The association between serum albumin/prealbumin level and disease severity in non-CF bronchiectasis.

abstract：:1. It is well documented that cisplatin (CDDP) treatment increases the expression of adenosine A(1) receptors in both kidney and testes. However, the effect of adenosine at these receptors is controversial. Adenosine A(1) receptors have been documented to be involved in either cytoprotection or aggravation of nephroto...

journal_title：Clinical and experimental pharmacology & physiology

authors： Saad SY,Najjar TA,Alashari M

更新日期：2004-12-01 00:00:00

abstract：:The resistance of breast cancer cells to drugs is a major obstacle to effective cancer chemotherapy. Here, we study the function mechanisms of long non-coding RNA XIST in chemoresistance of breast cancer to doxorubicin. We examined the 50% inhibitive concentration of doxorubicin to MDA-MB-231 and MDA-MB-231/ADM cells,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang M,Wang F,Xiang Z,Huang T,Zhou WB

更新日期：2020-08-01 00:00:00

abstract：:1. This study was designed to test the haemodynamic and renal effects in sheep of dihydrocyclosporin D (dCyD), an immunosuppressant agent derived from the fungus Tolypocladium inflatum Gams. 2. dCyD was infused for 5 days at 12 mg/kg per day. Mean arterial pressure (MAP) was elevated after 24 h, but thereafter returne...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tresham JJ,Whitworth JA,de Lima JJ,McDougall JG,Scoggins BA

更新日期：1988-05-01 00:00:00

abstract：:1. The present study evaluated changes in autonomic control of the cardiovascular system in conscious rats following blockade of endothelin (ET) receptors with bosentan. 2. Rats were treated with bosentan or vehicle (5% gum arabic) for 7 days by gavage. 3. Baseline heart rate (HR) was higher in the bosentan-treated gr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Souza HC,Terzini GC,da Silva VJ,Martins-Pinge MC,Salgado HC,Salgado MC

更新日期：2008-07-01 00:00:00

abstract：:1. Four, six and eight hours after gavage of rats with alpha-mercapto-beta-(2-furan)acrylic acid (MFA) (25 mg/kg) serum zinc concentration was increased ten-fold over control levels and a mean molar ratio of 1 albumin:0-4 zinc:0-8 MFA was found for seventeen sera. 2. At pH 7-5 a maximum of 1 mole of MFA could be bound...

journal_title：Clinical and experimental pharmacology & physiology

authors： Giroux E,Prakash NJ,Schechter PJ

更新日期：1977-01-01 00:00:00

abstract：:Hantaviruses are enveloped negative (-) single-stranded RNA viruses belongs to Hantaviridae family, hosted by small rodents and entering into the human body through inhalation, causing haemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) also known as hantavirus cardiopulmonary syndrom...

journal_title：Clinical and experimental pharmacology & physiology

authors： Munir N,Jahangeer M,Hussain S,Mahmood Z,Ashiq M,Ehsan F,Akram M,Ali Shah SM,Riaz M,Sana A

更新日期：2020-09-07 00:00:00

abstract：:1. The present study was performed to test the hypothesis that the reactive oxygen species (ROS)-angiotensinogen (AGT)-renin angiotensin system (RAS) axis is sequentially activated in the development of diabetic nephropathy in Zucker diabetic fatty (ZDF) obese rats. 2. Genetic pairs of male ZDF obese and control ZDF l...

journal_title：Clinical and experimental pharmacology & physiology

authors： Miyata K,Ohashi N,Suzaki Y,Katsurada A,Kobori H

更新日期：2008-08-01 00:00:00

abstract：:1. Investigations of the role of cAMP in the stimulation of the steroidogenesis of zona glomerulosa (ZG) cells by increased extracellular K+ concentration are reviewed. 2. Possible reasons for discrepancies in the results of different investigators on whether K+ increases the cAMP content or output of ZG tissue or dis...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tait JF,Tait SA

更新日期：1999-12-01 00:00:00

abstract：:1. The effect of bromocriptine (a prolactin suppressant drug) on the serum levels of calcium was studied in the male rat. The drug was administered subcutaneously at a dosage of 100 microgram per 100 g body weight three times per day. 2. Chronic treatment with bromocriptine had no significant effect on the serum calci...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tan CM,Tan GJ

