Mancia G,Zanchetti A

    更新日期:1980-09-01 00:00:00

  • Oestrogen receptors and cardiovascular disease.

    abstract::1. Animal and human studies indicate that female sex hormones are protective against the development of coronary atherosclerosis. 2. Experiments on vascular smooth muscle cells suggest a direct effect of oestrogen on vascular tissue. Although oestrogen receptors (ER) in vascular tissues and an association between ER s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1996.tb02775.x

    authors: Baysal K,Losordo DW

    更新日期:1996-06-01 00:00:00

  • Rutaecarpine attenuates osteoclastogenesis by impairing macrophage colony stimulating factor and receptor activator of nuclear factor κ-B ligand-stimulated signalling pathways.

    abstract::Rutaecarpine is a major alkaloid isolated from Evodia rutaecarpa. Here, we investigated the effects of rutaecarpine on osteoclast differentiation induced by macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor κ-B ligand (RANKL) in bone marrow-derived macrophages (BMMs). Treatment with...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 信件

    doi:10.1111/1440-1681.12941

    authors: Fukuma Y,Sakai E,Komaki S,Nishishita K,Okamoto K,Tsukuba T

    更新日期:2018-08-01 00:00:00

  • Lack of effect of bromocriptine on serum levels of calcium in the rat.

    abstract::1. The effect of bromocriptine (a prolactin suppressant drug) on the serum levels of calcium was studied in the male rat. The drug was administered subcutaneously at a dosage of 100 microgram per 100 g body weight three times per day. 2. Chronic treatment with bromocriptine had no significant effect on the serum calci...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1978.tb00708.x

    authors: Tan CM,Tan GJ

    更新日期:1978-09-01 00:00:00

  • Characterization of lymphocyte beta 2-adrenoceptor signalling in patients with left ventricular volume overload disease.

    abstract::1. Studies using animal experimental models have suggested that the beta2-adrenoceptor is uncoupled in association with alterations in the expression of G-protein-coupled receptor kinases (GRK) 2/3 in heart failure. However, the functional expression of the components of this pathway in human disease has not been full...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2002.03625.x

    authors: Dzimiri N,Basco C,Moorji A,Afrane B,Al-Halees Z

    更新日期:2002-03-01 00:00:00

  • A rat model of ischaemic or dilated cardiomyopathy for investigating left ventricular repair surgery.

    abstract::1. The effects of left ventricular repair (LVR) surgery for ischaemic or dilated cardiomyopathy are not fully understood. The development of a proper animal model will help to resolve this issue. 2. The ischaemic cardiomyopathy (ICM) model used was as follows. Twenty-six rats developed ICM with a large akinetic left v...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2002.03708.x

    authors: Nishina T,Miwa S,Yuasa S,Nishimura K,Komeda M

    更新日期:2002-08-01 00:00:00

  • Anti-angiogenesis effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive properties under experimental model.

    abstract::Angiogenesis is a process through which new capillaries are formed from pre-existing ones, which contributes significantly to the pathogenesis of numerous diseases, such as cancer and chronic inflammatory disorders. The β-D-mannuronic acid (M2000) is a novel non-steroidal anti-inflammatory drug (NSAID) with immunosupp...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12907

    authors: Rastegari-Pouyani M,Mostafaie A,Mansouri K,Mortazavi-Jahromi SS,Mohammadi-Motlagh HR,Mirshafiey A

    更新日期:2018-04-01 00:00:00

  • Effect of pregnancy in the rabbit on the pressor response to angiotensin and noradrenaline.

    abstract::The pressor responses to angiotensin II injections of 29, 117 and 468 pmol/kg and infusion at 54 pmol/kg per min were compared in near-term pregnant and matched non-pregnant rabbits. The responses to noradrenaline injections of 652, 2608 and 10 432 pmol/kg and infusion at 1185 pmol/kg per min were similarly compared. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1985.tb00911.x

    authors: Joels N,Humphreys PW

    更新日期:1985-11-01 00:00:00

  • Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease.

