Abstract:
:1. Pulmonary veins are the most important focus for the initiation of atrial fibrillation. Diabetes mellitus may be associated with hypertonicity and increased occurrence of atrial fibrillation. 2. The purpose of the present study was to investigate whether hypertonicity alters the electrophysiological characteristics of pulmonary veins and atria to enhance the genesis of atrial fibrillation. 3. A whole-cell patch-clamp technique was used to investigate action potentials and ionic currents in rabbit isolated single pulmonary vein and atrial cardiomyocytes during immersion in isotonic and hypertonic (1.2x normal osmolality) solutions. 4. Hypertonicity increased the spontaneous beating rates of pulmonary vein cardiomyocytes from 2.3 +/- 0.3 to 3.4 +/- 0.3 Hz (n = 11; P < 0.001). Hypertonicity prolonged action potential duration to a greater extent in atrial cardiomyocytes than in pulmonary vein cardiomyocytes. Compared with atrial cardiomyocytes, hypertonicity increased the transient inward currents and Na(+)/Ca(2+) exchange currents to a greater extent in pulmonary vein cardiomyocytes, but decreased the delayed rectified potassium currents to a lesser extent. 5. Hypertonicity plays an important role in the electrical activity of pulmonary vein and atrial cardiomyocytes, which may have a potential role in the pathophysiology of atrial fibrillation.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Lee SH,Chen YC,Cheng CC,Higa S,Chen YJ,Chen SAdoi
10.1111/j.1440-1681.2008.05085.xsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
419-24issue
4eissn
0305-1870issn
1440-1681pii
CEP5085journal_volume
36pub_type
杂志文章abstract::Placental growth factor (PlGF) is decreased in early gestation of pregnant women who subsequently develop pre-eclampsia. In this study, pre-emptive treatment with PlGF to prevent pre-eclampsia was evaluated in an in vivo rodent model of experimental pre-eclampsia (EPE) induced by TNF-α and in an in vitro model of huma...
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