更新日期：1978-09-01 00:00:00

abstract：:1. At any one instant, most receptors are now recognized to be able to stimulate multiple signal transduction pathways in a cell when activated by an appropriate hormone. These different signalling pathways appear to allow for distinct cellular responses, such as cell proliferation, differentiation, and shape change. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Crouch MF,Frew IJ,Simson L,Davy DA

更新日期：1997-08-01 00:00:00

abstract：:Acute kidney injury (AKI) is a rapid loss of kidney function resulting in accumulation of end metabolic products and associated abnormalities in fluid, electrolyte and acid-base homeostasis. The pathophysiology of AKI is complex and multifactorial involving numerous vascular, tubular and inflammatory pathways. Neurohu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hering D,Winklewski PJ

更新日期：2017-02-01 00:00:00

abstract：:The epithelial sodium channel (ENaC) has long been recognized as playing a vital role in blood pressure (BP) regulation due to its involvement in fluid balance. The genes encoding the three ENaC subunits are likewise important contributors to hypertension, both in rare monogenic diseases and in the general population....

journal_title：Clinical and experimental pharmacology & physiology

authors： Büsst CJ

更新日期：2013-08-01 00:00:00

abstract：:1. Hyperhomocysteinaemia (HHcy) is associated with endothelial dysfunction and has been recognized as a risk factor of cardiovascular disease. The present study aimed to investigate the effect of homocysteine (Hcy) on endothelial function in vivo and in vitro, and the underlying signalling pathways. 2. The HHcy animal...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yan TT,Li Q,Zhang XH,Wu WK,Sun J,Li L,Zhang Q,Tan HM

更新日期：2010-11-01 00:00:00

abstract：:This study investigated whether the specific alpha-antagonist, prazosin, stimulated basal plasma renin levels and heart rate. Furthermore the beta-adrenergic nervous system was also investigated to ascertain whether it was involved in this effect. Prazosin (0.1 or 1 mg/kg) was injected subcutaneously (s.c.) to conscio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Atkinson J,Luthi P,Sonnay M,Boillat N

更新日期：1986-07-01 00:00:00

abstract：:1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor-active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD-2, flash chromatography and gel permeation chro...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wynne KN,Familari M,Boublik JH,Drummer OH,Rae ID,Funder JW

更新日期：1987-10-01 00:00:00

abstract：:1. Renomedullary interstitial cells (RMIC), abundant throughout the medulla of the kidney, have been demonstrated to have binding sites for many vasoactive peptides, including atrial natriuretic peptide, endothelin, angiotensin II and bradykinin (BK). These observations would support the hypothesis that interactions b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dean R,Maric C,Aldred GP,Casley D,Zhuo J,Harris P,Alcorn D,Mendelsohn FA

更新日期：1999-01-01 00:00:00

abstract：:The effector mechanisms responsible for the bradycardia evoked by bilateral lesions of the brainstem coinciding with the A1 catecholamine cells were analyzed in four groups of rabbits. Sham or lesion operations were carried out in animals with intact cardiac effectors, with cardiac sympathetic block induced by propran...

journal_title：Clinical and experimental pharmacology & physiology

authors： Denoroy L,West MJ,Chalmers J

更新日期：1984-03-01 00:00:00

abstract：:1. Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2. We studied the possible cross-talk between PAR2 and vanilloid receptor 1 (VR1). The VR1 antagonist capsazepine partially inhibited the PAR2-mediated increase in gastri...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawabata A,Kinoshita M,Kuroda R,Kakehi K

更新日期：2002-04-01 00:00:00

abstract：:1. The effects of dietary sodium on blood pressure and levels of sodium, other electrolytes and noradrenaline (NA) in the cerebrospinal fluid (CSF) and blood of 15 patients with essential hypertension were studied. The CSF and blood sampling was carried out after 7 days of a high salt intake (16-18 g/day) and after 7 ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawano Y,Yoshida K,Kawamura M,Yoshimi H,Ashida T,Abe H,Imanishi M,Kimura G,Kojima S,Kuramochi M

更新日期：1992-04-01 00:00:00

abstract：:1. Rabbits were treated with the antiparasitic drug ivermectin at subcutaneous doses of 0.2, 1 and 2.5 mg/kg and blood collected weekly for 4 weeks thereafter for measuring some blood parameters. At a dose of 0.2 or 1 mg/kg the drug had no significant effect on any of the parameters measured. At a dose of 2.5 mg/kg, t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ali BH