    abstract::Hypoxia-inducible factor-1 alpha (HIF-1α) and nuclear receptor related-1 (Nurr1) play pivotal roles in the development and survival of dopaminergic neurons, and deficiencies in these genes may be involved in Parkinson's disease (PD) pathogenesis. Recently, anthelminthic benzimidazoles were shown to promote HIF-1α tran...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13162

    authors: Kandil EA,Sayed RH,Ahmed LA,Abd El Fattah MA,El-Sayeh BM

    更新日期:2019-12-01 00:00:00

  • Excess weight in children and adolescents is associated with altered subendocardial blood supply among girls but not boys.

    abstract::Subendocardial viability ratio (SEVR) is a reliable index of myocardial supply-workload balance. This study sought to investigate whether overweight/obese children and adolescents have altered SEVR and to identify which are the associated factors. This cross-sectional study involved 789 individuals. Central haemodynam...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 信件

    doi:10.1111/1440-1681.12922

    authors: Zaniqueli D,Alvim RO,Baldo MP,Luiz SG,Cunha RS,Mill JG

    更新日期:2018-05-01 00:00:00

  • Effects of amiodarone and L8040, novel antianginal and antiarrhythmic drugs, on cardiac and coronary haemodynamics and on cardiac intracellular potentials.

    abstract::1. The effects on the coronary and systemic haemodynamics of intravenous and intracoronary injections of two benzfuran derivatives, amiodarone and its brominated analogue (L8040), were studied in open-chest anaesthetized dogs. The effects of L8040 on cardiac intracellular potentials after 6 weeks of 20 mg/kg intraperi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1976.tb00620.x

    authors: Singh BN,Jewitt DE,Downey JM,Kirk ES,Sonnenblick EH

    更新日期:1976-09-01 00:00:00

  • Comparison of digoxin versus low-dose amiodarone for ventricular rate control in patients with chronic atrial fibrillation.

    abstract::1. Rapid ventricular rate (VR) and rhythm irregularity during atrial fibrillation (AF) impair cardiac performance. Although digoxin has been widely used in patients with AF, its efficacy for the control of VR and rhythm irregularity is unsatisfactory. Whether low-dose amiodarone is more effective remains unclear. 2. W...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1440-1681.2001.03454.x

    authors: Tse HF,Lam YM,Lau CP,Cheung BM,Kumana CR

    更新日期:2001-05-01 00:00:00

  • Azithromycin inhibits muscarinic 2 receptor-activated and voltage-activated Ca2+ permeant ion channels and Ca2+ sensitization, relaxing airway smooth muscle contraction.

    abstract::Azithromycin (AZM) has been used for the treatment of asthma and chronic obstructive pulmonary disease (COPD); however, the effects and underlying mechanisms of AZM remain largely unknown. The effects of AZM on airway smooth muscles (ASMs) and the underlying mechanisms were studied using isometric muscle force measure...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13062

    authors: Wang Q,Yu MF,Zhang WJ,Liu BB,Zhao QY,Luo X,Xu H,She YS,Zang DA,Qiu JY,Shen J,Peng YB,Zhao P,Xue L,Chen W,Ma LQ,Nie X,Shen C,Chen S,Chen S,Liu Q,Dai J,Qin G,Zheng YM,Wang YX,ZhuGe R,Chen J,Liu QH

    更新日期:2019-04-01 00:00:00

  • Unidirectional transfer of D-xylose across the rat placenta.

    abstract::1. The transplacental transfer of D-xylose was investigated in the present study. 2. Umbilical perfusion of the rat term placenta was used to study materno-foetal (M-F) and foetomaternal (F-M) transfer of this compound. 3. D-Xylose was found to cross the rat term placenta very quickly in the M-F direction, with subseq...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1998.tb02144.x

    authors: Staud F,Fendrich Z,Karlícek R,Pávek P

    更新日期:1998-01-01 00:00:00

  • Effect of furazolidone and nitrofurazone on brain gamma-amino butyric acid and glutamate concentrations in chickens.

