Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle.

abstract：:1. Calcified arteriosclerotic lesions have been recognized early in life as abnormalities in coronary arteries. 2. We examined coronary arterial plaques as an undecalcified tissue and revealed widespread mineralization within the plaque. Non-collagenous proteins that regulate calcification, such as osteopontin, have b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fitzpatrick LA

更新日期：1996-03-01 00:00:00

abstract：:1. The effect of cicletanine, a novel antihypertensive agent with natriuretic activity, on blood pressure and progression of renal failure of 5/6 nephrectomized spontaneously hypertensive rats with salt loading was examined. 2. All nephrectomized rats were randomly assigned to one of four groups and their diet was cha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nakamoto H,Suzuki H,Ohishi A,Katsumata H,Sakaguchi H,Saruta T

更新日期：1999-03-01 00:00:00

abstract：:Preterm birth (PTB) is the single largest cause of death in infants and young children. The rate of PTB is significantly higher in male infants, particularly those that are born very preterm. Here we present evidence to suggest that the decidual renin-angiotensin system may play a role in inhibiting inflammation and m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pringle KG,Zakar T,Lumbers ER

更新日期：2017-05-01 00:00:00

abstract：:1. Econazole is used clinically as an antifungal drug with many different in vitro effects. However, the effects of econazole on prostate cancer cells are unknown. The effects of econazole on intracellular Ca2+ concentrations ([Ca2+]i) in and the proliferation of human PC3 prostate cancer cells was explored in the pre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Huang JK,Liu CS,Chou CT,Liu SI,Hsu SS,Chang HT,Hsieh CH,Chang CH,Chen WC,Jan CR

更新日期：2005-09-01 00:00:00

abstract：:1. Effects of FR139317, an endothelin ETA receptor antagonist, on renal haemodynamic and excretory responses to acute nitric oxide (NO) blockade were examined using anaesthetized rats. 2. Intrarenal arterial infusion of NG-nitro-L-arginine (NOARG), the NO synthase inhibitor, at a rate of 40 micrograms/kg per min, prod...

journal_title：Clinical and experimental pharmacology & physiology

authors： Matsumura Y,Kuro T,Hashimoto N,Taira S

更新日期：1998-06-01 00:00:00

abstract：:1. Angiotensin (Ang) II causes growth-related effects on vascular smooth muscle cells in vitro and in vivo. 2. Chronic infusions of AngII systemically, at doses that are initially subpressor, result in slowly progressive increases in arterial pressure ('slow-pressor' hypertension). It has been suggested that the hyper...

journal_title：Clinical and experimental pharmacology & physiology

authors： Edgley A,Kett M,Anderson W

更新日期：2001-12-01 00:00:00

abstract：:Pathogenic inflammation mediated by overactive type 1 helper T cell (Th1) responses could exacerbate and perpetuate Crohn's disease. Programmed death (PD)-1 and its ligand PD-L1 pathway could be upregulated to suppress inflammation. We wondered why this pathway is ineffective at suppressing pathogenic Th1 inflammation...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ma F,Zhao M,Song Z,Wang Z

更新日期：2019-09-01 00:00:00

abstract：:1. There was no significant difference between the systolic blood pressure (SBP) of offspring derived from SHRSP mother and WKY father and the SBP of offspring derived from WKY mother and SHRSP father at the developing stage (5-13 weeks of age). 2. The degree of genetic determinations of SBP in stroke-prone spontaneou...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ikeda K,Nara Y,Nabica T,Fujimoto A,Endo J,Ishino H,Yamori Y

更新日期：1991-09-01 00:00:00

abstract：:1. Deviation supersensitivity and post-junctional supersensitivity are important determinants in the control of the response of smooth muscle. 2. Post-junctional supersensitivity is a process whereby effector cells have augmented responsiveness as a consequence of an impaired physiological stimulus. Deviation supersen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head RJ

更新日期：1989-06-01 00:00:00

abstract：:Severe drug eruption (SDE), a common skin disease, becomes dangerous when it occurs in patients with human immunodeficiency virus (HIV). However, the molecular mechanisms are poorly understood. Forty patients including HIV+ SDE+ (n = 15), HIV- SDE+ (n = 15) and HIV+ SDE- (n = 10) subjects were enrolled in our study. A...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tang JT,Li YY,Zhang Y,Liu J,Guan W,Wang RR,He LP,Zhang JB,Kuang YQ