更新日期：1990-10-01 00:00:00

abstract：:1. The aim of the present study was to determine the brain sites mediating aspects of respiratory and cardiovascular control in adult humans using non-invasive functional magnetic resonance (fMRI) procedures, thereby avoiding the spatial and temporal sampling limitations associated with classic neural assessment techn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Harper RM,Gozal D,Bandler R,Spriggs D,Lee J,Alger J

更新日期：1998-06-01 00:00:00

abstract：:Receptors for parathyroid hormone (PTH) in the renal tubule are coupled to adenylate cyclase stimulation. PTH causes a rise in urinary cAMP by leakage from adenylate cyclase stimulation. PTH causes a rise in urinary cAMP by leakage from cells of the proximal convoluted tubule. The effects of alpha-adrenergic agonists ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Woodcock EA,McLeod JK,Johnston CI

更新日期：1984-07-01 00:00:00

abstract：:Lamotrigine (LTG) is one of the most widely used antiepileptic drugs. Confusion still exists in the literature as to the relative influence of age, body weight, and concomitant drug therapy on LTG pharmacokinetics. So, the objective of this study is to evaluate the influence of patient-related factors and comedication...

journal_title：Clinical and experimental pharmacology & physiology

authors： Baldoni AO,Freitas-Lima P,de Santi Ferreira FI,Martinez EZ,Queiroz RH,Sakamoto AC,Alexandre V,Perucca E,Pereira LR

更新日期：2016-07-01 00:00:00

abstract：:1. Although measuring the rate of firing of multi-unit muscle sympathetic nerve activity (MSNA) has provided important information in many aspects of cardiovascular medicine, measuring single-unit vasoconstrictor activity provides a better understanding of the possible mechanisms underlying disturbed sympathetic nervo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lambert E,Dawood T,Schlaich M,Straznicky N,Esler M,Lambert G

更新日期：2008-04-01 00:00:00

abstract：:The distribution and binding characteristics of the radioligand (-)-[125I]-cyanopindolol (CYP) have been examined in slide mounted mouse kidney sections, using the technique of in vitro labelling and autoradiography. (-)-[125I]-CYP binding to sections was of high affinity (KD = 55.8 pmol/l, s.e.m. = 8.1, n = 4) to a s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lew R,Summers RJ

更新日期：1986-03-01 00:00:00

abstract：:1. Congenital long QT syndrome (LQTS) is a genetically heterogeneous disease. The aim of the present study was to identify the gene mutation in a Chinese family with LQTS and investigate the functional changes associated with the mutation. 2. Polymerase chain reaction and DNA sequencing were used to screen for the KCN...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang HT,Sun CF,Cui CC,Xue XL,Zhang AF,Li HB,Wang DQ,Shu J

更新日期：2009-08-01 00:00:00

abstract：:1. The effect of pretreatment with nifedipine on naloxone-stimulated corticotrophin-releasing hormone (CRH)-induced adrenocorticotrophin (ACTH) release in humans was investigated. The mean peak plasma ACTH and cortisol levels and the mean peak change in cortisol levels from basal were significantly lower in the nifedi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hockings GI,Grice JE,Walters MM,Jackson RV

更新日期：1991-05-01 00:00:00

abstract：:1. A method is described which allows the determination of liquid junction potentials between biological fluid samples of less than 1 nL with a reproducibility of 10%. This was achieved by use of a micro-method and the use of 3% agarose added to the electrolyte in the measuring electrodes. 2. Validation was performed ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sugo E,Györy AZ

更新日期：1989-07-01 00:00:00

abstract：:1. Iron overload contributes to the pathogenesis of various diseases and directly induces tissue injury. In the present study, we investigated the relationship between heart and liver injury induced by iron overload and cellular endoplasmic reticulum (ER) stress to explore the molecular mechanism of iron overload-indu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lou LX,Geng B,Chen Y,Yu F,Zhao J,Tang CS

更新日期：2009-07-01 00:00:00

abstract：:1. This study investigated components of blood pressure variability in elderly subjects with isolated systolic hypertension (ISH) using both ambulatory blood pressure monitoring (ABPM) and casual clinic blood pressure measurement. These were then used to determine sample size requirements for clinical trials of differ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Silagy CA,McNeil JJ,McGrath BP

更新日期：1992-05-01 00:00:00