    abstract::1. The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, birds on the small dose of FZ or NF lost about 9% of their bod...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1988.tb01042.x

    authors: Ali BH

    更新日期:1988-12-01 00:00:00

  • Insights into motor performance and muscle fatigue based on transcranial stimulation of the human motor cortex.

    abstract::1. Direct cortical stimulation of motor and sensory areas of the cortex in experimental animals and some neurosurgical patients has provided much useful physiological information. Some of the benefits of this approach can be provided in awake volunteer subjects using new techniques which activate the motor cortex thor...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1996.tb01148.x

    authors: Gandevia SC

    更新日期:1996-10-01 00:00:00

  • The hepatic transport of taurocholic acid in the rat: development of a mathematical model.

    abstract::1. The transport of taurocholic acid from portal blood to bile was studied in the anaesthetized rat by injecting a radiolabelled pulse of bile acid. 2. The transport process was very rapid, 50% of the dose being secreted within 5 min, and the total dose within 15 min. 3. The transport process had a large capacity. The...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1976.tb00588.x

    authors: Iser JH,Packer JS,Smallwood RA,Hoffman NE

    更新日期:1976-01-01 00:00:00

  • A novel model of constrictive pericarditis associated with myocardial fibrosis in rats.

    abstract::An efficient animal model is fundamental for studies on the underlying mechanisms of constrictive pericarditis (CP). A novel CP rat model was established by pericardial injection composing of lipopolysaccharides (LPS) and talcum powder without thoracotomy. Pathological changes were confirmed by histological staining. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13449

    authors: Qiao W,Xiao YJ,Wang X,Sun LJ,Chen YX,Ren WD

    更新日期:2020-12-21 00:00:00

  • Lowering of blood pressure during chronic suppression of central sympathetic outflow: insight from computer simulations.

    abstract::1. Chronic electrical stimulation of the carotid sinuses has provided unique insight into the mechanisms that cause sustained reductions in blood pressure during chronic suppression of central sympathetic outflow. 2. Because renal denervation does not abolish the sustained fall in arterial pressure in response to baro...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2009.05291.x

    authors: Iliescu R,Lohmeier TE

    更新日期:2010-02-01 00:00:00

  • Modelling of frequency-dependent effects of lignocaine homologues on the maximum upstroke velocity of action potentials in guinea-pig papillary muscles.

    abstract::1. The effects of 14 lignocaine homologues on the maximum upstroke velocity (Vmax) of the action potentials (AP) were studied in guinea-pig papillary muscles. These drugs possess one, two or three methyl groups in different positions: an ortho-chloro, -carbomethoxy or -ethyl group instead of an ortho-methyl group; or ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1992.tb00489.x

    authors: Hamamoto T,Ichiyama M,Takahashi Y,Ban T

    更新日期:1992-06-01 00:00:00

  • Effects of anaesthesia on the removal from plasma of intravenously injected chylomicron-like lipid emulsions in rats and mice.

    abstract::1. In order to find an anaesthesia with minimum perturbation to the metabolism of chylomicrons, the effects of seven different anaesthetic agents on clearance from plasma of chylomicron-like emulsions were compared. 2. Avertin, urethane, fentanyl, and a ketamine/xylazine mixture all slowed the removal from plasma of e...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1993.tb01502.x

    authors: Mortimer BC,Umeda Y,Elsegood CL,Redgrave TG

    更新日期:1993-01-01 00:00:00

  • Euphorbia thymifolia suppresses herpes simplex virus-2 infection by directly inactivating virus infectivity.

