Abstract:
:In a 41-year-old hirsute woman, severe hypercalcemia led to the discovery of hyperparathyroidism related to the involvement (hyperplasia/or adenoma) of the 4 parathyroid glands. Plasma and urinary DHA, plasma DHA-sulfate and delta 5 steroid precursors were elevated. Steroid hormone hypersecretion was stimulated by hCG and ACTH, and exhibited a paradoxical rise during dexamethasone administration. Computerized tomography scanning as well as arteriography disclosed bilateral adrenal hyperplasia and left adrenal adenoma. Bilateral adrenal vein catheterization indicated a left/right gradient for delta 5 steroids and delta 5 steroid sulfates. At surgery a left brown adrenal encapsulated adenoma was removed with a hyperplastic adrenal gland. Results of in vitro studies (adrenal steroid content and incubation) together with postadrenalectomy hormonal results suggest that the left brown adrenal adenoma was the main source of excessive androgen production. The infrequent association of an androgen-producing adrenal adenoma with hyperparathyroidism raises the hypothesis of multiple endocrine neoplasia syndrome. However, evidence for this diagnosis is lacking in the absence of other glandular involvement and of family history.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Guillausseau PJ,Boitard C,Le Charpentier Y,Cedard L,Nahoul K,Blacker C,Kaloustian E,Courtalhac-Kaloustian F,Dubost C,Lubetzki Jdoi
10.1007/BF03347005subject
Has Abstractpub_date
1987-12-01 00:00:00pages
593-9issue
6eissn
0391-4097issn
1720-8386journal_volume
10pub_type
杂志文章abstract::Androgens' metabolism and activity are gaining a more and more important role in human physiology particularly referring to aging and to neurodegenerative diseases. Androgen treatment is often required for long-lasting disorders. In order to improve their duration and effects, androgens can be administered as esters o...
journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
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更新日期:1983-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,随机对照试验
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更新日期:2011-06-01 00:00:00
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更新日期:2016-12-01 00:00:00
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更新日期:1982-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
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更新日期:1998-07-01 00:00:00
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
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更新日期:1987-02-01 00:00:00
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