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The triglycerides and glucose index is associated with cardiovascular risk factors in metabolically obese normal-weight subjects.

Abstract：

PURPOSE:The aim of this study was to determine whether the triglycerides and glucose (TyG) index is associated with the presence of metabolically obese normal-weight (MONW) phenotype and related cardiovascular risk factors. METHODS:Apparently healthy men and non-pregnant women aged 20-65 years were enrolled in a population-based cross-sectional study. Overweight, obesity, smoking, alcohol consumption, pregnancy, diagnosis of hypertension, diabetes, cardiovascular disease, liver disease, renal disease, malignancy, and medical treatment were exclusion criteria. Subjects were allocated into the MONW or normal-weight groups. MONW phenotype was defined by normal weight and the presence of at least one of the following cardiovascular risk factors: elevated blood pressure, hyperglycemia, hypertriglyceridemia, and low HDL cholesterol. RESULTS:A total of 542 subjects were enrolled and allocated into the MONW (n = 354) and normal-weight (n = 188) groups. The adjusted logistic regression analysis showed that the elevated TyG index is significantly associated with the presence of MONW phenotype (OR = 11.14; 95% CI 6.04-20.57), hyperglycemia (OR = 3.18; 95% CI 1.95-5.21), hypertriglyceridemia (OR = 399.19; 95% CI 94.01-1694.98), and low HDL-C (OR = 2.60; 95% CI 1.74-3.87), but not with elevated blood pressure (OR = 1.55; 95% CI 0.93-2.60). CONCLUSION:Results of this study support that the TyG index may be a useful indicator to detect MONW phenotype and associated cardiovascular risk factors.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Morales-Gurrola G,Simental-Mendía LE,Castellanos-Juárez FX,Salas-Pacheco JM,Guerrero-Romero F

doi

10.1007/s40618-020-01184-x

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

995-1000

issue

7

eissn

0391-4097

issn

1720-8386

pii

10.1007/s40618-020-01184-x

journal_volume

43

pub_type

杂志文章

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