cAMP produced by pituitary adenylate cyclase-activating polypeptide 27 inhibits atrial natriuretic peptide secretion in rabbit beating atria.

abstract：:1. The study examines whether intracerebroventricular (ICV) infusion of atrial natriuretic peptide (human ANP,1-28) influences renal electrolyte and water excretion, vasopressin release, renal and femoral blood flows in conscious ewes. The blood flow was measured by chronically implanted ultrasonic flow probes. 2. ICV...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gunnarsson U

更新日期：1994-03-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in 5% of hospitalized patients and in 50% of sepsis patients with acute renal dysfunction. However, there have been no safe and effective therapeutic strategies. The hypoxia condition is closely related to renal injury and function under AKI. As hypoxia-inducible factor 1α (HIF-1α) is ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang H,Liu N,Li R,Tian J,Hu W,Zhang J

更新日期：2018-10-01 00:00:00

abstract：:1. Epidermal growth factor is a potent mitogen that causes natriuresis, diuresis and inhibition of arginine vasopressin-induced water reabsorption. 2. The aim of this study was to determine any interaction between epidermal growth factor and the V1 (vascular) and/or V2 (antidiuretic) arginine vasopressin receptor subt...

journal_title：Clinical and experimental pharmacology & physiology

authors： Grant SL,Phillips PA,Gow CB

更新日期：1994-03-01 00:00:00

abstract：:1. The effects of ATP and some of its more stable analogues have been examined upon preparations of epididymal and prostatic halves of vasa deferentia and of cauda epididymides from rats that had undergone vasectomy by medial transection of the vas deferens. 2. After unilateral vasectomy, the potencies of ATP, beta, g...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ventura S,DeGaris RM,Stead CK,Pennefather JN

更新日期：1990-08-01 00:00:00

abstract：:Chronic low back pain (LBP) has high prevalence in the adult population which is associated with enormous disability. Hence, our aim was to further characterise our LBP rat model by using immunohistological and immunohistochemical methods at an advanced stage (day 49) of the model. Male Sprague-Dawley rats were anaest...

journal_title：Clinical and experimental pharmacology & physiology

authors： Park TSW,Khan N,Kuo A,Nicholson JR,Corradini L,Smith MT

更新日期：2020-09-05 00:00:00

abstract：:Hypertension leads to electrophysiological changes in the heart. Chronic exercise induced by a treadmill-running programme (TRP) is considered a potential non-pharmacological treatment for hypertension and may have implications in heart remodelling. However, it is not known whether the TRP is able to improve the elect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Roman-Campos D,Carneiro-Júnior MA,Prímola-Gomes TN,Silva KA,Quintão-Júnior JF,Gondim AN,Duarte HL,Cruz JS,Natali AJ

更新日期：2012-02-01 00:00:00

abstract：:Cerebral blood flow (CBF) and cerebral O2 metabolism (CMRO2) changes were measured in these studies during treatment with three reputed cerebral vasodilators: bradykinin, adenosine triphosphate (ATP) and increased arterial PCO2. Intracerebrovascular bradykinin infusions increased CMRO2 and CBF to a similar degree. Int...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hoffman WE,Miletich DJ,Volkman PH,Albrecht RF

更新日期：1983-03-01 00:00:00

abstract：:1. Left ventricular (LV) hypertrophy has been implicated in the reduction of baroreflex sensitivity present in hypertension. The aim of the current study was to investigate the mean arterial pressure-heart rate reflex (MAP-HR) in a model which induced left ventricular hypertrophy but no sustained blood pressure elevat...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kingwell BA,Krause L,Julius S

更新日期：1994-01-01 00:00:00

abstract：:1. Ventilatory measurements and functional residual capacity (FRC) were recorded from anaesthetized rats and ferrets using a whole body plethysmograph. Simulation of aspects of human chronic obstructive airways disease (COAD) was attempted by making animals acutely hypoxic or hypoxic and hypercapnic by causing them to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Austin CA,Wach RA,Bee D,Finlay M,Emery CJ,Suggett AJ,Barer GR

更新日期：1987-11-01 00:00:00

abstract：:1. The effect of cicletanine, a novel antihypertensive agent with natriuretic activity, on blood pressure and progression of renal failure of 5/6 nephrectomized spontaneously hypertensive rats with salt loading was examined. 2. All nephrectomized rats were randomly assigned to one of four groups and their diet was cha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nakamoto H,Suzuki H,Ohishi A,Katsumata H,Sakaguchi H,Saruta T

