Abstract：
BACKGROUND:The Arnolfini portrait painted by Jan van Eyck in 1434 remains one of the most puzzling yet alluring paintings of prerenaissance western art. PURPOSE:The painting is renowned for its exactitude in brush strokes, textures and the distinctive morphology of the main character Arnolfini. The nature of these requires pathological consideration. METHODS:Diagnostic and pathological analysis of the painting. RESULTS:A number of pathological abnormalities are noted in the face of the main character including loss of outer third of the eyebrow (Sign of Hertoghe), bilateral ptosis and melasma of the forehead. These together support a diagnosis of hypothyroidism. CONCLUSIONS:This novel diagnosis offers an additional perspective to this enigmatic portrait, and can add to the comprehension of the method, origin and pathological associations of this prominent painting from a genius artist.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Ashrafian Hdoi
10.1007/s40618-017-0751-6subject
Has Abstractpub_date
2018-01-01 00:00:00pages
145-147issue
1eissn
0391-4097issn
1720-8386pii
10.1007/s40618-017-0751-6journal_volume
41pub_type
杂志文章abstract：:Thyrocytes from normal and goitrous portions of the thyroid gland from a patient with an enormous (635 gm) goiter were cultured in media, and their relative abilities to uptake thymidine, synthesize DNA, and secrete Tg and T4 were assessed. Tg, T4 and the ratio Tg/T4 in media at 72 h were 120 micrograms/dl, 1.6 microg...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348184
更新日期：1987-10-01 00:00:00
abstract：:Seventy years after the first successful radioiodine treatment of metastatic differentiated thyroid cancer (DTC), radioiodine (131I) therapy for this type of tumor is still without alternative. During the last decade, some key issues such as individual dosimetry, and preparation of 131I therapy by recombinant human TS...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：:Metabolic diseases are associated with chronic low-grade inflammation, which has been indicated as a potential mediator of endothelial dysfunction and cardiovascular disease. Visceral adiposity is thought to be the starting condition of the inflammatory state through the release of inflammatory cytokines, including TN...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-018-0872-6
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:Neuroendocrine dysfunction in polycystic ovary syndrome (PCOS) was addressed by studying the steroid hormone changes in women with PCOS with either high or normal LH levels leading to inferences regarding the primacy of elevated LH in the pathophysiology of PCOS. METHODS:A cross-sectional study was designed ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345319
更新日期：2005-11-01 00:00:00
abstract：:The aim of the study was to assess iodine status in over 3800 young male subjects aged 18, living in 6 different provinces of Piemonte and in Aosta Valley, Italy. A cross-sectional study on 3837 young male subjects undergoing medical evaluation preliminary to military enrolment was performed. Spot urine samples were o...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349155
更新日期：2003-12-01 00:00:00
abstract：:An abnormal regulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with risk factors for cardiovascular disease and Type 2 diabetes mellitus. The objective of this study was to examine if morning saliva cortisols show similar associations. Twenty-eight men, all 53 yr of age, delivered during an ordi...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347017
更新日期：2003-07-01 00:00:00
abstract：:Disulfide bonds are formed between the sulfhydryl groups in two cysteine residues of a protein. The formation of these bonds is necessary for the proper folding of a protein into its active three-dimensional form. In this study, the genes associated with disulfide bond formation of proteins from the rat thyroid cell l...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345141
更新日期：2003-02-01 00:00:00
abstract：:The effects of short term administration of 200 MRC U of synthetic salmon calcitonin (sCT) daily on carbohydrate metabolism were investigated in 10 patients with various bone diseases, 3 of whom had type II diabetes mellitus and 3 of whom had impaired glucose tolerance. Blood glucose levels during the nocturnal postab...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350629
更新日期：1985-02-01 00:00:00
abstract：:Thyroid diseases may lead to endothelial dysfunction; however, the mechanism underlying the endothelial dysfunction in thyroid disease is not clear yet. Asymmetric dimethylarginine (ADMA), a novel inhibitor of endothelial nitric oxide synthase (eNOS), blocks nitric oxide (NO) synthesis from L-arginine. Symmetric dimet...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347423
更新日期：2007-03-01 00:00:00
abstract：:Whole-body vibration is reported to increase muscle performance, bone mineral density and stimulate the secretion of lipolytic and protein anabolic hormones, such as GH and testosterone, that might be used for the treatment of obesity. To date, as no controlled trial has examined the effects of vibration exercise on t...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03351056
更新日期：2004-04-01 00:00:00
abstract：BACKGROUND:Hyperglycemia is a common, but not well-characterized side effect of glucocorticoid treatment. AIM:To study the effect of pulse dexamethasone treatment on carbohydrate metabolism among multiple myeloma patients. MATERIAL/SUBJECTS AND METHODS:A randomized crossover observational study in a teaching hospital...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40618-013-0027-8
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Adiponectin, a fat derived cytokine, is a potential independent contributor to bone mineral density (BMD); however, its action on bone metabolism in humans is still unclear. AIM:The aim of this study was to investigate the relationship of adiponectin with bone mass indices and bone metabolic markers in midd...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/7744
更新日期：2012-03-01 00:00:00
abstract：:During a systematic study of women with idiopathic galactorrhea, we observed several patients with normal random serum prolactin (PRL) levels and normal menses, but abnormal sellar tomograms characteristic of a pituitary adenoma. To test the hypothesis that these women might have intermittent PRL hypersecretion, we st...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348450
更新日期：1984-10-01 00:00:00
abstract：:Peroxisome proliferator activated receptor (PPAR)gamma plays a pivotal role in regulating adipocyte differentiation and metabolism, but also has an antiproliferative effect in several tissues, including colonic mucosa, where it is highly expressed. Loss-of-function mutations have been reported in about 10% of sporadic...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345249