更新日期：2020-06-01 00:00:00

abstract：:1. The worldwide epidemic of obesity in adults has been mirrored in children in developed and developing countries. 2. Central obesity appears to be driving a cluster of abnormalities often referred to as the metabolic syndrome. 3. The definition of the metabolic syndrome in children is not suited to arbitrary cut-off...

journal_title：Clinical and experimental pharmacology & physiology

authors： Beilin L,Huang RC

更新日期：2008-04-01 00:00:00

abstract：:1. Measurements were made on blood pH, PCO2 and PO2 in mice after a single injection and following five weeks continuous clonidine hydrochloride treatment. 2. A single injection of clonidine hydrochloride exerts no effect on blood pH, PCO2 and PO2 but five weeks of continuous clonidine hydrochloride treatment lowers t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gan EK,Abdul Sattar MZ

更新日期：1982-11-01 00:00:00

abstract：:1. An antisense oligonucleotide (ASO) is a short strand of deoxyribonucleotide analogue that hybridizes with the complementary mRNA in a sequence-specific manner via Watson-Crick base pairing. Formation of the ASO-mRNA heteroduplex either triggers RNase H activity, leading to mRNA degradation, induces translational ar...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chan JH,Lim S,Wong WS

更新日期：2006-05-01 00:00:00

abstract：:Preeclampsia is a complication affecting pregnant women worldwide, which leads to maternal and fetal morbidity and mortality. In this study, we evaluated the efficacy of ferulic acid (FA) on an Nω -nitro-L-arginine methyl ester hydrochloride (L-NAME) induced rat model of preeclampsia. L-NAME was administered to pregna...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gong W,Wan J,Yuan Q,Man Q,Zhang X

更新日期：2017-10-01 00:00:00

abstract：:1. Stretch-induced muscle injury results in the damage that causes reduced force and increased membrane permeability. This muscle damage is caused, in part, by ionic entry through stretch-activated channels and blocking these channels with Gd3+ or streptomycin reduces the force deficit associated with damage. 2. Dystr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yeung EW,Allen DG

更新日期：2004-08-01 00:00:00

abstract：:This study investigated whether the specific alpha-antagonist, prazosin, stimulated basal plasma renin levels and heart rate. Furthermore the beta-adrenergic nervous system was also investigated to ascertain whether it was involved in this effect. Prazosin (0.1 or 1 mg/kg) was injected subcutaneously (s.c.) to conscio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Atkinson J,Luthi P,Sonnay M,Boillat N

更新日期：1986-07-01 00:00:00

abstract：:1. Elevated plasma lipoprotein (a) (Lp(a)) concentrations have been correlated with an increased risk of premature cardiovascular disease. The plasma Lp(a) concentration is quantitatively heritable and the apolipoprotein (Apo) A gene is known as a major locus-determining Lp(a) concentration. 2. The aim of the present ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Park HY,Nabika T,Notsu Y,Kobayashi S,Masuda J

更新日期：1999-04-01 00:00:00

abstract：:1. There is evidence that different aetiologies of heart failure, especially ischaemic vs dilated cardiomyopathy (ICM and DCM, respectively), may influence the prognosis of patients with this disease. Patients with ICM have a worse prognosis than those with DCM; the mechanisms underlying this difference have not yet b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lee S,Lu R,Müller-Ehmsen J,Schwinger RH,Brixius K

更新日期：2010-12-01 00:00:00

abstract：:1. Na+/H+ exchange, an ethylisopropylamiloride (EIPA)-sensitive Na+ and HCO3- dependent system and a diisothio-cyanatostilbenedisulphonic acid (DIDS)-sensitive Na+ and HCO3- transporter, contribute to sodium influx and intracellular pH (pHi) regulation in vascular smooth muscle. 2. In cultured cells from the human int...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bobik A,Little PJ,Neylon CB

更新日期：1991-02-01 00:00:00

abstract：:1. The left anterior descending coronary artery (LAD) was completely ligated for 90 min (i.e. myocardial ischaemia was produced) in the dog anaesthetized with pentobarbital. 2. Bevantolol, a beta 1-adrenoceptor antagonist, was injected (1 mg/kg, intravenously) 5 min before LAD occlusion. The bevantolol injection decre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Miura I,Nasa Y,Ichihara K,Abiko Y

