The effects of indomethacin in treated hypertensive patients.

Abstract:

:1. Twelve treated hypertensive patients (ages 58-71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period. 2. Blood pressure was increased in all patients throughout the indomethacin treatment period (P less than 0.001)--average mean blood pressure increases were 9 mmHg (casual), 8 mmHg (supine), 10 mmHg (standing). 3. The blood pressure increase during indomethacin treatment was independent of the particular antihypertensive regimen in use. 4. Plasma aldosterone concentration was reduced by 50% (P less than 0.01), plasma renin activity was reduced by 43% (P = 0.102) and plasma urea concentration was increased by 17% (P less than 0.001) during indomethacin treatment. 5. The findings confirm that indomethacin impairs the blood pressure lowering effect of antihypertensive regimens.

authors

Wing LM,Bune AJ,Chalmers JP,Graham JR,West MJ

doi

10.1111/j.1440-1681.1981.tb00763.x

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

537-41

issue

5

eissn

0305-1870

issn

1440-1681

journal_volume

8

pub_type

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