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:The data about cardiovascular (CV) changes in patients with asymptomatic primary hyperparathyroidism (PHPT) are scarce. AIM:The aim of this study is to compare cardiac structure and functions in patients with asymptomatic PHPT and controls by using tissue Doppler echocardiography. SUBJECTS AND METHODS:Thir...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/8961
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Levothyroxine (L-T4) treatment aims to minimize the risk of differentiated thyroid cancer (DTC) recurrence and should be tailored to patient risk stratification and potential morbidity from adverse effects. AIM:To evaluate the effectiveness of current recommendations on L-T4 treatment of DTC patients in cli...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/8369
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Visfatin [pre-B cell colony- enhancing factor (PBEF)] is a cytokine highly expressed in visceral fat that exhibits insulin-mimetic properties. However, its role in insulin-resistant states, such as in metabolic syndrome (MetS), remains largely unknown. OBJECTIVE:To investigate the possible differences of pl...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346300
更新日期：2007-04-01 00:00:00
abstract：:Orbital fibroblasts exhibit a unique phenotype including exaggerated responses to proinflammatory cytokines. We hypothesize that the unusual susceptability of these fibroblasts to molecular cues underlies the involvement of the orbit in Graves' ophthalmopathy. A number of attributes of orbital fibroblasts are reviewed...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03345273
更新日期：2004-03-01 00:00:00
abstract：:Pheochromocytoma resection is often complicated by intra-operative hypertension and post-resection hypotension. Factors associated with these hemodynamic alterations are not well defined. The aim of this study was to analyse the clinical-laboratory features associated with hemodynamic parameters during pheochromocytom...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346458
更新日期：2009-03-01 00:00:00
abstract：AIM:The optimal GH regimen, in terms of cost-effectiveness, in children with normal GH immunoreactivity but reduced bioactivity is still debated. METHODS:In 12 GH-deficient (GHD) and 12 bioinactive GH children undergoing GH treatment we evaluated the increase in growth velocity, the difference between target height an...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347461
更新日期：2011-05-01 00:00:00
abstract：:Vitamin D via its receptor has essential actions on parathyroid cells, inhibiting PTH secretion, and parathyroid cell proliferation. While the effects of vitamin D depletion in the pathogenesis of secondary hyperparathyroidism in elderly individuals or in the occurrence of parathyroid hyperplasia in patients with rena...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2011-07-01 00:00:00
abstract：:Abnormalities of the gene encoding the sequence-specific DNA-binding protein, nuclear phosphorprotein p53, are among the most common genetic alterations observed in human cancers. A mutation of this tumor suppressor gene has been reported with a low prevalence in differentiated thyroid carcinomas, while the prevalence...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347774
更新日期：1994-11-01 00:00:00
abstract：:Antithyroid drugs may be proposed as the firstline therapy for hyperthyroidism due to Graves' disease since some patients undergo prolonged remission after drug withdrawal. On the other hand, some studies, though controversial, indicated that methimazole (MMI) has some immunomodulating activity. We retrospectively ana...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346433
更新日期：2008-10-01 00:00:00
abstract：:We hereby present a rare variant of multiple endocrine neoplasia type 2A (MEN2A) associated with a rare skin disease primary cutaneous lichen amyloidosis and discrete malignant pheochromocytoma in both adrenal glands and pancreatic tail, and interestingly accompanied ganglioneuroma located in retroperitoneum in a 34-y...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347557
更新日期：2005-09-01 00:00:00
abstract：:Nutritional and hormonal milieu in utero affect fetal growth. Both parties involved have an independent chance, for the occurrence of a developmental error at any stage of their constant developing system. Studies suggest that pregnancy outcome is associated with fetal demand for nutrients and the materno-placental ca...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03345248
更新日期：2003-09-01 00:00:00
abstract：PURPOSE:We did a meta-analysis with meta-regression to evaluate the relationship between hemoglobin A1c (A1C) reduction and the primary CV outcome of cardiovascular outcome trials (CVOTs). METHODS:We used a random effects meta-analysis of the 12 CVOTs to quantify the effect of A1C reduction on major cardiovascular eve...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,meta分析
doi：10.1007/s40618-019-01047-0
更新日期：2019-10-01 00:00:00
abstract：:The autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is caused by diverse mutations in one allele of the gene that encodes the arginine vasopressin (AVP) precursor protein, AVP-neurophysin II (AVP-NP II). Most of the mutations identified so far are located in either the signal peptide or NP II ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345549
更新日期：2006-03-01 00:00:00
abstract：:In vitro studies have shown that 1,25 dihydroxyvitamin D3 [1,25(OH)2D3] decreases cytokine production by monocytes and lymphocytes. In addition, intravenous or oral pulse calcitriol treatment suppresses interleukin 6 (IL6) and interleukin1beta (IL1beta) in hemodialysis patients. We studied the effect of a daily 12-wee...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章
doi：10.1007/BF03347358
更新日期：2003-08-01 00:00:00
abstract：:Osteoporosis is a multifactorial chronic disease that may become even more prevalent and more of a public health problem in the decades to come. Recent research has indicated that a number of macro- and micronutrients are involved in the development of bone health. In the past decade it became evident that vitamin K p...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:Insulin degradation in IM-9 cultured human lymphocytes occurs extracellularly. In the presence of 0.1% bovine serum albumin, insulin degradation products are formed that are soluble in 5% trichloroacetic acid. In the presence of 5% bovine serum albumin, the major products of insulin degradation are insoluble in 5% tri...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348223
更新日期：1980-01-01 00:00:00
