The effect of prednisone on serum thyrotropin, thyroxine and triiodothyronine concentrations in hypothyroid patients.

Abstract:

:The effect of exogenous prednisone on serum thyrotropin (TSH), thyroxine (T4), and triiodothyronine (T3) concentrations was investigated in four patients with non-functioning thyroid glands receiving T4 replacement therapy. Orally administered prednisone, in a dose of 20 mg each day for nine days, resulted in a significant decrease in mean serum TSH levels (p less than 0.01) without significant changes in levels of serum T4, T3, and thyroxine binding globulin (TBG). These findings suggest an inhibitory action of relatively low pharmacologic doses of prednisone on TSH release without changes in circulating thyroid hormone concentrations or inhibition of the peripheral conversion of T4 to T3.

journal_name

J Endocrinol Invest

authors

Jensen J,Nolan G,Jubiz W

doi

10.1007/BF03350367

keywords:

subject

Has Abstract

pub_date

1978-04-01 00:00:00

pages

171-3

issue

2

eissn

0391-4097

issn

1720-8386

journal_volume

1

pub_type

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