Abstract:
:The Authors have studied the effects of somatostatin (SRIF) treatment in an infant affected by hypoglycemia due to nesidioblastosis. During iv infusion with SRIF we observed a marked increase of blood glucose levels; concomitantly insulin secretion was almost completely suppressed. In contrast, during treatment with protamine zinc-somatostatin (PZ-SRIF), a long acting SRIF preparation, the blood glucose levels did not rise and insulin concentrations were inappropriately elevated. Therefore in this case the long term treatment of hypoglycemia due to nesidioblastosis with PZ-somatostatin was unfeasible.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Roti E,Ghinelli C,Bandini P,Del Rossi C,Emanuele R,Robuschi G,Gnudi Adoi
10.1007/BF03350454subject
Has Abstractpub_date
1981-04-01 00:00:00pages
209-12issue
2eissn
0391-4097issn
1720-8386journal_volume
4pub_type
杂志文章abstract::Somatostatin and its derivatives have been predominantly studied and succesfully used in endocrinological diseases. This article reviews the rationale of the use of somatostatin and its derivatives in ophthalmology based on current understanding of its action in the eye and summarizes previously published controlled s...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::The effects of short term administration of 200 MRC U of synthetic salmon calcitonin (sCT) daily on carbohydrate metabolism were investigated in 10 patients with various bone diseases, 3 of whom had type II diabetes mellitus and 3 of whom had impaired glucose tolerance. Blood glucose levels during the nocturnal postab...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350629
更新日期:1985-02-01 00:00:00
abstract::We have measured eye muscle antibodies, in immunoblotting, in the serum from five patients with severe ophthalmopathy associated with Graves' hyperthyroidism who underwent plasmapheresis, correlating their levels with clinical features of the eye disorder and response to treatment. Blood taken before each plasma excha...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348906
更新日期:1993-10-01 00:00:00
abstract:INTRODUCTION:Phosphodiesterase 5 inhibitors (PDE5i) were developed while investigating novel treatments for coronary artery disease, but their andrological side effects shifted their indication toward the management of erectile dysfunction. Although PDE5i are now also indicated for pulmonary arterial hypertension and t...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-015-0339-y
更新日期:2016-02-01 00:00:00
abstract::Recent data seem to suggest that LHRH may be involved in the modulation of PRL secretion. We studied the PRL pattern in 9 males (age range 18-38 yr) with idiopathic hypogonadotropic hypogonadism (IHH) before and during long-term pulsatile LHRH therapy (120-160 ng/kg bw every 120 min sc) in order to evaluate variations...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350751
更新日期:1989-09-01 00:00:00
abstract:PURPOSE:To report the clinical implications of an initial experience with transoral endoscopic thyroidectomy vestibular approach (TOETVA). METHODS:From March to November 2017, five cases of TOETVA were performed. Data reported include patient demographics, indication for surgery, extent of surgery, operative time, the...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-017-0808-6
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine whether the triglycerides and glucose (TyG) index is associated with the presence of metabolically obese normal-weight (MONW) phenotype and related cardiovascular risk factors. METHODS:Apparently healthy men and non-pregnant women aged 20-65 years were enrolled in a popul...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-020-01184-x
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:This study was aimed at assessing the incidence and timing of thyroid nodules recurrence, defined as appearance of new benign or malignant nodules in contralateral lobe in patients with benign thyroid nodules or thyroid microcarcinoma treated with lobo-isthmectomy. Patient's characteristics and risk factors ass...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-018-0946-5
更新日期:2018-12-01 00:00:00
abstract::In a 41-year-old hirsute woman, severe hypercalcemia led to the discovery of hyperparathyroidism related to the involvement (hyperplasia/or adenoma) of the 4 parathyroid glands. Plasma and urinary DHA, plasma DHA-sulfate and delta 5 steroid precursors were elevated. Steroid hormone hypersecretion was stimulated by hCG...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347005
更新日期:1987-12-01 00:00:00
abstract::A 33-year-old female presented in 1966 with striking pigmentation, typical of Addison's disease, and amenorrhea. Endocrine assessment then showed normal basal serum cortisol and urinary hydroxysteroid levels, but serum cortisol did not respond to stimulation with either exogenous ACTH or lysine vasopressin. Steroid re...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349957
更新日期:1989-03-01 00:00:00
abstract::Measurement of serum Tg using ultrasensitive assays is proposed to replace TSH-stimulated Tg measurement in the follow-up of differentiated thyroid cancer (DTC). Aim of our study was to verify this possibility using two ultrasensitive Tg assays. We selected 215 DTC patients with undetectable (<1 ng/ml) basal serum Tg ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/7571
更新日期:2011-09-01 00:00:00
abstract::Thyroid-stimulating antibody (TSAb) activity and the TSH-binding inhibitory immunoglobulin (TBII) index were assessed in 158 patients with Graves' disease who had been treated with 131I 6-14 years earlier. Twenty-one patients (13%) were still hyperthyroid, 45 (28%) were euthyroid, 44 (28%) were subclinically hypothyro...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349039
更新日期:1996-11-01 00:00:00
abstract::The effects of growth hormone-releasing hormone (GHRH) were studied on densely granulated somatotroph adenoma cells and sparsely granulated somatotroph adenoma cells in culture by measuring release of growth hormone (GH) as well as ultrastructural morphometrical parameters and comparing them with those of control aden...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350727
更新日期:1989-07-01 00:00:00
abstract::The outcome of radioiodine therapy of Graves' hyperthyroidism was retrospectively evaluated in 274 consecutive patients treated from 1975 to 1984. At 1-yr follow-up, permanent hypothyroidism occurred in 36.9% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.3% after 7-10 yr. ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348615
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:In vitro islet expansion has recently drawn interest for its potential application in diabetes therapy, while how islet cells adapt to in vitro circumstances is not quite clear. AIM:Proteomics changes of cultivated islet cells under different conditions were examined in this study. MATERIAL/SUBJECTS AND ME...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/7275
更新日期:2011-12-01 00:00:00
abstract::Prolactin, growth hormone and thyroid stimulating hormone responses to thyrotropin releasing hormone (TRH) and metoclopramide were determined in 12 alcoholic men with biopsy proven liver disease and were compared to those of 8 age matched normal controls. All subjects were challenged with TRH (400 micrograms) and meto...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350515
更新日期:1982-09-01 00:00:00
abstract:: ...