    abstract::1. The ethyl acetate (EtOAc) extract and 3-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-d-glucose (3OG46HG) of Euphorbia thymifolia Linnea have been shown to exhibit anti-herpes simplex virus (HSV)-2 activity in vitro. In the present study, we investigated the mode of action of these two compounds in suppressing HSV-2 multi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2005.04194.x

    authors: Yang CM,Cheng HY,Lin TC,Chiang LC,Lin CC

    更新日期:2005-05-01 00:00:00

  • Association of the aldosterone synthase gene -344T>C polymorphism with essential hypertension and glucose homeostasis: a case-control study in a Han Chinese population.

    abstract::1. Aldosterone is a hormone that affects both blood pressure and glucose homeostasis. We studied the association of the aldosterone synthase gene (CYP11B2) polymorphism -344T>C with essential hypertension (EH) and glucose homeostasis in people in China. 2. We investigated the polymorphism -344T>C in CYP11B2 using a ca...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2011.05555.x

    authors: Li XM,Ling Y,Lu DR,Lu ZQ,Yi QL,Liu Y,Chen HY,Gao X

    更新日期:2011-09-01 00:00:00

  • The effect of hypertensive episodes and cardiac hypertrophy on the canine cardiac baroreflex.

    abstract::1. Left ventricular (LV) hypertrophy has been implicated in the reduction of baroreflex sensitivity present in hypertension. The aim of the current study was to investigate the mean arterial pressure-heart rate reflex (MAP-HR) in a model which induced left ventricular hypertrophy but no sustained blood pressure elevat...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1994.tb02433.x

    authors: Kingwell BA,Krause L,Julius S

    更新日期:1994-01-01 00:00:00

  • Sample size requirements for clinical trials of isolated systolic hypertension.

    abstract::1. This study investigated components of blood pressure variability in elderly subjects with isolated systolic hypertension (ISH) using both ambulatory blood pressure monitoring (ABPM) and casual clinic blood pressure measurement. These were then used to determine sample size requirements for clinical trials of differ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1992.tb00455.x

    authors: Silagy CA,McNeil JJ,McGrath BP

    更新日期:1992-05-01 00:00:00

  • Reduced store-operated Ca2+ entry impairs mesenteric artery function in response to high external glucose in type 2 diabetic ZDF rats.

    abstract::Diabetes is a major risk factor for cardiovascular disease, affecting both endothelial and smooth muscle cells. Store-operated Ca2+ channels (SOCCs) have been implicated in many diabetic complications. Vascular dysfunction is common in patients with diabetes, but the role of SOCCs in diabetic vasculopathy is still unc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13300

    authors: Schach C,Wester M,Leibl F,Redel A,Gruber M,Maier LS,Endemann D,Wagner S

    更新日期:2020-07-01 00:00:00

  • MiR-599 regulates LPS-mediated apoptosis and inflammatory responses through the JAK2/STAT3 signalling pathway via targeting ROCK1 in human umbilical vein endothelial cells.

    abstract::MicroRNA plays an integral role in the development of atherosclerosis. Our study aimed to investigate the roles of miR-599 in lipopolysaccharide (LPS)-induced endothelial damage in human umbilical vein endothelial cells (HUVECs). HUVECs were transfected with a miR-599 mimic and negative control, and then exposed to LP...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13316

    authors: Wang J,Du A,Wang H,Li Y

    更新日期:2020-08-01 00:00:00

  • Nephropreventing effect of hypoxia-inducible factor 1α in a rat model of ischaemic/reperfusion acute kidney injury.

    abstract::Acute kidney injury (AKI) occurs in 5% of hospitalized patients and in 50% of sepsis patients with acute renal dysfunction. However, there have been no safe and effective therapeutic strategies. The hypoxia condition is closely related to renal injury and function under AKI. As hypoxia-inducible factor 1α (HIF-1α) is ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12947

    authors: Wang H,Liu N,Li R,Tian J,Hu W,Zhang J

    更新日期:2018-10-01 00:00:00