Isolation of opiate receptor ligands in coffee.


:1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor-active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD-2, flash chromatography and gel permeation chromatography. 3. Examination of the final concentrate by GC-MS showed the presence of a number of isomeric (iso)feruloylquinic acid lactones. 4. It is suggested that the synthesis and biological testing of each quinide isomer will establish which is responsible for the opiate receptor activity of instant coffee.


Wynne KN,Familari M,Boublik JH,Drummer OH,Rae ID,Funder JW




Has Abstract


1987-10-01 00:00:00












  • The inhibitory response of the rabbit anococcygeus muscle.

    abstract::1. Strips of rabbit anococcygeus muscle were submaximally contracted by the addition of phenylephrine to the bath fluid. 2. Acetylcholine, dimethylphenylpiperazinium and electrical field stimulation caused relaxation. Relaxation induced by acetylcholine and field stimulation was blocked by tetrodotoxin but only the ac...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wai SS,Coupar IM

    更新日期:1976-03-01 00:00:00

  • Physiological role of large, Ca2+-activated K+ channels in human glomerular mesangial cells.

    abstract::1. Contraction assays and patch clamp methods were used to determine the role of K+ channels in the regulation of contractile tone of human mesangial cells (MC) in culture. 2. MC contraction was induced by vasoconstrictor agents, such as angiotensin II (AngII; 100 nmol/L) and glybenclamide (Glyb), but not by iberiotox...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Sansom SC,Stockand JD

    更新日期:1996-01-01 00:00:00

  • Resistance of sympathetic cardiac nerve function in the pithed rat to prejunctional effects of angiotensin II.

    abstract::1. The spinal sympathetic outflow (C7-T2) of pithed male Wistar rats was electrically stimulated (30-50 V, 0.5 ms, 0.1-1.0 Hz) and heart rate and arterial blood pressure were recorded. D-Tubocurarine (1 mg/kg) and atropine (1 mg/kg) were administered intravenously (i.v.) to reduce voluntary and parasympathetic nerve a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Rechtman MP,King RG,Boura AL

    更新日期:1988-12-01 00:00:00

  • Mechanisms of myocardial protection by amino acids: facts and hypotheses.

    abstract::1. Positive inotropic effect of taurine and improvement of cardiac performance of failing heart are mediated through the modulation of Ca2+ movement through the sarcolemma. 2. Cardioprotection with glutamate and aspartate is related to enhanced anaerobic energy formation in mitochondria coupled with succinate formatio...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Pisarenko OI

    更新日期:1996-08-01 00:00:00

  • Relative inhibitory potency and plasma drug levels of angiotensin converting enzyme inhibitors in the rat.

    abstract::1. 125I-351A, a tyrosyl derivative of the angiotensin converting enzyme (ACE) inhibitor lisinopril, was used as a radioligand, and radioinhibitor binding and displacement assays have been established. 2. The in vitro potency of a range of ACE inhibitors against rat ACE was determined using the radioinhibitor binding d...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Johnston CI,Cubela R,Jackson B

    更新日期:1988-02-01 00:00:00

  • Histone modifications and skeletal muscle metabolic gene expression.

    abstract::1. Skeletal muscle oxidative function and metabolic gene expression are co-ordinately downregulated in metabolic diseases such as insulin resistance, obesity and Type 2 diabetes. Altering skeletal muscle metabolic gene expression to favour enhanced energy expenditure is considered a potential therapy to combat these d...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: McGee SL,Hargreaves M

    更新日期:2010-03-01 00:00:00

  • Enhancement by L-dopa of the renal action of aldosterone in the rat.

    abstract::1. The administration of aldosterone to adrenalectomized rats produces an increase in K+ and decrease in Na+ excretion in the urine. The relationship of the post-aldosterone to the pre-aldosterone urinary sodium and potassium excretion is termed the renal response to aldosterone. 2. The administration of L-dopa enhanc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Adam WR

    更新日期:1979-01-01 00:00:00

  • The action of aspirin on plasma kininogen and other plasma proteins in rheumatoid patients: relationship to disease activity.

