Isolation of opiate receptor ligands in coffee.

abstract：:The chemosensitive cardiac vagal and sympathetic afferent reflexes are implicated in driving pathophysiological changes in sympathetic nerve activity (SNA) in cardiovascular disease states. This study investigated the impact of sex and ovarian hormones on the chemosensitive cardiac afferent reflex. Experiments were pe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pinkham MI,Barrett CJ

更新日期：2015-06-01 00:00:00

abstract：:1. We have tested the effects of 2 month oral treatment with the KATP opener, nitric oxide (NO) donor and anti-oxidant molecule nicorandil (0.1 mg/kg per day) on major physiological parameters and heart function of 4-, 12- and 24-month-old rats. 2. Several methods were used: (i) measurement of blood pressure using a n...

journal_title：Clinical and experimental pharmacology & physiology

authors： Garnier-Raveaud S,Faury G,Mazenot C,Cand F,Godin-Ribuot D,Verdetti J

更新日期：2002-05-01 00:00:00

abstract：:1. Ventilatory measurements and functional residual capacity (FRC) were recorded from anaesthetized rats and ferrets using a whole body plethysmograph. Simulation of aspects of human chronic obstructive airways disease (COAD) was attempted by making animals acutely hypoxic or hypoxic and hypercapnic by causing them to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Austin CA,Wach RA,Bee D,Finlay M,Emery CJ,Suggett AJ,Barer GR

更新日期：1987-11-01 00:00:00

abstract：:1. The role of the arterial and cardiac baroreceptors on the arginine vasopressin (AVP) and plasma renin activity (PRA) responses to haemorrhage was studied in conscious rabbits. They were bled at a rate of approximately 3% of their blood volume (BV)/min, both when the autonomic nervous system (ANS) was intact and dur...

journal_title：Clinical and experimental pharmacology & physiology

authors： Courneya CA,Korner PI,Oliver JR,Woods RL

更新日期：1992-11-01 00:00:00

abstract：:1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their plasma kininogen level, 9.2 +/- 0.7 microgram bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 +/- 0.5 microgram/ml). 2. When the rheumatoid pati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sharma JN,Zeitlin IJ,Brooks PM,Buchanan WW,Dick WC

更新日期：1980-07-01 00:00:00

abstract：:1. It is well documented that cisplatin (CDDP) treatment increases the expression of adenosine A(1) receptors in both kidney and testes. However, the effect of adenosine at these receptors is controversial. Adenosine A(1) receptors have been documented to be involved in either cytoprotection or aggravation of nephroto...

journal_title：Clinical and experimental pharmacology & physiology

authors： Saad SY,Najjar TA,Alashari M

更新日期：2004-12-01 00:00:00

abstract：:1. To characterize the anti-arrhythmic properties of a new calcium antagonist, monatepil [corrected], AJ-2615, the preventive effects of AJ-2615 were compared with those of the existing calcium antagonists, diltiazem and verapamil, in experimental models of arrhythmia. 2. AJ-2615 (0.1-3.0 mg/kg, i.v.) suppressed ventr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yamamoto T,Hosoki K,Karasawa T

更新日期：1993-07-01 00:00:00

abstract：:1. In order to explore the mechanisms responsible for the hypernoradrenergic innervation of the vasculature in the spontaneously hypertensive rat (SHR) the tissue content of nerve growth factor messenger ribonucleic acid (NGFmRNA) was examined. 2. The concentration of NGFmRNA was markedly elevated in mesenteric veins ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Falckh PH,Harkin LA,Head RJ

更新日期：1992-08-01 00:00:00

abstract：:1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in healthy patients undergoing third molar dental extraction. P...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reith D,Medlicott NJ,Kumara De Silva R,Yang L,Hickling J,Zacharias M

更新日期：2009-01-01 00:00:00

abstract：:Pharmacological cardiac organ protection during cardiopulmonary bypass presents an opportunity for improvement. A number of different strategies have been established to minimize ischemia/reperfusion-induced damage to the heart. Among these, cardioplegia with histidine-tryptophan-ketoglutarate solution and hypothermia...