更新日期：1999-03-01 00:00:00

abstract：:1. The effects of endogenous and exogenous acetylcholine (ACh) on nitrergic relaxations elicited by electrical field stimulation (EFS) were studied in guinea-pig endothelium-denuded basilar artery preparations precontracted with 1 mumol/L prostaglandin F2 alpha and a possible role of K+ channels in mediating the effec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang F,Li CG,Rand MJ

更新日期：1999-04-01 00:00:00

abstract：:1. In order to explore the mechanisms responsible for the hypernoradrenergic innervation of the vasculature in the spontaneously hypertensive rat (SHR) the tissue content of nerve growth factor messenger ribonucleic acid (NGFmRNA) was examined. 2. The concentration of NGFmRNA was markedly elevated in mesenteric veins ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Falckh PH,Harkin LA,Head RJ

更新日期：1992-08-01 00:00:00

abstract：:1. It is well documented that cisplatin (CDDP) treatment increases the expression of adenosine A(1) receptors in both kidney and testes. However, the effect of adenosine at these receptors is controversial. Adenosine A(1) receptors have been documented to be involved in either cytoprotection or aggravation of nephroto...

journal_title：Clinical and experimental pharmacology & physiology

authors： Saad SY,Najjar TA,Alashari M

更新日期：2004-12-01 00:00:00

abstract：:1. Measurements were made on blood pH, PCO2 and PO2 in mice after a single injection and following five weeks continuous clonidine hydrochloride treatment. 2. A single injection of clonidine hydrochloride exerts no effect on blood pH, PCO2 and PO2 but five weeks of continuous clonidine hydrochloride treatment lowers t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gan EK,Abdul Sattar MZ

更新日期：1982-11-01 00:00:00

abstract：:The intrarenal renin-angiotensin system (RAS) plays a critical role in the pathogenesis and progression of hypertension and kidney disease. In angiotensin (Ang) II-dependent hypertension, collecting duct renin synthesis and secretion are stimulated despite suppression of juxtaglomerular (JG) renin. This effect is medi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gonzalez AA,Prieto MC

更新日期：2015-01-01 00:00:00

abstract：:Melanoma is an aggressive skin malignancy with a high mortality. Astrocyte elevated gene-1 (AEG-1), a downstream target of Ras and c-Myc, has been implicated in the development of multiple tumours, but its role in melanoma remains unclear. In the present study, the role of AEG-1 in melanoma was explored through AEG-1 ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Y,Peng G,Wang Y,Cui L,Wu W,Wang L,Liu C,Han X

更新日期：2017-07-01 00:00:00

abstract：:Contrast media are considered to cause acute kidney injury by activating various factors that induce renal vasoconstriction. We analysed the renal microvascular haemodynamic response using the Doppler flow wire method. Then changes in urinary liver-type fatty acid-binding protein levels following contrast medium admin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kurihara O,Seino Y,Shibata Y,Matsushita M,Komiyama H,Kato K,Murakami D,Munakata R,Takano M,Miyauchi Y,Hata N,Shimizu W

更新日期：2016-11-01 00:00:00

abstract：:1. This study aimed to characterize the effect of nicorandil (NC) on myocardial stunning and the role of ATP-sensitive K+ (KATP) channel opening property in its cardioprotective action. 2. In open-chest anaesthetized rabbits, myocardial stunning was induced by 10 min of coronary occlusion followed by 30 min of reperfu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iwamoto T,Miura T,Urabe K,Itoya M,Shimamoto K,Iimura O

更新日期：1993-09-01 00:00:00

abstract：:1. The neuronal release of acetylcholine (ACh) and its autoregulation by neuromodulators, substance P (SP) and methionine enkephalin (MEK), have been studied using superfused rodent cerebral slices. Nicotine exerts significant effects on autoregulation of ACh release, which may have toxicological implications. 2. Posi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sastry BV

更新日期：1995-04-01 00:00:00

abstract：:Pathogenic inflammation mediated by overactive type 1 helper T cell (Th1) responses could exacerbate and perpetuate Crohn's disease. Programmed death (PD)-1 and its ligand PD-L1 pathway could be upregulated to suppress inflammation. We wondered why this pathway is ineffective at suppressing pathogenic Th1 inflammation...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ma F,Zhao M,Song Z,Wang Z