journal_title:Journal of endocrinological investigation
pub_type: 历史文章,杂志文章
doi:10.1007/s40618-018-0896-y
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Thyroid hormone resistance (RTH β) is a rare genetic disorder characterized by an altered response of target tissue to the action of thyroid hormone. Few studies on RTH β have been carried out in southern European populations. We aimed to describe the clinical and genetic characteristics at the time of diagno...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-1007-4
更新日期:2019-08-01 00:00:00
abstract::Tumor-induced osteomalacia (TIO), also known as "oncogenic osteomalacia", is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to re...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-018-0849-5
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Neonatal hypothyroidism has serious effects on growth, development, and metabolism. AIM:This study aims to investigate the effects of the neonatal hypothyroidism on carbohydrate metabolism, islet insulin secretion and morphology of the pancreatic islets in adult male offspring. MATERIALS/SUBJECTS AND METHO...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8468
更新日期:2013-01-01 00:00:00
abstract::Metabolic diseases are associated with chronic low-grade inflammation, which has been indicated as a potential mediator of endothelial dysfunction and cardiovascular disease. Visceral adiposity is thought to be the starting condition of the inflammatory state through the release of inflammatory cytokines, including TN...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-018-0872-6
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The aim of the current study was to evaluate the association of osteoprotegerin and vascular endothelial growth factor (VEGF) with glycemic indices and diabetes status. METHODS:A total of 44 normoalbuminuric Type 1 diabetic patients and 44 healthy control subjects, matched for age, body mass index, sex rati...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347110
更新日期:2013-07-01 00:00:00
abstract::The 24-h profiles of plasma cortisol (F), 11-beta-hydroxyandrostenedione (11OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The data were submitted to a detailed quantitative analysis including the estimation o...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348129
更新日期:1987-06-01 00:00:00
abstract::The role of androgens in human sexuality as regards the mechanism of erection and the pathogenesis of impotence is under debate. In addition, it is difficult to define the psychosocial impact of both hypogonadism and androgen replacement. However, sexual hormones largely influence mood, well-being, and quality of life...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::Lipopolysaccharide (LPS)-induced inflammatory stress activates the hypothalamus-pituitary-adrenal (HPA) function. Interleukin-I (IL-1) is one of the key factors during this event; however, the mechanisms mediating IL-1 stimulation of HPA axis are still unclear. The present study evaluated the possible involvement of g...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349841
更新日期:1996-02-01 00:00:00
abstract::Dopamine agonists have been associated with increased risk of cardiac valve regurgitation in patients with Parkinson's disease. Whether these drugs might be harmful for patients with hyperprolactinemia is still unsettled. Occasional case reports and 7 studies on the relationship between cabergoline and cardiac valve r...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,meta分析,评审
doi:10.1007/BF03345662
更新日期:2008-12-01 00:00:00
abstract::The purpose of this study was to detect in vitro growth hormone (GH) and prolactin (PRL) secretion from adenomas clinically associated with GH or PRL hypersecretion. The reverse hemolytic plaque assay (RHPA) was applied in order to reveal possible differences among various morphologic adenoma types, and to examine the...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343628
更新日期:1999-10-01 00:00:00
abstract::Brain beta-endorphin (beta-EP) plays an important role in regulating the hypothalamus-pituitary-gonadal axis activity. Cerebrospinal fluid (CSF) beta-EP levels seem to reflect the central rather than pituitary secretion. With the aim to correlate the changes of plasma estradiol (E2), progesterone, luteinizing hormone ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349526
更新日期:1990-02-01 00:00:00
abstract::We hereby present a rare variant of multiple endocrine neoplasia type 2A (MEN2A) associated with a rare skin disease primary cutaneous lichen amyloidosis and discrete malignant pheochromocytoma in both adrenal glands and pancreatic tail, and interestingly accompanied ganglioneuroma located in retroperitoneum in a 34-y...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347557
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:We developed clinical practice guidelines to assess the individual risk-benefit profile of androgen replacement therapy in adult male hypogonadism (HG), defined by the presence of specific signs and symptoms and serum testosterone (T) below 12 nmol/L. PARTICIPANTS:The task force consisted of eight clinicians...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-014-0155-9
更新日期:2015-01-01 00:00:00