journal_title：Clinical and experimental pharmacology & physiology

authors： Salameh A,Halling M,Seidel T,Dhein S

更新日期：2015-12-01 00:00:00

abstract：:1. Positive inotropic effect of taurine and improvement of cardiac performance of failing heart are mediated through the modulation of Ca2+ movement through the sarcolemma. 2. Cardioprotection with glutamate and aspartate is related to enhanced anaerobic energy formation in mitochondria coupled with succinate formatio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pisarenko OI

更新日期：1996-08-01 00:00:00

abstract：:Cardiac output and rhythm depend on the release and the take-up of calcium from the sarcoplasmic reticulum (SR). Excessive diastolic calcium leak from the SR due to dysfunctional calcium release channels (RyR2) contributes to the formation of delayed after-depolarizations, which underlie the fatal arrhythmias that occ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Walweel K,Oo YW,Laver DR

更新日期：2017-01-01 00:00:00

abstract：:1. It has been demonstrated that blood pressure variability (BPV) is increased in hypertension and related to organ damage. It will be important to lower BPV in the treatment of hypertension. The present study was designed to investigate the effect of ketanserin, a 5-HT2A receptor antagonist with a weak alpha1-adrenoc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Miao CY,Xie HH,Yu H,Chu ZX,Su DF

更新日期：2003-03-01 00:00:00

abstract：:1. The effects of taurine on the development of atherosclerotic lesions were investigated in apolipoprotein (apo) E-deficient mice, an animal model with severe hypercholesterolaemia and extensive atherosclerosis. These mice were fed a normal laboratory chow containing 2% taurine for 12 weeks. 2. Serum total cholestero...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kondo Y,Toda Y,Kitajima H,Oda H,Nagate T,Kameo K,Murakami S

更新日期：2001-10-01 00:00:00

abstract：:1. Renin gene expression was investigated in kidneys from 13 foetal and four adult sheep. 2. The levels of renal renin mRNA in foetuses were greater than those in adult sheep (P < 0.001). 3. There was no significant difference in renin mRNA levels between foetuses aged 91 and 134 days (term 150 days). 4. The levels of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang DY,Lumbers ER,Simonetta G

更新日期：1996-08-01 00:00:00

abstract：:Aerobic glycolysis plays a crucial role in cancer progression. Ketamine is often used for cancer pain relief in clinical settings. Moreover, ketamine inhibits proliferation and induces apoptosis in many cancer cell types. However, the anti-tumour mechanism of ketamine is still poorly understood. In the present study, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hu J,Duan W,Liu Y

更新日期：2020-05-01 00:00:00

abstract：:1. Inhibiting the renin-angiotensin-aldosterone system prevents left ventricular (LV) remodelling after myocardial infarction (MI). 2. The present study was designed to assess the effects of a combination of perindopril and losartan on LV remodelling, cardiac function and serum procollagen type III amino terminal pept...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li L,Liu RY,Zhao XY,Zhang JY,Jia M,Lu PQ

更新日期：2009-07-01 00:00:00

abstract：:1. Adult soft-shelled turtles were exposed to hyperosmotic and dehydration stresses. 2. Acute treatment for 0.5, 1 or 2 h with sodium chloride (3.6%, single intramuscular injection, 2 mL volume) caused depletion of pineal serotonin contents followed by elevation of norepinephrine and epinephrine levels. In addition, i...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mahapatra MS,Mahata SK,Maiti B

更新日期：1991-10-01 00:00:00

abstract：:1. The aim of the present study was to investigate the mechanism underlying biochanin A-induced relaxation of the aorta in spontaneously hypertensive rats (SHR). 2. The tension in isolated ring preparations of thoracic aortas from normotensive (Wistar-Kyoto (WKY) rats) and SHR at 5 and 10 weeks of age was measured iso...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang HP,Gao Q,Mei RH,Zhao MH,Lu Y,Li XY,Bruce IC,Xia Q

更新日期：2006-09-01 00:00:00

abstract：:Recently, the roles of gene polymorphisms in poor responsiveness to aspirin were extensively investigated, with conflicting results. Therefore, we performed this meta-analysis to better assess the relationship between candidate genetic variants and poor responsiveness to aspirin. Eligible articles were searched in Pub...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang J,Chen X,Zhou J,Hu S,Tang Y