更新日期：2019-09-01 00:00:00

abstract：:1. After a severe burn, a marked decrease in myocardial blood flow results in ischaemic and hypoxic injury, which subsequently leads to apoptosis or necrosis. Phosphatidylinositol 3-kinase (PI3-K)/Akt is an important intracellular signal transduction molecule that regulates cell proliferation, differentiation, glucose...

journal_title：Clinical and experimental pharmacology & physiology

authors： Song HP,Zhang L,Dang YM,Yan H,Chu ZG,Huang YS

更新日期：2010-05-01 00:00:00

abstract：:Pharmacological cardiac organ protection during cardiopulmonary bypass presents an opportunity for improvement. A number of different strategies have been established to minimize ischemia/reperfusion-induced damage to the heart. Among these, cardioplegia with histidine-tryptophan-ketoglutarate solution and hypothermia...

journal_title：Clinical and experimental pharmacology & physiology

authors： Salameh A,Halling M,Seidel T,Dhein S

更新日期：2015-12-01 00:00:00

abstract：:1. Hypoxia arises in solid tumour because of inefficient blood supply. While hypoxic cells are resistant to radiotherapy and probably to many chemotherapeutic drugs they can, in principle, be turned to advantage through the development of hypoxia-activated cytotoxic drugs (bioreductive drugs). 2. Three general approac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wilson WR,Pruijn FB

更新日期：1995-11-01 00:00:00

abstract：:1. Epidemiological evidence indicates that low birthweight increases the risk of a number of adult-onset diseases. It is now apparent that many babies with a low birthweight may have been subjected to a combination of reduced growth rates in utero as well as preterm birth. However, the long-term effects of preterm bir...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cock ML,Camm EJ,Louey S,Joyce BJ,Harding R

更新日期：2001-11-01 00:00:00

abstract：:The effect of indomethacin suppositories on both acute urinary colic and urinary calculus, resistant or refractory to conventional therapy with analgesics and spasmolytics was investigated. Fifty-five patients with acute urinary colic refractory to treatment with repeated injections of antispasmodics and analgesics ha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Al-Waili NS

更新日期：1986-03-01 00:00:00

abstract：:1. The chronotropic and inotropic effects of the anti-anginal agent SG-75 (2-nicotinamidoethyl nitrate) and 1-verapamil were investigated in isolated blood-perfused canine atrial preparations. The compounds were administered via the cannulated sinus node artery. 2. SG-75 induced a selective negative inotropic as oppos...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chiba S,Furukawa Y,Kobayashi M

更新日期：1980-03-01 00:00:00

abstract：:1. In an isolated right atrial preparation, an increase in right atrial pressure (RAP) produces an increase in atrial rate. This rate response is larger and occurs faster when there is background vagal or muscarinic stimulation. 2. We hypothesized that in the latter situation, an increase in RAP antagonizes the effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Han S,Wilson SJ,Bolter CP

更新日期：2010-09-01 00:00:00

abstract：:1. Landrace swine were identified as malignant hyperpyrexia susceptible (MHS) or control by the contracture responses of gracilis muscle fibre bundles to 3% halothane, 2 mmol/l caffeine and 80 mmol/l KCl. The effects of calmodulin-antagonist drugs on the contractile behaviour of control and MHS preparations were inves...

journal_title：Clinical and experimental pharmacology & physiology

authors： Collins SP,White MD,Denborough MA

更新日期：1988-06-01 00:00:00

abstract：:1. There is controversy regarding plasma catecholamine levels in patients with hypertrophic cardiomyopathy (HCM) and few data exist on serial plasma catecholamine measurements during exercise. The present study determined whether cardiovascular and plasma catecholamine responses to exercise were altered in patients wi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Omodani H,Kinugawa T,Ogino K,Furuse Y,Yamaguchi M,Mori M,Endo A,Kato M,Kato T,Osaki S,Miyakoda H,Igawa O,Hisatome I,Shigemasa C

更新日期：1998-12-01 00:00:00

abstract：:1. This study investigated the effect of progesterone, which, under certain circumstances, can antagonize both the mineralocorticoid and glucocorticoid activities of steroid hormones, on the development and maintenance of adrenocorticotrophic hormone (ACTH)-induced hypertension in conscious sheep. 2. Progesterone (500...

journal_title：Clinical and experimental pharmacology & physiology

authors： Spence CD,Reid AF,Coghlan JP,Mills EH,Whitworth JA,Scoggins BA

更新日期：1989-08-01 00:00:00