更新日期：1991-04-01 00:00:00

abstract：:Autophagy promotes cell survival or induces apoptosis in cancer cells. While SIRT1 and AMPK induce autophagy in both normal and cancer cells, Akt and mTOR can inhibit it. Calycosin, a methoxyisoflavone, protects against several types of solid tumours including colorectal cancer. However, the mechanisms behind the anti...

journal_title：Clinical and experimental pharmacology & physiology

authors： El-Kott AF,Al-Kahtani MA,Shati AA

更新日期：2019-10-01 00:00:00

abstract：:1. Sevoflurane produces QT prolongation on the electrocardiogram, predominantly via inhibition of the slow delayed rectifier K(+) current. DPI 201-106 is an experimental drug that produces QT prolongation by reducing Na(+) channel inactivation, thereby mimicking congenital long QT syndrome type 3 (LQT3). The present s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kang J,Chen XL,Reynolds WP,Rampe D

更新日期：2007-12-01 00:00:00

abstract：:1. DOCA and 9 alpha-fludrocortisone were given to mice on a high-sodium diet for periods of up to 20 weeks, resulting in decreases in plasma renin concentration, renal renin concentration and renal renin mRNA with both treatments. 2. Plasma renin concentration was suppressed prior to suppression of renin mRNA and rena...

journal_title：Clinical and experimental pharmacology & physiology

authors： Barrett G,Morgan T,Smith M,Aldred P

更新日期：1989-08-01 00:00:00

abstract：:This in vivo study tested the hypothesis that the modulation of acetylcholine (ACh) release by the M1 muscarinic receptor (mAChR) in the neuromuscular junction of disused muscles may affect the tensions of the muscles during the neuromuscular monitoring of a rocuronium-induced neuromuscular block and compared the resu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kim YB,Yang HS,Kim HJ,Choi HR,In J,Yoon SY,Ro YJ

更新日期：2018-12-01 00:00:00

abstract：:The amino acid sequence of human renin was identified for the first time. This was determined from the nucleotide sequence of exons in the human renin gene identified in a genomic library by recombinant DNA techniques. Examination of amino acid residues involved in the enzymatic hydrolysis by human renin of the unique...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris BJ,Catanzaro DF,Hardman J,Mesterovic N,Tellam J,Hort Y,Bennetts BH,Shine J

更新日期：1984-07-01 00:00:00

abstract：:1. The therapeutic effect of green tea extract (GTE) on the aortic collagen content and its characteristics were investigated in streptozotocin diabetic rats. 2. Diabetes was induced in rats by a single intra peritoneal injection of streptozotocin (60 mg/kg bodyweight). Six weeks after diabetes induction, GTE was admi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Babu PV,Sabitha KE,Shyamaladevi CS

更新日期：2006-04-01 00:00:00

abstract：:1. The aim of the present study was to examine the role of dopaminergic and glutamatergic receptors on different stages of the amphetamine (AMPH) sensitized effect in schedule-induced polydipsia (SIP) in rats. 2. Three experiments were designed to evaluate the roles of DAD2 receptor antagonist haloperidol (HAL) and gl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu YP,Tung CS,Lin PJ,Wan FJ

更新日期：2010-09-01 00:00:00

abstract：:Repaglinide is a short-acting insulin secretagogue, which often results in considerable interindividual variability in therapeutic efficacy when widely used in a clinical setting. Among various reasons under discussion is genetic polymorphism, especially the genes related to insulin secretion and resistance. Recent st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Song JF,Wang T,Zhu J,Zhou XY,Lu Q,Guo H,Zhang F,Wang Y,Li W,Wang DD,Cui YW,Lv DM,Yin XX

更新日期：2015-01-01 00:00:00

abstract：:1. The choice of initial pharmacological therapy is one area where the different hypertension management guidelines vary in recommending either the use of diuretics and beta-blockers as preferred drugs or choosing from any of the five major classes of antihypertensives. 2. Improvement in cardiovascular morbidity and m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tomlinson B

更新日期：1997-12-01 00:00:00

abstract：:1. There is controversy regarding plasma catecholamine levels in patients with hypertrophic cardiomyopathy (HCM) and few data exist on serial plasma catecholamine measurements during exercise. The present study determined whether cardiovascular and plasma catecholamine responses to exercise were altered in patients wi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Omodani H,Kinugawa T,Ogino K,Furuse Y,Yamaguchi M,Mori M,Endo A,Kato M,Kato T,Osaki S,Miyakoda H,Igawa O,Hisatome I,Shigemasa C

更新日期：1998-12-01 00:00:00