更新日期：2018-05-21 00:00:00

abstract：:1. Intrarenal oxygen availability is the balance between supply, mainly dependent on renal blood flow, and demand, determined by the basal metabolic demand and the energy-requiring tubular electrolyte transport. Renal blood flow is maintained within close limits in order to sustain stable glomerular filtration, so inc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Palm F,Nordquist L

更新日期：2011-07-01 00:00:00

abstract：:1. Ion gradients across the cell membrane are important for proper cellular communication and homeostasis. With the exception of erythrocytes, chloride (Cl), one of the most important free anions in animal cells, is not distributed at thermodynamic equilibrium across the plasma membrane. The K-Cl cotransporter (COT), ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gagnon KB,Fyffe RE,Adragna NC,Lauf PK

更新日期：2007-07-01 00:00:00

abstract：:The possibility that serotonin (5HT) nerve endings in the dorsomedial medulla oblongata participate in the control of blood pressure was investigated in stroke-prone hypertensive rats and in normotensive rats. 5HT nerves were destroyed by injecting 5,7-dihydroxytryptamine bilaterally into the solitary tract nucleus. I...

journal_title：Clinical and experimental pharmacology & physiology

authors： Howe PR,Rogers PF,King RA,Smith RM

更新日期：1983-05-01 00:00:00

abstract：:The effect of indomethacin suppositories on both acute urinary colic and urinary calculus, resistant or refractory to conventional therapy with analgesics and spasmolytics was investigated. Fifty-five patients with acute urinary colic refractory to treatment with repeated injections of antispasmodics and analgesics ha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Al-Waili NS

更新日期：1986-03-01 00:00:00

abstract：:1. RNA interference in vivo has tremendous potential, both with respect to the elucidation of protein function in animals and as a therapeutic platform in humans. In vitro, short interfering RNA (siRNA) has been shown to completely silence gene expression in mammalian cells at low picomolar concentrations. 2. Although...

journal_title：Clinical and experimental pharmacology & physiology

authors： White PJ

更新日期：2008-11-01 00:00:00

abstract：:1. Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant numbe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Urakami H,Abe Y,Grisham MB

更新日期：2007-09-01 00:00:00

abstract：:Placental growth factor (PlGF) is decreased in early gestation of pregnant women who subsequently develop pre-eclampsia. In this study, pre-emptive treatment with PlGF to prevent pre-eclampsia was evaluated in an in vivo rodent model of experimental pre-eclampsia (EPE) induced by TNF-α and in an in vitro model of huma...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chau K,Bobek G,Xu B,Stait-Gardner T,Price W,Hennessy A,Makris A

更新日期：2020-01-01 00:00:00

abstract：:1. The transport of taurocholic acid from portal blood to bile was studied in the anaesthetized rat by injecting a radiolabelled pulse of bile acid. 2. The transport process was very rapid, 50% of the dose being secreted within 5 min, and the total dose within 15 min. 3. The transport process had a large capacity. The...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iser JH,Packer JS,Smallwood RA,Hoffman NE

更新日期：1976-01-01 00:00:00

abstract：:The effector mechanisms responsible for the bradycardia evoked by bilateral lesions of the brainstem coinciding with the A1 catecholamine cells were analyzed in four groups of rabbits. Sham or lesion operations were carried out in animals with intact cardiac effectors, with cardiac sympathetic block induced by propran...

journal_title：Clinical and experimental pharmacology & physiology

authors： Denoroy L,West MJ,Chalmers J

更新日期：1984-03-01 00:00:00

abstract：:Skeletal muscle is an important site for insulin to regulate blood glucose levels. It is estimated that skeletal muscle is responsible for ~80% of insulin-mediated glucose disposal in the post-prandial period. The classical action of insulin to increase muscle glucose uptake involves insulin binding to insulin recepto...

journal_title：Clinical and experimental pharmacology & physiology

authors： Keske MA,Dwyer RM,Russell RD,Blackwood SJ,Brown AA,Hu D,Premilovac D,Richards SM,Rattigan S

更新日期：2017-01-01 00:00:00