    abstract::1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their plasma kininogen level, 9.2 +/- 0.7 microgram bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 +/- 0.5 microgram/ml). 2. When the rheumatoid pati...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章


    authors: Sharma JN,Zeitlin IJ,Brooks PM,Buchanan WW,Dick WC

    更新日期:1980-07-01 00:00:00

  • Spontaneous and agonist-induced contractions and endothelium-dependent relaxation in aortae from SHRSP and WKY rats under various levels of passive force.

    abstract::1. The influence of the passive force on the contraction and endothelium-dependent relaxation in aortae of normotensive Wistar Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) were compared. 2. Force changes of endothelium-intact and -removed preparations were measured isometrically by a force...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Sekiguchi F,Adachi T,Matsubara H,Matsuda K,Kita K,Shimamura K,Sunano S

    更新日期:1996-06-01 00:00:00

  • Piretanide and urinary excretion of ions in rat. Effect of indomethacin.

    abstract::1. Piretanide is a new loop diuretic resembling furosemide. The effects of this diuretic on various parameters of renal function and on the excretion of the major ions were studied on anaesthetized, hydrated rats. 2. Piretanide induced a marked diuresis and increased sodium, potassium, chloride and calcium excretion. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nguyen-Simonnet H,Gauthier C,Pellet M

    更新日期:1981-07-01 00:00:00

  • Concentration of guanidines in normal human plasma.

    abstract::1. The concentration of methylguanidine and guanidinosuccinic acid has been measured in normal human plasma and discrepancies between various published methods for measuring methylguanidine have been resolved. Previous methods have been modified to allow these guanidines, together with guanidinoacetic acid and creatin...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lazdins I,Dawborn JK

    更新日期:1978-01-01 00:00:00

  • Dual nitric oxide mechanisms of cholestasis-induced bradycardia in the rat.

    abstract::1. Cholestatic liver disease is associated with nitric oxide (NO) overproduction and bradycardia. Nitric oxide has a dual effect on sinoatrial node and its effects depend on its concentration. Nitric oxide can increase heart rate by activating hyperpolarization-activated pacemaker current (If) but, at high concentrati...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Mani AR,Nahavandi A,Moosavi M,Safarinejad R,Dehpour AR

    更新日期:2002-10-01 00:00:00

  • Functional interaction between DPI 201-106, a drug that mimics congenital long QT syndrome, and sevoflurane on the guinea-pig cardiac action potential.

    abstract::1. Sevoflurane produces QT prolongation on the electrocardiogram, predominantly via inhibition of the slow delayed rectifier K(+) current. DPI 201-106 is an experimental drug that produces QT prolongation by reducing Na(+) channel inactivation, thereby mimicking congenital long QT syndrome type 3 (LQT3). The present s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kang J,Chen XL,Reynolds WP,Rampe D

    更新日期:2007-12-01 00:00:00

  • Propofol block of cardiac sodium currents in rat isolated myocardial cells is increased at depolarized resting potentials.

    abstract::1. The effect of propofol on cardiac whole-cell sodium currents and single sodium channels in rat isolated ventricular myocytes was examined using patch-clamp techniques. 2. Propofol caused a block of the whole-cell sodium current, the potency of block depending on the holding potential. When cells were held at -90 mV...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Saint DA,Tang Y

    更新日期:1998-05-01 00:00:00

  • Deleterious effects of salt intake other than effects on blood pressure.

    abstract::1. Salt intake is not only known to play an important role in determining blood pressure (BP) but has been shown to have other deleterious effects independent of BP. 2. Epidemiological and animal studies have provided evidence that salt intake may have an adverse effect on stroke mortality independent of BP. 3. Signif...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Antonios TF,MacGregor GA

    更新日期:1995-03-01 00:00:00

  • Subacute pyridostigmine exposure increases heart rate recovery and cardiac parasympathetic tone in rats.

    abstract::Heart rate recovery (HRR) describes the rapid deceleration of heart rate after strenuous exercise and is an indicator of parasympathetic tone. A reduction in parasympathetic tone occurs in patients with congestive heart failure, resulting in prolonged HRR. Acetylcholinesterase inhibitors, such as pyridostigmine, can e...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Bharadwaj M,Pope C,Davis M,Katz S,Cook C,Maxwell L

    更新日期:2017-08-01 00:00:00

  • Beneficial effect of T-1095, a selective inhibitor of renal Na+-glucose cotransporters, on metabolic index and insulin secretion in spontaneously diabetic GK rats.

    abstract::1. To investigate the pharmacological effects of T-1095, this novel derivative of phlorizin was administered to GK rats for 8 weeks. T-1095 treatment significantly lowered plasma glucose and glycosylated haemoglobin (HbA1c) levels, but did not significantly affect bodyweight. 2. T-1095 treatment did not affect 3.3 mmo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nunoi K,Yasuda K,Adachi T,Okamoto Y,Shihara N,Uno M,Tamon A,Suzuki N,Oku A,Tsuda K

    更新日期:2002-05-01 00:00:00

  • Nephropreventing effect of hypoxia-inducible factor 1α in a rat model of ischaemic/reperfusion acute kidney injury.

    abstract::Acute kidney injury (AKI) occurs in 5% of hospitalized patients and in 50% of sepsis patients with acute renal dysfunction. However, there have been no safe and effective therapeutic strategies. The hypoxia condition is closely related to renal injury and function under AKI. As hypoxia-inducible factor 1α (HIF-1α) is ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang H,Liu N,Li R,Tian J,Hu W,Zhang J

    更新日期:2018-10-01 00:00:00

  • Lack of effect of age on the cardiovascular response to neuropeptide Y injection in the rat nucleus tractus solitarius.

    abstract::1. Neuropeptide Y (NPY) is colocalized with catecholamines in central regions involved in blood pressure regulation and exerts depressor responses in the nucleus tractus solitarius (NTS). Ageing is accompanied by a decline in baroreflex function and a reduction in NPY concentrations in some brain areas. The present st...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Morris MJ,Pavia JM

    更新日期:1997-02-01 00:00:00

  • Central choline suppresses plasma renin response to graded haemorrhage in rats.

    abstract::Central administration of choline increases blood pressure in normotensive and hypotensive states by increasing plasma concentrations of vasopressin and catecholamines. We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body. Plasma renin activity (PRA)...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Isbil-Buyukcoskun N,Ilcol YO,Cansev M,Hamurtekin E,Ozluk K,Ulus IH

    更新日期:2008-09-01 00:00:00

  • The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors.

    abstract::The pharmacological actions of 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP), a putative presynaptic GABA(B) receptor modulator, were examined in electrically stimulated rat neocortical brain slices preloaded with [3H]-GABA or [3H]-glutamic acid. At 10 mmol/L, BSPP inhibited the release of [3H]-GAB...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Parker DA,Marino V,Ong J,Puspawati NM,Prager RH

    更新日期:2008-09-01 00:00:00

  • Efficacy of Sargassum polycystum (Phaeophyceae) sulphated polysaccharide against paracetamol-induced DNA fragmentation and modulation of membrane-bound phosphatases during toxic hepatitis.

    abstract::1. The aim of the present study was to assess the protective effect of Sargassum polycystum (sulphated polysaccharide) extract against paracetamol-induced DNA strand breaks and modulation of membrane-bound phosphatases, protein thiols and inorganic cations during toxic hepatitis. 2. Seaweed extract (200 mg/kg per day ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Raghavendran HB,Sathivel A,Yogeeta RS,Devaki T

    更新日期:2007-03-01 00:00:00

  • Comparison of digoxin versus low-dose amiodarone for ventricular rate control in patients with chronic atrial fibrillation.

    abstract::1. Rapid ventricular rate (VR) and rhythm irregularity during atrial fibrillation (AF) impair cardiac performance. Although digoxin has been widely used in patients with AF, its efficacy for the control of VR and rhythm irregularity is unsatisfactory. Whether low-dose amiodarone is more effective remains unclear. 2. W...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tse HF,Lam YM,Lau CP,Cheung BM,Kumana CR

    更新日期:2001-05-01 00:00:00

  • Sequential activation of the reactive oxygen species/angiotensinogen/renin-angiotensin system axis in renal injury of type 2 diabetic rats.

    abstract::1. The present study was performed to test the hypothesis that the reactive oxygen species (ROS)-angiotensinogen (AGT)-renin angiotensin system (RAS) axis is sequentially activated in the development of diabetic nephropathy in Zucker diabetic fatty (ZDF) obese rats. 2. Genetic pairs of male ZDF obese and control ZDF l...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Miyata K,Ohashi N,Suzaki Y,Katsurada A,Kobori H

    更新日期:2008-08-01 00:00:00

  • The hepatic transport of taurocholic acid in the rat: development of a mathematical model.

    abstract::1. The transport of taurocholic acid from portal blood to bile was studied in the anaesthetized rat by injecting a radiolabelled pulse of bile acid. 2. The transport process was very rapid, 50% of the dose being secreted within 5 min, and the total dose within 15 min. 3. The transport process had a large capacity. The...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Iser JH,Packer JS,Smallwood RA,Hoffman NE

    更新日期:1976-01-01 00:00:00

  • Characterization of lymphocyte beta 2-adrenoceptor signalling in patients with left ventricular volume overload disease.

    abstract::1. Studies using animal experimental models have suggested that the beta2-adrenoceptor is uncoupled in association with alterations in the expression of G-protein-coupled receptor kinases (GRK) 2/3 in heart failure. However, the functional expression of the components of this pathway in human disease has not been full...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Dzimiri N,Basco C,Moorji A,Afrane B,Al-Halees Z

    更新日期:2002-03-01 00:00:00

  • Cyp2c19 genotype and omeprazole hydroxylation phenotype in Chinese Li population.

    abstract::1. CYP2C19 is a polymorphism of cytochrome P450, which is responsible for the metabolism of many drugs. The genetic polymorphism shows interethnic variation and it has been demonstrated that the frequency of poor metabolizers (PM) and the distribution of alleles of CYP2C19 vary among Chinese ethnic nationalities. The ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang JH,Li PQ,Fu QY,Li QX,Cai WW

    更新日期:2007-05-01 00:00:00

  • Female, but not male, mice show delayed cutaneous wound healing following aspirin administration.

    abstract::Cyclo-oxygenase (COX) is an enzyme that participates in the wound healing process. Aspirin, a non-steroidal anti-inflammatory drug, simultaneously inhibits the aromatase activity of COX-1 and COX-2 isoforms, which is needed for prostaglandin synthesis. The aim of the present study was to determine whether aspirin, and...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: dos Santos JS,Monte-Alto-Costa A

    更新日期:2013-02-01 00:00:00

  • Integrative role of the lamina terminalis in the regulation of cardiovascular and body fluid homeostasis.

    abstract::1. Cardiovascular and body fluid homeostasis depends upon the activation and co-ordination of reflexes and behavioural responses. In order to accomplish this, the brain receives and processes both neural and chemical input. Once in the brain, information from sources signalling the status of the cardiovascular system ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Johnson AK,Cunningham JT,Thunhorst RL

    更新日期:1996-02-01 00:00:00

  • Mechanisms mediating propofol protection of pulmonary epithelial cells against lipopolysaccharide-induced cell death.

    abstract::Propofol (2,6-diisopropylphenol) is an anaesthetic agent with anti-oxidant properties. The aim of the present study was to determine whether propofol can protect pulmonary epithelial (A549) cells against lipopolysaccharide (LPS)-induced cell death and, if so, the mechanisms involved. The effects of LPS alone and in co...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gu X,Lu Y,Chen J,He H,Li P,Yang T,Li L,Liu G,Chen Y,Zhang L

    更新日期:2012-05-01 00:00:00